Cadherin-17 precursor - Rattus norvegicus (Rat)

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P55281 (CAD17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cadherin-17

Alternative name(s):
Liver-intestine cadherin
Short name=LI-cadherin

Gene names

Name:

Cdh17

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Liver and intestine.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 7 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-dependent cell-cell adhesion Inferred from electronic annotation. Source: Compara homophilic cell adhesion Inferred from electronic annotation. Source: Compara
Cellular_component	basolateral plasma membrane Inferred from direct assay Ref.1. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro proton-dependent oligopeptide secondary active transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

21

Potential

Chain

806

Cadherin-17

PRO_0000003814

Regions

Topological domain

765

Extracellular Potential

Transmembrane

21

Helical; Potential

Topological domain

20

Cytoplasmic Potential

Domain

99

Cadherin 1

Domain

116

Cadherin 2

Domain

96

Cadherin 3

Domain

109

Cadherin 4

Domain

117

Cadherin 5

Domain

101

Cadherin 6

Domain

110

Cadherin 7

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P55281 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E1A0B03646562C01
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827

91,863

        10         20         30         40         50         60 
MVSAQLHFLC LLTLYLTGAY GQEGKFSGPL KPMTFSIFEG QEPSQIIFQF KANPPAVTFE 

        70         80         90        100        110        120 
LTGETDGIFK IEKDGLLYHT RVLDRETRAV HHLQLAALDS QGAIVDGPVP IIIEVKDIND 

       130        140        150        160        170        180 
NRPTFLQTKY EGSVRQNSRP GKPFMYVNAT DLDDPATPNG QLFYQIVIQL PKINNVMYFQ 

       190        200        210        220        230        240 
IDNKTGAISL TPEGSQVLDP IKNPYYNLVV SVKDMGGQNE NSFSDTTSVD ITVRENIWKA 

       250        260        270        280        290        300 
PEPVEIRENL TDPHPIKITQ VQWNDPGAHY SLINKEKLPQ FPFSIDQEGN IYVTQPLDRE 

       310        320        330        340        350        360 
EKDSHVFFAT AKDENGKPLA YPLEIRVKVI DINDNPPTCL SQVTVFEVQE NEVLGSSIGI 

       370        380        390        400        410        420 
FAAHDMDEAN NINSILKYRL VDQTPKVPSD ELFLIDEYGG KVQLGKRSLK KQDSPQYNLT 

       430        440        450        460        470        480 
VEVSDIDFKT LCSLQVNVID INDQIPIFER SDYGSKTLSE DTAIGSTILI IQATDDDEPF 

       490        500        510        520        530        540 
TGSSKILYKI VQGDTEGRLE VVTDPMTNTG YVKIRKPLDF ETEPVTSIVF KAENPEPLVN 

       550        560        570        580        590        600 
GIEYNASSFA SFELTVTDVN EVPVFPQQIF QANVSEDTAI GTKVGTVTAR DPEGLTVSYS 

       610        620        630        640        650        660 
LKDNKRGWLK IDSVTGDIFS TAPLDRETES VYRVQVVATE VGGSSLSSTA YFHLVLMDVN 

       670        680        690        700        710        720 
DNPPRLAKDY TGLFFCHPLS APGSLIFEAT DDDQQSVRRP KFTFALGRES LQSDWEVSKI 

       730        740        750        760        770        780 
NGTHARLSTK HTRFEEQVYD IPILINDGGQ PPMEGIVSLS VTFCQCVDGS CFRPAGNQVG 

       790        800        810        820 
IPTVGMAVGI LLTTFLVIGI ILAVVFIRMR KDKVEDPQSP ENKPLRS

References

[1]

"Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine."
Berndorff D., Gessner R., Kreft B., Schnoy N., Lajous-Petter A.-M., Loch N., Reutter W., Hortsch M., Tauber R.
J. Cell Biol. 125:1353-1369(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78997 mRNA. Translation: CAA55631.1.
IPI	IPI00215358.
PIR	A53954.
RefSeq	NP_446429.1. NM_053977.2.
UniGene	Rn.76726.
3D structure databases
ProteinModelPortal	P55281.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000021612.
Proteomic databases
PaxDb	P55281.
PRIDE	P55281.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000021612; ENSRNOP00000021612; ENSRNOG00000015562.
GeneID	117048.
KEGG	rno:117048.
UCSC	RGD:619748. rat.
Organism-specific databases
CTD	1015.
RGD	619748. Cdh17.
Phylogenomic databases
eggNOG	NOG313822.
GeneTree	ENSGT00530000063788.
HOGENOM	HOG000231613.
HOVERGEN	HBG050767.
InParanoid	P55281.
KO	K06811.
OMA	GKFSGPL.
OrthoDB	EOG4D7Z59.
Gene expression databases
Genevestigator	P55281.
GermOnline	ENSRNOG00000015562. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.40.60. 6 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 7 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	619867.

Entry information

Entry name

CAD17_RAT

Accession

Primary (citable) accession number: P55281

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents