Reviewed, UniProtKB/Swiss-Prot P55287 (CAD11_HUMAN)

Names and origin

Protein names

Recommended name:
    Cadherin-11
Alternative name(s):
    Osteoblast cadherin
      Short name=OB-cadherin
    OSF-4

Gene names

Name:

CDH11

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	796 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Gene Ontology (GO)
Biological process	homophilic cell adhesion Non-traceable author statement. Source: UniProtKB ossification Ref.2 Non-traceable author statement. Source: UniProtKB skeletal system development Ref.2 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CRK	P46108	1	EBI-1754095,EBI-886

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55287-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55287-2)

The sequence of this isoform differs from the canonical sequence as follows:
     632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
     694-796: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 53	31	Potential		PRO_0000003785
	Chain	54 – 796	743	Cadherin-11		PRO_0000003786
Regions
	Topological domain	54 – 617	564	Extracellular Potential
	Transmembrane	618 – 640	23	Potential
	Topological domain	641 – 796	156	Cytoplasmic Potential
	Domain	54 – 159	106	Cadherin 1
	Domain	160 – 268	109	Cadherin 2
	Domain	269 – 383	115	Cadherin 3
	Domain	384 – 486	103	Cadherin 4
	Domain	487 – 612	126	Cadherin 5
Amino acid modifications
	Glycosylation	455	1	N-linked (GlcNAc...) Potential
	Glycosylation	540	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	632 – 693	62	VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2.		VSP_000640
	Alternative sequence	694 – 796	103	Missing in isoform 2.		VSP_000641
	Natural variant	255	1	T → M: dbSNP rs35195.		VAR_031945
	Natural variant	275	1	M → I: dbSNP rs4424934.		VAR_031946
	Natural variant	373	1	S → A: dbSNP rs35213.		VAR_031947
Experimental info
	Sequence conflict	271 – 272	2	SV → RL in AAA35622. Ref.1
	Sequence conflict	271 – 272	2	SV → RL Ref.3
	Sequence conflict	340	1	K → E in AAA35622. Ref.1
	Sequence conflict	340	1	K → E Ref.3
	Sequence conflict	471	1	K → Q in AAA35622. Ref.1
	Sequence conflict	471	1	K → Q Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: E17090EC95C59936	FASTA	796	87,965
	10 20 30 40 50 60 MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 70 80 90 100 110 120 FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 130 140 150 160 170 180 RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 190 200 210 220 230 240 VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 250 260 270 280 290 300 MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 310 320 330 340 350 360 GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 370 380 390 400 410 420 NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 430 440 450 460 470 480 IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 490 500 510 520 530 540 VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 550 560 570 580 590 600 FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 610 620 630 640 650 660 LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV FEEEDVRENI 670 680 690 700 710 720 ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY QYMPRPGLRP APNSVDVDDF 730 740 750 760 770 780 INTRIQEADN DPTAPPYDSI QIYGYEGRGS VAGSLSSLES ATTDSDLDYD YLQNWGPRFK 790 KLADLYGSKD TFDDDS
	Isoform 2 [UniParc]. Checksum: 7EBFA6CEB0EABFED		693	76,457
	10 20 30 40 50 60 MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR SKRGWVWNQF 70 80 90 100 110 120 FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI FVIDDKSGNI HATKTLDREE 130 140 150 160 170 180 RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ DINDNPPEFL HETYHANVPE RSNVGTSVIQ 190 200 210 220 230 240 VTASDADDPT YGNSAKLVYS ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD 250 260 270 280 290 300 MGGHMGGLSG TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 310 320 330 340 350 360 GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA NVHIDPKFIS 370 380 390 400 410 420 NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT VVGRVHAKDP DAANSPIRYS 430 440 450 460 470 480 IDRHTDLDRF FTINPEDGFI KTTKPLDREE TAWLNITVFA AEIHNRHQEA KVPVAIRVLD 490 500 510 520 530 540 VNDNAPKFAA PYEGFICESD QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN 550 560 570 580 590 600 FTVRDNRDNT AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 610 620 630 640 650 660 LLSCNAEAYI LNAGLSTGAL IAILACIVIL LGCPSLMEPP SPREDMRLLY LGFQLMLFSY 670 680 690 VKVNRRFCLL GVFIKLPFLY VVATESPTTL TSL

References

[1]	"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed: 7982033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts." Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E. J. Biol. Chem. 269:12092-12098(1994) [PubMed: 8163513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ILE-275 AND ALA-373. Tissue: Osteosarcoma.
[3]	"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." Suzuki S., Sano K., Tanihara H. Cell Regul. 2:261-270(1991) [PubMed: 2059658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1). Tissue: Fetal brain.
[4]	"Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells." Kools P.F.J., Hogendoorn P.C.W., Bovee J.V.M.G., van Roy F. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L34056 mRNA. Translation: AAA35622.1. D21254 mRNA. Translation: BAA04798.1. D21255 mRNA. Translation: BAA04799.1. AF060370, AF060369 Genomic DNA. Translation: AAD27755.1. AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
PIR	A38992.
RefSeq	NP_001788.2.
UniGene	Hs.116471
3D structure databases
HSSP	HSSP built from PDB template 1I7W based on UniProtKB P09803.
SMR	P55287. Positions 55-375.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55287.
PTM databases
PhosphoSite	P55287.
Genome annotation databases
Ensembl	ENSG00000140937. Homo sapiens. [Contig view]
GeneID	1009.
KEGG	hsa:1009.
Organism-specific databases
H-InvDB	HIX0013098.
HGNC	HGNC:1750. CDH11.
HPA	CAB013072.
MIM	600023. gene.
PharmGKB	PA26284.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P55287.
Gene expression databases
ArrayExpress	P55287.
CleanEx	HS_CDH11.
GermOnline	ENSG00000140937. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR000233. Cadherin_C_term. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4242.
SOURCE	Search...

Entry information

Entry name

CAD11_HUMAN

Accession

Primary (citable) accession number: P55287
Secondary accession number(s): Q15065 , Q15066, Q9UQ93, Q9UQ94

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 1, 2007
Last modified:	November 25, 2008
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)