P55289 (CAD12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-12

Alternative name(s):
Brain cadherin
Short name=BR-cadherin
Neural type cadherin 2
Short name=N-cadherin 2

Gene names

Name:

CDH12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	794 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Brain.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adherens junction organization Traceable author statement. Source: Reactome cell junction assembly Traceable author statement. Source: Reactome homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 54	31	Potential		PRO_0000003791
	Chain	55 – 794	740	Cadherin-12		PRO_0000003792
Regions
	Topological domain	55 – 609	555	Extracellular Potential
	Transmembrane	610 – 637	28	Helical; Potential
	Topological domain	638 – 794	157	Cytoplasmic Potential
	Domain	55 – 160	106	Cadherin 1
	Domain	161 – 269	109	Cadherin 2
	Domain	270 – 384	115	Cadherin 3
	Domain	385 – 487	103	Cadherin 4
	Domain	488 – 609	122	Cadherin 5
Amino acid modifications
	Glycosylation	256	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Glycosylation	537	1	N-linked (GlcNAc...) Potential
	Glycosylation	545	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	68	1	V → M. Ref.2 Corresponds to variant rs4371716 [ dbSNP | Ensembl ].		VAR_048505
	Natural variant	86	1	E → K. Corresponds to variant rs7236 [ dbSNP | Ensembl ].		VAR_014917
	Natural variant	284	1	I → V. Corresponds to variant rs17328673 [ dbSNP | Ensembl ].		VAR_048506
	Natural variant	475	1	I → T. Corresponds to variant rs12108814 [ dbSNP | Ensembl ].		VAR_048507
Experimental info
	Sequence conflict	349	1	E → D in AAB48539. Ref.2
	Sequence conflict	416	1	S → G in AAA35623. Ref.1
	Sequence conflict	644	1	D → H in AAA35623. Ref.1
	Sequence conflict	733	1	Y → I in AAA35623. Ref.1
	Sequence conflict	761	1	A → T in AAB48539. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P55289 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 76DF39AB56E7BC2D	FASTA	794	88,332
	10 20 30 40 50 60 MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ 70 80 90 100 110 120 FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE 130 140 150 160 170 180 EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL 190 200 210 220 230 240 QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK 250 260 270 280 290 300 DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 310 320 330 340 350 360 NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH 370 380 390 400 410 420 SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY 430 440 450 460 470 480 FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL 490 500 510 520 530 540 DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV 550 560 570 580 590 600 RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 610 620 630 640 650 660 CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY 670 680 690 700 710 720 DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR 730 740 750 760 770 780 LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD 790 MFGEEESYNP DKVT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene." Selig S., Bruno S., Scharf J.M., Wang C.H., Vitale E., Gilliam T.C., Kunkel L.M. Proc. Natl. Acad. Sci. U.S.A. 92:3702-3706(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-68. Tissue: Brain cortex.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34057 mRNA. Translation: AAA35623.1. L33477 mRNA. Translation: AAB48539.1. AK314800 mRNA. Translation: BAG37328.1. CH471118 Genomic DNA. Translation: EAX10736.1. BC047608 mRNA. Translation: AAH47608.1.
IPI	IPI00296942.
PIR	I59372.
RefSeq	NP_004052.2. NM_004061.3.
UniGene	Hs.113684.
3D structure databases
ProteinModelPortal	P55289.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55289. 1 interaction.
STRING	9606.ENSP00000284308.
PTM databases
PhosphoSite	P55289.
Polymorphism databases
DMDM	158937438.
Proteomic databases
PaxDb	P55289.
PRIDE	P55289.
Protocols and materials databases
DNASU	1010.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382254; ENSP00000371689; ENSG00000154162. ENST00000504376; ENSP00000423577; ENSG00000154162.
GeneID	1010.
KEGG	hsa:1010.
UCSC	uc003jgk.2. human.
Organism-specific databases
CTD	1010.
GeneCards	GC05M021786.
H-InvDB	HIX0164254. HIX0164262. HIX0164263.
HGNC	HGNC:1751. CDH12.
HPA	HPA029325.
MIM	600562. gene.
neXtProt	NX_P55289.
PharmGKB	PA26285.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG236183.
HOGENOM	HOG000231252.
HOVERGEN	HBG005217.
InParanoid	P55289.
KO	K06804.
OMA	KPNFTVH.
PhylomeDB	P55289.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	P55289.
Bgee	P55289.
CleanEx	HS_CDH12.
Genevestigator	P55289.
GermOnline	ENSG00000154162. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDH12. human.
GenomeRNAi	1010.
NextBio	4246.
SOURCE	Search...

Entry information

Entry name

CAD12_HUMAN

Accession

Primary (citable) accession number: P55289
Secondary accession number(s): B2RBT1, Q86UD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 21, 2007
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.