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P55283

- CADH4_HUMAN

UniProt

P55283 - CADH4_HUMAN

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Protein

Cadherin-4

Gene

CDH4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. cell adhesion Source: ProtInc
  3. cell-cell junction organization Source: Reactome
  4. cell junction assembly Source: Reactome
  5. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
REACT_21402. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Retinal cadherin
Short name:
R-CAD
Short name:
R-cadherin
Gene namesi
Name:CDH4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:1763. CDH4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini170 – 734565ExtracellularSequence AnalysisAdd
BLAST
Transmembranei735 – 75622HelicalSequence AnalysisAdd
BLAST
Topological domaini757 – 916160CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 169149Sequence AnalysisPRO_0000003749Add
BLAST
Chaini170 – 916747Cadherin-4PRO_0000003750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiP55283.
PaxDbiP55283.
PRIDEiP55283.

PTM databases

PhosphoSiteiP55283.

Expressioni

Tissue specificityi

Expressed mainly in brain but also found in other tissues.

Gene expression databases

BgeeiP55283.
CleanExiHS_CDH4.
ExpressionAtlasiP55283. baseline and differential.
GenevestigatoriP55283.

Organism-specific databases

HPAiHPA015613.

Interactioni

Protein-protein interaction databases

BioGridi107437. 3 interactions.
IntActiP55283. 1 interaction.
STRINGi9606.ENSP00000353656.

Structurei

3D structure databases

ProteinModelPortaliP55283.
SMRiP55283. Positions 31-711, 828-913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 277108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 392115Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 507115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini508 – 613106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini614 – 724111Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi873 – 88816Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP55283.
KOiK06797.
OMAiPMEVFSI.
OrthoDBiEOG7RJPQM.
PhylomeDBiP55283.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55283-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE
60 70 80 90 100
GEKLLQVKFS SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF
110 120 130 140 150
TVTAWDSQTA EKWDAVVRLL VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD
160 170 180 190 200
TLLPWPQHQN ANGLRRRKRD WVIPPINVPE NSRGPFPQQL VRIRSDKDND
210 220 230 240 250
IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH ASYHLRAHAV
260 270 280 290 300
DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT
310 320 330 340 350
ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE
360 370 380 390 400
KVQQYTVIVQ ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE
410 420 430 440 450
VPENRVETVV ANLTVMDRDQ PHSPNWNAVY RIISGDPSGH FSVRTDPVTN
460 470 480 490 500
EGMVTVVKAV DYELNRAFML TVMVSNQAPL ASGIQMSFQS TAGVTISIMD
510 520 530 540 550
INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ AVRYSKLSDP
560 570 580 590 600
ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT
610 620 630 640 650
LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE
660 670 680 690 700
LPFVPAAVRK NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL
710 720 730 740 750
SNTSIIKVKV CPCDDNGDCT TIGAVAAAGL GTGAIVAILI CILILLTMVL
760 770 780 790 800
LFVMWMKRRE KERHTKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL
810 820 830 840 850
QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG DIGDFINEGL
860 870 880 890 900
RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG
910
PRFKKLADMY GGGEED
Length:916
Mass (Da):100,281
Last modified:November 8, 2005 - v2
Checksum:iE4512F94E58046D7
GO
Isoform 2 (identifier: P55283-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.

Show »
Length:842
Mass (Da):92,388
Checksum:iDD1D6C1B9EF29D32
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881T → A in BAG54080. (PubMed:14702039)Curated
Sequence conflicti223 – 2231D → N in AAA35627. (PubMed:7982033)Curated
Sequence conflicti274 – 2741R → H in AAA35627. (PubMed:7982033)Curated
Sequence conflicti284 – 2841G → C in AAA35627. (PubMed:7982033)Curated
Sequence conflicti299 – 2991V → I in AAA35627. (PubMed:7982033)Curated
Sequence conflicti347 – 3471L → W in AAA35627. (PubMed:7982033)Curated
Sequence conflicti390 – 3901P → S in AAA35627. (PubMed:7982033)Curated
Sequence conflicti405 – 4051R → S in AAA35627. (PubMed:7982033)Curated
Sequence conflicti405 – 4051R → S no nucleotide entry (PubMed:2059658)Curated
Sequence conflicti502 – 5021N → S in BAG54080. (PubMed:14702039)Curated
Sequence conflicti540 – 5401Q → R in BAG54080. (PubMed:14702039)Curated
Sequence conflicti566 – 5661A → V in AAA35627. (PubMed:7982033)Curated
Sequence conflicti566 – 5661A → V no nucleotide entry (PubMed:2059658)Curated
Sequence conflicti641 – 6411D → H in AAA35627. (PubMed:7982033)Curated
Sequence conflicti641 – 6411D → H no nucleotide entry (PubMed:2059658)Curated
Sequence conflicti778 – 7792DN → EK in AAA35627. (PubMed:7982033)Curated
Sequence conflicti778 – 7792DN → EK no nucleotide entry (PubMed:2059658)Curated
Sequence conflicti826 – 8261A → P in AAA35627. (PubMed:7982033)Curated
Sequence conflicti826 – 8261A → P no nucleotide entry (PubMed:2059658)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411A → V.
Corresponds to variant rs34937312 [ dbSNP | Ensembl ].
VAR_048504
Natural varianti625 – 6251K → R.2 Publications
Corresponds to variant rs6142884 [ dbSNP | Ensembl ].
VAR_033699

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7474Missing in isoform 2. 1 PublicationVSP_045548Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34059 mRNA. Translation: AAA35627.1.
AK124724 mRNA. Translation: BAG54080.1.
AL365401
, AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2.
AL162457
, AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1.
AL109911
, AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1.
AL365229
, AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1.
AL079336 Genomic DNA. No translation available.
AL160412 Genomic DNA. No translation available.
AL391316 Genomic DNA. No translation available.
AL450463 Genomic DNA. No translation available.
BX640515 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75409.1.
BC101651 mRNA. Translation: AAI01652.1.
BC112150 mRNA. Translation: AAI12151.1.
CCDSiCCDS13488.1. [P55283-1]
CCDS58784.1. [P55283-2]
PIRiC38992.
RefSeqiNP_001239268.1. NM_001252339.2. [P55283-2]
NP_001785.2. NM_001794.4. [P55283-1]
UniGeneiHs.473231.

Genome annotation databases

EnsembliENST00000543233; ENSP00000443301; ENSG00000179242. [P55283-2]
ENST00000614565; ENSP00000484928; ENSG00000179242. [P55283-1]
GeneIDi1002.
KEGGihsa:1002.
UCSCiuc002ybn.2. human. [P55283-1]

Polymorphism databases

DMDMi81175161.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34059 mRNA. Translation: AAA35627.1 .
AK124724 mRNA. Translation: BAG54080.1 .
AL365401
, AL109911 , AL162457 , AL365229 Genomic DNA. Translation: CAC26840.2 .
AL162457
, AL109911 , AL365229 , AL365401 Genomic DNA. Translation: CAH73749.1 .
AL109911
, AL162457 , AL365229 , AL365401 Genomic DNA. Translation: CAI19181.1 .
AL365229
, AL109911 , AL162457 , AL365401 Genomic DNA. Translation: CAI16510.1 .
AL079336 Genomic DNA. No translation available.
AL160412 Genomic DNA. No translation available.
AL391316 Genomic DNA. No translation available.
AL450463 Genomic DNA. No translation available.
BX640515 Genomic DNA. No translation available.
CH471077 Genomic DNA. Translation: EAW75409.1 .
BC101651 mRNA. Translation: AAI01652.1 .
BC112150 mRNA. Translation: AAI12151.1 .
CCDSi CCDS13488.1. [P55283-1 ]
CCDS58784.1. [P55283-2 ]
PIRi C38992.
RefSeqi NP_001239268.1. NM_001252339.2. [P55283-2 ]
NP_001785.2. NM_001794.4. [P55283-1 ]
UniGenei Hs.473231.

3D structure databases

ProteinModelPortali P55283.
SMRi P55283. Positions 31-711, 828-913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107437. 3 interactions.
IntActi P55283. 1 interaction.
STRINGi 9606.ENSP00000353656.

PTM databases

PhosphoSitei P55283.

Polymorphism databases

DMDMi 81175161.

Proteomic databases

MaxQBi P55283.
PaxDbi P55283.
PRIDEi P55283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543233 ; ENSP00000443301 ; ENSG00000179242 . [P55283-2 ]
ENST00000614565 ; ENSP00000484928 ; ENSG00000179242 . [P55283-1 ]
GeneIDi 1002.
KEGGi hsa:1002.
UCSCi uc002ybn.2. human. [P55283-1 ]

Organism-specific databases

CTDi 1002.
GeneCardsi GC20P059827.
HGNCi HGNC:1763. CDH4.
HPAi HPA015613.
MIMi 603006. gene.
neXtProti NX_P55283.
PharmGKBi PA26300.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118906.
HOGENOMi HOG000231254.
HOVERGENi HBG106438.
InParanoidi P55283.
KOi K06797.
OMAi PMEVFSI.
OrthoDBi EOG7RJPQM.
PhylomeDBi P55283.
TreeFami TF316817.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.
REACT_21402. CDO in myogenesis.

Miscellaneous databases

GeneWikii CDH4.
GenomeRNAii 1002.
NextBioi 4212.
PROi P55283.
SOURCEi Search...

Gene expression databases

Bgeei P55283.
CleanExi HS_CDH4.
ExpressionAtlasi P55283. baseline and differential.
Genevestigatori P55283.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR009124. Cadherin/Desmocollin.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01820. DESMOCOLLIN.
SMARTi SM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 7 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
    Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
    Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-625.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain cortex.
  6. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
    Suzuki S., Sano K., Tanihara H.
    Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 393-916 (ISOFORM 1), VARIANT ARG-625.
    Tissue: Fetal brain.

Entry informationi

Entry nameiCADH4_HUMAN
AccessioniPrimary (citable) accession number: P55283
Secondary accession number(s): B3KWB8
, G3V1P8, Q2M208, Q5VZ44, Q9BZ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3