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Protein

Cadherin-12

Gene

CDH12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-12
Alternative name(s):
Brain cadherin
Short name:
BR-cadherin
Neural type cadherin 2
Short name:
N-cadherin 2
Gene namesi
Name:CDH12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1751. CDH12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 609555ExtracellularSequence AnalysisAdd
BLAST
Transmembranei610 – 63728HelicalSequence AnalysisAdd
BLAST
Topological domaini638 – 794157CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26285.

Polymorphism and mutation databases

BioMutaiCDH12.
DMDMi158937438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 5431Sequence AnalysisPRO_0000003791Add
BLAST
Chaini55 – 794740Cadherin-12PRO_0000003792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Modified residuei787 – 7871PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP55289.
PRIDEiP55289.

PTM databases

PhosphoSiteiP55289.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP55289.
CleanExiHS_CDH12.
GenevisibleiP55289. HS.

Organism-specific databases

HPAiHPA029325.

Interactioni

Protein-protein interaction databases

BioGridi107445. 1 interaction.
IntActiP55289. 1 interaction.
STRINGi9606.ENSP00000371689.

Structurei

3D structure databases

ProteinModelPortaliP55289.
SMRiP55289. Positions 55-590, 690-783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 160106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 269109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 384115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 487103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini488 – 609122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG236183.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55289.
KOiK06804.
OMAiEMSPVGA.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55289.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ
60 70 80 90 100
RVKRGWVWNQ FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT
110 120 130 140 150
VFTIDETTGD IHAIRSLDRE EKPFYTLRAQ AVDIETRKPL EPESEFIIKV
160 170 180 190 200
QDINDNEPKF LDGPYVATVP EMSPVGAYVL QVKATDADDP TYGNSARVVY
210 220 230 240 250
SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK DMGGQLGGLA
260 270 280 290 300
GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ
310 320 330 340 350
NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA
360 370 380 390 400
SNLHLDHRFH SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG
410 420 430 440 450
TIIGAVTAQD LDVGSSAVRY FIDWKSDGDS YFTIDGNEGT IATNELLDRE
460 470 480 490 500
STAQYNFSII ASKVSNPLLT SKVNILINVL DVNEFPPEIS VPYETAVCEN
510 520 530 540 550
AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV RDFRNNTAGI
560 570 580 590 600
ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS
610 620 630 640 650
CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK
660 670 680 690 700
EDIRDNVIHY DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL
710 720 730 740 750
PRQRPPMEDN TDIRDFIHQR LQENDVDPTA PPYDSLATYA YEGSGSVAES
760 770 780 790
LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD MFGEEESYNP DKVT
Length:794
Mass (Da):88,332
Last modified:August 21, 2007 - v2
Checksum:i76DF39AB56E7BC2D
GO
Isoform 2 (identifier: P55289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-215: Missing.

Note: No experimental confirmation available.
Show »
Length:754
Mass (Da):84,001
Checksum:i88AF2E3E7AB59C91
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti349 – 3491E → D in AAB48539 (PubMed:7731968).Curated
Sequence conflicti416 – 4161S → G in AAA35623 (PubMed:7982033).Curated
Sequence conflicti644 – 6441D → H in AAA35623 (PubMed:7982033).Curated
Sequence conflicti733 – 7331Y → I in AAA35623 (PubMed:7982033).Curated
Sequence conflicti761 – 7611A → T in AAB48539 (PubMed:7731968).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681V → M.1 Publication
Corresponds to variant rs4371716 [ dbSNP | Ensembl ].
VAR_048505
Natural varianti86 – 861E → K.
Corresponds to variant rs7236 [ dbSNP | Ensembl ].
VAR_014917
Natural varianti284 – 2841I → V.
Corresponds to variant rs17328673 [ dbSNP | Ensembl ].
VAR_048506
Natural varianti475 – 4751I → T.
Corresponds to variant rs12108814 [ dbSNP | Ensembl ].
VAR_048507

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 21540Missing in isoform 2. 1 PublicationVSP_056449Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34057 mRNA. Translation: AAA35623.1.
L33477 mRNA. Translation: AAB48539.1.
AK295123 mRNA. Translation: BAH11982.1.
AK314800 mRNA. Translation: BAG37328.1.
AC022139 Genomic DNA. No translation available.
AC026716 Genomic DNA. No translation available.
AC034239 Genomic DNA. No translation available.
AC091938 Genomic DNA. No translation available.
AC093263 Genomic DNA. No translation available.
AC108089 Genomic DNA. No translation available.
AC109455 Genomic DNA. No translation available.
AC138854 Genomic DNA. No translation available.
AC138940 Genomic DNA. No translation available.
AC139497 Genomic DNA. No translation available.
AC140132 Genomic DNA. No translation available.
AC140171 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10736.1.
BC047608 mRNA. Translation: AAH47608.1.
CCDSiCCDS3890.1. [P55289-1]
PIRiI59372.
RefSeqiNP_004052.2. NM_004061.3. [P55289-1]
UniGeneiHs.113684.

