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P55272

- CDN2B_RAT

UniProt

P55272 - CDN2B_RAT

Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

Cdkn2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. aging Source: RGD
    2. cell cycle arrest Source: Ensembl
    3. cellular response to nutrient Source: Ensembl
    4. G2/M transition of mitotic cell cycle Source: Ensembl
    5. liver development Source: RGD
    6. megakaryocyte differentiation Source: Ensembl
    7. mitotic cell cycle checkpoint Source: Ensembl
    8. negative regulation of cell proliferation Source: RGD
    9. negative regulation of epithelial cell proliferation Source: Ensembl
    10. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    11. positive regulation of epithelial cell differentiation Source: RGD
    12. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    13. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    14. response to cytokine Source: RGD
    15. response to organic cyclic compound Source: RGD
    16. spleen development Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_203770. Oxidative Stress Induced Senescence.
    REACT_215142. Oncogene Induced Senescence.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor B
    Alternative name(s):
    p14-INK4b
    p15-INK4b
    Gene namesi
    Name:Cdkn2b
    Synonyms:Ink4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi2324. Cdkn2b.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: RGD

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 130130Cyclin-dependent kinase 4 inhibitor BPRO_0000004808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP55272.
    PRIDEiP55272.

    Expressioni

    Tissue specificityi

    Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.

    Gene expression databases

    GenevestigatoriP55272.

    Interactioni

    Subunit structurei

    Heterodimer of CDKN2B with CDK4 or CDK6.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000008898.

    Structurei

    3D structure databases

    ProteinModelPortaliP55272.
    SMRiP55272. Positions 1-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati5 – 3430ANK 1Add
    BLAST
    Repeati38 – 6629ANK 2Add
    BLAST
    Repeati71 – 10030ANK 3Add
    BLAST
    Repeati104 – 13027ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG287192.
    GeneTreeiENSGT00390000004527.
    HOGENOMiHOG000290191.
    HOVERGENiHBG050870.
    InParanoidiP55272.
    KOiK04685.
    OMAiIGNHLWV.
    OrthoDBiEOG7TTQ94.
    PhylomeDBiP55272.
    TreeFamiTF352389.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform Long (identifier: P55272-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS    50
    AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV 100
    CDAWGRLPVD LAEEQGHRDI ARYLHAATGD 130
    Length:130
    Mass (Da):13,749
    Last modified:October 1, 1996 - v1
    Checksum:iAC45B21FA69FAD92
    GO
    Isoform Short (identifier: P55272-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-45: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:85
    Mass (Da):9,174
    Checksum:i18B7A5B6D45C86EC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4545Missing in isoform Short. CuratedVSP_018702Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79760 mRNA. Translation: AAB35360.1.
    AF474978 mRNA. Translation: AAL76340.1.
    AF474979 mRNA. Translation: AAL76341.1.
    S77734 Genomic DNA. No translation available.
    RefSeqiNP_570825.1. NM_130812.2. [P55272-1]
    UniGeneiRn.105626.

    Genome annotation databases

    EnsembliENSRNOT00000008898; ENSRNOP00000008898; ENSRNOG00000006735. [P55272-1]
    GeneIDi25164.
    KEGGirno:25164.
    UCSCiRGD:2324. rat. [P55272-1]

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S79760 mRNA. Translation: AAB35360.1 .
    AF474978 mRNA. Translation: AAL76340.1 .
    AF474979 mRNA. Translation: AAL76341.1 .
    S77734 Genomic DNA. No translation available.
    RefSeqi NP_570825.1. NM_130812.2. [P55272-1 ]
    UniGenei Rn.105626.

    3D structure databases

    ProteinModelPortali P55272.
    SMRi P55272. Positions 1-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000008898.

    Proteomic databases

    PaxDbi P55272.
    PRIDEi P55272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000008898 ; ENSRNOP00000008898 ; ENSRNOG00000006735 . [P55272-1 ]
    GeneIDi 25164.
    KEGGi rno:25164.
    UCSCi RGD:2324. rat. [P55272-1 ]

    Organism-specific databases

    CTDi 1030.
    RGDi 2324. Cdkn2b.

    Phylogenomic databases

    eggNOGi NOG287192.
    GeneTreei ENSGT00390000004527.
    HOGENOMi HOG000290191.
    HOVERGENi HBG050870.
    InParanoidi P55272.
    KOi K04685.
    OMAi IGNHLWV.
    OrthoDBi EOG7TTQ94.
    PhylomeDBi P55272.
    TreeFami TF352389.

    Enzyme and pathway databases

    Reactomei REACT_194748. Senescence-Associated Secretory Phenotype (SASP).
    REACT_203770. Oxidative Stress Induced Senescence.
    REACT_215142. Oncogene Induced Senescence.

    Miscellaneous databases

    NextBioi 605637.
    PROi P55272.

    Gene expression databases

    Genevestigatori P55272.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)."
      Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H., Kikuchi Y., Mitani H.
      Mol. Carcinog. 14:23-27(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Buckles L.K., Shull J.D.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ACI/SegHsd and COP.
      Tissue: Lung.
    3. "Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors."
      Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.
      Cancer Res. 55:1607-1612(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.

    Entry informationi

    Entry nameiCDN2B_RAT
    AccessioniPrimary (citable) accession number: P55272
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3