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P55272

- CDN2B_RAT

UniProt

P55272 - CDN2B_RAT

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Protein
Cyclin-dependent kinase 4 inhibitor B
Gene
Cdkn2b, Ink4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: Ensembl
  2. aging Source: RGD
  3. cell cycle arrest Source: Ensembl
  4. cellular response to nutrient Source: Ensembl
  5. liver development Source: RGD
  6. megakaryocyte differentiation Source: Ensembl
  7. mitotic cell cycle checkpoint Source: Ensembl
  8. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  9. negative regulation of cell proliferation Source: RGD
  10. negative regulation of epithelial cell proliferation Source: Ensembl
  11. positive regulation of epithelial cell differentiation Source: RGD
  12. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  13. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  14. response to cytokine Source: RGD
  15. response to organic cyclic compound Source: RGD
  16. spleen development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_203770. Oxidative Stress Induced Senescence.
REACT_215142. Oncogene Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene namesi
Name:Cdkn2b
Synonyms:Ink4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi2324. Cdkn2b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: RGD
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Cyclin-dependent kinase 4 inhibitor B
PRO_0000004808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55272.
PRIDEiP55272.

Expressioni

Tissue specificityi

Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.

Gene expression databases

GenevestigatoriP55272.

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008898.

Structurei

3D structure databases

ProteinModelPortaliP55272.
SMRiP55272. Positions 1-130.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3430ANK 1
Add
BLAST
Repeati38 – 6629ANK 2
Add
BLAST
Repeati71 – 10030ANK 3
Add
BLAST
Repeati104 – 13027ANK 4
Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG287192.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55272.
KOiK04685.
OMAiIGNHLWV.
OrthoDBiEOG7TTQ94.
PhylomeDBiP55272.
TreeFamiTF352389.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform Long (identifier: P55272-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS    50
AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV 100
CDAWGRLPVD LAEEQGHRDI ARYLHAATGD 130
Length:130
Mass (Da):13,749
Last modified:October 1, 1996 - v1
Checksum:iAC45B21FA69FAD92
GO
Isoform Short (identifier: P55272-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.

Note: No experimental confirmation available.

Show »
Length:85
Mass (Da):9,174
Checksum:i18B7A5B6D45C86EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545Missing in isoform Short.
VSP_018702Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79760 mRNA. Translation: AAB35360.1.
AF474978 mRNA. Translation: AAL76340.1.
AF474979 mRNA. Translation: AAL76341.1.
S77734 Genomic DNA. No translation available.
RefSeqiNP_570825.1. NM_130812.2. [P55272-1]
UniGeneiRn.105626.

Genome annotation databases

EnsembliENSRNOT00000008898; ENSRNOP00000008898; ENSRNOG00000006735. [P55272-1]
GeneIDi25164.
KEGGirno:25164.
UCSCiRGD:2324. rat. [P55272-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79760 mRNA. Translation: AAB35360.1 .
AF474978 mRNA. Translation: AAL76340.1 .
AF474979 mRNA. Translation: AAL76341.1 .
S77734 Genomic DNA. No translation available.
RefSeqi NP_570825.1. NM_130812.2. [P55272-1 ]
UniGenei Rn.105626.

3D structure databases

ProteinModelPortali P55272.
SMRi P55272. Positions 1-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000008898.

Proteomic databases

PaxDbi P55272.
PRIDEi P55272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000008898 ; ENSRNOP00000008898 ; ENSRNOG00000006735 . [P55272-1 ]
GeneIDi 25164.
KEGGi rno:25164.
UCSCi RGD:2324. rat. [P55272-1 ]

Organism-specific databases

CTDi 1030.
RGDi 2324. Cdkn2b.

Phylogenomic databases

eggNOGi NOG287192.
GeneTreei ENSGT00390000004527.
HOGENOMi HOG000290191.
HOVERGENi HBG050870.
InParanoidi P55272.
KOi K04685.
OMAi IGNHLWV.
OrthoDBi EOG7TTQ94.
PhylomeDBi P55272.
TreeFami TF352389.

Enzyme and pathway databases

Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
REACT_203770. Oxidative Stress Induced Senescence.
REACT_215142. Oncogene Induced Senescence.

Miscellaneous databases

NextBioi 605637.
PROi P55272.

Gene expression databases

Genevestigatori P55272.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)."
    Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H., Kikuchi Y., Mitani H.
    Mol. Carcinog. 14:23-27(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Buckles L.K., Shull J.D.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ACI/SegHsd and COP.
    Tissue: Lung.
  3. "Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors."
    Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.
    Cancer Res. 55:1607-1612(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.

Entry informationi

Entry nameiCDN2B_RAT
AccessioniPrimary (citable) accession number: P55272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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