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P55287 (CAD11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name=OB-cadherin
Gene names
Name:CDH11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length796 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subunit structure

Interacts with PCDH8 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Involvement in disease

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Sequence similarities

Contains 5 cadherin domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55287-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55287-2)

The sequence of this isoform differs from the canonical sequence as follows:
     632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
     694-796: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 5331 Potential
PRO_0000003785
Chain54 – 796743Cadherin-11
PRO_0000003786

Regions

Topological domain54 – 617564Extracellular Potential
Transmembrane618 – 64023Helical; Potential
Topological domain641 – 796156Cytoplasmic Potential
Domain54 – 159106Cadherin 1
Domain160 – 268109Cadherin 2
Domain269 – 383115Cadherin 3
Domain384 – 486103Cadherin 4
Domain487 – 612126Cadherin 5

Amino acid modifications

Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5401N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence632 – 69362VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2.
VSP_000640
Alternative sequence694 – 796103Missing in isoform 2.
VSP_000641
Natural variant2551T → M.
Corresponds to variant rs35195 [ dbSNP | Ensembl ].
VAR_031945
Natural variant2751M → I. Ref.2
Corresponds to variant rs1130821 [ dbSNP | Ensembl ].
VAR_031946
Natural variant3731S → A. Ref.2 Ref.3
Corresponds to variant rs35213 [ dbSNP | Ensembl ].
VAR_031947

Experimental info

Sequence conflict271 – 2722SV → RL in AAA35622. Ref.1
Sequence conflict271 – 2722SV → RL no nucleotide entry Ref.5
Sequence conflict3401K → E in AAA35622. Ref.1
Sequence conflict3401K → E no nucleotide entry Ref.5
Sequence conflict4711K → Q in AAA35622. Ref.1
Sequence conflict4711K → Q no nucleotide entry Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: E17090EC95C59936

FASTA79687,965
        10         20         30         40         50         60 
MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 

        70         80         90        100        110        120 
FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 

       130        140        150        160        170        180 
RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 

       190        200        210        220        230        240 
VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 

       250        260        270        280        290        300 
MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 

       310        320        330        340        350        360 
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 

       370        380        390        400        410        420 
NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 

       430        440        450        460        470        480 
IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 

       490        500        510        520        530        540 
VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 

       550        560        570        580        590        600 
FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 

       610        620        630        640        650        660 
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 

       670        680        690        700        710        720 
ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 

       730        740        750        760        770        780 
INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 

       790 
KLADLYGSKD TFDDDS 

« Hide

Isoform 2 [UniParc].

Checksum: 7EBFA6CEB0EABFED
Show »

FASTA69376,457

References

« Hide 'large scale' references
[1]"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ILE-275 AND ALA-373.
Tissue: Osteosarcoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-373.
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
Suzuki S., Sano K., Tanihara H.
Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1).
Tissue: Fetal brain.
[6]"Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells."
Kools P.F.J., Hogendoorn P.C.W., Bovee J.V.M.G., van Roy F.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668.
[7]"USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst."
Oliveira A.M., Hsi B.L., Weremowicz S., Rosenberg A.E., Dal Cin P., Joseph N., Bridge J.A., Perez-Atayde A.R., Fletcher J.A.
Cancer Res. 64:1920-1923(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL TRANSLOCATION WITH USP6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34056 mRNA. Translation: AAA35622.1.
D21254 mRNA. Translation: BAA04798.1.
D21255 mRNA. Translation: BAA04799.1.
AK291251 mRNA. Translation: BAF83940.1.
AC010533 Genomic DNA. No translation available.
AF060370, AF060369 Genomic DNA. Translation: AAD27755.1.
AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
PIRA38992.
RefSeqNP_001788.2. NM_001797.2.
XP_005255818.1. XM_005255761.2.
XP_005255819.1. XM_005255762.1.
XP_005255820.1. XM_005255763.1.
XP_005255821.1. XM_005255764.1.
UniGeneHs.116471.

3D structure databases

ProteinModelPortalP55287.
SMRP55287. Positions 54-593, 691-787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107444. 2 interactions.
IntActP55287. 3 interactions.
MINTMINT-1180975.
STRING9606.ENSP00000268603.

PTM databases

PhosphoSiteP55287.

Polymorphism databases

DMDM146345381.

Proteomic databases

PaxDbP55287.
PRIDEP55287.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268603; ENSP00000268603; ENSG00000140937. [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937. [P55287-2]
GeneID1009.
KEGGhsa:1009.
UCSCuc002eoi.3. human. [P55287-1]
uc002eoj.3. human. [P55287-2]

Organism-specific databases

CTD1009.
GeneCardsGC16M064977.
H-InvDBHIX0013098.
HGNCHGNC:1750. CDH11.
HPACAB013072.
MIM600023. gene.
neXtProtNX_P55287.
PharmGKBPA26284.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG301154.
HOVERGENHBG005217.
InParanoidP55287.
KOK06803.
OMAHENYHAN.
OrthoDBEOG7GBFW7.
PhylomeDBP55287.
TreeFamTF329887.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP55287.
BgeeP55287.
CleanExHS_CDH11.
GenevestigatorP55287.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDH11. human.
GeneWikiCDH11.
GenomeRNAi1009.
NextBio4242.
PROP55287.
SOURCESearch...

Entry information

Entry nameCAD11_HUMAN
AccessionPrimary (citable) accession number: P55287
Secondary accession number(s): A8K5D6 expand/collapse secondary AC list , A8MZC8, B7WP28, Q15065, Q15066, Q9UQ93, Q9UQ94
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM