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P55289

- CAD12_HUMAN

UniProt

P55289 - CAD12_HUMAN

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Protein
Cadherin-12
Gene
CDH12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. cell junction assembly Source: Reactome
  3. cell-cell junction organization Source: Reactome
  4. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-12
Alternative name(s):
Brain cadherin
Short name:
BR-cadherin
Neural type cadherin 2
Short name:
N-cadherin 2
Gene namesi
Name:CDH12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1751. CDH12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 609555Extracellular Reviewed prediction
Add
BLAST
Transmembranei610 – 63728Helical; Reviewed prediction
Add
BLAST
Topological domaini638 – 794157Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 5431 Reviewed prediction
PRO_0000003791Add
BLAST
Chaini55 – 794740Cadherin-12
PRO_0000003792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi537 – 5371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiP55289.
PRIDEiP55289.

PTM databases

PhosphoSiteiP55289.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

ArrayExpressiP55289.
BgeeiP55289.
CleanExiHS_CDH12.
GenevestigatoriP55289.

Organism-specific databases

HPAiHPA029325.

Interactioni

Protein-protein interaction databases

IntActiP55289. 1 interaction.
STRINGi9606.ENSP00000284308.

Structurei

3D structure databases

ProteinModelPortaliP55289.
SMRiP55289. Positions 55-590, 690-783.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 160106Cadherin 1
Add
BLAST
Domaini161 – 269109Cadherin 2
Add
BLAST
Domaini270 – 384115Cadherin 3
Add
BLAST
Domaini385 – 487103Cadherin 4
Add
BLAST
Domaini488 – 609122Cadherin 5
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236183.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55289.
KOiK06804.
OMAiEMSPVGA.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55289.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55289-1 [UniParc]FASTAAdd to Basket

« Hide

MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ    50
RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT 100
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV 150
QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY 200
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA 250
GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 300
NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA 350
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG 400
TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE 450
STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN 500
AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI 550
ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 600
CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK 650
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL 700
PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES 750
LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT 794
Length:794
Mass (Da):88,332
Last modified:August 21, 2007 - v2
Checksum:i76DF39AB56E7BC2D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681V → M.1 Publication
Corresponds to variant rs4371716 [ dbSNP | Ensembl ].
VAR_048505
Natural varianti86 – 861E → K.
Corresponds to variant rs7236 [ dbSNP | Ensembl ].
VAR_014917
Natural varianti284 – 2841I → V.
Corresponds to variant rs17328673 [ dbSNP | Ensembl ].
VAR_048506
Natural varianti475 – 4751I → T.
Corresponds to variant rs12108814 [ dbSNP | Ensembl ].
VAR_048507

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti349 – 3491E → D in AAB48539. 1 Publication
Sequence conflicti416 – 4161S → G in AAA35623. 1 Publication
Sequence conflicti644 – 6441D → H in AAA35623. 1 Publication
Sequence conflicti733 – 7331Y → I in AAA35623. 1 Publication
Sequence conflicti761 – 7611A → T in AAB48539. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34057 mRNA. Translation: AAA35623.1.
L33477 mRNA. Translation: AAB48539.1.
AK314800 mRNA. Translation: BAG37328.1.
CH471118 Genomic DNA. Translation: EAX10736.1.
BC047608 mRNA. Translation: AAH47608.1.
CCDSiCCDS3890.1.
PIRiI59372.
RefSeqiNP_004052.2. NM_004061.3.
UniGeneiHs.113684.

Genome annotation databases

EnsembliENST00000382254; ENSP00000371689; ENSG00000154162.
ENST00000504376; ENSP00000423577; ENSG00000154162.
GeneIDi1010.
KEGGihsa:1010.
UCSCiuc003jgk.2. human.

Polymorphism databases

DMDMi158937438.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34057 mRNA. Translation: AAA35623.1 .
L33477 mRNA. Translation: AAB48539.1 .
AK314800 mRNA. Translation: BAG37328.1 .
CH471118 Genomic DNA. Translation: EAX10736.1 .
BC047608 mRNA. Translation: AAH47608.1 .
CCDSi CCDS3890.1.
PIRi I59372.
RefSeqi NP_004052.2. NM_004061.3.
UniGenei Hs.113684.

3D structure databases

ProteinModelPortali P55289.
SMRi P55289. Positions 55-590, 690-783.
ModBasei Search...

Protein-protein interaction databases

IntActi P55289. 1 interaction.
STRINGi 9606.ENSP00000284308.

PTM databases

PhosphoSitei P55289.

Polymorphism databases

DMDMi 158937438.

Proteomic databases

PaxDbi P55289.
PRIDEi P55289.

Protocols and materials databases

DNASUi 1010.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382254 ; ENSP00000371689 ; ENSG00000154162 .
ENST00000504376 ; ENSP00000423577 ; ENSG00000154162 .
GeneIDi 1010.
KEGGi hsa:1010.
UCSCi uc003jgk.2. human.

Organism-specific databases

CTDi 1010.
GeneCardsi GC05M021786.
H-InvDBi HIX0164254.
HIX0164262.
HIX0164263.
HGNCi HGNC:1751. CDH12.
HPAi HPA029325.
MIMi 600562. gene.
neXtProti NX_P55289.
PharmGKBi PA26285.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG236183.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P55289.
KOi K06804.
OMAi EMSPVGA.
OrthoDBi EOG7GBFW7.
PhylomeDBi P55289.
TreeFami TF329887.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSi CDH12. human.
GeneWikii CDH12.
GenomeRNAii 1010.
NextBioi 4246.
PROi P55289.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55289.
Bgeei P55289.
CleanExi HS_CDH12.
Genevestigatori P55289.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
    Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
    Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene."
    Selig S., Bruno S., Scharf J.M., Wang C.H., Vitale E., Gilliam T.C., Kunkel L.M.
    Proc. Natl. Acad. Sci. U.S.A. 92:3702-3706(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-68.
    Tissue: Brain cortex.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCAD12_HUMAN
AccessioniPrimary (citable) accession number: P55289
Secondary accession number(s): B2RBT1, Q86UD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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