Cadherin-8 precursor - Homo sapiens (Human)

Contribute

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P55286 (CADH8_HUMAN)

Last modified June 16, 2009. Version 72. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Cadherin-8

Gene names

Name:

CDH8

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	799 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Gene Ontology (GO)
Biological process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

29

Potential

Propeptide

32

Potential

PRO_0000003773

Chain

738

Cadherin-8

PRO_0000003774

Regions

Topological domain

560

Extracellular Potential

Transmembrane

21

Potential

Topological domain

157

Cytoplasmic Potential

Domain

106

Cadherin 1

Domain

109

Cadherin 2

Domain

115

Cadherin 3

Domain

103

Cadherin 4

Domain

122

Cadherin 5

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

1

V → D in AAA35628. Ref.4

Sequence conflict

1

K → QK in AAA35628. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P55286-1 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 9B119B86039C6A0A
Show »

799

88,253

        10         20         30         40         50         60 
MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG EEQRILNRSK 

        70         80         90        100        110        120 
RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDVTGDIHA 

       130        140        150        160        170        180 
IKRLDREEKA EYTLTAQAVD WETSKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 

       190        200        210        220        230        240 
ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 

       250        260        270        280        290        300 
LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 

       310        320        330        340        350        360 
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV 

       370        380        390        400        410        420 
HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 

       430        440        450        460        470        480 
TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV 

       490        500        510        520        530        540 
PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV 

       550        560        570        580        590        600 
NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS 

       610        620        630        640        650        660 
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 

       670        680        690        700        710        720 
RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 

       730        740        750        760        770        780 
VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 

       790 
PRFKRLGELY SVGESDKET

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J. 349:159-167(2000) [PubMed: 10861224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed: 7982033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-799. Tissue: Brain.
[5]	"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." Suzuki S., Sano K., Tanihara H. Cell Regul. 2:261-270(1991) [PubMed: 2059658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-799. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
	AB035305 mRNA. Translation: BAA87419.1. AK124734 mRNA. Translation: BAG54083.1. BC113416 mRNA. Translation: AAI13417.1. L34060 mRNA. Translation: AAA35628.1. Different initiation.
IPI	IPI00024036.
RefSeq	NP_001787.2.
UniGene	Hs.368322
3D structure databases
HSSP	HSSP built from PDB template 1I7W based on UniProtKB P09803.
SMR	P55286. Positions 63-383.
ModBase	Search...
PTM databases
PhosphoSite	P55286.
Proteomic databases
PeptideAtlas	P55286.
PRIDE	P55286.
Genome annotation databases
Ensembl	ENSG00000150394. Homo sapiens. [Contig view]
GeneID	1006.
KEGG	hsa:1006.
Organism-specific databases
GeneCards	GC16M060244.
H-InvDB	HIX0026933.
HGNC	HGNC:1767. CDH8.
HPA	HPA014908.
MIM	603008. gene.
PharmGKB	PA26304.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P55286.
HOVERGEN	P55286.
OMA	P55286. TIKKNEX.
Gene expression databases
ArrayExpress	P55286.
Bgee	P55286.
CleanEx	HS_CDH8.
GermOnline	ENSG00000150394. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR000233. Cadherin_C_term. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4230.
SOURCE	Search...

Entry information

Entry name

CADH8_HUMAN

Accession

Primary (citable) accession number: P55286
Secondary accession number(s): B3KWC1, Q14DC6, Q9ULB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 27, 2001
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents