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Protein

Desmocollin-2

Gene

Dsc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmocollin-2
Alternative name(s):
Epithelial type 2 desmocollin
Gene namesi
Name:Dsc2
Synonyms:Dsc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:103221. Dsc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini136 – 694ExtracellularSequence analysisAdd BLAST559
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 902CytoplasmicSequence analysisAdd BLAST187

GO - Cellular componenti

  • cell-cell adherens junction Source: MGI
  • cytoplasmic vesicle Source: MGI
  • desmosome Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intercalated disc Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000000387128 – 135Sequence analysisAdd BLAST108
ChainiPRO_0000003872136 – 902Desmocollin-2Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi629N-linked (GlcNAc...)Sequence analysis1
Modified residuei865PhosphoserineBy similarity1
Modified residuei869PhosphoserineBy similarity1
Modified residuei874PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP55292.
PaxDbiP55292.
PeptideAtlasiP55292.
PRIDEiP55292.

PTM databases

iPTMnetiP55292.
PhosphoSitePlusiP55292.

Expressioni

Tissue specificityi

In all epithelia tested and heart.

Gene expression databases

BgeeiENSMUSG00000024331.
CleanExiMM_DSC2.
MM_DSC3.
ExpressionAtlasiP55292. baseline and differential.
GenevisibleiP55292. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042905.

Structurei

3D structure databases

ProteinModelPortaliP55292.
SMRiP55292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 243Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini244 – 355Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini356 – 471Cadherin 3PROSITE-ProRule annotationAdd BLAST116
Domaini472 – 579Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Domaini580 – 694Cadherin 5PROSITE-ProRule annotationAdd BLAST115

Domaini

Calcium may be bound by the cadherin-like repeats.Curated
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231253.
HOVERGENiHBG102801.
InParanoidiP55292.
KOiK07601.
OMAiKIKVQDM.
OrthoDBiEOG091G01IB.
PhylomeDBiP55292.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2A (identifier: P55292-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVGSMRSG SPAFGLGHLL TLAILALASD ACKEVVLQVP SELPAEKFVG
60 70 80 90 100
RVNLMDCLKS ADIVHLSDPD FQVLEDGSVY TTSSVVLSSG QRSFTIWLFS
110 120 130 140 150
TDSQEEREIS VHLEGPVEVL NKRPHTEKVL SRAKRRWAPI PCSMLENSLG
160 170 180 190 200
PFPLFLQQIQ SDTAQNYTIY YSIRGPGVDK EPLNLFYVER DTGNLYCTGR
210 220 230 240 250
VDREQYESFE LTAFATTPDG YTPEYPLPLL IKIEDENDNY PIFTQKLYSF
260 270 280 290 300
TVQENSRIGS IVGEVCATDL DEPDTMHTRL RYSILEQSPS PPMLFTMHPS
310 320 330 340 350
TGVITTTSAQ LDRELIDKYQ LLIKVQDMDG QYFGLHTTAK CIITIEDVND
360 370 380 390 400
NLPTFTRTTY VTSVEENTVN VEILRLTVQD KDLVNSPNWR ANYTILKGNE
410 420 430 440 450
NGNFKIVTDP KTNEGILCVI KPLDYEERQQ VTLQIGVVNE APYTREASSK
460 470 480 490 500
SPMSTATVTV TVTNQDEGPE CIPPMQTVRI QENVPVGTRN DGYKAYDPET
510 520 530 540 550
RSSSGIRYRK LSDPRGWVTV NEDSGSITIF RALDREAETV RNGIYNITVL
560 570 580 590 600
ALDADGRSCT GTLGIILEDV NDNGPFIPKQ TVVICKATMS SAEIVAVDLD
610 620 630 640 650
DPVNGPPFDF SLESSDSEVQ RMWRLTRIND TAARLSYQND PSFGSYAVPI
660 670 680 690 700
RVTDRLGLSS VTTLNVLVCD CITESDCTLR SGERTGYADV RLGPWAILAI
710 720 730 740 750
LLGIALLFCI LFTLVCSVSR ASKQQKILPD DLAQQNLIVS NTEAPGDDKV
760 770 780 790 800
YSTNGLTTQT MGASGQTAFT TMGTGVKSGG QETIEMVKGG QQTLDSRRGA
810 820 830 840 850
GYHHHTLDPC RGGHVEVDNY RHTYSEWYNF IQPRLGDKVQ FCHTDDNQKL
860 870 880 890 900
AQDYVLTYNY EGKGSAAGSV GCCSDLQEED GLEFLDHLEP KFRTLAEVCA

KR
Length:902
Mass (Da):99,961
Last modified:October 1, 1996 - v1
Checksum:iE233F8CB20ACCAB0
GO
Isoform 2B (identifier: P55292-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     838-848: KVQFCHTDDNQ → ETIRGHTLIKN
     849-902: Missing.

Show »
Length:848
Mass (Da):93,957
Checksum:iCC89EA19BE0A3ECF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000659838 – 848KVQFCHTDDNQ → ETIRGHTLIKN in isoform 2B. CuratedAdd BLAST11
Alternative sequenceiVSP_000660849 – 902Missing in isoform 2B. CuratedAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33779 mRNA. Translation: AAA79177.1.
L33779 mRNA. Translation: AAA79176.1.
X73885 mRNA. Translation: CAA52089.1.
CCDSiCCDS29077.1. [P55292-2]
PIRiA54742.
RefSeqiNP_001304294.1. NM_001317365.1. [P55292-1]
NP_038533.1. NM_013505.4. [P55292-2]
UniGeneiMm.280547.

Genome annotation databases

EnsembliENSMUST00000039247; ENSMUSP00000042905; ENSMUSG00000024331. [P55292-2]
ENSMUST00000075214; ENSMUSP00000074702; ENSMUSG00000024331. [P55292-1]
GeneIDi13506.
KEGGimmu:13506.
UCSCiuc008eec.1. mouse. [P55292-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33779 mRNA. Translation: AAA79177.1.
L33779 mRNA. Translation: AAA79176.1.
X73885 mRNA. Translation: CAA52089.1.
CCDSiCCDS29077.1. [P55292-2]
PIRiA54742.
RefSeqiNP_001304294.1. NM_001317365.1. [P55292-1]
NP_038533.1. NM_013505.4. [P55292-2]
UniGeneiMm.280547.

3D structure databases

ProteinModelPortaliP55292.
SMRiP55292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042905.

PTM databases

iPTMnetiP55292.
PhosphoSitePlusiP55292.

Proteomic databases

MaxQBiP55292.
PaxDbiP55292.
PeptideAtlasiP55292.
PRIDEiP55292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039247; ENSMUSP00000042905; ENSMUSG00000024331. [P55292-2]
ENSMUST00000075214; ENSMUSP00000074702; ENSMUSG00000024331. [P55292-1]
GeneIDi13506.
KEGGimmu:13506.
UCSCiuc008eec.1. mouse. [P55292-1]

Organism-specific databases

CTDi1824.
MGIiMGI:103221. Dsc2.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231253.
HOVERGENiHBG102801.
InParanoidiP55292.
KOiK07601.
OMAiKIKVQDM.
OrthoDBiEOG091G01IB.
PhylomeDBiP55292.
TreeFamiTF316817.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiP55292.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024331.
CleanExiMM_DSC2.
MM_DSC3.
ExpressionAtlasiP55292. baseline and differential.
GenevisibleiP55292. MM.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 2 hits.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSC2_MOUSE
AccessioniPrimary (citable) accession number: P55292
Secondary accession number(s): Q64734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.