P55283 (CADH4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-4

Alternative name(s):
Retinal cadherin
Short name=R-CAD
Short name=R-cadherin

Gene names

Name:

CDH4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	916 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed mainly in brain but also found in other tissues.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adherens junction organization Traceable author statement. Source: Reactome axon guidance Inferred from electronic annotation. Source: Compara cell adhesion Traceable author statement Ref.6. Source: ProtInc cell junction assembly Traceable author statement. Source: Reactome heterophilic cell-cell adhesion Inferred from electronic annotation. Source: Compara homophilic cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of axon extension Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55283-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55283-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-74: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 169	149	Potential		PRO_0000003749
	Chain	170 – 916	747	Cadherin-4		PRO_0000003750
Regions
	Topological domain	170 – 734	565	Extracellular Potential
	Transmembrane	735 – 756	22	Helical; Potential
	Topological domain	757 – 916	160	Cytoplasmic Potential
	Domain	170 – 277	108	Cadherin 1
	Domain	278 – 392	115	Cadherin 2
	Domain	393 – 507	115	Cadherin 3
	Domain	508 – 613	106	Cadherin 4
	Domain	614 – 724	111	Cadherin 5
	Compositional bias	873 – 888	16	Ser-rich
Amino acid modifications
	Glycosylation	283	1	N-linked (GlcNAc...) Potential
	Glycosylation	412	1	N-linked (GlcNAc...) Potential
	Glycosylation	557	1	N-linked (GlcNAc...) Potential
	Glycosylation	632	1	N-linked (GlcNAc...) Potential
	Glycosylation	661	1	N-linked (GlcNAc...) Potential
	Glycosylation	702	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 74	74	Missing in isoform 2.		VSP_045548
	Natural variant	141	1	A → V. Corresponds to variant rs34937312 [ dbSNP | Ensembl ].		VAR_048504
	Natural variant	625	1	K → R. Ref.1 Ref.6 Corresponds to variant rs6142884 [ dbSNP | Ensembl ].		VAR_033699
Experimental info
	Sequence conflict	88	1	T → A in BAG54080. Ref.2
	Sequence conflict	223	1	D → N in AAA35627. Ref.1
	Sequence conflict	274	1	R → H in AAA35627. Ref.1
	Sequence conflict	284	1	G → C in AAA35627. Ref.1
	Sequence conflict	299	1	V → I in AAA35627. Ref.1
	Sequence conflict	347	1	L → W in AAA35627. Ref.1
	Sequence conflict	390	1	P → S in AAA35627. Ref.1
	Sequence conflict	405	1	R → S in AAA35627. Ref.1
	Sequence conflict	405	1	R → S no nucleotide entry Ref.6
	Sequence conflict	502	1	N → S in BAG54080. Ref.2
	Sequence conflict	540	1	Q → R in BAG54080. Ref.2
	Sequence conflict	566	1	A → V in AAA35627. Ref.1
	Sequence conflict	566	1	A → V no nucleotide entry Ref.6
	Sequence conflict	641	1	D → H in AAA35627. Ref.1
	Sequence conflict	641	1	D → H no nucleotide entry Ref.6
	Sequence conflict	778 – 779	2	DN → EK in AAA35627. Ref.1
	Sequence conflict	778 – 779	2	DN → EK no nucleotide entry Ref.6
	Sequence conflict	826	1	A → P in AAA35627. Ref.1
	Sequence conflict	826	1	A → P no nucleotide entry Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: E4512F94E58046D7	FASTA	916	100,281
	10 20 30 40 50 60 MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE GEKLLQVKFS 70 80 90 100 110 120 SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF TVTAWDSQTA EKWDAVVRLL 130 140 150 160 170 180 VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD TLLPWPQHQN ANGLRRRKRD WVIPPINVPE 190 200 210 220 230 240 NSRGPFPQQL VRIRSDKDND IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH 250 260 270 280 290 300 ASYHLRAHAV DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT 310 320 330 340 350 360 ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE KVQQYTVIVQ 370 380 390 400 410 420 ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE VPENRVETVV ANLTVMDRDQ 430 440 450 460 470 480 PHSPNWNAVY RIISGDPSGH FSVRTDPVTN EGMVTVVKAV DYELNRAFML TVMVSNQAPL 490 500 510 520 530 540 ASGIQMSFQS TAGVTISIMD INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ 550 560 570 580 590 600 AVRYSKLSDP ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT 610 620 630 640 650 660 LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE LPFVPAAVRK 670 680 690 700 710 720 NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL SNTSIIKVKV CPCDDNGDCT 730 740 750 760 770 780 TIGAVAAAGL GTGAIVAILI CILILLTMVL LFVMWMKRRE KERHTKQLLI DPEDDVRDNI 790 800 810 820 830 840 LKYDEEGGGE EDQDYDLSQL QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG 850 860 870 880 890 900 DIGDFINEGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG 910 PRFKKLADMY GGGEED
	Isoform 2 [UniParc]. Checksum: DD1D6C1B9EF29D32	FASTA	842	92,388
	10 20 30 40 50 60 MDFKVGADGT VFATRELQVP SEQVAFTVTA WDSQTAEKWD AVVRLLVAQT SSPHSGHKPQ 70 80 90 100 110 120 KGKKVVALDP SPPPKDTLLP WPQHQNANGL RRRKRDWVIP PINVPENSRG PFPQQLVRIR 130 140 150 160 170 180 SDKDNDIPIR YSITGVGADQ PPMEVFSIDS MSGRMYVTRP MDREEHASYH LRAHAVDMNG 190 200 210 220 230 240 NKVENPIDLY IYVIDMNDNR PEFINQVYNG SVDEGSKPGT YVMTVTANDA DDSTTANGMV 250 260 270 280 290 300 RYRIVTQTPQ SPSQNMFTIN SETGDIVTVA AGLDREKVQQ YTVIVQATDM EGNLNYGLSN 310 320 330 340 350 360 TATAIITVTD VNDNPPEFTA STFAGEVPEN RVETVVANLT VMDRDQPHSP NWNAVYRIIS 370 380 390 400 410 420 GDPSGHFSVR TDPVTNEGMV TVVKAVDYEL NRAFMLTVMV SNQAPLASGI QMSFQSTAGV 430 440 450 460 470 480 TISIMDINEA PYFPSNHKLI RLEEGVPPGT VLTTFSAVDP DRFMQQAVRY SKLSDPASWL 490 500 510 520 530 540 HINATNGQIT TAAVLDRESL YTKNNVYEAT FLAADNGIPP ASGTGTLQIY LIDINDNAPE 550 560 570 580 590 600 LLPKEAQICE KPNLNAINIT AADADVDPNI GPYVFELPFV PAAVRKNWTI TRLNGDYAQL 610 620 630 640 650 660 SLRILYLEAG MYDVPIIVTD SGNPPLSNTS IIKVKVCPCD DNGDCTTIGA VAAAGLGTGA 670 680 690 700 710 720 IVAILICILI LLTMVLLFVM WMKRREKERH TKQLLIDPED DVRDNILKYD EEGGGEEDQD 730 740 750 760 770 780 YDLSQLQQPE AMGHVPSKAP GVRRVDERPV GAEPQYPIRP MVPHPGDIGD FINEGLRAAD 790 800 810 820 830 840 NDPTAPPYDS LLVFDYEGSG STAGSVSSLN SSSSGDQDYD YLNDWGPRFK KLADMYGGGE ED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S. Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-625. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain cortex.
[6]	"Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue." Suzuki S., Sano K., Tanihara H. Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 393-916 (ISOFORM 1), VARIANT ARG-625. Tissue: Fetal brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34059 mRNA. Translation: AAA35627.1. AK124724 mRNA. Translation: BAG54080.1. AL365401 , AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2. AL162457 , AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1. AL109911 , AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1. AL365229 , AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1. AL079336 Genomic DNA. No translation available. AL160412 Genomic DNA. No translation available. AL391316 Genomic DNA. No translation available. AL450463 Genomic DNA. No translation available. BX640515 Genomic DNA. No translation available. CH471077 Genomic DNA. Translation: EAW75409.1. BC101651 mRNA. Translation: AAI01652.1. BC112150 mRNA. Translation: AAI12151.1.
IPI	IPI00024034.
PIR	C38992.
RefSeq	NP_001239267.1. NM_001252338.1. NP_001239268.1. NM_001252339.1. NP_001785.2. NM_001794.3.
UniGene	Hs.473231.
3D structure databases
ProteinModelPortal	P55283.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353656.
PTM databases
PhosphoSite	P55283.
Polymorphism databases
DMDM	81175161.
Proteomic databases
PaxDb	P55283.
PRIDE	P55283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360469; ENSP00000353656; ENSG00000179242. ENST00000543233; ENSP00000443301; ENSG00000179242.
GeneID	1002.
KEGG	hsa:1002.
UCSC	uc002ybn.2. human.
Organism-specific databases
CTD	1002.
GeneCards	GC20P059827.
HGNC	HGNC:1763. CDH4.
HPA	HPA015613.
MIM	603006. gene.
neXtProt	NX_P55283.
PharmGKB	PA26300.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000231254.
HOVERGEN	HBG106438.
InParanoid	P55283.
KO	K06797.
OMA	PMEVFSI.
OrthoDB	EOG483D43.
PhylomeDB	P55283.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	P55283.
Bgee	P55283.
CleanEx	HS_CDH4.
Genevestigator	P55283.
GermOnline	ENSG00000179242. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 6 hits. 4.10.900.10. 1 hit.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR009124. Cadherin/Desmocollin. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. IPR014868. Cadherin_pro_dom. IPR027397. Catenin_binding_dom. [Graphical view]
Pfam	PF00028. Cadherin. 4 hits. PF01049. Cadherin_C. 1 hit. PF08758. Cadherin_pro. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01820. DESMOCOLLIN.
SMART	SM00112. CA. 5 hits. SM01055. Cadherin_pro. 1 hit. [Graphical view]
SUPFAM	SSF49313. Cadherin. 6 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1002.
NextBio	4212.
SOURCE	Search...

Entry information

Entry name

CADH4_HUMAN

Accession

Primary (citable) accession number: P55283
Secondary accession number(s): B3KWB8 , G3V1P8, Q2M208, Q5VZ44, Q9BZ05

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 8, 2005
Last modified:	May 29, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.