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P55281

- CAD17_RAT

UniProt

P55281 - CAD17_RAT

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Protein

Cadherin-17

Gene

Cdh17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProt

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProt
  2. homophilic cell adhesion Source: UniProt
  3. oligopeptide transmembrane transport Source: UniProt
  4. oligopeptide transport Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
Liver-intestine cadherin
Short name:
LI-cadherin
Gene namesi
Name:Cdh17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi619748. Cdh17.

Subcellular locationi

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 827806Cadherin-17PRO_0000003814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55281.
PRIDEiP55281.

Expressioni

Tissue specificityi

Liver and intestine.

Gene expression databases

GenevestigatoriP55281.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021612.

Structurei

3D structure databases

ProteinModelPortaliP55281.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 786765ExtracellularSequence AnalysisAdd
BLAST
Topological domaini808 – 82720CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei787 – 80721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12799Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini128 – 243116Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 33996Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini340 – 448109Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini449 – 565117Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini566 – 666101Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini667 – 776110Cadherin 7PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 7 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313822.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiP55281.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG7KWSH1.
PhylomeDBiP55281.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55281-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSAQLHFLC LLTLYLTGAY GQEGKFSGPL KPMTFSIFEG QEPSQIIFQF
60 70 80 90 100
KANPPAVTFE LTGETDGIFK IEKDGLLYHT RVLDRETRAV HHLQLAALDS
110 120 130 140 150
QGAIVDGPVP IIIEVKDIND NRPTFLQTKY EGSVRQNSRP GKPFMYVNAT
160 170 180 190 200
DLDDPATPNG QLFYQIVIQL PKINNVMYFQ IDNKTGAISL TPEGSQVLDP
210 220 230 240 250
IKNPYYNLVV SVKDMGGQNE NSFSDTTSVD ITVRENIWKA PEPVEIRENL
260 270 280 290 300
TDPHPIKITQ VQWNDPGAHY SLINKEKLPQ FPFSIDQEGN IYVTQPLDRE
310 320 330 340 350
EKDSHVFFAT AKDENGKPLA YPLEIRVKVI DINDNPPTCL SQVTVFEVQE
360 370 380 390 400
NEVLGSSIGI FAAHDMDEAN NINSILKYRL VDQTPKVPSD ELFLIDEYGG
410 420 430 440 450
KVQLGKRSLK KQDSPQYNLT VEVSDIDFKT LCSLQVNVID INDQIPIFER
460 470 480 490 500
SDYGSKTLSE DTAIGSTILI IQATDDDEPF TGSSKILYKI VQGDTEGRLE
510 520 530 540 550
VVTDPMTNTG YVKIRKPLDF ETEPVTSIVF KAENPEPLVN GIEYNASSFA
560 570 580 590 600
SFELTVTDVN EVPVFPQQIF QANVSEDTAI GTKVGTVTAR DPEGLTVSYS
610 620 630 640 650
LKDNKRGWLK IDSVTGDIFS TAPLDRETES VYRVQVVATE VGGSSLSSTA
660 670 680 690 700
YFHLVLMDVN DNPPRLAKDY TGLFFCHPLS APGSLIFEAT DDDQQSVRRP
710 720 730 740 750
KFTFALGRES LQSDWEVSKI NGTHARLSTK HTRFEEQVYD IPILINDGGQ
760 770 780 790 800
PPMEGIVSLS VTFCQCVDGS CFRPAGNQVG IPTVGMAVGI LLTTFLVIGI
810 820
ILAVVFIRMR KDKVEDPQSP ENKPLRS
Length:827
Mass (Da):91,863
Last modified:October 1, 1996 - v1
Checksum:iE1A0B03646562C01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78997 mRNA. Translation: CAA55631.1.
PIRiA53954.
RefSeqiNP_446429.1. NM_053977.2.
UniGeneiRn.76726.

Genome annotation databases

EnsembliENSRNOT00000021612; ENSRNOP00000021612; ENSRNOG00000015562.
GeneIDi117048.
KEGGirno:117048.
UCSCiRGD:619748. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78997 mRNA. Translation: CAA55631.1 .
PIRi A53954.
RefSeqi NP_446429.1. NM_053977.2.
UniGenei Rn.76726.

3D structure databases

ProteinModelPortali P55281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021612.

Proteomic databases

PaxDbi P55281.
PRIDEi P55281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021612 ; ENSRNOP00000021612 ; ENSRNOG00000015562 .
GeneIDi 117048.
KEGGi rno:117048.
UCSCi RGD:619748. rat.

Organism-specific databases

CTDi 1015.
RGDi 619748. Cdh17.

Phylogenomic databases

eggNOGi NOG313822.
GeneTreei ENSGT00740000115559.
HOGENOMi HOG000231613.
HOVERGENi HBG050767.
InParanoidi P55281.
KOi K06811.
OMAi GKPFMYV.
OrthoDBi EOG7KWSH1.
PhylomeDBi P55281.
TreeFami TF316817.

Miscellaneous databases

NextBioi 619867.
PROi P55281.

Gene expression databases

Genevestigatori P55281.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 7 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine."
    Berndorff D., Gessner R., Kreft B., Schnoy N., Lajous-Petter A.-M., Loch N., Reutter W., Hortsch M., Tauber R.
    J. Cell Biol. 125:1353-1369(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiCAD17_RAT
AccessioniPrimary (citable) accession number: P55281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3