SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P55287

- CAD11_HUMAN

UniProt

P55287 - CAD11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cadherin-11
Gene
CDH11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. cell adhesion Source: ProtInc
  3. cell junction assembly Source: Reactome
  4. cell-cell junction organization Source: Reactome
  5. corticospinal tract morphogenesis Source: Ensembl
  6. homophilic cell adhesion Source: InterPro
  7. ossification Source: UniProtKB
  8. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:CDH11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1750. CDH11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 617564Extracellular Reviewed prediction
Add
BLAST
Transmembranei618 – 64023Helical; Reviewed prediction
Add
BLAST
Topological domaini641 – 796156Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Organism-specific databases

PharmGKBiPA26284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Propeptidei23 – 5331 Reviewed prediction
PRO_0000003785Add
BLAST
Chaini54 – 796743Cadherin-11
PRO_0000003786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi540 – 5401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP55287.
PaxDbiP55287.
PRIDEiP55287.

PTM databases

PhosphoSiteiP55287.

Expressioni

Tissue specificityi

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Gene expression databases

ArrayExpressiP55287.
BgeeiP55287.
CleanExiHS_CDH11.
GenevestigatoriP55287.

Organism-specific databases

HPAiCAB013072.

Interactioni

Subunit structurei

Interacts with PCDH8 By similarity.

Protein-protein interaction databases

BioGridi107444. 2 interactions.
IntActiP55287. 3 interactions.
MINTiMINT-1180975.
STRINGi9606.ENSP00000268603.

Structurei

3D structure databases

ProteinModelPortaliP55287.
SMRiP55287. Positions 54-593, 691-787.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1
Add
BLAST
Domaini160 – 268109Cadherin 2
Add
BLAST
Domaini269 – 383115Cadherin 3
Add
BLAST
Domaini384 – 486103Cadherin 4
Add
BLAST
Domaini487 – 612126Cadherin 5
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 5 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301154.
HOVERGENiHBG005217.
InParanoidiP55287.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG7GBFW7.
PhylomeDBiP55287.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55287-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR    50
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI 100
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ 150
DINDNPPEFL HETYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS 200
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG 250
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 300
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA 350
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT 400
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE 450
TAWLNITVFA AEIHNRHQEA KVPVAIRVLD VNDNAPKFAA PYEGFICESD 500
QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN FTVRDNRDNT 550
AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 600
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV 650
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY 700
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS 750
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS 796
Length:796
Mass (Da):87,965
Last modified:May 1, 2007 - v2
Checksum:iE17090EC95C59936
GO
Isoform 2 (identifier: P55287-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
     694-796: Missing.

Show »
Length:693
Mass (Da):76,457
Checksum:i7EBFA6CEB0EABFED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551T → M.
Corresponds to variant rs35195 [ dbSNP | Ensembl ].
VAR_031945
Natural varianti275 – 2751M → I.1 Publication
Corresponds to variant rs1130821 [ dbSNP | Ensembl ].
VAR_031946
Natural varianti373 – 3731S → A.2 Publications
Corresponds to variant rs35213 [ dbSNP | Ensembl ].
VAR_031947

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei632 – 69362VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2.
VSP_000640Add
BLAST
Alternative sequencei694 – 796103Missing in isoform 2.
VSP_000641Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2722SV → RL in AAA35622. 1 Publication
Sequence conflicti271 – 2722SV → RL no nucleotide entry 1 Publication
Sequence conflicti340 – 3401K → E in AAA35622. 1 Publication
Sequence conflicti340 – 3401K → E no nucleotide entry 1 Publication
Sequence conflicti471 – 4711K → Q in AAA35622. 1 Publication
Sequence conflicti471 – 4711K → Q no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34056 mRNA. Translation: AAA35622.1.
D21254 mRNA. Translation: BAA04798.1.
D21255 mRNA. Translation: BAA04799.1.
AK291251 mRNA. Translation: BAF83940.1.
AC010533 Genomic DNA. No translation available.
AF060370, AF060369 Genomic DNA. Translation: AAD27755.1.
AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
CCDSiCCDS10803.1. [P55287-1]
PIRiA38992.
RefSeqiNP_001788.2. NM_001797.2. [P55287-1]
XP_005255818.1. XM_005255761.2. [P55287-1]
XP_005255819.1. XM_005255762.1. [P55287-1]
XP_005255820.1. XM_005255763.1. [P55287-1]
XP_005255821.1. XM_005255764.1. [P55287-2]
UniGeneiHs.116471.

Genome annotation databases

EnsembliENST00000268603; ENSP00000268603; ENSG00000140937. [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937. [P55287-2]
GeneIDi1009.
KEGGihsa:1009.
UCSCiuc002eoi.3. human. [P55287-1]
uc002eoj.3. human. [P55287-2]

Polymorphism databases

DMDMi146345381.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34056 mRNA. Translation: AAA35622.1 .
D21254 mRNA. Translation: BAA04798.1 .
D21255 mRNA. Translation: BAA04799.1 .
AK291251 mRNA. Translation: BAF83940.1 .
AC010533 Genomic DNA. No translation available.
AF060370 , AF060369 Genomic DNA. Translation: AAD27755.1 .
AF060370 , AF060369 Genomic DNA. Translation: AAD27756.1 .
CCDSi CCDS10803.1. [P55287-1 ]
PIRi A38992.
RefSeqi NP_001788.2. NM_001797.2. [P55287-1 ]
XP_005255818.1. XM_005255761.2. [P55287-1 ]
XP_005255819.1. XM_005255762.1. [P55287-1 ]
XP_005255820.1. XM_005255763.1. [P55287-1 ]
XP_005255821.1. XM_005255764.1. [P55287-2 ]
UniGenei Hs.116471.

3D structure databases

ProteinModelPortali P55287.
SMRi P55287. Positions 54-593, 691-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107444. 2 interactions.
IntActi P55287. 3 interactions.
MINTi MINT-1180975.
STRINGi 9606.ENSP00000268603.

PTM databases

PhosphoSitei P55287.

Polymorphism databases

DMDMi 146345381.

Proteomic databases

MaxQBi P55287.
PaxDbi P55287.
PRIDEi P55287.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268603 ; ENSP00000268603 ; ENSG00000140937 . [P55287-1 ]
ENST00000394156 ; ENSP00000377711 ; ENSG00000140937 . [P55287-2 ]
GeneIDi 1009.
KEGGi hsa:1009.
UCSCi uc002eoi.3. human. [P55287-1 ]
uc002eoj.3. human. [P55287-2 ]

Organism-specific databases

CTDi 1009.
GeneCardsi GC16M064977.
H-InvDB HIX0013098.
HGNCi HGNC:1750. CDH11.
HPAi CAB013072.
MIMi 600023. gene.
neXtProti NX_P55287.
PharmGKBi PA26284.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301154.
HOVERGENi HBG005217.
InParanoidi P55287.
KOi K06803.
OMAi HENYHAN.
OrthoDBi EOG7GBFW7.
PhylomeDBi P55287.
TreeFami TF329887.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSi CDH11. human.
GeneWikii CDH11.
GenomeRNAii 1009.
NextBioi 4242.
PROi P55287.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55287.
Bgeei P55287.
CleanExi HS_CDH11.
Genevestigatori P55287.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
    Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
    Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
    Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
    J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ILE-275 AND ALA-373.
    Tissue: Osteosarcoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-373.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
    Suzuki S., Sano K., Tanihara H.
    Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1).
    Tissue: Fetal brain.
  6. "Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells."
    Kools P.F.J., Hogendoorn P.C.W., Bovee J.V.M.G., van Roy F.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668.
  7. Cited for: CHROMOSOMAL TRANSLOCATION WITH USP6.

Entry informationi

Entry nameiCAD11_HUMAN
AccessioniPrimary (citable) accession number: P55287
Secondary accession number(s): A8K5D6
, A8MZC8, B7WP28, Q15065, Q15066, Q9UQ93, Q9UQ94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi