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P55271 (CDN2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene names
Name:Cdkn2b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.

Subunit structure

Heterodimer of CDKN2B with CDK4 or CDK6 By similarity.

Tissue specificity

Expressed ubiquitously.

Induction

By TGF-beta.

Sequence similarities

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Contains 4 ANK repeats.

Ontologies

Keywords
   Biological processCell cycle
   DiseaseTumor suppressor
   DomainANK repeat
Repeat
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG2/M transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to nutrient

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

megakaryocyte differentiation

Inferred from electronic annotation. Source: Ensembl

mitotic cell cycle checkpoint

Inferred from electronic annotation. Source: Ensembl

negative regulation of G1/S transition of mitotic cell cycle

Inferred from mutant phenotype PubMed 23154982. Source: MGI

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: Ensembl

response to cytokine

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from genetic interaction PubMed 22560297. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 130130Cyclin-dependent kinase 4 inhibitor B
PRO_0000144185

Regions

Repeat5 – 3430ANK 1
Repeat38 – 6629ANK 2
Repeat71 – 10030ANK 3
Repeat104 – 13027ANK 4

Amino acid modifications

Modified residue121Phosphothreonine Ref.4

Secondary structure

..................... 130
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55271 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7AAD60FF552BCFF9

FASTA13013,789
        10         20         30         40         50         60 
MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS AQVAELLLLH 

        70         80         90        100        110        120 
GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV CDAWGRLPVD LAEEQGHRDI 

       130 
ARYLHAATGD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of murine p16INK4a and p15INK4b genes."
Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.
Oncogene 11:635-645(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
Malumbres M., de Castro I.P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernandez-Piqueras J.
Oncogene 14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6J X DBA.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[4]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
[5]"Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C)."
Yuan C., Li J., Selby T.L., Byeon I.-J., Tsai M.-D.
J. Mol. Biol. 294:201-211(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66085, U66084 Genomic DNA. Translation: AAB39833.1.
BC002010 mRNA. Translation: AAH02010.1.
RefSeqNP_031696.1. NM_007670.4.
UniGeneMm.423094.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D9SNMR-A1-130[»]
ProteinModelPortalP55271.
SMRP55271. Positions 1-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60249N.

PTM databases

PhosphoSiteP55271.

Proteomic databases

PRIDEP55271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802.
GeneID12579.
KEGGmmu:12579.
UCSCuc008tok.2. mouse.

Organism-specific databases

CTD1030.
MGIMGI:104737. Cdkn2b.

Phylogenomic databases

eggNOGNOG287192.
HOGENOMHOG000290191.
HOVERGENHBG050870.
InParanoidP55271.
KOK04685.
OMAIGNHLWV.
OrthoDBEOG7TTQ94.
PhylomeDBP55271.
TreeFamTF352389.

Gene expression databases

BgeeP55271.
GenevestigatorP55271.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55271.
NextBio281704.
PROP55271.
SOURCESearch...

Entry information

Entry nameCDN2B_MOUSE
AccessionPrimary (citable) accession number: P55271
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot