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P55283

- CADH4_HUMAN

UniProt

P55283 - CADH4_HUMAN

Protein

Cadherin-4

Gene

CDH4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. axon guidance Source: Ensembl
    3. cell adhesion Source: ProtInc
    4. cell-cell junction organization Source: Reactome
    5. cell junction assembly Source: Reactome
    6. heterophilic cell-cell adhesion Source: Ensembl
    7. homophilic cell adhesion Source: Ensembl
    8. positive regulation of axon extension Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.
    REACT_21402. CDO in myogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-4
    Alternative name(s):
    Retinal cadherin
    Short name:
    R-CAD
    Short name:
    R-cadherin
    Gene namesi
    Name:CDH4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:1763. CDH4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26300.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 169149Sequence AnalysisPRO_0000003749Add
    BLAST
    Chaini170 – 916747Cadherin-4PRO_0000003750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi412 – 4121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi632 – 6321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi661 – 6611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    MaxQBiP55283.
    PaxDbiP55283.
    PRIDEiP55283.

    PTM databases

    PhosphoSiteiP55283.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain but also found in other tissues.

    Gene expression databases

    ArrayExpressiP55283.
    BgeeiP55283.
    CleanExiHS_CDH4.
    GenevestigatoriP55283.

    Organism-specific databases

    HPAiHPA015613.

    Interactioni

    Protein-protein interaction databases

    BioGridi107437. 3 interactions.
    IntActiP55283. 1 interaction.
    STRINGi9606.ENSP00000353656.

    Structurei

    3D structure databases

    ProteinModelPortaliP55283.
    SMRiP55283. Positions 31-711, 828-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini170 – 734565ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini757 – 916160CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei735 – 75622HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini170 – 277108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 392115Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 507115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini508 – 613106Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini614 – 724111Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi873 – 88816Ser-richAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000231254.
    HOVERGENiHBG106438.
    InParanoidiP55283.
    KOiK06797.
    OMAiPMEVFSI.
    OrthoDBiEOG7RJPQM.
    PhylomeDBiP55283.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01820. DESMOCOLLIN.
    SMARTiSM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 7 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55283-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAGAGVLLL LLSLSGALRA HNEDLTTRET CKAGFSEDDY TALISQNILE    50
    GEKLLQVKFS SCVGTKGTQY ETNSMDFKVG ADGTVFATRE LQVPSEQVAF 100
    TVTAWDSQTA EKWDAVVRLL VAQTSSPHSG HKPQKGKKVV ALDPSPPPKD 150
    TLLPWPQHQN ANGLRRRKRD WVIPPINVPE NSRGPFPQQL VRIRSDKDND 200
    IPIRYSITGV GADQPPMEVF SIDSMSGRMY VTRPMDREEH ASYHLRAHAV 250
    DMNGNKVENP IDLYIYVIDM NDNRPEFINQ VYNGSVDEGS KPGTYVMTVT 300
    ANDADDSTTA NGMVRYRIVT QTPQSPSQNM FTINSETGDI VTVAAGLDRE 350
    KVQQYTVIVQ ATDMEGNLNY GLSNTATAII TVTDVNDNPP EFTASTFAGE 400
    VPENRVETVV ANLTVMDRDQ PHSPNWNAVY RIISGDPSGH FSVRTDPVTN 450
    EGMVTVVKAV DYELNRAFML TVMVSNQAPL ASGIQMSFQS TAGVTISIMD 500
    INEAPYFPSN HKLIRLEEGV PPGTVLTTFS AVDPDRFMQQ AVRYSKLSDP 550
    ASWLHINATN GQITTAAVLD RESLYTKNNV YEATFLAADN GIPPASGTGT 600
    LQIYLIDIND NAPELLPKEA QICEKPNLNA INITAADADV DPNIGPYVFE 650
    LPFVPAAVRK NWTITRLNGD YAQLSLRILY LEAGMYDVPI IVTDSGNPPL 700
    SNTSIIKVKV CPCDDNGDCT TIGAVAAAGL GTGAIVAILI CILILLTMVL 750
    LFVMWMKRRE KERHTKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL 800
    QQPEAMGHVP SKAPGVRRVD ERPVGAEPQY PIRPMVPHPG DIGDFINEGL 850
    RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD QDYDYLNDWG 900
    PRFKKLADMY GGGEED 916
    Length:916
    Mass (Da):100,281
    Last modified:November 8, 2005 - v2
    Checksum:iE4512F94E58046D7
    GO
    Isoform 2 (identifier: P55283-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-74: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:842
    Mass (Da):92,388
    Checksum:iDD1D6C1B9EF29D32
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881T → A in BAG54080. (PubMed:14702039)Curated
    Sequence conflicti223 – 2231D → N in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti274 – 2741R → H in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti284 – 2841G → C in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti299 – 2991V → I in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti347 – 3471L → W in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti390 – 3901P → S in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti405 – 4051R → S in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti405 – 4051R → S no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti502 – 5021N → S in BAG54080. (PubMed:14702039)Curated
    Sequence conflicti540 – 5401Q → R in BAG54080. (PubMed:14702039)Curated
    Sequence conflicti566 – 5661A → V in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti566 – 5661A → V no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti641 – 6411D → H in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti641 – 6411D → H no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti778 – 7792DN → EK in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti778 – 7792DN → EK no nucleotide entry (PubMed:2059658)Curated
    Sequence conflicti826 – 8261A → P in AAA35627. (PubMed:7982033)Curated
    Sequence conflicti826 – 8261A → P no nucleotide entry (PubMed:2059658)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti141 – 1411A → V.
    Corresponds to variant rs34937312 [ dbSNP | Ensembl ].
    VAR_048504
    Natural varianti625 – 6251K → R.2 Publications
    Corresponds to variant rs6142884 [ dbSNP | Ensembl ].
    VAR_033699

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7474Missing in isoform 2. 1 PublicationVSP_045548Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34059 mRNA. Translation: AAA35627.1.
    AK124724 mRNA. Translation: BAG54080.1.
    AL365401
    , AL109911, AL162457, AL365229 Genomic DNA. Translation: CAC26840.2.
    AL162457
    , AL109911, AL365229, AL365401 Genomic DNA. Translation: CAH73749.1.
    AL109911
    , AL162457, AL365229, AL365401 Genomic DNA. Translation: CAI19181.1.
    AL365229
    , AL109911, AL162457, AL365401 Genomic DNA. Translation: CAI16510.1.
    AL079336 Genomic DNA. No translation available.
    AL160412 Genomic DNA. No translation available.
    AL391316 Genomic DNA. No translation available.
    AL450463 Genomic DNA. No translation available.
    BX640515 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75409.1.
    BC101651 mRNA. Translation: AAI01652.1.
    BC112150 mRNA. Translation: AAI12151.1.
    CCDSiCCDS13488.1. [P55283-1]
    CCDS58784.1. [P55283-2]
    PIRiC38992.
    RefSeqiNP_001239268.1. NM_001252339.2. [P55283-2]
    NP_001785.2. NM_001794.4. [P55283-1]
    UniGeneiHs.473231.

    Genome annotation databases

    EnsembliENST00000543233; ENSP00000443301; ENSG00000179242. [P55283-2]
    GeneIDi1002.
    KEGGihsa:1002.
    UCSCiuc002ybn.2. human. [P55283-1]

    Polymorphism databases

    DMDMi81175161.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34059 mRNA. Translation: AAA35627.1 .
    AK124724 mRNA. Translation: BAG54080.1 .
    AL365401
    , AL109911 , AL162457 , AL365229 Genomic DNA. Translation: CAC26840.2 .
    AL162457
    , AL109911 , AL365229 , AL365401 Genomic DNA. Translation: CAH73749.1 .
    AL109911
    , AL162457 , AL365229 , AL365401 Genomic DNA. Translation: CAI19181.1 .
    AL365229
    , AL109911 , AL162457 , AL365401 Genomic DNA. Translation: CAI16510.1 .
    AL079336 Genomic DNA. No translation available.
    AL160412 Genomic DNA. No translation available.
    AL391316 Genomic DNA. No translation available.
    AL450463 Genomic DNA. No translation available.
    BX640515 Genomic DNA. No translation available.
    CH471077 Genomic DNA. Translation: EAW75409.1 .
    BC101651 mRNA. Translation: AAI01652.1 .
    BC112150 mRNA. Translation: AAI12151.1 .
    CCDSi CCDS13488.1. [P55283-1 ]
    CCDS58784.1. [P55283-2 ]
    PIRi C38992.
    RefSeqi NP_001239268.1. NM_001252339.2. [P55283-2 ]
    NP_001785.2. NM_001794.4. [P55283-1 ]
    UniGenei Hs.473231.

    3D structure databases

    ProteinModelPortali P55283.
    SMRi P55283. Positions 31-711, 828-913.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107437. 3 interactions.
    IntActi P55283. 1 interaction.
    STRINGi 9606.ENSP00000353656.

    PTM databases

    PhosphoSitei P55283.

    Polymorphism databases

    DMDMi 81175161.

    Proteomic databases

    MaxQBi P55283.
    PaxDbi P55283.
    PRIDEi P55283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543233 ; ENSP00000443301 ; ENSG00000179242 . [P55283-2 ]
    GeneIDi 1002.
    KEGGi hsa:1002.
    UCSCi uc002ybn.2. human. [P55283-1 ]

    Organism-specific databases

    CTDi 1002.
    GeneCardsi GC20P059827.
    HGNCi HGNC:1763. CDH4.
    HPAi HPA015613.
    MIMi 603006. gene.
    neXtProti NX_P55283.
    PharmGKBi PA26300.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000231254.
    HOVERGENi HBG106438.
    InParanoidi P55283.
    KOi K06797.
    OMAi PMEVFSI.
    OrthoDBi EOG7RJPQM.
    PhylomeDBi P55283.
    TreeFami TF316817.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.
    REACT_21402. CDO in myogenesis.

    Miscellaneous databases

    GeneWikii CDH4.
    GenomeRNAii 1002.
    NextBioi 4212.
    PROi P55283.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55283.
    Bgeei P55283.
    CleanExi HS_CDH4.
    Genevestigatori P55283.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR009124. Cadherin/Desmocollin.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR014868. Cadherin_pro_dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    PF08758. Cadherin_pro. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01820. DESMOCOLLIN.
    SMARTi SM00112. CA. 5 hits.
    SM01055. Cadherin_pro. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 7 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin."
      Tanihara H., Sano K., Heimark R.L., St John T., Suzuki S.
      Cell Adhes. Commun. 2:15-26(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-625.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain cortex.
    6. "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue."
      Suzuki S., Sano K., Tanihara H.
      Cell Regul. 2:261-270(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 393-916 (ISOFORM 1), VARIANT ARG-625.
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiCADH4_HUMAN
    AccessioniPrimary (citable) accession number: P55283
    Secondary accession number(s): B3KWB8
    , G3V1P8, Q2M208, Q5VZ44, Q9BZ05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3