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P55288 (CAD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name=OB-cadherin
Gene names
Name:Cdh11
Synonyms:Cad-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length796 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subunit structure

Interacts with PCDH8 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

Developmental stage

In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn. Ref.5

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 5329 Potential
PRO_0000003787
Chain54 – 796743Cadherin-11
PRO_0000003788

Regions

Topological domain54 – 617564Extracellular Potential
Transmembrane618 – 64023Helical; Potential
Topological domain641 – 796156Cytoplasmic Potential
Domain54 – 159106Cadherin 1
Domain160 – 268109Cadherin 2
Domain269 – 383115Cadherin 3
Domain384 – 486103Cadherin 4
Domain487 – 612126Cadherin 5

Amino acid modifications

Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5401N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4621E → D in CAA54674. Ref.1
Sequence conflict5891T → L in BAA06730. Ref.2
Sequence conflict6551D → N in BAA06730. Ref.2
Sequence conflict7511V → M in CAA54674. Ref.1
Sequence conflict7771P → Q in BAA06730. Ref.2
Sequence conflict7821L → P in BAA06730. Ref.2

Secondary structure

................................................... 796
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55288 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0D584D24641DD529

FASTA79688,112
        10         20         30         40         50         60 
MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR SKRGWVWNQF 

        70         80         90        100        110        120 
FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 

       130        140        150        160        170        180 
RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HEIYHANVPE RSNVGTSVIQ 

       190        200        210        220        230        240 
VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 

       250        260        270        280        290        300 
MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 

       310        320        330        340        350        360 
GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA NVHIDPKFIS 

       370        380        390        400        410        420 
NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 

       430        440        450        460        470        480 
IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNISVFA AEIHNRHQET KVPVAIRVLD 

       490        500        510        520        530        540 
VNDNAPKFAA PYEGFICESD HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN 

       550        560        570        580        590        600 
FTVRDNRDNT AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 

       610        620        630        640        650        660 
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 

       670        680        690        700        710        720 
ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 

       730        740        750        760        770        780 
INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 

       790 
KLADLYGSKD TFDDDS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression analysis of a novel mesodermally expressed cadherin."
Hoffmann I.H., Balling R.
Dev. Biol. 169:337-346(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos."
Kimura Y., Matsunami H., Inoue T., Shimamura K., Uchida N., Ueno T., Miyazaki T., Takeichi M.
Dev. Biol. 169:347-358(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Calvaria.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[5]"A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
Munro S.B., Blaschuk O.W.
Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
Strain: C57BL/6.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77557 mRNA. Translation: CAA54674.1.
D31963 mRNA. Translation: BAA06730.1.
D21253 mRNA. Translation: BAA04797.1.
BC046314 mRNA. Translation: AAH46314.1.
CCDSCCDS22571.1.
PIRA53584.
I48277.
I49556.
RefSeqNP_033996.4. NM_009866.4.
XP_006530686.1. XM_006530623.1.
XP_006530687.1. XM_006530624.1.
XP_006530688.1. XM_006530625.1.
XP_006530689.1. XM_006530626.1.
UniGeneMm.1571.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A4CX-ray2.90A/B54-151[»]
2A4EX-ray3.20A54-260[»]
ProteinModelPortalP55288.
SMRP55288. Positions 54-593, 691-787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59088N.
STRING10090.ENSMUSP00000074681.

Chemistry

ChEMBLCHEMBL2163173.

PTM databases

PhosphoSiteP55288.

Proteomic databases

MaxQBP55288.
PaxDbP55288.
PRIDEP55288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
GeneID12552.
KEGGmmu:12552.
UCSCuc009mzu.1. mouse.

Organism-specific databases

CTD1009.
MGIMGI:99217. Cdh11.

Phylogenomic databases

eggNOGNOG301154.
GeneTreeENSGT00700000104267.
HOGENOMHOG000231252.
HOVERGENHBG005217.
InParanoidP55288.
KOK06803.
OMAHENYHAN.
OrthoDBEOG7GBFW7.
PhylomeDBP55288.
TreeFamTF329887.

Gene expression databases

BgeeP55288.
CleanExMM_CDH11.
GenevestigatorP55288.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55288.
NextBio281602.
PROP55288.
SOURCESearch...

Entry information

Entry nameCAD11_MOUSE
AccessionPrimary (citable) accession number: P55288
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot