Reviewed,
UniProtKB/Swiss-Prot P55289 (CAD12_HUMAN)
Last modified
June 16, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cadherin-12 Alternative name(s): Brain cadherin Short name=BR-cadherin Neural type cadherin 2 Short name=N-cadherin 2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 794 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Subcellular location | |
| Tissue specificity | Brain. |
| Sequence similarities | Contains 5 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | homophilic cell adhesion Non-traceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||
| Propeptide | 24 – 54 | 31 | Potential | PRO_0000003791 | |||||
| Chain | 55 – 794 | 740 | Cadherin-12 | PRO_0000003792 | |||||
Regions | |||||||||
| Topological domain | 55 – 609 | 555 | Extracellular Potential | ||||||
| Transmembrane | 610 – 637 | 28 | Potential | ||||||
| Topological domain | 638 – 794 | 157 | Cytoplasmic Potential | ||||||
| Domain | 55 – 160 | 106 | Cadherin 1 | ||||||
| Domain | 161 – 269 | 109 | Cadherin 2 | ||||||
| Domain | 270 – 384 | 115 | Cadherin 3 | ||||||
| Domain | 385 – 487 | 103 | Cadherin 4 | ||||||
| Domain | 488 – 609 | 122 | Cadherin 5 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 286 | 1 | Phosphoserine Ref.6 | ||||||
| Glycosylation | 256 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 456 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 537 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 545 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 68 | 1 | V → M: dbSNP rs4371716. Ref.2 | VAR_048505 | |||||
| Natural variant | 86 | 1 | E → K: dbSNP rs7236. | VAR_014917 | |||||
| Natural variant | 284 | 1 | I → V: dbSNP rs17328673. | VAR_048506 | |||||
| Natural variant | 475 | 1 | I → T: dbSNP rs12108814. | VAR_048507 | |||||
Experimental info | |||||||||
| Sequence conflict | 349 | 1 | E → D in AAB48539. Ref.2 | ||||||
| Sequence conflict | 416 | 1 | S → G in AAA35623. Ref.1 | ||||||
| Sequence conflict | 644 | 1 | D → H in AAA35623. Ref.1 | ||||||
| Sequence conflict | 733 | 1 | Y → I in AAA35623. Ref.1 | ||||||
| Sequence conflict | 761 | 1 | A → T in AAB48539. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed: 7982033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene." Selig S., Bruno S., Scharf J.M., Wang C.H., Vitale E., Gilliam T.C., Kunkel L.M. Proc. Natl. Acad. Sci. U.S.A. 92:3702-3706(1995) [PubMed: 7731968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-68. Tissue: Brain cortex. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286, MASS SPECTROMETRY. Tissue: Epithelium. |
Cross-references
Sequence databases | |
|---|---|
| L34057 mRNA. Translation: AAA35623.1. L33477 mRNA. Translation: AAB48539.1. AK314800 mRNA. Translation: BAG37328.1. CH471118 Genomic DNA. Translation: EAX10736.1. BC047608 mRNA. Translation: AAH47608.1. | |
| IPI | IPI00296942. |
| PIR | I59372. |
| RefSeq | NP_004052.2. |
| UniGene | Hs.113684 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1I7W based on UniProtKB P09803. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P55289. |
Genome annotation databases | |
| Ensembl | ENSG00000154162. Homo sapiens. [Contig view] |
| GeneID | 1010. |
| KEGG | hsa:1010. |
Organism-specific databases | |
| GeneCards | GC05M021786. |
| H-InvDB | HIX0032687. HIX0057563. HIX0057564. HIX0057700. HIX0058607. |
| HGNC | HGNC:1751. CDH12. |
| MIM | 600562. gene. |
| PharmGKB | PA26285. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P55289. |
| HOVERGEN | P55289. |
| OMA | P55289. FGQNAEI. |
Gene expression databases | |
| ArrayExpress | P55289. |
| Bgee | P55289. |
| CleanEx | HS_CDH12. |
| GermOnline | ENSG00000154162. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR000233. Cadherin_C_term. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 2 hits. |
| Pfam | PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| PROSITE | PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 4246. |
| SOURCE | Search... |
Entry information
| Entry name | CAD12_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P55289 Secondary accession number(s): B2RBT1, Q86UD2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


