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P55288

- CAD11_MOUSE

UniProt

P55288 - CAD11_MOUSE

Protein

Cadherin-11

Gene

Cdh11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. corticospinal tract morphogenesis Source: MGI
    2. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-11
    Alternative name(s):
    OSF-4
    Osteoblast cadherin
    Short name:
    OB-cadherin
    Gene namesi
    Name:Cdh11
    Synonyms:Cad-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:99217. Cdh11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 5329Sequence AnalysisPRO_0000003787Add
    BLAST
    Chaini54 – 796743Cadherin-11PRO_0000003788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    MaxQBiP55288.
    PaxDbiP55288.
    PRIDEiP55288.

    PTM databases

    PhosphoSiteiP55288.

    Expressioni

    Tissue specificityi

    Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

    Developmental stagei

    In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.1 Publication

    Gene expression databases

    BgeeiP55288.
    CleanExiMM_CDH11.
    GenevestigatoriP55288.

    Interactioni

    Subunit structurei

    Interacts with PCDH8.By similarity

    Protein-protein interaction databases

    DIPiDIP-59088N.
    STRINGi10090.ENSMUSP00000074681.

    Structurei

    Secondary structure

    1
    796
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi59 – 635
    Helixi64 – 663
    Beta strandi68 – 703
    Beta strandi72 – 765
    Beta strandi84 – 863
    Beta strandi88 – 947
    Turni98 – 1003
    Beta strandi101 – 1033
    Turni105 – 1073
    Beta strandi109 – 1124
    Turni118 – 1203
    Beta strandi122 – 13211
    Turni133 – 1353
    Beta strandi138 – 1403
    Beta strandi143 – 1508
    Beta strandi158 – 16912
    Beta strandi177 – 1804
    Turni189 – 1913
    Beta strandi193 – 1953
    Beta strandi198 – 2047
    Turni205 – 2073
    Beta strandi208 – 2103
    Turni212 – 2143
    Beta strandi216 – 2194
    Beta strandi226 – 2283
    Beta strandi230 – 23910
    Turni240 – 2434
    Beta strandi249 – 25911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A4CX-ray2.90A/B54-151[»]
    2A4EX-ray3.20A54-260[»]
    ProteinModelPortaliP55288.
    SMRiP55288. Positions 54-593, 691-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55288.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini54 – 617564ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini641 – 796156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei618 – 64023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 612126Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301154.
    GeneTreeiENSGT00700000104267.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiP55288.
    KOiK06803.
    OMAiHENYHAN.
    OrthoDBiEOG7GBFW7.
    PhylomeDBiP55288.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55288-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR    50
    SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI 100
    FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ 150
    DINDNPPEFL HEIYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS 200
    ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG 250
    TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 300
    GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA 350
    NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT 400
    VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE 450
    TAWLNISVFA AEIHNRHQET KVPVAIRVLD VNDNAPKFAA PYEGFICESD 500
    HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN FTVRDNRDNT 550
    AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 600
    LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV 650
    FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY 700
    QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS 750
    VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS 796
    Length:796
    Mass (Da):88,112
    Last modified:October 1, 1996 - v1
    Checksum:i0D584D24641DD529
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti462 – 4621E → D in CAA54674. (PubMed:7750649)Curated
    Sequence conflicti589 – 5891T → L in BAA06730. (PubMed:7750650)Curated
    Sequence conflicti655 – 6551D → N in BAA06730. (PubMed:7750650)Curated
    Sequence conflicti751 – 7511V → M in CAA54674. (PubMed:7750649)Curated
    Sequence conflicti777 – 7771P → Q in BAA06730. (PubMed:7750650)Curated
    Sequence conflicti782 – 7821L → P in BAA06730. (PubMed:7750650)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77557 mRNA. Translation: CAA54674.1.
    D31963 mRNA. Translation: BAA06730.1.
    D21253 mRNA. Translation: BAA04797.1.
    BC046314 mRNA. Translation: AAH46314.1.
    CCDSiCCDS22571.1.
    PIRiA53584.
    I48277.
    I49556.
    RefSeqiNP_033996.4. NM_009866.4.
    XP_006530686.1. XM_006530623.1.
    XP_006530687.1. XM_006530624.1.
    XP_006530688.1. XM_006530625.1.
    XP_006530689.1. XM_006530626.1.
    UniGeneiMm.1571.

    Genome annotation databases

    EnsembliENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
    GeneIDi12552.
    KEGGimmu:12552.
    UCSCiuc009mzu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77557 mRNA. Translation: CAA54674.1 .
    D31963 mRNA. Translation: BAA06730.1 .
    D21253 mRNA. Translation: BAA04797.1 .
    BC046314 mRNA. Translation: AAH46314.1 .
    CCDSi CCDS22571.1.
    PIRi A53584.
    I48277.
    I49556.
    RefSeqi NP_033996.4. NM_009866.4.
    XP_006530686.1. XM_006530623.1.
    XP_006530687.1. XM_006530624.1.
    XP_006530688.1. XM_006530625.1.
    XP_006530689.1. XM_006530626.1.
    UniGenei Mm.1571.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A4C X-ray 2.90 A/B 54-151 [» ]
    2A4E X-ray 3.20 A 54-260 [» ]
    ProteinModelPortali P55288.
    SMRi P55288. Positions 54-593, 691-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59088N.
    STRINGi 10090.ENSMUSP00000074681.

    Chemistry

    ChEMBLi CHEMBL2163173.

    PTM databases

    PhosphoSitei P55288.

    Proteomic databases

    MaxQBi P55288.
    PaxDbi P55288.
    PRIDEi P55288.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075190 ; ENSMUSP00000074681 ; ENSMUSG00000031673 .
    GeneIDi 12552.
    KEGGi mmu:12552.
    UCSCi uc009mzu.1. mouse.

    Organism-specific databases

    CTDi 1009.
    MGIi MGI:99217. Cdh11.

    Phylogenomic databases

    eggNOGi NOG301154.
    GeneTreei ENSGT00700000104267.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi P55288.
    KOi K06803.
    OMAi HENYHAN.
    OrthoDBi EOG7GBFW7.
    PhylomeDBi P55288.
    TreeFami TF329887.

    Miscellaneous databases

    EvolutionaryTracei P55288.
    NextBioi 281602.
    PROi P55288.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55288.
    CleanExi MM_CDH11.
    Genevestigatori P55288.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression analysis of a novel mesodermally expressed cadherin."
      Hoffmann I.H., Balling R.
      Dev. Biol. 169:337-346(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos."
      Kimura Y., Matsunami H., Inoue T., Shimamura K., Uchida N., Ueno T., Miyazaki T., Takeichi M.
      Dev. Biol. 169:347-358(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
      Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
      J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Calvaria.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    5. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
      Munro S.B., Blaschuk O.W.
      Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
      Strain: C57BL/6.
      Tissue: Testis.

    Entry informationi

    Entry nameiCAD11_MOUSE
    AccessioniPrimary (citable) accession number: P55288
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3