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Protein

Cadherin-11

Gene

Cdh11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • corticospinal tract morphogenesis Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:Cdh11
Synonyms:Cad-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99217. Cdh11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 617ExtracellularSequence analysisAdd BLAST564
Transmembranei618 – 640HelicalSequence analysisAdd BLAST23
Topological domaini641 – 796CytoplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2163173.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000000378725 – 53Sequence analysisAdd BLAST29
ChainiPRO_000000378854 – 796Cadherin-11Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Modified residuei788PhosphoserineCombined sources1
Modified residuei791PhosphothreonineCombined sources1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP55288.
PaxDbiP55288.
PeptideAtlasiP55288.
PRIDEiP55288.

PTM databases

iPTMnetiP55288.
PhosphoSitePlusiP55288.

Expressioni

Tissue specificityi

Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

Developmental stagei

In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.1 Publication

Gene expression databases

BgeeiENSMUSG00000031673.
CleanExiMM_CDH11.
GenevisibleiP55288. MM.

Interactioni

Subunit structurei

Interacts with PCDH8.By similarity

Protein-protein interaction databases

DIPiDIP-59088N.
STRINGi10090.ENSMUSP00000074681.

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi59 – 63Combined sources5
Helixi64 – 66Combined sources3
Beta strandi68 – 70Combined sources3
Beta strandi72 – 76Combined sources5
Beta strandi84 – 86Combined sources3
Beta strandi88 – 94Combined sources7
Turni98 – 100Combined sources3
Beta strandi101 – 103Combined sources3
Turni105 – 107Combined sources3
Beta strandi109 – 112Combined sources4
Turni118 – 120Combined sources3
Beta strandi122 – 132Combined sources11
Turni133 – 135Combined sources3
Beta strandi138 – 140Combined sources3
Beta strandi143 – 150Combined sources8
Beta strandi158 – 169Combined sources12
Beta strandi177 – 180Combined sources4
Turni189 – 191Combined sources3
Beta strandi193 – 195Combined sources3
Beta strandi198 – 204Combined sources7
Turni205 – 207Combined sources3
Beta strandi208 – 210Combined sources3
Turni212 – 214Combined sources3
Beta strandi216 – 219Combined sources4
Beta strandi226 – 228Combined sources3
Beta strandi230 – 239Combined sources10
Turni240 – 243Combined sources4
Beta strandi249 – 259Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A4CX-ray2.90A/B54-151[»]
2A4EX-ray3.20A54-260[»]
ProteinModelPortaliP55288.
SMRiP55288.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 612Cadherin 5PROSITE-ProRule annotationAdd BLAST126

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55288.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG091G0241.
PhylomeDBiP55288.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55288-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HEIYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT
410 420 430 440 450
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE
460 470 480 490 500
TAWLNISVFA AEIHNRHQET KVPVAIRVLD VNDNAPKFAA PYEGFICESD
510 520 530 540 550
HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN FTVRDNRDNT
560 570 580 590 600
AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA
610 620 630 640 650
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV
660 670 680 690 700
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY
710 720 730 740 750
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS
760 770 780 790
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS
Length:796
Mass (Da):88,112
Last modified:October 1, 1996 - v1
Checksum:i0D584D24641DD529
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti462E → D in CAA54674 (PubMed:7750649).Curated1
Sequence conflicti589T → L in BAA06730 (PubMed:7750650).Curated1
Sequence conflicti655D → N in BAA06730 (PubMed:7750650).Curated1
Sequence conflicti751V → M in CAA54674 (PubMed:7750649).Curated1
Sequence conflicti777P → Q in BAA06730 (PubMed:7750650).Curated1
Sequence conflicti782L → P in BAA06730 (PubMed:7750650).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77557 mRNA. Translation: CAA54674.1.
D31963 mRNA. Translation: BAA06730.1.
D21253 mRNA. Translation: BAA04797.1.
BC046314 mRNA. Translation: AAH46314.1.
CCDSiCCDS22571.1.
PIRiA53584.
I48277.
I49556.
RefSeqiNP_033996.4. NM_009866.5.
XP_006530686.1. XM_006530623.3.
XP_006530687.1. XM_006530624.2.
XP_006530689.1. XM_006530626.3.
UniGeneiMm.1571.
Mm.460482.

Genome annotation databases

EnsembliENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
GeneIDi12552.
KEGGimmu:12552.
UCSCiuc009mzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77557 mRNA. Translation: CAA54674.1.
D31963 mRNA. Translation: BAA06730.1.
D21253 mRNA. Translation: BAA04797.1.
BC046314 mRNA. Translation: AAH46314.1.
CCDSiCCDS22571.1.
PIRiA53584.
I48277.
I49556.
RefSeqiNP_033996.4. NM_009866.5.
XP_006530686.1. XM_006530623.3.
XP_006530687.1. XM_006530624.2.
XP_006530689.1. XM_006530626.3.
UniGeneiMm.1571.
Mm.460482.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A4CX-ray2.90A/B54-151[»]
2A4EX-ray3.20A54-260[»]
ProteinModelPortaliP55288.
SMRiP55288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59088N.
STRINGi10090.ENSMUSP00000074681.

Chemistry databases

ChEMBLiCHEMBL2163173.

PTM databases

iPTMnetiP55288.
PhosphoSitePlusiP55288.

Proteomic databases

MaxQBiP55288.
PaxDbiP55288.
PeptideAtlasiP55288.
PRIDEiP55288.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
GeneIDi12552.
KEGGimmu:12552.
UCSCiuc009mzu.1. mouse.

Organism-specific databases

CTDi1009.
MGIiMGI:99217. Cdh11.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55288.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG091G0241.
PhylomeDBiP55288.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-MMU-418990. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTraceiP55288.
PROiP55288.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031673.
CleanExiMM_CDH11.
GenevisibleiP55288. MM.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD11_MOUSE
AccessioniPrimary (citable) accession number: P55288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.