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P55272 (CDN2B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene names
Name:Cdkn2b
Synonyms:Ink4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.

Subunit structure

Heterodimer of CDKN2B with CDK4 or CDK6.

Tissue specificity

Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.

Sequence similarities

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Contains 4 ANK repeats.

Ontologies

Keywords
   Biological processCell cycle
   Coding sequence diversityAlternative initiation
   DiseaseTumor suppressor
   DomainANK repeat
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from expression pattern PubMed 21147108. Source: RGD

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to nutrient

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from expression pattern PubMed 11042273. Source: RGD

megakaryocyte differentiation

Inferred from electronic annotation. Source: Ensembl

mitotic cell cycle checkpoint

Inferred from electronic annotation. Source: Ensembl

negative regulation of G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from mutant phenotype Ref.1. Source: RGD

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell differentiation

Inferred from expression pattern PubMed 17158884. Source: RGD

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from expression pattern PubMed 15333329. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 11513834. Source: RGD

spleen development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 11509832. Source: RGD

   Molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative initiation. [Align] [Select]
Isoform Long (identifier: P55272-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P55272-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130Cyclin-dependent kinase 4 inhibitor B
PRO_0000004808

Regions

Repeat5 – 3430ANK 1
Repeat38 – 6629ANK 2
Repeat71 – 10030ANK 3
Repeat104 – 13027ANK 4

Amino acid modifications

Modified residue121Phosphothreonine By similarity

Natural variations

Alternative sequence1 – 4545Missing in isoform Short.
VSP_018702

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: AC45B21FA69FAD92

FASTA13013,749
        10         20         30         40         50         60 
MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH 

        70         80         90        100        110        120 
GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI 

       130 
ARYLHAATGD 

« Hide

Isoform Short [UniParc].

Checksum: 18B7A5B6D45C86EC
Show »

FASTA859,174

References

[1]"Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)."
Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H., Kikuchi Y., Mitani H.
Mol. Carcinog. 14:23-27(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Buckles L.K., Shull J.D.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: ACI/SegHsd and COP.
Tissue: Lung.
[3]"Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors."
Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.
Cancer Res. 55:1607-1612(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S79760 mRNA. Translation: AAB35360.1.
AF474978 mRNA. Translation: AAL76340.1.
AF474979 mRNA. Translation: AAL76341.1.
S77734 Genomic DNA. No translation available.
RefSeqNP_570825.1. NM_130812.2. [P55272-1]
UniGeneRn.105626.

3D structure databases

ProteinModelPortalP55272.
SMRP55272. Positions 1-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000008898.

Proteomic databases

PaxDbP55272.
PRIDEP55272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000008898; ENSRNOP00000008898; ENSRNOG00000006735. [P55272-1]
GeneID25164.
KEGGrno:25164.
UCSCRGD:2324. rat. [P55272-1]

Organism-specific databases

CTD1030.
RGD2324. Cdkn2b.

Phylogenomic databases

eggNOGNOG287192.
GeneTreeENSGT00390000004527.
HOGENOMHOG000290191.
HOVERGENHBG050870.
InParanoidP55272.
KOK04685.
OMAIGNHLWV.
OrthoDBEOG7TTQ94.
PhylomeDBP55272.
TreeFamTF352389.

Gene expression databases

GenevestigatorP55272.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605637.
PROP55272.

Entry information

Entry nameCDN2B_RAT
AccessionPrimary (citable) accession number: P55272
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families