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P55286 (CADH8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-8
Gene names
Name:CDH8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Sequence caution

The sequence AAA35628.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Propeptide30 – 6132 Potential
PRO_0000003773
Chain62 – 799738Cadherin-8
PRO_0000003774

Regions

Topological domain62 – 621560Extracellular Potential
Transmembrane622 – 64221Helical; Potential
Topological domain643 – 799157Cytoplasmic Potential
Domain62 – 167106Cadherin 1
Domain168 – 276109Cadherin 2
Domain277 – 391115Cadherin 3
Domain392 – 494103Cadherin 4
Domain495 – 616122Cadherin 5

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4731N-linked (GlcNAc...) Potential
Glycosylation5441N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3551V → D in AAA35628. Ref.4
Sequence conflict6481K → QK in AAA35628. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P55286 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 9B119B86039C6A0A

FASTA79988,253
        10         20         30         40         50         60 
MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG EEQRILNRSK 

        70         80         90        100        110        120 
RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDVTGDIHA 

       130        140        150        160        170        180 
IKRLDREEKA EYTLTAQAVD WETSKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 

       190        200        210        220        230        240 
ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 

       250        260        270        280        290        300 
LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 

       310        320        330        340        350        360 
NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV 

       370        380        390        400        410        420 
HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 

       430        440        450        460        470        480 
TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV 

       490        500        510        520        530        540 
PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV 

       550        560        570        580        590        600 
NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS 

       610        620        630        640        650        660 
NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 

       670        680        690        700        710        720 
RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 

       730        740        750        760        770        780 
VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 

       790 
PRFKRLGELY SVGESDKET 

« Hide

References

« Hide 'large scale' references
[1]"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-799.
Tissue: Brain.
[5]"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
Suzuki S., Sano K., Tanihara H.
Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-799.
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB035305 mRNA. Translation: BAA87419.1.
AK124734 mRNA. Translation: BAG54083.1.
BC113416 mRNA. Translation: AAI13417.1.
L34060 mRNA. Translation: AAA35628.1. Different initiation.
RefSeqNP_001787.2. NM_001796.4.
XP_005255816.1. XM_005255759.2.
UniGeneHs.368322.

3D structure databases

ProteinModelPortalP55286.
SMRP55286. Positions 63-597, 697-790.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107441. 1 interaction.
STRING9606.ENSP00000299345.

PTM databases

PhosphoSiteP55286.

Polymorphism databases

DMDM13432121.

Proteomic databases

PaxDbP55286.
PeptideAtlasP55286.
PRIDEP55286.

Protocols and materials databases

DNASU1006.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000577390; ENSP00000462701; ENSG00000150394.
GeneID1006.
KEGGhsa:1006.
UCSCuc002eog.2. human.

Organism-specific databases

CTD1006.
GeneCardsGC16M061681.
HGNCHGNC:1767. CDH8.
HPAHPA014908.
MIM603008. gene.
neXtProtNX_P55286.
PharmGKBPA26304.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330572.
HOGENOMHOG000231252.
HOVERGENHBG005217.
InParanoidP55286.
KOK06800.
OMAGIVQSCN.
PhylomeDBP55286.
TreeFamTF329887.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP55286.
BgeeP55286.
CleanExHS_CDH8.
GenevestigatorP55286.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCDH8. human.
GeneWikiCDH8.
GenomeRNAi1006.
NextBio4230.
PROP55286.
SOURCESearch...

Entry information

Entry nameCADH8_HUMAN
AccessionPrimary (citable) accession number: P55286
Secondary accession number(s): B3KWC1, Q14DC6, Q9ULB2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM