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Protein

Cyclin-dependent kinase 4 inhibitor B

Gene

Cdkn2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor B
Alternative name(s):
p14-INK4b
p15-INK4b
Gene namesi
Name:Cdkn2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104737. Cdkn2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441851 – 130Cyclin-dependent kinase 4 inhibitor BAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP55271.
PaxDbiP55271.
PeptideAtlasiP55271.
PRIDEiP55271.

PTM databases

iPTMnetiP55271.
PhosphoSitePlusiP55271.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Inductioni

By TGF-beta.

Gene expression databases

BgeeiENSMUSG00000073802.
ExpressionAtlasiP55271. baseline and differential.
GenevisibleiP55271. MM.

Interactioni

Subunit structurei

Heterodimer of CDKN2B with CDK4 or CDK6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60249N.
STRINGi10090.ENSMUSP00000095595.

Structurei

Secondary structure

1130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 15Combined sources7
Helixi19 – 27Combined sources9
Turni41 – 45Combined sources5
Helixi51 – 60Combined sources10
Turni69 – 72Combined sources4
Helixi75 – 82Combined sources8
Helixi85 – 93Combined sources9
Beta strandi102 – 106Combined sources5
Helixi108 – 115Combined sources8
Helixi118 – 128Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9SNMR-A1-130[»]
ProteinModelPortaliP55271.
SMRiP55271.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55271.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 34ANK 1Add BLAST30
Repeati38 – 66ANK 2Add BLAST29
Repeati71 – 100ANK 3Add BLAST30
Repeati104 – 130ANK 4Add BLAST27

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55271.
KOiK04685.
OMAiVNCYGRR.
OrthoDBiEOG091G0WSF.
PhylomeDBiP55271.
TreeFamiTF352389.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS
60 70 80 90 100
AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV
110 120 130
CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
Length:130
Mass (Da):13,789
Last modified:October 1, 1996 - v1
Checksum:i7AAD60FF552BCFF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66085, U66084 Genomic DNA. Translation: AAB39833.1.
BC002010 mRNA. Translation: AAH02010.1.
CCDSiCCDS18351.1.
RefSeqiNP_031696.1. NM_007670.4.
UniGeneiMm.423094.

Genome annotation databases

EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802.
GeneIDi12579.
KEGGimmu:12579.
UCSCiuc008tok.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66085, U66084 Genomic DNA. Translation: AAB39833.1.
BC002010 mRNA. Translation: AAH02010.1.
CCDSiCCDS18351.1.
RefSeqiNP_031696.1. NM_007670.4.
UniGeneiMm.423094.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9SNMR-A1-130[»]
ProteinModelPortaliP55271.
SMRiP55271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60249N.
STRINGi10090.ENSMUSP00000095595.

PTM databases

iPTMnetiP55271.
PhosphoSitePlusiP55271.

Proteomic databases

EPDiP55271.
PaxDbiP55271.
PeptideAtlasiP55271.
PRIDEiP55271.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097981; ENSMUSP00000095595; ENSMUSG00000073802.
GeneIDi12579.
KEGGimmu:12579.
UCSCiuc008tok.2. mouse.

Organism-specific databases

CTDi1030.
MGIiMGI:104737. Cdkn2b.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiP55271.
KOiK04685.
OMAiVNCYGRR.
OrthoDBiEOG091G0WSF.
PhylomeDBiP55271.
TreeFamiTF352389.

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Miscellaneous databases

EvolutionaryTraceiP55271.
PROiP55271.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073802.
ExpressionAtlasiP55271. baseline and differential.
GenevisibleiP55271. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2B_MOUSE
AccessioniPrimary (citable) accession number: P55271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.