Reviewed,
UniProtKB/Swiss-Prot P55287 (CAD11_HUMAN)
Last modified
February 9, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Cadherin-11 Alternative name(s): Osteoblast cadherin Short name=OB-cadherin OSF-4 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 796 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Subcellular location | |
| Tissue specificity | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. |
| Sequence similarities | Contains 5 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Ligand | Calcium |
| PTM | Cleavage on pair of basic residues Glycoprotein Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | homophilic cell adhesion Non-traceable author statement. Source: UniProtKB ossification Ref.2Non-traceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB plasma membraneInferred from Experiment. Source: Reactome |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P55287-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P55287-2) The sequence of this isoform differs from the canonical sequence as follows: 632-693: VIVVLFVTLR...PDGINGFIPR → GCPSLMEPPS...TESPTTLTSL 694-796: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 22 | 22 | Potential | ||||||
| Propeptide | 23 – 53 | 31 | Potential | PRO_0000003785 | |||||
| Chain | 54 – 796 | 743 | Cadherin-11 | PRO_0000003786 | |||||
Regions | |||||||||
| Topological domain | 54 – 617 | 564 | Extracellular Potential | ||||||
| Transmembrane | 618 – 640 | 23 | Potential | ||||||
| Topological domain | 641 – 796 | 156 | Cytoplasmic Potential | ||||||
| Domain | 54 – 159 | 106 | Cadherin 1 | ||||||
| Domain | 160 – 268 | 109 | Cadherin 2 | ||||||
| Domain | 269 – 383 | 115 | Cadherin 3 | ||||||
| Domain | 384 – 486 | 103 | Cadherin 4 | ||||||
| Domain | 487 – 612 | 126 | Cadherin 5 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 714 | 1 | Phosphoserine By similarity | ||||||
| Glycosylation | 455 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 540 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 632 – 693 | 62 | VIVVL…GFIPR → GCPSLMEPPSPREDMRLLYL GFQLMLFSYVKVNRRFCLLG VFIKLPFLYVVATESPTTLT SL in isoform 2. | VSP_000640 | |||||
| Alternative sequence | 694 – 796 | 103 | Missing in isoform 2. | VSP_000641 | |||||
| Natural variant | 255 | 1 | T → M: dbSNP rs35195. | VAR_031945 | |||||
| Natural variant | 275 | 1 | M → I: dbSNP rs1130821. Ref.2 | VAR_031946 | |||||
| Natural variant | 373 | 1 | S → A: dbSNP rs35213. Ref.2 Ref.3 | VAR_031947 | |||||
Experimental info | |||||||||
| Sequence conflict | 271 – 272 | 2 | SV → RL in AAA35622. Ref.1 | ||||||
| Sequence conflict | 271 – 272 | 2 | SV → RL Ref.5 | ||||||
| Sequence conflict | 340 | 1 | K → E in AAA35622. Ref.1 | ||||||
| Sequence conflict | 340 | 1 | K → E Ref.5 | ||||||
| Sequence conflict | 471 | 1 | K → Q in AAA35622. Ref.1 | ||||||
| Sequence conflict | 471 | 1 | K → Q Ref.5 | ||||||
Sequences
| ||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed: 7982033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. |
| [2] | "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts." Okazaki M., Takeshita S., Kawai S., Kikuno R., Tsujimura A., Kudo A., Amann E. J. Biol. Chem. 269:12092-12098(1994) [PubMed: 8163513] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ILE-275 AND ALA-373. Tissue: Osteosarcoma. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-373. |
| [4] | "The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A.Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." Suzuki S., Sano K., Tanihara H. Cell Regul. 2:261-270(1991) [PubMed: 2059658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-796 (ISOFORM 1). Tissue: Fetal brain. |
| [6] | "Alternative cadherin-11 transcripts encoding truncated adhesion molecules are detectable in both human cancer and normal cells." Kools P.F.J., Hogendoorn P.C.W., Bovee J.V.M.G., van Roy F. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 600-668. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L34056 mRNA. Translation: AAA35622.1. D21254 mRNA. Translation: BAA04798.1. D21255 mRNA. Translation: BAA04799.1. AK291251 mRNA. Translation: BAF83940.1. AC010533 Genomic DNA. No translation available. AF060370, AF060369 Genomic DNA. Translation: AAD27755.1. AF060370, AF060369 Genomic DNA. Translation: AAD27756.1. |
| IPI | IPI00293539. IPI00304227. |
| PIR | A38992. |
| RefSeq | NP_001788.2. |
| UniGene | Hs.116471 |
3D structure databases | |
| SMR | P55287. Positions 54-151, 55-375, 391-489, 725-786. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P55287. 1 interaction. |
| STRING | P55287. |
PTM databases | |
| PhosphoSite | P55287. |
Proteomic databases | |
| PRIDE | P55287. |
Genome annotation databases | |
| Ensembl | ENST00000268603; ENSP00000268603; ENSG00000140937; Homo sapiens. [Genome view] ENST00000394156; ENSP00000377711; ENSG00000140937; Homo sapiens. [Genome view] |
| GeneID | 1009. |
| KEGG | hsa:1009. |
| UCSC | uc002eoi.1. human. uc002eoj.1. human. |
Organism-specific databases | |
| CTD | 1009. |
| GeneCards | GC16M063538. |
| H-InvDB | HIX0013098. |
| HGNC | HGNC:1750. CDH11. |
| HPA | CAB013072. |
| MIM | 600023. gene. |
| PharmGKB | PA26284. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12847. |
| HOVERGEN | P55287. |
| InParanoid | P55287. |
| OMA | HQEAKVP. |
| OrthoDB | EOG9B2WGP. |
| PhylomeDB | P55287. |
Enzyme and pathway databases | |
| Reactome | REACT_20676. Cell junction organization. |
Gene expression databases | |
| ArrayExpress | P55287. |
| Bgee | P55287. |
| CleanEx | HS_CDH11. |
| Genevestigator | P55287. |
| GermOnline | ENSG00000140937. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 5 hits. |
| Pfam | PF00028. Cadherin. 4 hits. PF01049. Cadherin_C. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| PROSITE | PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 4242. |
| SOURCE | Search... |
Entry information
| Entry name | CAD11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P55287 Secondary accession number(s): A8K5D6 Q9UQ94 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


