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P55287

- CAD11_HUMAN

UniProt

P55287 - CAD11_HUMAN

Protein

Cadherin-11

Gene

CDH11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. cell adhesion Source: ProtInc
    3. cell-cell junction organization Source: Reactome
    4. cell junction assembly Source: Reactome
    5. corticospinal tract morphogenesis Source: Ensembl
    6. homophilic cell adhesion Source: InterPro
    7. ossification Source: UniProtKB
    8. skeletal system development Source: ProtInc

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-11
    Alternative name(s):
    OSF-4
    Osteoblast cadherin
    Short name:
    OB-cadherin
    Gene namesi
    Name:CDH11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1750. CDH11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

    Organism-specific databases

    PharmGKBiPA26284.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 5331Sequence AnalysisPRO_0000003785Add
    BLAST
    Chaini54 – 796743Cadherin-11PRO_0000003786Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    MaxQBiP55287.
    PaxDbiP55287.
    PRIDEiP55287.

    PTM databases

    PhosphoSiteiP55287.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.

    Gene expression databases

    ArrayExpressiP55287.
    BgeeiP55287.
    CleanExiHS_CDH11.
    GenevestigatoriP55287.

    Organism-specific databases

    HPAiCAB013072.

    Interactioni

    Subunit structurei

    Interacts with PCDH8.By similarity

    Protein-protein interaction databases

    BioGridi107444. 2 interactions.
    IntActiP55287. 3 interactions.
    MINTiMINT-1180975.
    STRINGi9606.ENSP00000268603.

    Structurei

    3D structure databases

    ProteinModelPortaliP55287.
    SMRiP55287. Positions 54-593, 691-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini54 – 617564ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini641 – 796156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei618 – 64023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 612126Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301154.
    HOVERGENiHBG005217.
    InParanoidiP55287.
    KOiK06803.
    OMAiHENYHAN.
    OrthoDBiEOG7GBFW7.
    PhylomeDBiP55287.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55287-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKENYCLQAA LVCLGMLCHS HAFAPERRGH LRPSFHGHHE KGKEGQVLQR    50
    SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGTI 100
    FVIDDKSGNI HATKTLDREE RAQYTLMAQA VDRDTNRPLE PPSEFIVKVQ 150
    DINDNPPEFL HETYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS 200
    ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG 250
    TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN 300
    GLVTYNIVDG DGMESFEITT DYETQEGVIK LKKPVDFETK RAYSLKVEAA 350
    NVHIDPKFIS NGPFKDTVTV KISVEDADEP PMFLAPSYIH EVQENAAAGT 400
    VVGRVHAKDP DAANSPIRYS IDRHTDLDRF FTINPEDGFI KTTKPLDREE 450
    TAWLNITVFA AEIHNRHQEA KVPVAIRVLD VNDNAPKFAA PYEGFICESD 500
    QTKPLSNQPI VTISADDKDD TANGPRFIFS LPPEIIHNPN FTVRDNRDNT 550
    AGVYARRGGF SRQKQDLYLL PIVISDGGIP PMSSTNTLTI KVCGCDVNGA 600
    LLSCNAEAYI LNAGLSTGAL IAILACIVIL LVIVVLFVTL RRQKKEPLIV 650
    FEEEDVRENI ITYDDEGGGE EDTEAFDIAT LQNPDGINGF IPRKDIKPEY 700
    QYMPRPGLRP APNSVDVDDF INTRIQEADN DPTAPPYDSI QIYGYEGRGS 750
    VAGSLSSLES ATTDSDLDYD YLQNWGPRFK KLADLYGSKD TFDDDS 796
    Length:796
    Mass (Da):87,965
    Last modified:May 1, 2007 - v2
    Checksum:iE17090EC95C59936
    GO
    Isoform 2 (identifier: P55287-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL
         694-796: Missing.

    Show »
    Length:693
    Mass (Da):76,457
    Checksum:i7EBFA6CEB0EABFED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti271 – 2722SV → RL in AAA35622. (PubMed:7982033)Curated
    Sequence conflicti271 – 2722SV → RL no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti340 – 3401K → E in AAA35622. (PubMed:7982033)Curated
    Sequence conflicti340 – 3401K → E no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti471 – 4711K → Q in AAA35622. (PubMed:7982033)Curated
    Sequence conflicti471 – 4711K → Q no nucleotide entry (PubMed:2059658)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti255 – 2551T → M.
    Corresponds to variant rs35195 [ dbSNP | Ensembl ].
    VAR_031945
    Natural varianti275 – 2751M → I.1 Publication
    Corresponds to variant rs1130821 [ dbSNP | Ensembl ].
    VAR_031946
    Natural varianti373 – 3731S → A.2 Publications
    Corresponds to variant rs35213 [ dbSNP | Ensembl ].
    VAR_031947

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei632 – 69362VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2. 1 PublicationVSP_000640Add
    BLAST
    Alternative sequencei694 – 796103Missing in isoform 2. 1 PublicationVSP_000641Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34056 mRNA. Translation: AAA35622.1.
    D21254 mRNA. Translation: BAA04798.1.
    D21255 mRNA. Translation: BAA04799.1.
    AK291251 mRNA. Translation: BAF83940.1.
    AC010533 Genomic DNA. No translation available.
    AF060370, AF060369 Genomic DNA. Translation: AAD27755.1.
    AF060370, AF060369 Genomic DNA. Translation: AAD27756.1.
    CCDSiCCDS10803.1. [P55287-1]
    PIRiA38992.
    RefSeqiNP_001788.2. NM_001797.2. [P55287-1]
    XP_005255818.1. XM_005255761.2. [P55287-1]
    XP_005255819.1. XM_005255762.1. [P55287-1]
    XP_005255820.1. XM_005255763.1. [P55287-1]
    XP_005255821.1. XM_005255764.1. [P55287-2]
    UniGeneiHs.116471.

    Genome annotation databases

    EnsembliENST00000268603; ENSP00000268603; ENSG00000140937. [P55287-1]
    ENST00000394156; ENSP00000377711; ENSG00000140937. [P55287-2]
    GeneIDi1009.
    KEGGihsa:1009.
    UCSCiuc002eoi.3. human. [P55287-1]
    uc002eoj.3. human. [P55287-2]

    Polymorphism databases

    DMDMi146345381.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34056 mRNA. Translation: AAA35622.1 .
    D21254 mRNA. Translation: BAA04798.1 .
    D21255 mRNA. Translation: BAA04799.1 .
    AK291251 mRNA. Translation: BAF83940.1 .
    AC010533 Genomic DNA. No translation available.
    AF060370 , AF060369 Genomic DNA. Translation: AAD27755.1 .
    AF060370 , AF060369 Genomic DNA. Translation: AAD27756.1 .
    CCDSi CCDS10803.1. [P55287-1 ]
    PIRi A38992.
    RefSeqi NP_001788.2. NM_001797.2. [P55287-1 ]
    XP_005255818.1. XM_005255761.2. [P55287-1 ]
    XP_005255819.1. XM_005255762.1. [P55287-1 ]
    XP_005255820.1. XM_005255763.1. [P55287-1 ]
    XP_005255821.1. XM_005255764.1. [P55287-2 ]
    UniGenei Hs.116471.

    3D structure databases

    ProteinModelPortali P55287.
    SMRi P55287. Positions 54-593, 691-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107444. 2 interactions.
    IntActi P55287. 3 interactions.
    MINTi MINT-1180975.
    STRINGi 9606.ENSP00000268603.

    PTM databases

    PhosphoSitei P55287.

    Polymorphism databases

    DMDMi 146345381.

    Proteomic databases

    MaxQBi P55287.
    PaxDbi P55287.
    PRIDEi P55287.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268603 ; ENSP00000268603 ; ENSG00000140937 . [P55287-1 ]
    ENST00000394156 ; ENSP00000377711 ; ENSG00000140937 . [P55287-2 ]
    GeneIDi 1009.
    KEGGi hsa:1009.
    UCSCi uc002eoi.3. human. [P55287-1 ]
    uc002eoj.3. human. [P55287-2 ]

    Organism-specific databases

    CTDi 1009.
    GeneCardsi GC16M064977.
    H-InvDB HIX0013098.
    HGNCi HGNC:1750. CDH11.
    HPAi CAB013072.
    MIMi 600023. gene.
    neXtProti NX_P55287.
    PharmGKBi PA26284.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301154.
    HOVERGENi HBG005217.
    InParanoidi P55287.
    KOi K06803.
    OMAi HENYHAN.
    OrthoDBi EOG7GBFW7.
    PhylomeDBi P55287.
    TreeFami TF329887.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    ChiTaRSi CDH11. human.
    GeneWikii CDH11.
    GenomeRNAii 1009.
    NextBioi 4242.
    PROi P55287.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55287.
    Bgeei P55287.
    CleanExi HS_CDH11.
    Genevestigatori P55287.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
      Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
      Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts."
      Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E.
      J. Biol. Chem. 269:12092-12098(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ILE-275 AND ALA-373.
      Tissue: Osteosarcoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-373.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
      Suzuki S., Sano K., Tanihara H.
      Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1).
      Tissue: Fetal brain.
    6. "Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells."
      Kools P.F.J., Hogendoorn P.C.W., Bovee J.V.M.G., van Roy F.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668.
    7. Cited for: CHROMOSOMAL TRANSLOCATION WITH USP6.

    Entry informationi

    Entry nameiCAD11_HUMAN
    AccessioniPrimary (citable) accession number: P55287
    Secondary accession number(s): A8K5D6
    , A8MZC8, B7WP28, Q15065, Q15066, Q9UQ93, Q9UQ94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3