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P55271

- CDN2B_MOUSE

UniProt

P55271 - CDN2B_MOUSE

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Protein

Cyclin-dependent kinase 4 inhibitor B

Gene
Cdkn2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. cellular response to nutrient Source: Ensembl
  4. G2/M transition of mitotic cell cycle Source: Ensembl
  5. liver development Source: Ensembl
  6. megakaryocyte differentiation Source: Ensembl
  7. mitotic cell cycle checkpoint Source: Ensembl
  8. negative regulation of epithelial cell proliferation Source: Ensembl
  9. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
  10. positive regulation of epithelial cell differentiation Source: Ensembl
  11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  12. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  13. response to cytokine Source: Ensembl
  14. response to organic cyclic compound Source: Ensembl
  15. spleen development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene namesi
Name:Cdkn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:104737. Cdkn2b.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 130130Cyclin-dependent kinase 4 inhibitor BPRO_0000144185Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP55271.

PTM databases

PhosphoSiteiP55271.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Inductioni

By TGF-beta.

Gene expression databases

BgeeiP55271.
GenevestigatoriP55271.

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6 By similarity.

Protein-protein interaction databases

DIPiDIP-60249N.

Structurei

Secondary structure

1
130
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 157
Helixi19 – 279
Turni41 – 455
Helixi51 – 6010
Turni69 – 724
Helixi75 – 828
Helixi85 – 939
Beta strandi102 – 1065
Helixi108 – 1158
Helixi118 – 12811

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9SNMR-A1-130[»]
ProteinModelPortaliP55271.
SMRiP55271. Positions 1-130.

Miscellaneous databases

EvolutionaryTraceiP55271.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 3430ANK 1Add
BLAST
Repeati38 – 6629ANK 2Add
BLAST
Repeati71 – 10030ANK 3Add
BLAST
Repeati104 – 13027ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG287192.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55271.
KOiK04685.
OMAiIGNHLWV.
OrthoDBiEOG7TTQ94.
PhylomeDBiP55271.
TreeFamiTF352389.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55271-1 [UniParc]FASTAAdd to Basket

« Hide

MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS    50
AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV 100
CDAWGRLPVD LAEEQGHRDI ARYLHAATGD 130
Length:130
Mass (Da):13,789
Last modified:October 1, 1996 - v1
Checksum:i7AAD60FF552BCFF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66085, U66084 Genomic DNA. Translation: AAB39833.1.
BC002010 mRNA. Translation: AAH02010.1.
CCDSiCCDS18351.1.
RefSeqiNP_031696.1. NM_007670.4.
UniGeneiMm.423094.

Genome annotation databases

EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802.
GeneIDi12579.
KEGGimmu:12579.
UCSCiuc008tok.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U66085 , U66084 Genomic DNA. Translation: AAB39833.1 .
BC002010 mRNA. Translation: AAH02010.1 .
CCDSi CCDS18351.1.
RefSeqi NP_031696.1. NM_007670.4.
UniGenei Mm.423094.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D9S NMR - A 1-130 [» ]
ProteinModelPortali P55271.
SMRi P55271. Positions 1-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60249N.

PTM databases

PhosphoSitei P55271.

Proteomic databases

PRIDEi P55271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097981 ; ENSMUSP00000095595 ; ENSMUSG00000073802 .
GeneIDi 12579.
KEGGi mmu:12579.
UCSCi uc008tok.2. mouse.

Organism-specific databases

CTDi 1030.
MGIi MGI:104737. Cdkn2b.

Phylogenomic databases

eggNOGi NOG287192.
HOGENOMi HOG000290191.
HOVERGENi HBG050870.
InParanoidi P55271.
KOi K04685.
OMAi IGNHLWV.
OrthoDBi EOG7TTQ94.
PhylomeDBi P55271.
TreeFami TF352389.

Enzyme and pathway databases

Reactomei REACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

EvolutionaryTracei P55271.
NextBioi 281704.
PROi P55271.
SOURCEi Search...

Gene expression databases

Bgeei P55271.
Genevestigatori P55271.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine p16INK4a and p15INK4b genes."
    Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.
    Oncogene 11:635-645(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
    Malumbres M., de Castro I.P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernandez-Piqueras J.
    Oncogene 14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J X DBA.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C)."
    Yuan C., Li J., Selby T.L., Byeon I.-J., Tsai M.-D.
    J. Mol. Biol. 294:201-211(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCDN2B_MOUSE
AccessioniPrimary (citable) accession number: P55271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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