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P55281

- CAD17_RAT

UniProt

P55281 - CAD17_RAT

Protein

Cadherin-17

Gene

Cdh17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: UniProt

    GO - Biological processi

    1. calcium-dependent cell-cell adhesion Source: UniProt
    2. homophilic cell adhesion Source: UniProt
    3. oligopeptide transmembrane transport Source: UniProt
    4. oligopeptide transport Source: UniProt

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-17
    Alternative name(s):
    Liver-intestine cadherin
    Short name:
    LI-cadherin
    Gene namesi
    Name:Cdh17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi619748. Cdh17.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: RGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 827806Cadherin-17PRO_0000003814Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi545 – 5451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi573 – 5731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP55281.
    PRIDEiP55281.

    Expressioni

    Tissue specificityi

    Liver and intestine.

    Gene expression databases

    GenevestigatoriP55281.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021612.

    Structurei

    3D structure databases

    ProteinModelPortaliP55281.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 786765ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini808 – 82720CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei787 – 80721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 12799Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini128 – 243116Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 33996Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini340 – 448109Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini449 – 565117Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini566 – 666101Cadherin 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini667 – 776110Cadherin 7PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 7 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313822.
    GeneTreeiENSGT00740000115559.
    HOGENOMiHOG000231613.
    HOVERGENiHBG050767.
    InParanoidiP55281.
    KOiK06811.
    OMAiGKPFMYV.
    OrthoDBiEOG7KWSH1.
    PhylomeDBiP55281.
    TreeFamiTF316817.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 7 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55281-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSAQLHFLC LLTLYLTGAY GQEGKFSGPL KPMTFSIFEG QEPSQIIFQF    50
    KANPPAVTFE LTGETDGIFK IEKDGLLYHT RVLDRETRAV HHLQLAALDS 100
    QGAIVDGPVP IIIEVKDIND NRPTFLQTKY EGSVRQNSRP GKPFMYVNAT 150
    DLDDPATPNG QLFYQIVIQL PKINNVMYFQ IDNKTGAISL TPEGSQVLDP 200
    IKNPYYNLVV SVKDMGGQNE NSFSDTTSVD ITVRENIWKA PEPVEIRENL 250
    TDPHPIKITQ VQWNDPGAHY SLINKEKLPQ FPFSIDQEGN IYVTQPLDRE 300
    EKDSHVFFAT AKDENGKPLA YPLEIRVKVI DINDNPPTCL SQVTVFEVQE 350
    NEVLGSSIGI FAAHDMDEAN NINSILKYRL VDQTPKVPSD ELFLIDEYGG 400
    KVQLGKRSLK KQDSPQYNLT VEVSDIDFKT LCSLQVNVID INDQIPIFER 450
    SDYGSKTLSE DTAIGSTILI IQATDDDEPF TGSSKILYKI VQGDTEGRLE 500
    VVTDPMTNTG YVKIRKPLDF ETEPVTSIVF KAENPEPLVN GIEYNASSFA 550
    SFELTVTDVN EVPVFPQQIF QANVSEDTAI GTKVGTVTAR DPEGLTVSYS 600
    LKDNKRGWLK IDSVTGDIFS TAPLDRETES VYRVQVVATE VGGSSLSSTA 650
    YFHLVLMDVN DNPPRLAKDY TGLFFCHPLS APGSLIFEAT DDDQQSVRRP 700
    KFTFALGRES LQSDWEVSKI NGTHARLSTK HTRFEEQVYD IPILINDGGQ 750
    PPMEGIVSLS VTFCQCVDGS CFRPAGNQVG IPTVGMAVGI LLTTFLVIGI 800
    ILAVVFIRMR KDKVEDPQSP ENKPLRS 827
    Length:827
    Mass (Da):91,863
    Last modified:October 1, 1996 - v1
    Checksum:iE1A0B03646562C01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78997 mRNA. Translation: CAA55631.1.
    PIRiA53954.
    RefSeqiNP_446429.1. NM_053977.2.
    UniGeneiRn.76726.

    Genome annotation databases

    EnsembliENSRNOT00000021612; ENSRNOP00000021612; ENSRNOG00000015562.
    GeneIDi117048.
    KEGGirno:117048.
    UCSCiRGD:619748. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78997 mRNA. Translation: CAA55631.1 .
    PIRi A53954.
    RefSeqi NP_446429.1. NM_053977.2.
    UniGenei Rn.76726.

    3D structure databases

    ProteinModelPortali P55281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021612.

    Proteomic databases

    PaxDbi P55281.
    PRIDEi P55281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021612 ; ENSRNOP00000021612 ; ENSRNOG00000015562 .
    GeneIDi 117048.
    KEGGi rno:117048.
    UCSCi RGD:619748. rat.

    Organism-specific databases

    CTDi 1015.
    RGDi 619748. Cdh17.

    Phylogenomic databases

    eggNOGi NOG313822.
    GeneTreei ENSGT00740000115559.
    HOGENOMi HOG000231613.
    HOVERGENi HBG050767.
    InParanoidi P55281.
    KOi K06811.
    OMAi GKPFMYV.
    OrthoDBi EOG7KWSH1.
    PhylomeDBi P55281.
    TreeFami TF316817.

    Miscellaneous databases

    NextBioi 619867.
    PROi P55281.

    Gene expression databases

    Genevestigatori P55281.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 7 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine."
      Berndorff D., Gessner R., Kreft B., Schnoy N., Lajous-Petter A.-M., Loch N., Reutter W., Hortsch M., Tauber R.
      J. Cell Biol. 125:1353-1369(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCAD17_RAT
    AccessioniPrimary (citable) accession number: P55281
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3