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P55283 (CADH4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name=R-CAD
Short name=R-cadherin
Gene names
Name:CDH4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length916 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed mainly in brain but also found in other tissues.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P55283-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P55283-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 169149 Potential
PRO_0000003749
Chain170 – 916747Cadherin-4
PRO_0000003750

Regions

Topological domain170 – 734565Extracellular Potential
Transmembrane735 – 75622Helical; Potential
Topological domain757 – 916160Cytoplasmic Potential
Domain170 – 277108Cadherin 1
Domain278 – 392115Cadherin 2
Domain393 – 507115Cadherin 3
Domain508 – 613106Cadherin 4
Domain614 – 724111Cadherin 5
Compositional bias873 – 88816Ser-rich

Amino acid modifications

Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation4121N-linked (GlcNAc...) Potential
Glycosylation5571N-linked (GlcNAc...) Potential
Glycosylation6321N-linked (GlcNAc...) Potential
Glycosylation6611N-linked (GlcNAc...) Potential
Glycosylation7021N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 7474Missing in isoform 2.
VSP_045548
Natural variant1411A → V.
Corresponds to variant rs34937312 [ dbSNP | Ensembl ].
VAR_048504
Natural variant6251K → R. Ref.1 Ref.6
Corresponds to variant rs6142884 [ dbSNP | Ensembl ].
VAR_033699

Experimental info

Sequence conflict881T → A in BAG54080. Ref.2
Sequence conflict2231D → N in AAA35627. Ref.1
Sequence conflict2741R → H in AAA35627. Ref.1
Sequence conflict2841G → C in AAA35627. Ref.1
Sequence conflict2991V → I in AAA35627. Ref.1
Sequence conflict3471L → W in AAA35627. Ref.1
Sequence conflict3901P → S in AAA35627. Ref.1
Sequence conflict4051R → S in AAA35627. Ref.1
Sequence conflict4051R → S no nucleotide entry Ref.6
Sequence conflict5021N → S in BAG54080. Ref.2
Sequence conflict5401Q → R in BAG54080. Ref.2
Sequence conflict5661A → V in AAA35627. Ref.1
Sequence conflict5661A → V no nucleotide entry Ref.6
Sequence conflict6411D → H in AAA35627. Ref.1
Sequence conflict6411D → H no nucleotide entry Ref.6
Sequence conflict778 – 7792DN → EK in AAA35627. Ref.1
Sequence conflict778 – 7792DN → EK no nucleotide entry Ref.6
Sequence conflict8261A → P in AAA35627. Ref.1
Sequence conflict8261A → P no nucleotide entry Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: E4512F94E58046D7

FASTA916100,281
        10         20         30         40         50         60 
MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE GEKLLQVKFS 

        70         80         90        100        110        120 
SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF TVTAWDSQTA EKWDAVVRLL 

       130        140        150        160        170        180 
VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD TLLPWPQHQN ANGLRRRKRD WVIPPINVPE 

       190        200        210        220        230        240 
NSRGPFPQQL VRIRSDKDND IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH 

       250        260        270        280        290        300 
ASYHLRAHAV DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT 

       310        320        330        340        350        360 
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE KVQQYTVIVQ 

       370        380        390        400        410        420 
ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE VPENRVETVV ANLTVMDRDQ 

       430        440        450        460        470        480 
PHSPNWNAVY RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL 

       490        500        510        520        530        540 
ASGIQMSFQS TAGVTISIMD INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ 

       550        560        570        580        590        600 
AVRYSKLSDP ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT 

       610        620        630        640        650        660 
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE LPFVPAAVRK 

       670        680        690        700        710        720 
NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL SNTSIIKVKV CPCDDNGDCT 

       730        740        750        760        770        780 
TIGAVAAAGL GTGAIVAILI CILILLTMVL LFVMWMKRRE KERHTKQLLI DPEDDVRDNI 

       790        800        810        820        830        840 
LKYDEEGGGE EDQDYDLSQL QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG 

       850        860        870        880        890        900 
DIGDFINEGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG 

       910 
PRFKKLADMY GGGEED 

« Hide

Isoform 2 [UniParc].

Checksum: DD1D6C1B9EF29D32
Show »

FASTA84292,388

References

« Hide 'large scale' references
[1]"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-625.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain cortex.
[6]"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
Suzuki S., Sano K., Tanihara H.
Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 393-916 (ISOFORM 1), VARIANT ARG-625.
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34059 mRNA. Translation: AAA35627.1.
AK124724 mRNA. Translation: BAG54080.1.
AL365401 expand/collapse EMBL AC list , AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2.
AL162457 expand/collapse EMBL AC list , AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1.
AL109911 expand/collapse EMBL AC list , AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1.
AL365229 expand/collapse EMBL AC list , AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1.
AL079336 Genomic DNA. No translation available.
AL160412 Genomic DNA. No translation available.
AL391316 Genomic DNA. No translation available.
AL450463 Genomic DNA. No translation available.
BX640515 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75409.1.
BC101651 mRNA. Translation: AAI01652.1.
BC112150 mRNA. Translation: AAI12151.1.
CCDSCCDS13488.1. [P55283-1]
CCDS58784.1. [P55283-2]
PIRC38992.
RefSeqNP_001239268.1. NM_001252339.2. [P55283-2]
NP_001785.2. NM_001794.4. [P55283-1]
UniGeneHs.473231.

3D structure databases

ProteinModelPortalP55283.
SMRP55283. Positions 31-711, 828-913.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107437. 3 interactions.
IntActP55283. 1 interaction.
STRING9606.ENSP00000353656.

PTM databases

PhosphoSiteP55283.

Polymorphism databases

DMDM81175161.

Proteomic databases

MaxQBP55283.
PaxDbP55283.
PRIDEP55283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360469; ENSP00000353656; ENSG00000179242. [P55283-1]
ENST00000543233; ENSP00000443301; ENSG00000179242. [P55283-2]
GeneID1002.
KEGGhsa:1002.
UCSCuc002ybn.2. human. [P55283-1]

Organism-specific databases

CTD1002.
GeneCardsGC20P059827.
HGNCHGNC:1763. CDH4.
HPAHPA015613.
MIM603006. gene.
neXtProtNX_P55283.
PharmGKBPA26300.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000231254.
HOVERGENHBG106438.
InParanoidP55283.
KOK06797.
OMAPMEVFSI.
OrthoDBEOG7RJPQM.
PhylomeDBP55283.
TreeFamTF316817.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressP55283.
BgeeP55283.
CleanExHS_CDH4.
GenevestigatorP55283.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 7 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCDH4.
GenomeRNAi1002.
NextBio4212.
PROP55283.
SOURCESearch...

Entry information

Entry nameCADH4_HUMAN
AccessionPrimary (citable) accession number: P55283
Secondary accession number(s): B3KWB8 expand/collapse secondary AC list , G3V1P8, Q2M208, Q5VZ44, Q9BZ05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM