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P55273

- CDN2D_HUMAN

UniProt

P55273 - CDN2D_HUMAN

Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

CDKN2D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
    2. protein binding Source: IntAct
    3. protein kinase binding Source: BHF-UCL

    GO - Biological processi

    1. autophagic cell death Source: BHF-UCL
    2. cell cycle arrest Source: BHF-UCL
    3. DNA synthesis involved in DNA repair Source: BHF-UCL
    4. G1/S transition of mitotic cell cycle Source: BHF-UCL
    5. mitotic cell cycle Source: Reactome
    6. negative regulation of cell growth Source: BHF-UCL
    7. negative regulation of cell proliferation Source: BHF-UCL
    8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
    9. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    10. negative regulation of phosphorylation Source: BHF-UCL
    11. negative regulation of protein serine/threonine kinase activity Source: GOC
    12. regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    13. response to retinoic acid Source: BHF-UCL
    14. response to UV Source: BHF-UCL
    15. response to vitamin D Source: BHF-UCL
    16. sensory perception of sound Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_169325. Oncogene Induced Senescence.
    REACT_169436. Oxidative Stress Induced Senescence.
    REACT_821. Cyclin D associated events in G1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor D
    Alternative name(s):
    p19-INK4d
    Gene namesi
    Name:CDKN2D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:1790. CDKN2D.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. cytosol Source: Reactome
    3. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    Orphaneti618. Familial melanoma.
    PharmGKBiPA26323.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Cyclin-dependent kinase 4 inhibitor DPRO_0000144188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP55273.
    PaxDbiP55273.
    PRIDEiP55273.

    PTM databases

    PhosphoSiteiP55273.

    Expressioni

    Gene expression databases

    BgeeiP55273.
    CleanExiHS_CDKN2D.
    GenevestigatoriP55273.

    Organism-specific databases

    HPAiCAB011201.

    Interactioni

    Subunit structurei

    Interacts with CDK6.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK6Q005342EBI-745859,EBI-295663

    Protein-protein interaction databases

    BioGridi107466. 7 interactions.
    DIPiDIP-6109N.
    IntActiP55273. 5 interactions.
    MINTiMINT-1475963.
    STRINGi9606.ENSP00000337056.

    Structurei

    Secondary structure

    1
    166
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi8 – 1811
    Helixi21 – 299
    Helixi45 – 484
    Helixi54 – 629
    Helixi77 – 837
    Helixi87 – 959
    Helixi110 – 1178
    Helixi120 – 1278
    Helixi142 – 1487
    Helixi152 – 1598

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BD8X-ray1.80A7-162[»]
    1BI8X-ray2.80B/D1-166[»]
    ProteinModelPortaliP55273.
    SMRiP55273. Positions 7-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55273.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 6929ANK 1Add
    BLAST
    Repeati73 – 10230ANK 2Add
    BLAST
    Repeati106 – 13530ANK 3Add
    BLAST
    Repeati138 – 16629ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000290191.
    HOVERGENiHBG050870.
    InParanoidiP55273.
    KOiK06623.
    OMAiVMMFGSS.
    OrthoDBiEOG7TTQ94.
    PhylomeDBiP55273.
    TreeFamiTF333311.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM    50
    FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV 100
    NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG 150
    AQDLVDILQG HMVAPL 166
    Length:166
    Mass (Da):17,700
    Last modified:October 1, 1996 - v1
    Checksum:i2FACD11CF56340DC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591Q → P in AAA85436. (PubMed:7739548)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49399 mRNA. Translation: AAB03772.1.
    U20498 mRNA. Translation: AAA85436.1.
    U40343 mRNA. Translation: AAB18139.1.
    AF061327 Genomic DNA. Translation: AAC27450.1.
    CR542158 mRNA. Translation: CAG46955.1.
    AF518878 Genomic DNA. Translation: AAM54045.1.
    BC001822 mRNA. Translation: AAH01822.1.
    AF044171 Genomic DNA. Translation: AAD02320.1.
    CCDSiCCDS12244.1.
    PIRiA57378.
    RefSeqiNP_001791.1. NM_001800.3.
    NP_524145.1. NM_079421.2.
    UniGeneiHs.435051.

    Genome annotation databases

    EnsembliENST00000335766; ENSP00000337056; ENSG00000129355.
    ENST00000393599; ENSP00000377224; ENSG00000129355.
    GeneIDi1032.
    KEGGihsa:1032.
    UCSCiuc002mpa.3. human.

    Polymorphism databases

    DMDMi1705730.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49399 mRNA. Translation: AAB03772.1 .
    U20498 mRNA. Translation: AAA85436.1 .
    U40343 mRNA. Translation: AAB18139.1 .
    AF061327 Genomic DNA. Translation: AAC27450.1 .
    CR542158 mRNA. Translation: CAG46955.1 .
    AF518878 Genomic DNA. Translation: AAM54045.1 .
    BC001822 mRNA. Translation: AAH01822.1 .
    AF044171 Genomic DNA. Translation: AAD02320.1 .
    CCDSi CCDS12244.1.
    PIRi A57378.
    RefSeqi NP_001791.1. NM_001800.3.
    NP_524145.1. NM_079421.2.
    UniGenei Hs.435051.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BD8 X-ray 1.80 A 7-162 [» ]
    1BI8 X-ray 2.80 B/D 1-166 [» ]
    ProteinModelPortali P55273.
    SMRi P55273. Positions 7-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107466. 7 interactions.
    DIPi DIP-6109N.
    IntActi P55273. 5 interactions.
    MINTi MINT-1475963.
    STRINGi 9606.ENSP00000337056.

    PTM databases

    PhosphoSitei P55273.

    Polymorphism databases

    DMDMi 1705730.

    Proteomic databases

    MaxQBi P55273.
    PaxDbi P55273.
    PRIDEi P55273.

    Protocols and materials databases

    DNASUi 1032.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335766 ; ENSP00000337056 ; ENSG00000129355 .
    ENST00000393599 ; ENSP00000377224 ; ENSG00000129355 .
    GeneIDi 1032.
    KEGGi hsa:1032.
    UCSCi uc002mpa.3. human.

    Organism-specific databases

    CTDi 1032.
    GeneCardsi GC19M010677.
    HGNCi HGNC:1790. CDKN2D.
    HPAi CAB011201.
    MIMi 600927. gene.
    neXtProti NX_P55273.
    Orphaneti 618. Familial melanoma.
    PharmGKBi PA26323.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000290191.
    HOVERGENi HBG050870.
    InParanoidi P55273.
    KOi K06623.
    OMAi VMMFGSS.
    OrthoDBi EOG7TTQ94.
    PhylomeDBi P55273.
    TreeFami TF333311.

    Enzyme and pathway databases

    Reactomei REACT_169168. Senescence-Associated Secretory Phenotype (SASP).
    REACT_169325. Oncogene Induced Senescence.
    REACT_169436. Oxidative Stress Induced Senescence.
    REACT_821. Cyclin D associated events in G1.

    Miscellaneous databases

    EvolutionaryTracei P55273.
    GeneWikii CDKN2D.
    GenomeRNAii 1032.
    NextBioi 4343.
    PROi P55273.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55273.
    CleanExi HS_CDKN2D.
    Genevestigatori P55273.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 2 hits.
    PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases."
      Okuda T., Hirai H., Valentine V.A., Shurtleff S.A., Kidd V.J., Lahti J.M., Sherr C.J., Downing J.R.
      Genomics 29:623-630(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    2. "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4."
      Chan F.K.M., Zhang J., Cheng L., Shapiro D.N., Winoto A.
      Mol. Cell. Biol. 15:2682-2688(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Thymus.
    3. "Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4."
      Guan K.L., Jenkins C.W., Li Y., O'Keefe C.L., Noh S., Wu X., Zariwala M., Matera A.G., Xiong Y.
      Mol. Biol. Cell 7:57-70(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. NIEHS SNPs program
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    8. Murthy S.K., Demetrick D.J.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.
    9. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-7, ACETYLATION AT MET-1.
      Tissue: Platelet.
    10. "Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells."
      Mahony D., Parry D.A., Lees E.
      Oncogene 16:603-611(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CDK6.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a."
      Russo A.A., Tong L., Lee J.O., Jeffrey P.D., Pavletich N.P.
      Nature 395:237-243(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF COMPLEX WITH CDK6.
    13. "Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a)."
      Baumgartner R., Fernandez-Catalan C., Winoto A., Huber R., Engh R.A., Holak T.A.
      Structure 6:1279-1290(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

    Entry informationi

    Entry nameiCDN2D_HUMAN
    AccessioniPrimary (citable) accession number: P55273
    Secondary accession number(s): Q13102, Q6FGE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3