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P55286

- CADH8_HUMAN

UniProt

P55286 - CADH8_HUMAN

Protein

Cadherin-8

Gene

CDH8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. cell adhesion Source: ProtInc
    3. cell-cell junction organization Source: Reactome
    4. cell junction assembly Source: Reactome
    5. homophilic cell adhesion Source: InterPro
    6. response to cold Source: Ensembl
    7. synaptic transmission, glutamatergic Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-8
    Gene namesi
    Name:CDH8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1767. CDH8.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome
    4. synaptic cleft Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 6132Sequence AnalysisPRO_0000003773Add
    BLAST
    Chaini62 – 799738Cadherin-8PRO_0000003774Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiP55286.
    PeptideAtlasiP55286.
    PRIDEiP55286.

    PTM databases

    PhosphoSiteiP55286.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

    Gene expression databases

    ArrayExpressiP55286.
    BgeeiP55286.
    CleanExiHS_CDH8.
    GenevestigatoriP55286.

    Organism-specific databases

    HPAiHPA014908.

    Interactioni

    Protein-protein interaction databases

    BioGridi107441. 1 interaction.
    STRINGi9606.ENSP00000299345.

    Structurei

    3D structure databases

    ProteinModelPortaliP55286.
    SMRiP55286. Positions 63-597, 729-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini62 – 621560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini643 – 799157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei622 – 64221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 167106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 276109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini277 – 391115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini392 – 494103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini495 – 616122Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330572.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiP55286.
    KOiK06800.
    OMAiSIEPHTA.
    PhylomeDBiP55286.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55286-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG    50
    EEQRILNRSK RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL 100
    SGDGAGTIFQ INDVTGDIHA IKRLDREEKA EYTLTAQAVD WETSKPLEPP 150
    SEFIIKVQDI NDNAPEFLNG PYHATVPEMS ILGTSVTNVT ATDADDPVYG 200
    NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY LVVIQAKDMG 250
    GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 300
    NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS 350
    YTLKVEAANV HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV 400
    HENAALNSVI GQVTARDPDI TSSPIRFSID RHTDLERQFN INADDGKITL 450
    ATPLDRELSV WHNITIIATE IRNHSQISRV PVAIKVLDVN DNAPEFASEY 500
    EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV NNPNFTIKKN 550
    EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS 600
    NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE 650
    PLIIKDDEDV RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI 700
    KPDLQFMPRQ GLAPVPNGVD VDEFINVRLH EADNDPTAPP YDSIQIYGYE 750
    GRGSVAGSLS SLESTTSDSD QNFDYLSDWG PRFKRLGELY SVGESDKET 799
    Length:799
    Mass (Da):88,253
    Last modified:April 27, 2001 - v2
    Checksum:i9B119B86039C6A0A
    GO

    Sequence cautioni

    The sequence AAA35628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti355 – 3551V → D in AAA35628. (PubMed:7982033)Curated
    Sequence conflicti648 – 6481K → QK in AAA35628. (PubMed:7982033)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035305 mRNA. Translation: BAA87419.1.
    AK124734 mRNA. Translation: BAG54083.1.
    BC113416 mRNA. Translation: AAI13417.1.
    L34060 mRNA. Translation: AAA35628.1. Different initiation.
    CCDSiCCDS10802.1.
    RefSeqiNP_001787.2. NM_001796.4.
    XP_005255816.1. XM_005255759.2.
    UniGeneiHs.368322.

    Genome annotation databases

    EnsembliENST00000577390; ENSP00000462701; ENSG00000150394.
    GeneIDi1006.
    KEGGihsa:1006.
    UCSCiuc002eog.2. human.

    Polymorphism databases

    DMDMi13432121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035305 mRNA. Translation: BAA87419.1 .
    AK124734 mRNA. Translation: BAG54083.1 .
    BC113416 mRNA. Translation: AAI13417.1 .
    L34060 mRNA. Translation: AAA35628.1 . Different initiation.
    CCDSi CCDS10802.1.
    RefSeqi NP_001787.2. NM_001796.4.
    XP_005255816.1. XM_005255759.2.
    UniGenei Hs.368322.

    3D structure databases

    ProteinModelPortali P55286.
    SMRi P55286. Positions 63-597, 729-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107441. 1 interaction.
    STRINGi 9606.ENSP00000299345.

    PTM databases

    PhosphoSitei P55286.

    Polymorphism databases

    DMDMi 13432121.

    Proteomic databases

    PaxDbi P55286.
    PeptideAtlasi P55286.
    PRIDEi P55286.

    Protocols and materials databases

    DNASUi 1006.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000577390 ; ENSP00000462701 ; ENSG00000150394 .
    GeneIDi 1006.
    KEGGi hsa:1006.
    UCSCi uc002eog.2. human.

    Organism-specific databases

    CTDi 1006.
    GeneCardsi GC16M061681.
    HGNCi HGNC:1767. CDH8.
    HPAi HPA014908.
    MIMi 603008. gene.
    neXtProti NX_P55286.
    PharmGKBi PA26304.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330572.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi P55286.
    KOi K06800.
    OMAi SIEPHTA.
    PhylomeDBi P55286.
    TreeFami TF329887.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    ChiTaRSi CDH8. human.
    GeneWikii CDH8.
    GenomeRNAii 1006.
    NextBioi 4230.
    PROi P55286.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55286.
    Bgeei P55286.
    CleanExi HS_CDH8.
    Genevestigatori P55286.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
      Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
      Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
      Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
      Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-799.
      Tissue: Brain.
    5. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
      Suzuki S., Sano K., Tanihara H.
      Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-799.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiCADH8_HUMAN
    AccessioniPrimary (citable) accession number: P55286
    Secondary accession number(s): B3KWC1, Q14DC6, Q9ULB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3