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P55281

- CAD17_RAT

UniProt

P55281 - CAD17_RAT

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Protein

Cadherin-17

Gene
Cdh17
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProt

GO - Biological processi

  1. calcium-dependent cell-cell adhesion Source: UniProt
  2. homophilic cell adhesion Source: UniProt
  3. oligopeptide transmembrane transport Source: UniProt
  4. oligopeptide transport Source: UniProt
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-17
Alternative name(s):
Liver-intestine cadherin
Short name:
LI-cadherin
Gene namesi
Name:Cdh17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi619748. Cdh17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 786765Extracellular Reviewed predictionAdd
BLAST
Transmembranei787 – 80721Helical; Reviewed predictionAdd
BLAST
Topological domaini808 – 82720Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 827806Cadherin-17PRO_0000003814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi573 – 5731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55281.
PRIDEiP55281.

Expressioni

Tissue specificityi

Liver and intestine.

Gene expression databases

GenevestigatoriP55281.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021612.

Structurei

3D structure databases

ProteinModelPortaliP55281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12799Cadherin 1Add
BLAST
Domaini128 – 243116Cadherin 2Add
BLAST
Domaini244 – 33996Cadherin 3Add
BLAST
Domaini340 – 448109Cadherin 4Add
BLAST
Domaini449 – 565117Cadherin 5Add
BLAST
Domaini566 – 666101Cadherin 6Add
BLAST
Domaini667 – 776110Cadherin 7Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 7 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313822.
GeneTreeiENSGT00740000115559.
HOGENOMiHOG000231613.
HOVERGENiHBG050767.
InParanoidiP55281.
KOiK06811.
OMAiGKPFMYV.
OrthoDBiEOG7KWSH1.
PhylomeDBiP55281.
TreeFamiTF316817.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55281-1 [UniParc]FASTAAdd to Basket

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MVSAQLHFLC LLTLYLTGAY GQEGKFSGPL KPMTFSIFEG QEPSQIIFQF    50
KANPPAVTFE LTGETDGIFK IEKDGLLYHT RVLDRETRAV HHLQLAALDS 100
QGAIVDGPVP IIIEVKDIND NRPTFLQTKY EGSVRQNSRP GKPFMYVNAT 150
DLDDPATPNG QLFYQIVIQL PKINNVMYFQ IDNKTGAISL TPEGSQVLDP 200
IKNPYYNLVV SVKDMGGQNE NSFSDTTSVD ITVRENIWKA PEPVEIRENL 250
TDPHPIKITQ VQWNDPGAHY SLINKEKLPQ FPFSIDQEGN IYVTQPLDRE 300
EKDSHVFFAT AKDENGKPLA YPLEIRVKVI DINDNPPTCL SQVTVFEVQE 350
NEVLGSSIGI FAAHDMDEAN NINSILKYRL VDQTPKVPSD ELFLIDEYGG 400
KVQLGKRSLK KQDSPQYNLT VEVSDIDFKT LCSLQVNVID INDQIPIFER 450
SDYGSKTLSE DTAIGSTILI IQATDDDEPF TGSSKILYKI VQGDTEGRLE 500
VVTDPMTNTG YVKIRKPLDF ETEPVTSIVF KAENPEPLVN GIEYNASSFA 550
SFELTVTDVN EVPVFPQQIF QANVSEDTAI GTKVGTVTAR DPEGLTVSYS 600
LKDNKRGWLK IDSVTGDIFS TAPLDRETES VYRVQVVATE VGGSSLSSTA 650
YFHLVLMDVN DNPPRLAKDY TGLFFCHPLS APGSLIFEAT DDDQQSVRRP 700
KFTFALGRES LQSDWEVSKI NGTHARLSTK HTRFEEQVYD IPILINDGGQ 750
PPMEGIVSLS VTFCQCVDGS CFRPAGNQVG IPTVGMAVGI LLTTFLVIGI 800
ILAVVFIRMR KDKVEDPQSP ENKPLRS 827
Length:827
Mass (Da):91,863
Last modified:October 1, 1996 - v1
Checksum:iE1A0B03646562C01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78997 mRNA. Translation: CAA55631.1.
PIRiA53954.
RefSeqiNP_446429.1. NM_053977.2.
UniGeneiRn.76726.

Genome annotation databases

EnsembliENSRNOT00000021612; ENSRNOP00000021612; ENSRNOG00000015562.
GeneIDi117048.
KEGGirno:117048.
UCSCiRGD:619748. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78997 mRNA. Translation: CAA55631.1 .
PIRi A53954.
RefSeqi NP_446429.1. NM_053977.2.
UniGenei Rn.76726.

3D structure databases

ProteinModelPortali P55281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021612.

Proteomic databases

PaxDbi P55281.
PRIDEi P55281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021612 ; ENSRNOP00000021612 ; ENSRNOG00000015562 .
GeneIDi 117048.
KEGGi rno:117048.
UCSCi RGD:619748. rat.

Organism-specific databases

CTDi 1015.
RGDi 619748. Cdh17.

Phylogenomic databases

eggNOGi NOG313822.
GeneTreei ENSGT00740000115559.
HOGENOMi HOG000231613.
HOVERGENi HBG050767.
InParanoidi P55281.
KOi K06811.
OMAi GKPFMYV.
OrthoDBi EOG7KWSH1.
PhylomeDBi P55281.
TreeFami TF316817.

Miscellaneous databases

NextBioi 619867.
PROi P55281.

Gene expression databases

Genevestigatori P55281.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 7 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine."
    Berndorff D., Gessner R., Kreft B., Schnoy N., Lajous-Petter A.-M., Loch N., Reutter W., Hortsch M., Tauber R.
    J. Cell Biol. 125:1353-1369(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiCAD17_RAT
AccessioniPrimary (citable) accession number: P55281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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