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P55288

- CAD11_MOUSE

UniProt

P55288 - CAD11_MOUSE

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Protein
Cadherin-11
Gene
Cdh11, Cad-11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. corticospinal tract morphogenesis Source: MGI
  2. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:Cdh11
Synonyms:Cad-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99217. Cdh11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 617564Extracellular Reviewed prediction
Add
BLAST
Transmembranei618 – 64023Helical; Reviewed prediction
Add
BLAST
Topological domaini641 – 796156Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Propeptidei25 – 5329 Reviewed prediction
PRO_0000003787Add
BLAST
Chaini54 – 796743Cadherin-11
PRO_0000003788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP55288.
PaxDbiP55288.
PRIDEiP55288.

PTM databases

PhosphoSiteiP55288.

Expressioni

Tissue specificityi

Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

Developmental stagei

In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.1 Publication

Gene expression databases

BgeeiP55288.
CleanExiMM_CDH11.
GenevestigatoriP55288.

Interactioni

Subunit structurei

Interacts with PCDH8 By similarity.

Protein-protein interaction databases

DIPiDIP-59088N.
STRINGi10090.ENSMUSP00000074681.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 635
Helixi64 – 663
Beta strandi68 – 703
Beta strandi72 – 765
Beta strandi84 – 863
Beta strandi88 – 947
Turni98 – 1003
Beta strandi101 – 1033
Turni105 – 1073
Beta strandi109 – 1124
Turni118 – 1203
Beta strandi122 – 13211
Turni133 – 1353
Beta strandi138 – 1403
Beta strandi143 – 1508
Beta strandi158 – 16912
Beta strandi177 – 1804
Turni189 – 1913
Beta strandi193 – 1953
Beta strandi198 – 2047
Turni205 – 2073
Beta strandi208 – 2103
Turni212 – 2143
Beta strandi216 – 2194
Beta strandi226 – 2283
Beta strandi230 – 23910
Turni240 – 2434
Beta strandi249 – 25911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A4CX-ray2.90A/B54-151[»]
2A4EX-ray3.20A54-260[»]
ProteinModelPortaliP55288.
SMRiP55288. Positions 54-593, 691-787.

Miscellaneous databases

EvolutionaryTraceiP55288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1
Add
BLAST
Domaini160 – 268109Cadherin 2
Add
BLAST
Domaini269 – 383115Cadherin 3
Add
BLAST
Domaini384 – 486103Cadherin 4
Add
BLAST
Domaini487 – 612126Cadherin 5
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301154.
GeneTreeiENSGT00700000104267.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55288.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55288.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55288-1 [UniParc]FASTAAdd to Basket

« Hide

MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR    50
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI 100
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ 150
DINDNPPEFL HEIYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS 200
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG 250
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 300
GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA 350
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT 400
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE 450
TAWLNISVFA AEIHNRHQET KVPVAIRVLD VNDNAPKFAA PYEGFICESD 500
HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN FTVRDNRDNT 550
AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 600
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV 650
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY 700
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS 750
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS 796
Length:796
Mass (Da):88,112
Last modified:October 1, 1996 - v1
Checksum:i0D584D24641DD529
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti462 – 4621E → D in CAA54674. 1 Publication
Sequence conflicti589 – 5891T → L in BAA06730. 1 Publication
Sequence conflicti655 – 6551D → N in BAA06730. 1 Publication
Sequence conflicti751 – 7511V → M in CAA54674. 1 Publication
Sequence conflicti777 – 7771P → Q in BAA06730. 1 Publication
Sequence conflicti782 – 7821L → P in BAA06730. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77557 mRNA. Translation: CAA54674.1.
D31963 mRNA. Translation: BAA06730.1.
D21253 mRNA. Translation: BAA04797.1.
BC046314 mRNA. Translation: AAH46314.1.
CCDSiCCDS22571.1.
PIRiA53584.
I48277.
I49556.
RefSeqiNP_033996.4. NM_009866.4.
XP_006530686.1. XM_006530623.1.
XP_006530687.1. XM_006530624.1.
XP_006530688.1. XM_006530625.1.
XP_006530689.1. XM_006530626.1.
UniGeneiMm.1571.

Genome annotation databases

EnsembliENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
GeneIDi12552.
KEGGimmu:12552.
UCSCiuc009mzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77557 mRNA. Translation: CAA54674.1 .
D31963 mRNA. Translation: BAA06730.1 .
D21253 mRNA. Translation: BAA04797.1 .
BC046314 mRNA. Translation: AAH46314.1 .
CCDSi CCDS22571.1.
PIRi A53584.
I48277.
I49556.
RefSeqi NP_033996.4. NM_009866.4.
XP_006530686.1. XM_006530623.1.
XP_006530687.1. XM_006530624.1.
XP_006530688.1. XM_006530625.1.
XP_006530689.1. XM_006530626.1.
UniGenei Mm.1571.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A4C X-ray 2.90 A/B 54-151 [» ]
2A4E X-ray 3.20 A 54-260 [» ]
ProteinModelPortali P55288.
SMRi P55288. Positions 54-593, 691-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59088N.
STRINGi 10090.ENSMUSP00000074681.

Chemistry

ChEMBLi CHEMBL2163173.

PTM databases

PhosphoSitei P55288.

Proteomic databases

MaxQBi P55288.
PaxDbi P55288.
PRIDEi P55288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075190 ; ENSMUSP00000074681 ; ENSMUSG00000031673 .
GeneIDi 12552.
KEGGi mmu:12552.
UCSCi uc009mzu.1. mouse.

Organism-specific databases

CTDi 1009.
MGIi MGI:99217. Cdh11.

Phylogenomic databases

eggNOGi NOG301154.
GeneTreei ENSGT00700000104267.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P55288.
KOi K06803.
OMAi HENYHAN.
OrthoDBi EOG7GBFW7.
PhylomeDBi P55288.
TreeFami TF329887.

Miscellaneous databases

EvolutionaryTracei P55288.
NextBioi 281602.
PROi P55288.
SOURCEi Search...

Gene expression databases

Bgeei P55288.
CleanExi MM_CDH11.
Genevestigatori P55288.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a novel mesodermally expressed cadherin."
    Hoffmann I.H., Balling R.
    Dev. Biol. 169:337-346(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos."
    Kimura Y., Matsunami H., Inoue T., Shimamura K., Uchida N., Ueno T., Miyazaki T., Takeichi M.
    Dev. Biol. 169:347-358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
    Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
    J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Calvaria.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  5. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Testis.

Entry informationi

Entry nameiCAD11_MOUSE
AccessioniPrimary (citable) accession number: P55288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi