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P55289

- CAD12_HUMAN

UniProt

P55289 - CAD12_HUMAN

Protein

Cadherin-12

Gene

CDH12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. cell-cell junction organization Source: Reactome
    3. cell junction assembly Source: Reactome
    4. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-12
    Alternative name(s):
    Brain cadherin
    Short name:
    BR-cadherin
    Neural type cadherin 2
    Short name:
    N-cadherin 2
    Gene namesi
    Name:CDH12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1751. CDH12.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26285.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 5431Sequence AnalysisPRO_0000003791Add
    BLAST
    Chaini55 – 794740Cadherin-12PRO_0000003792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiP55289.
    PRIDEiP55289.

    PTM databases

    PhosphoSiteiP55289.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    ArrayExpressiP55289.
    BgeeiP55289.
    CleanExiHS_CDH12.
    GenevestigatoriP55289.

    Organism-specific databases

    HPAiHPA029325.

    Interactioni

    Protein-protein interaction databases

    IntActiP55289. 1 interaction.
    STRINGi9606.ENSP00000284308.

    Structurei

    3D structure databases

    ProteinModelPortaliP55289.
    SMRiP55289. Positions 55-590, 690-783.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini55 – 609555ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini638 – 794157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei610 – 63728HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 160106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 269109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini270 – 384115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 487103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini488 – 609122Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG236183.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiP55289.
    KOiK06804.
    OMAiEMSPVGA.
    OrthoDBiEOG7GBFW7.
    PhylomeDBiP55289.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55289-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ    50
    RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT 100
    VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV 150
    QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY 200
    SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA 250
    GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 300
    NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA 350
    SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG 400
    TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE 450
    STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN 500
    AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI 550
    ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 600
    CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK 650
    EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL 700
    PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES 750
    LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT 794
    Length:794
    Mass (Da):88,332
    Last modified:August 21, 2007 - v2
    Checksum:i76DF39AB56E7BC2D
    GO
    Isoform 2 (identifier: P55289-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         176-215: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:754
    Mass (Da):84,001
    Checksum:i88AF2E3E7AB59C91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti349 – 3491E → D in AAB48539. (PubMed:7731968)Curated
    Sequence conflicti416 – 4161S → G in AAA35623. (PubMed:7982033)Curated
    Sequence conflicti644 – 6441D → H in AAA35623. (PubMed:7982033)Curated
    Sequence conflicti733 – 7331Y → I in AAA35623. (PubMed:7982033)Curated
    Sequence conflicti761 – 7611A → T in AAB48539. (PubMed:7731968)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681V → M.1 Publication
    Corresponds to variant rs4371716 [ dbSNP | Ensembl ].
    VAR_048505
    Natural varianti86 – 861E → K.
    Corresponds to variant rs7236 [ dbSNP | Ensembl ].
    VAR_014917
    Natural varianti284 – 2841I → V.
    Corresponds to variant rs17328673 [ dbSNP | Ensembl ].
    VAR_048506
    Natural varianti475 – 4751I → T.
    Corresponds to variant rs12108814 [ dbSNP | Ensembl ].
    VAR_048507

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei176 – 21540Missing in isoform 2. 1 PublicationVSP_056449Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34057 mRNA. Translation: AAA35623.1.
    L33477 mRNA. Translation: AAB48539.1.
    AK295123 mRNA. Translation: BAH11982.1.
    AK314800 mRNA. Translation: BAG37328.1.
    AC022139 Genomic DNA. No translation available.
    AC026716 Genomic DNA. No translation available.
    AC034239 Genomic DNA. No translation available.
    AC091938 Genomic DNA. No translation available.
    AC093263 Genomic DNA. No translation available.
    AC108089 Genomic DNA. No translation available.
    AC109455 Genomic DNA. No translation available.
    AC138854 Genomic DNA. No translation available.
    AC138940 Genomic DNA. No translation available.
    AC139497 Genomic DNA. No translation available.
    AC140132 Genomic DNA. No translation available.
    AC140171 Genomic DNA. No translation available.
    CH471118 Genomic DNA. Translation: EAX10736.1.
    BC047608 mRNA. Translation: AAH47608.1.
    CCDSiCCDS3890.1.
    PIRiI59372.
    RefSeqiNP_004052.2. NM_004061.3.
    UniGeneiHs.113684.

