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P55288

- CAD11_MOUSE

UniProt

P55288 - CAD11_MOUSE

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Protein

Cadherin-11

Gene

Cdh11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. corticospinal tract morphogenesis Source: MGI
  2. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_230395. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:Cdh11
Synonyms:Cad-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:99217. Cdh11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 617564ExtracellularSequence AnalysisAdd
BLAST
Transmembranei618 – 64023HelicalSequence AnalysisAdd
BLAST
Topological domaini641 – 796156CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 5329Sequence AnalysisPRO_0000003787Add
BLAST
Chaini54 – 796743Cadherin-11PRO_0000003788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP55288.
PaxDbiP55288.
PRIDEiP55288.

PTM databases

PhosphoSiteiP55288.

Expressioni

Tissue specificityi

Selectively expressed in osteoblastic cell lines, precursor cell lines of osteoblasts, and primary osteoblastic cells from calvaria, as well as in lung, testis, and brain tissues at low levels.

Developmental stagei

In the testis, expression is highest in fetal gonad and decreases 8-fold in newborn.1 Publication

Gene expression databases

BgeeiP55288.
CleanExiMM_CDH11.
GenevestigatoriP55288.

Interactioni

Subunit structurei

Interacts with PCDH8.By similarity

Protein-protein interaction databases

DIPiDIP-59088N.
STRINGi10090.ENSMUSP00000074681.

Structurei

Secondary structure

1
796
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi59 – 635Combined sources
Helixi64 – 663Combined sources
Beta strandi68 – 703Combined sources
Beta strandi72 – 765Combined sources
Beta strandi84 – 863Combined sources
Beta strandi88 – 947Combined sources
Turni98 – 1003Combined sources
Beta strandi101 – 1033Combined sources
Turni105 – 1073Combined sources
Beta strandi109 – 1124Combined sources
Turni118 – 1203Combined sources
Beta strandi122 – 13211Combined sources
Turni133 – 1353Combined sources
Beta strandi138 – 1403Combined sources
Beta strandi143 – 1508Combined sources
Beta strandi158 – 16912Combined sources
Beta strandi177 – 1804Combined sources
Turni189 – 1913Combined sources
Beta strandi193 – 1953Combined sources
Beta strandi198 – 2047Combined sources
Turni205 – 2073Combined sources
Beta strandi208 – 2103Combined sources
Turni212 – 2143Combined sources
Beta strandi216 – 2194Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi230 – 23910Combined sources
Turni240 – 2434Combined sources
Beta strandi249 – 25911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A4CX-ray2.90A/B54-151[»]
2A4EX-ray3.20A54-260[»]
ProteinModelPortaliP55288.
SMRiP55288. Positions 54-593, 691-787.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 612126Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301154.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiP55288.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55288.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55288-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKENYCLQAA LVCLSMLYHS QAFALERRSH LHPSFHGHHE KGKEGQVLQR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HEIYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVTYNIVDG DGIELFEITT DYETQDGVVK LKKPVDFETK RAYSLKIEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT
410 420 430 440 450
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE
460 470 480 490 500
TAWLNISVFA AEIHNRHQET KVPVAIRVLD VNDNAPKFAA PYEGFICESD
510 520 530 540 550
HPKALSNQPI VTVSADDQDD TANGPRFIFS LPPEIMHNPN FTVRDNRDNT
560 570 580 590 600
AGVYARRGGF SRQKQDFYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA
610 620 630 640 650
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV
660 670 680 690 700
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY
710 720 730 740 750
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS
760 770 780 790
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS
Length:796
Mass (Da):88,112
Last modified:October 1, 1996 - v1
Checksum:i0D584D24641DD529
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti462 – 4621E → D in CAA54674. (PubMed:7750649)Curated
Sequence conflicti589 – 5891T → L in BAA06730. (PubMed:7750650)Curated
Sequence conflicti655 – 6551D → N in BAA06730. (PubMed:7750650)Curated
Sequence conflicti751 – 7511V → M in CAA54674. (PubMed:7750649)Curated
Sequence conflicti777 – 7771P → Q in BAA06730. (PubMed:7750650)Curated
Sequence conflicti782 – 7821L → P in BAA06730. (PubMed:7750650)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77557 mRNA. Translation: CAA54674.1.
D31963 mRNA. Translation: BAA06730.1.
D21253 mRNA. Translation: BAA04797.1.
BC046314 mRNA. Translation: AAH46314.1.
CCDSiCCDS22571.1.
PIRiA53584.
I48277.
I49556.
RefSeqiNP_033996.4. NM_009866.4.
XP_006530686.1. XM_006530623.1.
XP_006530687.1. XM_006530624.1.
XP_006530688.1. XM_006530625.1.
XP_006530689.1. XM_006530626.1.
UniGeneiMm.1571.

Genome annotation databases

EnsembliENSMUST00000075190; ENSMUSP00000074681; ENSMUSG00000031673.
GeneIDi12552.
KEGGimmu:12552.
UCSCiuc009mzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77557 mRNA. Translation: CAA54674.1 .
D31963 mRNA. Translation: BAA06730.1 .
D21253 mRNA. Translation: BAA04797.1 .
BC046314 mRNA. Translation: AAH46314.1 .
CCDSi CCDS22571.1.
PIRi A53584.
I48277.
I49556.
RefSeqi NP_033996.4. NM_009866.4.
XP_006530686.1. XM_006530623.1.
XP_006530687.1. XM_006530624.1.
XP_006530688.1. XM_006530625.1.
XP_006530689.1. XM_006530626.1.
UniGenei Mm.1571.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A4C X-ray 2.90 A/B 54-151 [» ]
2A4E X-ray 3.20 A 54-260 [» ]
ProteinModelPortali P55288.
SMRi P55288. Positions 54-593, 691-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59088N.
STRINGi 10090.ENSMUSP00000074681.

Chemistry

ChEMBLi CHEMBL2163173.

PTM databases

PhosphoSitei P55288.

Proteomic databases

MaxQBi P55288.
PaxDbi P55288.
PRIDEi P55288.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075190 ; ENSMUSP00000074681 ; ENSMUSG00000031673 .
GeneIDi 12552.
KEGGi mmu:12552.
UCSCi uc009mzu.1. mouse.

Organism-specific databases

CTDi 1009.
MGIi MGI:99217. Cdh11.

Phylogenomic databases

eggNOGi NOG301154.
GeneTreei ENSGT00760000118954.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi P55288.
KOi K06803.
OMAi HENYHAN.
OrthoDBi EOG7GBFW7.
PhylomeDBi P55288.
TreeFami TF329887.

Enzyme and pathway databases

Reactomei REACT_230395. Adherens junctions interactions.

Miscellaneous databases

EvolutionaryTracei P55288.
NextBioi 281602.
PROi P55288.
SOURCEi Search...

Gene expression databases

Bgeei P55288.
CleanExi MM_CDH11.
Genevestigatori P55288.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a novel mesodermally expressed cadherin."
    Hoffmann I.H., Balling R.
    Dev. Biol. 169:337-346(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos."
    Kimura Y., Matsunami H., Inoue T., Shimamura K., Uchida N., Ueno T., Miyazaki T., Takeichi M.
    Dev. Biol. 169:347-358(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
    Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
    J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Calvaria.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  5. "A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
    Munro S.B., Blaschuk O.W.
    Biol. Reprod. 55:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Testis.

Entry informationi

Entry nameiCAD11_MOUSE
AccessioniPrimary (citable) accession number: P55288
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3