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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

CDKN2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

  • autophagic cell death Source: BHF-UCL
  • cell cycle arrest Source: BHF-UCL
  • DNA synthesis involved in DNA repair Source: BHF-UCL
  • G1/S transition of mitotic cell cycle Source: BHF-UCL
  • negative regulation of cell cycle G1/S phase transition Source: Ensembl
  • negative regulation of cell growth Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  • negative regulation of phosphorylation Source: BHF-UCL
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  • response to retinoic acid Source: BHF-UCL
  • response to UV Source: BHF-UCL
  • response to vitamin D Source: BHF-UCL
  • sensory perception of sound Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:HS05274-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-69231. Cyclin D associated events in G1.
SIGNORiP55273.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:CDKN2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1790. CDKN2D.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cyclin D2-CDK4 complex Source: Ensembl
  • cytoplasm Source: BHF-UCL
  • cytosol Source: Reactome
  • nucleoplasm Source: HPA
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi1032.
MalaCardsiCDKN2D.
OpenTargetsiENSG00000129355.
Orphaneti618. Familial melanoma.
PharmGKBiPA26323.

Polymorphism and mutation databases

BioMutaiCDKN2D.
DMDMi1705730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441881 – 166Cyclin-dependent kinase 4 inhibitor DAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP55273.
PaxDbiP55273.
PeptideAtlasiP55273.
PRIDEiP55273.

PTM databases

iPTMnetiP55273.
PhosphoSitePlusiP55273.

Expressioni

Gene expression databases

BgeeiENSG00000129355.
CleanExiHS_CDKN2D.
ExpressionAtlasiP55273. baseline and differential.
GenevisibleiP55273. HS.

Organism-specific databases

HPAiCAB011201.
HPA043546.

Interactioni

Subunit structurei

Interacts with CDK6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
C1orf94Q6P1W54EBI-745859,EBI-946029
CDK4P1180213EBI-745859,EBI-295644
CDK6Q0053414EBI-745859,EBI-295663
CTBP1Q13363-23EBI-745859,EBI-10171858
HSD17B14Q9BPX17EBI-745859,EBI-742664
IKZF3Q9UKT94EBI-745859,EBI-747204
INCA1Q0VD865EBI-745859,EBI-6509505
NR4A1P227363EBI-745859,EBI-721550
NR4A2F1D8N63EBI-745859,EBI-10214997

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107466. 11 interactors.
DIPiDIP-6109N.
IntActiP55273. 25 interactors.
MINTiMINT-1475963.
STRINGi9606.ENSP00000337056.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 18Combined sources11
Helixi21 – 29Combined sources9
Helixi45 – 48Combined sources4
Helixi54 – 62Combined sources9
Helixi77 – 83Combined sources7
Helixi87 – 95Combined sources9
Helixi110 – 117Combined sources8
Helixi120 – 127Combined sources8
Helixi142 – 148Combined sources7
Helixi152 – 159Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BD8X-ray1.80A7-162[»]
1BI8X-ray2.80B/D1-166[»]
ProteinModelPortaliP55273.
SMRiP55273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55273.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 69ANK 1Add BLAST29
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati138 – 166ANK 4Add BLAST29

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55273.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG091G0PMC.
PhylomeDBiP55273.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEEVRAGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSTAIALEL LKQGASPNVQ DTSGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NVPDGTGALP IHLAVQEGHT AVVSFLAAES DLHRRDARGL TPLELALQRG
160
AQDLVDILQG HMVAPL
Length:166
Mass (Da):17,700
Last modified:October 1, 1996 - v1
Checksum:i2FACD11CF56340DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159Q → P in AAA85436 (PubMed:7739548).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49399 mRNA. Translation: AAB03772.1.
U20498 mRNA. Translation: AAA85436.1.
U40343 mRNA. Translation: AAB18139.1.
AF061327 Genomic DNA. Translation: AAC27450.1.
CR542158 mRNA. Translation: CAG46955.1.
AF518878 Genomic DNA. Translation: AAM54045.1.
BC001822 mRNA. Translation: AAH01822.1.
AF044171 Genomic DNA. Translation: AAD02320.1.
CCDSiCCDS12244.1.
PIRiA57378.
RefSeqiNP_001791.1. NM_001800.3.
NP_524145.1. NM_079421.2.
UniGeneiHs.435051.

Genome annotation databases

EnsembliENST00000335766; ENSP00000337056; ENSG00000129355.
ENST00000393599; ENSP00000377224; ENSG00000129355.
GeneIDi1032.
KEGGihsa:1032.
UCSCiuc002mpa.4. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49399 mRNA. Translation: AAB03772.1.
U20498 mRNA. Translation: AAA85436.1.
U40343 mRNA. Translation: AAB18139.1.
AF061327 Genomic DNA. Translation: AAC27450.1.
CR542158 mRNA. Translation: CAG46955.1.
AF518878 Genomic DNA. Translation: AAM54045.1.
BC001822 mRNA. Translation: AAH01822.1.
AF044171 Genomic DNA. Translation: AAD02320.1.
CCDSiCCDS12244.1.
PIRiA57378.
RefSeqiNP_001791.1. NM_001800.3.
NP_524145.1. NM_079421.2.
UniGeneiHs.435051.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BD8X-ray1.80A7-162[»]
1BI8X-ray2.80B/D1-166[»]
ProteinModelPortaliP55273.
SMRiP55273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107466. 11 interactors.
DIPiDIP-6109N.
IntActiP55273. 25 interactors.
MINTiMINT-1475963.
STRINGi9606.ENSP00000337056.

PTM databases

iPTMnetiP55273.
PhosphoSitePlusiP55273.

Polymorphism and mutation databases

BioMutaiCDKN2D.
DMDMi1705730.

Proteomic databases

MaxQBiP55273.
PaxDbiP55273.
PeptideAtlasiP55273.
PRIDEiP55273.

Protocols and materials databases

DNASUi1032.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335766; ENSP00000337056; ENSG00000129355.
ENST00000393599; ENSP00000377224; ENSG00000129355.
GeneIDi1032.
KEGGihsa:1032.
UCSCiuc002mpa.4. human.

Organism-specific databases

CTDi1032.
DisGeNETi1032.
GeneCardsiCDKN2D.
HGNCiHGNC:1790. CDKN2D.
HPAiCAB011201.
HPA043546.
MalaCardsiCDKN2D.
MIMi600927. gene.
neXtProtiNX_P55273.
OpenTargetsiENSG00000129355.
Orphaneti618. Familial melanoma.
PharmGKBiPA26323.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55273.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG091G0PMC.
PhylomeDBiP55273.
TreeFamiTF333311.

Enzyme and pathway databases

BioCyciZFISH:HS05274-MONOMER.
ReactomeiR-HSA-2559580. Oxidative Stress Induced Senescence.
R-HSA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-HSA-2559585. Oncogene Induced Senescence.
R-HSA-69231. Cyclin D associated events in G1.
SIGNORiP55273.

Miscellaneous databases

EvolutionaryTraceiP55273.
GeneWikiiCDKN2D.
GenomeRNAii1032.
PROiP55273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129355.
CleanExiHS_CDKN2D.
ExpressionAtlasiP55273. baseline and differential.
GenevisibleiP55273. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2D_HUMAN
AccessioniPrimary (citable) accession number: P55273
Secondary accession number(s): Q13102, Q6FGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.