    Genome annotation databases

    EnsembliENST00000382254; ENSP00000371689; ENSG00000154162.
    ENST00000504376; ENSP00000423577; ENSG00000154162.
    ENST00000522262; ENSP00000428786; ENSG00000154162.
    GeneIDi1010.
    KEGGihsa:1010.
    UCSCiuc003jgk.2. human.

    Polymorphism databases

    DMDMi158937438.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34057 mRNA. Translation: AAA35623.1 .
    L33477 mRNA. Translation: AAB48539.1 .
    AK295123 mRNA. Translation: BAH11982.1 .
    AK314800 mRNA. Translation: BAG37328.1 .
    AC022139 Genomic DNA. No translation available.
    AC026716 Genomic DNA. No translation available.
    AC034239 Genomic DNA. No translation available.
    AC091938 Genomic DNA. No translation available.
    AC093263 Genomic DNA. No translation available.
    AC108089 Genomic DNA. No translation available.
    AC109455 Genomic DNA. No translation available.
    AC138854 Genomic DNA. No translation available.
    AC138940 Genomic DNA. No translation available.
    AC139497 Genomic DNA. No translation available.
    AC140132 Genomic DNA. No translation available.
    AC140171 Genomic DNA. No translation available.
    CH471118 Genomic DNA. Translation: EAX10736.1 .
    BC047608 mRNA. Translation: AAH47608.1 .
    CCDSi CCDS3890.1.
    PIRi I59372.
    RefSeqi NP_004052.2. NM_004061.3.
    UniGenei Hs.113684.

    3D structure databases

    ProteinModelPortali P55289.
    SMRi P55289. Positions 55-590, 690-783.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P55289. 1 interaction.
    STRINGi 9606.ENSP00000284308.

    PTM databases

    PhosphoSitei P55289.

    Polymorphism databases

    DMDMi 158937438.

    Proteomic databases

    PaxDbi P55289.
    PRIDEi P55289.

    Protocols and materials databases

    DNASUi 1010.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382254 ; ENSP00000371689 ; ENSG00000154162 .
    ENST00000504376 ; ENSP00000423577 ; ENSG00000154162 .
    ENST00000522262 ; ENSP00000428786 ; ENSG00000154162 .
    GeneIDi 1010.
    KEGGi hsa:1010.
    UCSCi uc003jgk.2. human.

    Organism-specific databases

    CTDi 1010.
    GeneCardsi GC05M021786.
    H-InvDB HIX0164254.
    HIX0164262.
    HIX0164263.
    HGNCi HGNC:1751. CDH12.
    HPAi HPA029325.
    MIMi 600562. gene.
    neXtProti NX_P55289.
    PharmGKBi PA26285.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG236183.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi P55289.
    KOi K06804.
    OMAi EMSPVGA.
    OrthoDBi EOG7GBFW7.
    PhylomeDBi P55289.
    TreeFami TF329887.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    ChiTaRSi CDH12. human.
    GeneWikii CDH12.
    GenomeRNAii 1010.
    NextBioi 4246.
    PROi P55289.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55289.
    Bgeei P55289.
    CleanExi HS_CDH12.
    Genevestigatori P55289.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
      Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
      Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene."
      Selig S., Bruno S., Scharf J.M., Wang C.H., Vitale E., Gilliam T.C., Kunkel L.M.
      Proc. Natl. Acad. Sci. U.S.A. 92:3702-3706(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-68.
      Tissue: Brain cortex.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCAD12_HUMAN
    AccessioniPrimary (citable) accession number: P55289
    Secondary accession number(s): B2RBT1, B7Z2U6, Q86UD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3