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Reviewed, UniProtKB/Swiss-Prot P55285 (CADH6_HUMAN)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cadherin-6
Alternative name(s):
    Kidney cadherin
      Short name=K-cadherin
Gene names
Name: CDH6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length790 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.

Sequence similarities

Contains 5 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
   LigandCalcium
   PTMCleavage on pair of basic residues
Glycoprotein
Gene Ontology (GO)
   Biological processhomophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from direct assay. Source: HPA

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay. Source: HPA

plasma membrane

Inferred from direct assay. Source: HPA

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55285-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55285-2)

The sequence of this isoform differs from the canonical sequence as follows:
     628-663: VTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEG → GKLVLPASYLPMVRGSHCYCDTLDLSASPIKAYSLI
     664-790: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 5335 Potential
PRO_0000003761
Chain54 – 790737Cadherin-6
PRO_0000003762

Regions

Topological domain54 – 615562Extracellular Potential
Transmembrane616 – 63621 Potential
Topological domain637 – 790154Cytoplasmic Potential
Domain54 – 159106Cadherin 1
Domain160 – 268109Cadherin 2
Domain269 – 383115Cadherin 3
Domain384 – 486103Cadherin 4
Domain487 – 608122Cadherin 5

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation3991N-linked (GlcNAc...) Ref.4
Glycosylation4371N-linked (GlcNAc...) Ref.5
Glycosylation4551N-linked (GlcNAc...) Ref.5
Glycosylation5361N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence628 – 66336VTVVL…YNDEG → GKLVLPASYLPMVRGSHCYC DTLDLSASPIKAYSLI in isoform 2.
VSP_000636
Alternative sequence664 – 790127Missing in isoform 2.
VSP_000637

Experimental info

Sequence conflict4211V → I Ref.3
Sequence conflict4251T → I Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C175004FC8A61100

FASTA79088,309
        10         20         30         40         50         60 
MRTYRYFLLL FWVGQPYPTL STPLSKRTSG FPAKKRALEL SGNSKNELNR SKRSWMWNQF 

        70         80         90        100        110        120 
FLLEEYTGSD YQYVGKLHSD QDRGDGSLKY ILSGDGAGDL FIINENTGDI QATKRLDREE 

       130        140        150        160        170        180 
KPVYILRAQA INRRTGRPVE PESEFIIKIH DINDNEPIFT KEVYTATVPE MSDVGTFVVQ 

       190        200        210        220        230        240 
VTATDADDPT YGNSAKVVYS ILQGQPYFSV ESETGIIKTA LLNMDRENRE QYQVVIQAKD 

       250        260        270        280        290        300 
MGGQMGGLSG TTTVNITLTD VNDNPPRFPQ STYQFKTPES SPPGTPIGRI KASDADVGEN 

       310        320        330        340        350        360 
AEIEYSITDG EGLDMFDVIT DQETQEGIIT VKKLLDFEKK KVYTLKVEAS NPYVEPRFLY 

       370        380        390        400        410        420 
LGPFKDSATV RIVVEDVDEP PVFSKLAYIL QIREDAQINT TIGSVTAQDP DAARNPVKYS 

       430        440        450        460        470        480 
VDRHTDMDRI FNIDSGNGSI FTSKLLDRET LLWHNITVIA TEINNPKQSS RVPLYIKVLD 

       490        500        510        520        530        540 
VNDNAPEFAE FYETFVCEKA KADQLIQTLH AVDKDDPYSG HQFSFSLAPE AASGSNFTIQ 

       550        560        570        580        590        600 
DNKDNTAGIL TRKNGYNRHE MSTYLLPVVI SDNDYPVQSS TGTVTVRVCA CDHHGNMQSC 

       610        620        630        640        650        660 
HAEALIHPTG LSTGALVAIL LCIVILLVTV VLFAALRRQR KKEPLIISKE DIRDNIVSYN 

       670        680        690        700        710        720 
DEGGGEEDTQ AFDIGTLRNP EAIEDNKLRR DIVPEALFLP RRTPTARDNT DVRDFINQRL 

       730        740        750        760        770        780 
KENDTDPTAP PYDSLATYAY EGTGSVADSL SSLESVTTDA DQDYDYLSDW GPRFKKLADM 

       790 
YGGVDSDKDS 

« Hide

Isoform 2.

Checksum: 97319C50BED1DC28
Show »

FASTA66373,864

References

« Hide 'large scale' references
[1]"Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells."
Shimoyama Y., Gotoh M., Terasaki T., Kitajima M., Hirohashi S.
Cancer Res. 55:2206-2211(1995) [PubMed: 7743525] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
[3]"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
Suzuki S., Sano K., Tanihara H.
Cell Regul. 2:261-270(1991) [PubMed: 2059658] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 377-790 (ISOFORM 1).
Tissue: Fetal brain.
[4]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-399, MASS SPECTROMETRY.
Tissue: Plasma.
[5]"Identification of N-glycosylation sites on secreted proteins of human hepatocellular carcinoma cells with a complementary proteomics approach."
Cao J., Shen C., Wang H., Shen H., Chen Y., Nie A., Yan G., Lu H., Liu Y., Yang P.
J. Proteome Res. 8:662-672(2009) [PubMed: 19196183] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-437 AND ASN-455, MASS SPECTROMETRY.

Cross-references

Sequence databases

D31784 mRNA. Translation: BAA06562.1.
BC000019 mRNA. Translation: AAH00019.1.
IPIIPI00024035.
IPI00217314.
PIRI37016.
RefSeqNP_004923.1.
UniGeneHs.171054

3D structure databases

HSSPHSSP built from PDB template 1I7W based on UniProtKB P09803.
SMRP55285. Positions 716-781.
ModBaseSearch...

PTM databases

PhosphoSiteP55285.

Proteomic databases

PRIDEP55285.

Genome annotation databases

EnsemblENSG00000113361. Homo sapiens. [Contig view]
GeneID1004.
KEGGhsa:1004.

Organism-specific databases

GeneCardsGC05P031229.
H-InvDBHIX0004778.
HGNCHGNC:1765. CDH6.
HPAHPA007047.
HPA007456.
MIM603007. gene.
PharmGKBPA26302.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP55285.
HOVERGENP55285.
OMAP55285. RHEMSTY.

Gene expression databases

ArrayExpressP55285.
BgeeP55285.
CleanExHS_CDH6.
GermOnlineENSG00000113361. Homo sapiens.

Family and domain databases

InterProIPR002126. Cadherin.
IPR000233. Cadherin_C_term.
[Graphical view]
Gene3DG3DSA:2.60.40.60. Cadherin. 5 hits.
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4220.
SOURCESearch...

Entry information

Entry nameCADH6_HUMAN
AccessionPrimary (citable) accession number: P55285
Secondary accession number(s): Q9BWS0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents