##gff-version 3 P55265 UniProtKB Chain 1 1226 . . . ID=PRO_0000171774;Note=Double-stranded RNA-specific adenosine deaminase P55265 UniProtKB Domain 133 199 . . . Note=Z-binding 1;Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00073,ECO:0000269|PubMed:10364558,ECO:0000269|PubMed:10535945,ECO:0000269|PubMed:16237447;Dbxref=PMID:10364558,PMID:10535945,PMID:16237447 P55265 UniProtKB Domain 293 357 . . . Note=Z-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00073 P55265 UniProtKB Domain 503 571 . . . Note=DRBM 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266 P55265 UniProtKB Domain 614 682 . . . Note=DRBM 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266 P55265 UniProtKB Domain 726 794 . . . Note=DRBM 3;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00266,ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Domain 886 1221 . . . Note=A to I editase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00240 P55265 UniProtKB Region 133 202 . . . Note=Interaction with Z-DNA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10364558,ECO:0000269|PubMed:10535945,ECO:0000269|PubMed:16237447;Dbxref=PMID:10364558,PMID:10535945,PMID:16237447 P55265 UniProtKB Region 208 238 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P55265 UniProtKB Region 258 286 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P55265 UniProtKB Region 574 610 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P55265 UniProtKB Region 716 725 . . . Note=N-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Region 795 801 . . . Note=C-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Compositional bias 574 597 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P55265 UniProtKB Active site 912 912 . . . Note=Proton donor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00240 P55265 UniProtKB Binding site 910 910 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00240 P55265 UniProtKB Binding site 966 966 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00240 P55265 UniProtKB Binding site 1036 1036 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00240 P55265 UniProtKB Modified residue 26 26 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24129315;Dbxref=PMID:24129315 P55265 UniProtKB Modified residue 285 285 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P55266 P55265 UniProtKB Modified residue 481 481 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P55265 UniProtKB Modified residue 601 601 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163 P55265 UniProtKB Modified residue 603 603 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P55265 UniProtKB Modified residue 614 614 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P55265 UniProtKB Modified residue 629 629 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P55265 UniProtKB Modified residue 636 636 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P55265 UniProtKB Modified residue 808 808 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:16964243,ECO:0007744|PubMed:17924679,ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:16964243,PMID:17924679,PMID:18220336,PMID:19690332,PMID:20068231,PMID:23186163 P55265 UniProtKB Modified residue 814 814 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 P55265 UniProtKB Modified residue 823 823 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 P55265 UniProtKB Modified residue 825 825 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:21406692,PMID:23186163 P55265 UniProtKB Cross-link 384 384 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P55265 UniProtKB Cross-link 408 408 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P55265 UniProtKB Cross-link 418 418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)%3B alternate P55265 UniProtKB Cross-link 418 418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 P55265 UniProtKB Cross-link 418 418 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25114211,ECO:0007744|PubMed:25755297,ECO:0007744|PubMed:28112733;Dbxref=PMID:25114211,PMID:25755297,PMID:28112733 P55265 UniProtKB Cross-link 580 580 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P55265 UniProtKB Cross-link 875 875 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P55265 UniProtKB Alternative sequence 1 295 . . . ID=VSP_019235;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 P55265 UniProtKB Alternative sequence 1 5 . . . ID=VSP_008872;Note=In isoform 4. MNPRQ->MMSPICDQTIDSRLKVEKATWWGRVGGGSRPHWQPPGVRPCPEEVQDP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 P55265 UniProtKB Alternative sequence 694 712 . . . ID=VSP_008873;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Alternative sequence 807 832 . . . ID=VSP_008874;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Natural variant 100 100 . . . ID=VAR_048725;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:7565688,ECO:0000269|PubMed:7972084,ECO:0000269|PubMed:9020165,ECO:0000269|Ref.4;Dbxref=dbSNP:rs1466731,PMID:15489334,PMID:17974005,PMID:7565688,PMID:7972084,PMID:9020165 P55265 UniProtKB Natural variant 193 193 . . . ID=VAR_069535;Note=In AGS6. P->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs145588689,PMID:23001123 P55265 UniProtKB Natural variant 384 384 . . . ID=VAR_017240;Note=K->R;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17974005,ECO:0000269|PubMed:7565688,ECO:0000269|PubMed:9020165,ECO:0000269|Ref.4;Dbxref=dbSNP:rs2229857,PMID:17974005,PMID:7565688,PMID:9020165 P55265 UniProtKB Natural variant 587 587 . . . ID=VAR_024407;Note=Y->C;Dbxref=dbSNP:rs17843865 P55265 UniProtKB Natural variant 806 806 . . . ID=VAR_035805;Note=In a breast cancer sample%3B somatic mutation. E->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs144119808,PMID:16959974 P55265 UniProtKB Natural variant 870 870 . . . ID=VAR_069536;Note=In AGS6. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122893,PMID:23001123 P55265 UniProtKB Natural variant 872 872 . . . ID=VAR_069537;Note=In AGS6. I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122897,PMID:23001123 P55265 UniProtKB Natural variant 892 892 . . . ID=VAR_069538;Note=In AGS6. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122892,PMID:23001123 P55265 UniProtKB Natural variant 923 923 . . . ID=VAR_017604;Note=In DSH. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12916015;Dbxref=dbSNP:rs28936680,PMID:12916015 P55265 UniProtKB Natural variant 966 966 . . . ID=VAR_021729;Note=In DSH. C->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15146470;Dbxref=PMID:15146470 P55265 UniProtKB Natural variant 999 999 . . . ID=VAR_069539;Note=In AGS6. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122896,PMID:23001123 P55265 UniProtKB Natural variant 1007 1007 . . . ID=VAR_069540;Note=In AGS6. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122822,PMID:23001123 P55265 UniProtKB Natural variant 1112 1112 . . . ID=VAR_069541;Note=In AGS6. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122895,PMID:23001123 P55265 UniProtKB Natural variant 1113 1113 . . . ID=VAR_069542;Note=In AGS6. D->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23001123;Dbxref=dbSNP:rs398122894,PMID:23001123 P55265 UniProtKB Natural variant 1155 1155 . . . ID=VAR_026669;Note=In DSH. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15659327;Dbxref=dbSNP:rs1044845711,PMID:15659327 P55265 UniProtKB Natural variant 1165 1165 . . . ID=VAR_017605;Note=In DSH. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12916015;Dbxref=dbSNP:rs28936681,PMID:12916015 P55265 UniProtKB Mutagenesis 418 418 . . . Note=Abolishes sumoylation. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16120648;Dbxref=PMID:16120648 P55265 UniProtKB Mutagenesis 708 801 . . . Note=Abolishes nuclear location. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 708 710 . . . Note=Decreased nuclear and partially cytoplasmic location. MMP->AMA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 712 715 . . . Note=No effect on nuclear location. No effect on RNA binding. KVRK->AVAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 716 724 . . . Note=Disrupts the bi-partite nuclear localization signal and abolishes nuclear location. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 716 716 . . . Note=Disrupts the bi-partite nuclear localization signal and abolishes nuclear location%3B when associated with S-719 and N-723. I->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 718 718 . . . Note=No effect on nuclear location%3B when associated with A-721 and A-724. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 719 719 . . . Note=Disrupts the bi-partite nuclear localization signal and abolishes nuclear location%3B when associated with N-716 and N-723. L->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 721 721 . . . Note=No effect on nuclear location%3B when associated with A-721 and A-724. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 723 723 . . . Note=Disrupts the bi-partite nuclear localization signal and abolishes nuclear location%3B when associated with N-716 and S-719. L->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 724 724 . . . Note=No effect on nuclear location%3B when associated with A-718 and A-721. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 725 801 . . . Note=Disrupts nuclear localization signal. No effect on RNA binding. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 777 778 . . . Note=Strongly impaired RNA binding. No effect on nuclear location. KK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Mutagenesis 801 801 . . . Note=Abolishes interaction with TNPO1%2C TNPO1-mediated nuclear import and nuclear location. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24753571;Dbxref=PMID:24753571 P55265 UniProtKB Sequence conflict 53 53 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Sequence conflict 245 245 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Sequence conflict 482 482 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Sequence conflict 873 873 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Sequence conflict 1093 1093 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Sequence conflict 1184 1184 . . . Note=E->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 P55265 UniProtKB Helix 127 130 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QGP P55265 UniProtKB Helix 135 150 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QBJ P55265 UniProtKB Beta strand 152 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QGP P55265 UniProtKB Helix 158 165 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QBJ P55265 UniProtKB Helix 169 181 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QBJ P55265 UniProtKB Beta strand 184 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QBJ P55265 UniProtKB Beta strand 194 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1QBJ P55265 UniProtKB Helix 294 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Helix 315 322 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Helix 324 326 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Helix 327 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Beta strand 342 346 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Beta strand 348 350 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Beta strand 352 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Helix 357 360 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Turn 361 363 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1XMK P55265 UniProtKB Helix 716 724 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Helix 727 738 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Beta strand 742 749 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Beta strand 758 764 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Beta strand 767 776 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Helix 777 796 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MDR P55265 UniProtKB Sequence conflict 13 13 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305