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Protein

Cadherin-4

Gene

CDH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179242-MONOMER.
ReactomeiR-HSA-375170. CDO in myogenesis.
R-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
Gene namesi
Name:CDH4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:1763. CDH4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini170 – 734ExtracellularSequence analysisAdd BLAST565
Transmembranei735 – 756HelicalSequence analysisAdd BLAST22
Topological domaini757 – 916CytoplasmicSequence analysisAdd BLAST160

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1002.
OpenTargetsiENSG00000179242.
PharmGKBiPA26300.

Polymorphism and mutation databases

BioMutaiCDH4.
DMDMi81175161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000000374921 – 169Sequence analysisAdd BLAST149
ChainiPRO_0000003750170 – 916Cadherin-4Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi283N-linked (GlcNAc...)Sequence analysis1
Glycosylationi412N-linked (GlcNAc...)Sequence analysis1
Glycosylationi557N-linked (GlcNAc...)Sequence analysis1
Glycosylationi632N-linked (GlcNAc...)Sequence analysis1
Glycosylationi661N-linked (GlcNAc...)Sequence analysis1
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

EPDiP55283.
MaxQBiP55283.
PaxDbiP55283.
PeptideAtlasiP55283.
PRIDEiP55283.

PTM databases

iPTMnetiP55283.
PhosphoSitePlusiP55283.

Expressioni

Tissue specificityi

Expressed mainly in brain but also found in other tissues.

Gene expression databases

BgeeiENSG00000179242.
CleanExiHS_CDH4.
ExpressionAtlasiP55283. baseline and differential.
GenevisibleiP55283. HS.

Organism-specific databases

HPAiHPA015613.

Interactioni

Protein-protein interaction databases

BioGridi107437. 6 interactors.
IntActiP55283. 2 interactors.
STRINGi9606.ENSP00000353656.

Structurei

3D structure databases

ProteinModelPortaliP55283.
SMRiP55283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 277Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini278 – 392Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini393 – 507Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini508 – 613Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini614 – 724Cadherin 5PROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi873 – 888Ser-richAdd BLAST16

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP55283.
KOiK06797.
OMAiCEKPSLN.
OrthoDBiEOG091G01FV.
PhylomeDBiP55283.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE
60 70 80 90 100
GEKLLQVKFS SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF
110 120 130 140 150
TVTAWDSQTA EKWDAVVRLL VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD
160 170 180 190 200
TLLPWPQHQN ANGLRRRKRD WVIPPINVPE NSRGPFPQQL VRIRSDKDND
210 220 230 240 250
IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH ASYHLRAHAV
260 270 280 290 300
DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT
310 320 330 340 350
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE
360 370 380 390 400
KVQQYTVIVQ ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE
410 420 430 440 450
VPENRVETVV ANLTVMDRDQ PHSPNWNAVY RIISGDPSGH FSVRTDPVTN
460 470 480 490 500
EGMVTVVKAV DYELNRAFML TVMVSNQAPL ASGIQMSFQS TAGVTISIMD
510 520 530 540 550
INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ AVRYSKLSDP
560 570 580 590 600
ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT
610 620 630 640 650
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE
660 670 680 690 700
LPFVPAAVRK NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL
710 720 730 740 750
SNTSIIKVKV CPCDDNGDCT TIGAVAAAGL GTGAIVAILI CILILLTMVL
760 770 780 790 800
LFVMWMKRRE KERHTKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL
810 820 830 840 850
QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG DIGDFINEGL
860 870 880 890 900
RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG
910
PRFKKLADMY GGGEED
Length:916
Mass (Da):100,281
Last modified:November 8, 2005 - v2
Checksum:iE4512F94E58046D7
GO
Isoform 2 (identifier: P55283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.
Show »
Length:842
Mass (Da):92,388
Checksum:iDD1D6C1B9EF29D32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88T → A in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti223D → N in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti274R → H in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti284G → C in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti299V → I in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti347L → W in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti390P → S in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti405R → S in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti405R → S no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti502N → S in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti540Q → R in BAG54080 (PubMed:14702039).Curated1
Sequence conflicti566A → V in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti566A → V no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti641D → H in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti641D → H no nucleotide entry (PubMed:2059658).Curated1
Sequence conflicti778 – 779DN → EK in AAA35627 (PubMed:7982033).Curated2
Sequence conflicti778 – 779DN → EK no nucleotide entry (PubMed:2059658).Curated2
Sequence conflicti826A → P in AAA35627 (PubMed:7982033).Curated1
Sequence conflicti826A → P no nucleotide entry (PubMed:2059658).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048504141A → V.Corresponds to variant rs34937312dbSNPEnsembl.1
Natural variantiVAR_033699625K → R.2 PublicationsCorresponds to variant rs6142884dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0455481 – 74Missing in isoform 2. 1 PublicationAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34059 mRNA. Translation: AAA35627.1.
AK124724 mRNA. Translation: BAG54080.1.
AL365401
, AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2.
AL162457
, AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1.
AL109911
, AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1.
AL365229
, AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1.
AL079336 Genomic DNA. No translation available.
AL160412 Genomic DNA. No translation available.
AL391316 Genomic DNA. No translation available.
AL450463 Genomic DNA. No translation available.
BX640515 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75409.1.
BC101651 mRNA. Translation: AAI01652.1.
BC112150 mRNA. Translation: AAI12151.1.
CCDSiCCDS13488.1. [P55283-1]
CCDS58784.1. [P55283-2]
PIRiC38992.
RefSeqiNP_001239268.1. NM_001252339.2. [P55283-2]
NP_001785.2. NM_001794.4. [P55283-1]
UniGeneiHs.473231.

Genome annotation databases

EnsembliENST00000543233; ENSP00000443301; ENSG00000179242. [P55283-2]
ENST00000614565; ENSP00000484928; ENSG00000179242. [P55283-1]
GeneIDi1002.
KEGGihsa:1002.
UCSCiuc032pok.1. human. [P55283-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34059 mRNA. Translation: AAA35627.1.
AK124724 mRNA. Translation: BAG54080.1.
AL365401
, AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2.
AL162457
, AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1.
AL109911
, AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1.
AL365229
, AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1.
AL079336 Genomic DNA. No translation available.
AL160412 Genomic DNA. No translation available.
AL391316 Genomic DNA. No translation available.
AL450463 Genomic DNA. No translation available.
BX640515 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75409.1.
BC101651 mRNA. Translation: AAI01652.1.
BC112150 mRNA. Translation: AAI12151.1.
CCDSiCCDS13488.1. [P55283-1]
CCDS58784.1. [P55283-2]
PIRiC38992.
RefSeqiNP_001239268.1. NM_001252339.2. [P55283-2]
NP_001785.2. NM_001794.4. [P55283-1]
UniGeneiHs.473231.

3D structure databases

ProteinModelPortaliP55283.
SMRiP55283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107437. 6 interactors.
IntActiP55283. 2 interactors.
STRINGi9606.ENSP00000353656.

PTM databases

iPTMnetiP55283.
PhosphoSitePlusiP55283.

Polymorphism and mutation databases

BioMutaiCDH4.
DMDMi81175161.

Proteomic databases

EPDiP55283.
MaxQBiP55283.
PaxDbiP55283.
PeptideAtlasiP55283.
PRIDEiP55283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543233; ENSP00000443301; ENSG00000179242. [P55283-2]
ENST00000614565; ENSP00000484928; ENSG00000179242. [P55283-1]
GeneIDi1002.
KEGGihsa:1002.
UCSCiuc032pok.1. human. [P55283-1]

Organism-specific databases

CTDi1002.
DisGeNETi1002.
GeneCardsiCDH4.
HGNCiHGNC:1763. CDH4.
HPAiHPA015613.
MIMi603006. gene.
neXtProtiNX_P55283.
OpenTargetsiENSG00000179242.
PharmGKBiPA26300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP55283.
KOiK06797.
OMAiCEKPSLN.
OrthoDBiEOG091G01FV.
PhylomeDBiP55283.
TreeFamiTF316817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179242-MONOMER.
ReactomeiR-HSA-375170. CDO in myogenesis.
R-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

GeneWikiiCDH4.
GenomeRNAii1002.
PROiP55283.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179242.
CleanExiHS_CDH4.
ExpressionAtlasiP55283. baseline and differential.
GenevisibleiP55283. HS.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH4_HUMAN
AccessioniPrimary (citable) accession number: P55283
Secondary accession number(s): B3KWB8
, G3V1P8, Q2M208, Q5VZ44, Q9BZ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.