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Protein

Cadherin-11

Gene

CDH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

  • adherens junction organization Source: Reactome
  • cell adhesion Source: ProtInc
  • corticospinal tract morphogenesis Source: Ensembl
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • ossification Source: UniProtKB
  • skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140937-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.
SIGNORiP55287.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Alternative name(s):
OSF-4
Osteoblast cadherin
Short name:
OB-cadherin
Gene namesi
Name:CDH11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1750. CDH11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 617ExtracellularSequence analysisAdd BLAST564
Transmembranei618 – 640HelicalSequence analysisAdd BLAST23
Topological domaini641 – 796CytoplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Organism-specific databases

DisGeNETi1009.
OpenTargetsiENSG00000140937.
PharmGKBiPA26284.

Polymorphism and mutation databases

BioMutaiCDH11.
DMDMi146345381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000378523 – 53Sequence analysisAdd BLAST31
ChainiPRO_000000378654 – 796Cadherin-11Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi540N-linked (GlcNAc...)Sequence analysis1
Modified residuei788PhosphoserineBy similarity1
Modified residuei791PhosphothreonineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP55287.
MaxQBiP55287.
PaxDbiP55287.
PeptideAtlasiP55287.
PRIDEiP55287.

PTM databases

iPTMnetiP55287.
PhosphoSitePlusiP55287.

Expressioni

Tissue specificityi

Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

Gene expression databases

BgeeiENSG00000140937.
CleanExiHS_CDH11.
ExpressionAtlasiP55287. baseline and differential.
GenevisibleiP55287. HS.

Organism-specific databases

HPAiCAB013072.

Interactioni

Subunit structurei

Interacts with PCDH8.By similarity

Protein-protein interaction databases

BioGridi107444. 2 interactors.
IntActiP55287. 5 interactors.
MINTiMINT-1180975.
STRINGi9606.ENSP00000268603.

Structurei

3D structure databases

ProteinModelPortaliP55287.
SMRiP55287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 612Cadherin 5PROSITE-ProRule annotationAdd BLAST126

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOVERGENiHBG005217.
InParanoidiP55287.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG091G0241.
PhylomeDBiP55287.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55287-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HETYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT
410 420 430 440 450
VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE
460 470 480 490 500
TAWLNITVFA AEIHNRHQEA KVPVAIRVLD VNDNAPKFAA PYEGFICESD
510 520 530 540 550
QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN FTVRDNRDNT
560 570 580 590 600
AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA
610 620 630 640 650
LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV
660 670 680 690 700
FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY
710 720 730 740 750
QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS
760 770 780 790
VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS
Length:796
Mass (Da):87,965
Last modified:May 1, 2007 - v2
Checksum:iE17090EC95C59936
GO
Isoform 2 (identifier: P55287-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
     694-796: Missing.

Show »
Length:693
Mass (Da):76,457
Checksum:i7EBFA6CEB0EABFED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271 – 272SV → RL in AAA35622 (PubMed:7982033).Curated2
Sequence conflicti271 – 272SV → RL no nucleotide entry (PubMed:2059658).Curated2
Sequence conflicti340K → E in AAA35622 (PubMed:7982033).Curated1
Sequence conflicti340K → E no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti471K → Q in AAA35622 (PubMed:7982033).Curated1
Sequence conflicti471K → Q no nucleotide entry (PubMed:2059658).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031945255T → M.Corresponds to variant rs35195dbSNPEnsembl.1
Natural variantiVAR_031946275M → I.1 PublicationCorresponds to variant rs1130821dbSNPEnsembl.1
Natural variantiVAR_031947373S → A.2 PublicationsCorresponds to variant rs35213dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000640632 – 693VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_000641694 – 796Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34056 mRNA. Translation: AAA35622.1.
D21254 mRNA. Translation: BAA04798.1.
D21255 mRNA. Translation: BAA04799.1.
AK291251 mRNA. Translation: BAF83940.1.
AC010533 Genomic DNA. No translation available.
AF060370, AF060369 Genomic DNA. Translation: AAD27755.1.
AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
CCDSiCCDS10803.1. [P55287-1]
CCDS81993.1. [P55287-2]
PIRiA38992.
RefSeqiNP_001295321.1. NM_001308392.1. [P55287-2]
NP_001788.2. NM_001797.3. [P55287-1]
XP_005255818.1. XM_005255761.3. [P55287-1]
XP_005255819.1. XM_005255762.2. [P55287-1]
XP_005255820.1. XM_005255763.2. [P55287-1]
XP_011521105.1. XM_011522803.2. [P55287-1]
UniGeneiHs.116471.
Hs.596112.

Genome annotation databases

EnsembliENST00000268603; ENSP00000268603; ENSG00000140937. [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937. [P55287-2]
GeneIDi1009.
KEGGihsa:1009.
UCSCiuc002eoi.4. human. [P55287-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34056 mRNA. Translation: AAA35622.1.
D21254 mRNA. Translation: BAA04798.1.
D21255 mRNA. Translation: BAA04799.1.
AK291251 mRNA. Translation: BAF83940.1.
AC010533 Genomic DNA. No translation available.
AF060370, AF060369 Genomic DNA. Translation: AAD27755.1.
AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
CCDSiCCDS10803.1. [P55287-1]
CCDS81993.1. [P55287-2]
PIRiA38992.
RefSeqiNP_001295321.1. NM_001308392.1. [P55287-2]
NP_001788.2. NM_001797.3. [P55287-1]
XP_005255818.1. XM_005255761.3. [P55287-1]
XP_005255819.1. XM_005255762.2. [P55287-1]
XP_005255820.1. XM_005255763.2. [P55287-1]
XP_011521105.1. XM_011522803.2. [P55287-1]
UniGeneiHs.116471.
Hs.596112.

3D structure databases

ProteinModelPortaliP55287.
SMRiP55287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107444. 2 interactors.
IntActiP55287. 5 interactors.
MINTiMINT-1180975.
STRINGi9606.ENSP00000268603.

PTM databases

iPTMnetiP55287.
PhosphoSitePlusiP55287.

Polymorphism and mutation databases

BioMutaiCDH11.
DMDMi146345381.

Proteomic databases

EPDiP55287.
MaxQBiP55287.
PaxDbiP55287.
PeptideAtlasiP55287.
PRIDEiP55287.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268603; ENSP00000268603; ENSG00000140937. [P55287-1]
ENST00000394156; ENSP00000377711; ENSG00000140937. [P55287-2]
GeneIDi1009.
KEGGihsa:1009.
UCSCiuc002eoi.4. human. [P55287-1]

Organism-specific databases

CTDi1009.
DisGeNETi1009.
GeneCardsiCDH11.
H-InvDBHIX0013098.
HGNCiHGNC:1750. CDH11.
HPAiCAB013072.
MIMi600023. gene.
neXtProtiNX_P55287.
OpenTargetsiENSG00000140937.
PharmGKBiPA26284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOVERGENiHBG005217.
InParanoidiP55287.
KOiK06803.
OMAiHENYHAN.
OrthoDBiEOG091G0241.
PhylomeDBiP55287.
TreeFamiTF329887.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140937-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.
SIGNORiP55287.

Miscellaneous databases

ChiTaRSiCDH11. human.
GeneWikiiCDH11.
GenomeRNAii1009.
PROiP55287.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140937.
CleanExiHS_CDH11.
ExpressionAtlasiP55287. baseline and differential.
GenevisibleiP55287. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD11_HUMAN
AccessioniPrimary (citable) accession number: P55287
Secondary accession number(s): A8K5D6
, A8MZC8, B7WP28, Q15065, Q15066, Q9UQ93, Q9UQ94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.