Genome annotation databases

EnsembliENST00000382254; ENSP00000371689; ENSG00000154162. [P55289-1]
ENST00000504376; ENSP00000423577; ENSG00000154162. [P55289-1]
ENST00000522262; ENSP00000428786; ENSG00000154162. [P55289-2]
ENST00000619694; ENSP00000480493; ENSG00000154162. [P55289-1]
GeneIDi1010.
KEGGihsa:1010.
UCSCiuc003jgk.2. human. [P55289-1]
uc011cno.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34057 mRNA. Translation: AAA35623.1.
L33477 mRNA. Translation: AAB48539.1.
AK295123 mRNA. Translation: BAH11982.1.
AK314800 mRNA. Translation: BAG37328.1.
AC022139 Genomic DNA. No translation available.
AC026716 Genomic DNA. No translation available.
AC034239 Genomic DNA. No translation available.
AC091938 Genomic DNA. No translation available.
AC093263 Genomic DNA. No translation available.
AC108089 Genomic DNA. No translation available.
AC109455 Genomic DNA. No translation available.
AC138854 Genomic DNA. No translation available.
AC138940 Genomic DNA. No translation available.
AC139497 Genomic DNA. No translation available.
AC140132 Genomic DNA. No translation available.
AC140171 Genomic DNA. No translation available.
CH471118 Genomic DNA. Translation: EAX10736.1.
BC047608 mRNA. Translation: AAH47608.1.
CCDSiCCDS3890.1. [P55289-1]
PIRiI59372.
RefSeqiNP_004052.2. NM_004061.3. [P55289-1]
UniGeneiHs.113684.

3D structure databases

ProteinModelPortaliP55289.
SMRiP55289. Positions 55-590, 690-783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107445. 1 interaction.
IntActiP55289. 1 interaction.
STRINGi9606.ENSP00000371689.

PTM databases

PhosphoSiteiP55289.

Polymorphism and mutation databases

BioMutaiCDH12.
DMDMi158937438.

Proteomic databases

PaxDbiP55289.
PRIDEiP55289.

Protocols and materials databases

DNASUi1010.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382254; ENSP00000371689; ENSG00000154162. [P55289-1]
ENST00000504376; ENSP00000423577; ENSG00000154162. [P55289-1]
ENST00000522262; ENSP00000428786; ENSG00000154162. [P55289-2]
ENST00000619694; ENSP00000480493; ENSG00000154162. [P55289-1]
GeneIDi1010.
KEGGihsa:1010.
UCSCiuc003jgk.2. human. [P55289-1]
uc011cno.1. human.

Organism-specific databases

CTDi1010.
GeneCardsiGC05M021786.
H-InvDBHIX0164254.
HIX0164262.
HIX0164263.
HGNCiHGNC:1751. CDH12.
HPAiHPA029325.
MIMi600562. gene.
neXtProtiNX_P55289.
PharmGKBiPA26285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG236183.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55289.
KOiK06804.
OMAiEMSPVGA.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55289.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSiCDH12. human.
GeneWikiiCDH12.
GenomeRNAii1010.
NextBioi35479079.
PROiP55289.
SOURCEiSearch...

Gene expression databases

BgeeiP55289.
CleanExiHS_CDH12.
GenevisibleiP55289. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
    Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
    Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene."
    Selig S., Bruno S., Scharf J.M., Wang C.H., Vitale E., Gilliam T.C., Kunkel L.M.
    Proc. Natl. Acad. Sci. U.S.A. 92:3702-3706(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT MET-68.
    Tissue: Brain cortex.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCAD12_HUMAN
AccessioniPrimary (citable) accession number: P55289
Secondary accession number(s): B2RBT1, B7Z2U6, Q86UD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 21, 2007
Last modified: June 24, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.