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P55271

- CDN2B_MOUSE

UniProt

P55271 - CDN2B_MOUSE

Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

Cdkn2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest By similarity.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. cellular response to nutrient Source: Ensembl
    4. G2/M transition of mitotic cell cycle Source: Ensembl
    5. liver development Source: Ensembl
    6. megakaryocyte differentiation Source: Ensembl
    7. mitotic cell cycle checkpoint Source: Ensembl
    8. negative regulation of epithelial cell proliferation Source: Ensembl
    9. negative regulation of G1/S transition of mitotic cell cycle Source: MGI
    10. positive regulation of epithelial cell differentiation Source: Ensembl
    11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    12. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    13. response to cytokine Source: Ensembl
    14. response to organic cyclic compound Source: Ensembl
    15. spleen development Source: MGI

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor B
    Alternative name(s):
    p14-INK4b
    p15-INK4b
    Gene namesi
    Name:Cdkn2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:104737. Cdkn2b.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 130130Cyclin-dependent kinase 4 inhibitor BPRO_0000144185Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei12 – 121Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP55271.

    PTM databases

    PhosphoSiteiP55271.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously.

    Inductioni

    By TGF-beta.

    Gene expression databases

    BgeeiP55271.
    GenevestigatoriP55271.

    Interactioni

    Subunit structurei

    Heterodimer of CDKN2B with CDK4 or CDK6.By similarity

    Protein-protein interaction databases

    DIPiDIP-60249N.

    Structurei

    Secondary structure

    1
    130
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 157
    Helixi19 – 279
    Turni41 – 455
    Helixi51 – 6010
    Turni69 – 724
    Helixi75 – 828
    Helixi85 – 939
    Beta strandi102 – 1065
    Helixi108 – 1158
    Helixi118 – 12811

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D9SNMR-A1-130[»]
    ProteinModelPortaliP55271.
    SMRiP55271. Positions 1-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55271.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati5 – 3430ANK 1Add
    BLAST
    Repeati38 – 6629ANK 2Add
    BLAST
    Repeati71 – 10030ANK 3Add
    BLAST
    Repeati104 – 13027ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG287192.
    HOGENOMiHOG000290191.
    HOVERGENiHBG050870.
    InParanoidiP55271.
    KOiK04685.
    OMAiIGNHLWV.
    OrthoDBiEOG7TTQ94.
    PhylomeDBiP55271.
    TreeFamiTF352389.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55271-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS    50
    AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV 100
    CDAWGRLPVD LAEEQGHRDI ARYLHAATGD 130
    Length:130
    Mass (Da):13,789
    Last modified:October 1, 1996 - v1
    Checksum:i7AAD60FF552BCFF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66085, U66084 Genomic DNA. Translation: AAB39833.1.
    BC002010 mRNA. Translation: AAH02010.1.
    CCDSiCCDS18351.1.
    RefSeqiNP_031696.1. NM_007670.4.
    UniGeneiMm.423094.

    Genome annotation databases

    EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802.
    GeneIDi12579.
    KEGGimmu:12579.
    UCSCiuc008tok.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66085 , U66084 Genomic DNA. Translation: AAB39833.1 .
    BC002010 mRNA. Translation: AAH02010.1 .
    CCDSi CCDS18351.1.
    RefSeqi NP_031696.1. NM_007670.4.
    UniGenei Mm.423094.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D9S NMR - A 1-130 [» ]
    ProteinModelPortali P55271.
    SMRi P55271. Positions 1-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60249N.

    PTM databases

    PhosphoSitei P55271.

    Proteomic databases

    PRIDEi P55271.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097981 ; ENSMUSP00000095595 ; ENSMUSG00000073802 .
    GeneIDi 12579.
    KEGGi mmu:12579.
    UCSCi uc008tok.2. mouse.

    Organism-specific databases

    CTDi 1030.
    MGIi MGI:104737. Cdkn2b.

    Phylogenomic databases

    eggNOGi NOG287192.
    HOGENOMi HOG000290191.
    HOVERGENi HBG050870.
    InParanoidi P55271.
    KOi K04685.
    OMAi IGNHLWV.
    OrthoDBi EOG7TTQ94.
    PhylomeDBi P55271.
    TreeFami TF352389.

    Enzyme and pathway databases

    Reactomei REACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Miscellaneous databases

    EvolutionaryTracei P55271.
    NextBioi 281704.
    PROi P55271.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55271.
    Genevestigatori P55271.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of murine p16INK4a and p15INK4b genes."
      Quelle D.E., Ashmun R.A., Hannon G.J., Rehberger P.A., Trono D., Richter K.H., Walker C., Beach D., Sherr C.J., Serrano M.
      Oncogene 11:635-645(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas."
      Malumbres M., de Castro I.P., Santos J., Melendez B., Mangues R., Serrano M., Pellicer A., Fernandez-Piqueras J.
      Oncogene 14:1361-1370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6J X DBA.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    5. "Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C)."
      Yuan C., Li J., Selby T.L., Byeon I.-J., Tsai M.-D.
      J. Mol. Biol. 294:201-211(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiCDN2B_MOUSE
    AccessioniPrimary (citable) accession number: P55271
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3