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P55281 (CAD17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-17
Alternative name(s):
Liver-intestine cadherin
Short name=LI-cadherin
Gene names
Name:Cdh17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length827 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Liver and intestine.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 7 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 827806Cadherin-17
PRO_0000003814

Regions

Topological domain22 – 786765Extracellular Potential
Transmembrane787 – 80721Helical; Potential
Topological domain808 – 82720Cytoplasmic Potential
Domain29 – 12799Cadherin 1
Domain128 – 243116Cadherin 2
Domain244 – 33996Cadherin 3
Domain340 – 448109Cadherin 4
Domain449 – 565117Cadherin 5
Domain566 – 666101Cadherin 6
Domain667 – 776110Cadherin 7

Amino acid modifications

Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P55281 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E1A0B03646562C01

FASTA82791,863
        10         20         30         40         50         60 
MVSAQLHFLC LLTLYLTGAY GQEGKFSGPL KPMTFSIFEG QEPSQIIFQF KANPPAVTFE 

        70         80         90        100        110        120 
LTGETDGIFK IEKDGLLYHT RVLDRETRAV HHLQLAALDS QGAIVDGPVP IIIEVKDIND 

       130        140        150        160        170        180 
NRPTFLQTKY EGSVRQNSRP GKPFMYVNAT DLDDPATPNG QLFYQIVIQL PKINNVMYFQ 

       190        200        210        220        230        240 
IDNKTGAISL TPEGSQVLDP IKNPYYNLVV SVKDMGGQNE NSFSDTTSVD ITVRENIWKA 

       250        260        270        280        290        300 
PEPVEIRENL TDPHPIKITQ VQWNDPGAHY SLINKEKLPQ FPFSIDQEGN IYVTQPLDRE 

       310        320        330        340        350        360 
EKDSHVFFAT AKDENGKPLA YPLEIRVKVI DINDNPPTCL SQVTVFEVQE NEVLGSSIGI 

       370        380        390        400        410        420 
FAAHDMDEAN NINSILKYRL VDQTPKVPSD ELFLIDEYGG KVQLGKRSLK KQDSPQYNLT 

       430        440        450        460        470        480 
VEVSDIDFKT LCSLQVNVID INDQIPIFER SDYGSKTLSE DTAIGSTILI IQATDDDEPF 

       490        500        510        520        530        540 
TGSSKILYKI VQGDTEGRLE VVTDPMTNTG YVKIRKPLDF ETEPVTSIVF KAENPEPLVN 

       550        560        570        580        590        600 
GIEYNASSFA SFELTVTDVN EVPVFPQQIF QANVSEDTAI GTKVGTVTAR DPEGLTVSYS 

       610        620        630        640        650        660 
LKDNKRGWLK IDSVTGDIFS TAPLDRETES VYRVQVVATE VGGSSLSSTA YFHLVLMDVN 

       670        680        690        700        710        720 
DNPPRLAKDY TGLFFCHPLS APGSLIFEAT DDDQQSVRRP KFTFALGRES LQSDWEVSKI 

       730        740        750        760        770        780 
NGTHARLSTK HTRFEEQVYD IPILINDGGQ PPMEGIVSLS VTFCQCVDGS CFRPAGNQVG 

       790        800        810        820 
IPTVGMAVGI LLTTFLVIGI ILAVVFIRMR KDKVEDPQSP ENKPLRS 

« Hide

References

[1]"Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine."
Berndorff D., Gessner R., Kreft B., Schnoy N., Lajous-Petter A.-M., Loch N., Reutter W., Hortsch M., Tauber R.
J. Cell Biol. 125:1353-1369(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78997 mRNA. Translation: CAA55631.1.
PIRA53954.
RefSeqNP_446429.1. NM_053977.2.
UniGeneRn.76726.

3D structure databases

ProteinModelPortalP55281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021612.

Proteomic databases

PaxDbP55281.
PRIDEP55281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021612; ENSRNOP00000021612; ENSRNOG00000015562.
GeneID117048.
KEGGrno:117048.
UCSCRGD:619748. rat.

Organism-specific databases

CTD1015.
RGD619748. Cdh17.

Phylogenomic databases

eggNOGNOG313822.
GeneTreeENSGT00740000115559.
HOGENOMHOG000231613.
HOVERGENHBG050767.
InParanoidP55281.
KOK06811.
OMAGKPFMYV.
OrthoDBEOG7KWSH1.
PhylomeDBP55281.
TreeFamTF316817.

Gene expression databases

GenevestigatorP55281.

Family and domain databases

Gene3D2.60.40.60. 6 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 7 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio619867.
PROP55281.

Entry information

Entry nameCAD17_RAT
AccessionPrimary (citable) accession number: P55281
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families