Reviewed, UniProtKB/Swiss-Prot P55265 (DSRAD_HUMAN)

Names and origin

Protein names

Recommended name:
    Double-stranded RNA-specific adenosine deaminase
      Short name=DRADA
    EC=3.5.4.-
Alternative name(s):
    136 kDa double-stranded RNA-binding protein
    P136
    K88DSRBP
    Interferon-inducible protein 4
      Short name=IFI-4

Gene names

Name:	ADAR
Synonyms:	ADAR1, DSRAD, G1P1, IFI4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site-selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression.
Subunit structure	Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90.
Subcellular location	Cytoplasm. Nucleus › nucleolus. Note= Isoform 1 is found predominantly in cytoplasm but appears to shuttle between the cytoplasm and nucleus. Isoform 5 is found exclusively in the nucleolus.
Tissue specificity	Ubiquitously expressed, highest levels were found in brain and lung.
Induction	Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed.
Post-translational modification	Sumoylation reduces RNA-editing activity.
Involvement in disease	Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) [MIM:127400]; also known as reticulate acropigmentation of Dohi. DSH is a pigmentary genodermatosis of autosomal dominant inheritance characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the dorsal parts of the hands and feet.
Sequence similarities	Contains 1 A to I editase domain. Contains 2 DRADA repeats. Contains 3 DRBM (double-stranded RNA-binding) domains.
Caution	The N-terminus of isoform 4 has been derived from EST and genomic sequences.

Ontologies

Keywords
Biological process	RNA-mediated gene silencing mRNA processing
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat
Ligand	DNA-binding Metal-binding RNA-binding Zinc
Molecular function	Hydrolase
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	base conversion or substitution editing Ref.3 Inferred from direct assay. Source: MGI gene silencing by RNA Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Ref.2 Traceable author statement. Source: UniProtKB nucleolus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW double-stranded RNA adenosine deaminase activity Ref.2 Ref.3 Non-traceable author statement. Source: UniProtKB double-stranded RNA binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55265-1)

Also known as: ADAR-a; p150;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Notes: Produced by alternative promoter usage.

Isoform 2 (identifier: P55265-2)

Also known as: ADAR-b;

The sequence of this isoform differs from the canonical sequence as follows:
     807-832: Missing.

Notes: Produced by alternative splicing of isoform 1.

Isoform 3 (identifier: P55265-3)

Also known as: ADAR-c;

The sequence of this isoform differs from the canonical sequence as follows:
     694-712: Missing.
     807-832: Missing.

Notes: Produced by alternative splicing of isoform 1.

Isoform 4 (identifier: P55265-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MNPRQ → MMSPICDQTIDSRLKVEKATWWGRVGGGSRPHWQPPGVRPCPEEVQDP

Notes: Produced by alternative splicing of isoform 1. No experimental confirmation available. The N-terminus has been derived from EST and genomic sequences.

Isoform 5 (identifier: P55265-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-295: Missing.

Notes: Produced by alternative promoter usage.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1226

1226

Double-stranded RNA-specific adenosine deaminase

PRO_0000171774

Regions

Repeat

133 – 202

70

DRADA 1

Repeat

293 – 360

68

DRADA 2

Domain

503 – 571

69

DRBM 1

Domain

614 – 682

69

DRBM 2

Domain

726 – 794

69

DRBM 3

Domain

886 – 1221

336

A to I editase

DNA binding

169 – 195

27

Sites

Active site

912

1

Proton donor By similarity

Metal binding

910

1

Zinc By similarity

Metal binding

966

1

Zinc By similarity

Metal binding

1036

1

Zinc By similarity

Amino acid modifications

Modified residue

601

1

Phosphothreonine

Modified residue

614

1

Phosphoserine

Modified residue

808

1

Phosphothreonine

Modified residue

818

1

Phosphothreonine

Modified residue

823

1

Phosphoserine

Modified residue

825

1

Phosphoserine

Cross-link

418

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Natural variations

Alternative sequence

1 – 295

295

Missing in isoform 5.

VSP_019235

Alternative sequence

1 – 5

5

MNPRQ → MMSPICDQTIDSRLKVEKAT WWGRVGGGSRPHWQPPGVRP CPEEVQDP in isoform 4.

VSP_008872

Alternative sequence

694 – 712

19

Missing in isoform 3.

VSP_008873

Alternative sequence

807 – 832

26

Missing in isoform 2 and isoform 3.

VSP_008874

Natural variant

384

1

R → K: dbSNP rs2229857.

VAR_017240

Natural variant

587

1

Y → C: dbSNP rs17843865.

VAR_024407

Natural variant

806

1

E → V in a breast cancer sample; somatic mutation.

VAR_035805

Natural variant

923

1

L → P in DSH.

VAR_017604

Natural variant

966

1

C → F in DSH.

VAR_021729

Natural variant

1155

1

R → W in DSH.

VAR_026669

Natural variant

1165

1

F → S in DSH.

VAR_017605

Experimental info

Mutagenesis

418

1

K → R: Abolishes sumoylation

Sequence conflict

53

1

E → G in CAA55967 and CAA55968. Ref.4

Sequence conflict

1184

1

E → K in CAA55967 and CAA55968. Ref.4

Secondary structure

1

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1226

Helix Strand Turn

Details...

Helix

127 – 130

4

Helix

135 – 150

16

Helix

158 – 165

8

Helix

169 – 181

13

Beta strand

184 – 192

9

Beta strand

194 – 197

4

Helix

294 – 309

16

Helix

315 – 322

8

Helix

324 – 326

3

Helix

327 – 339

13

Beta strand

342 – 346

5

Beta strand

348 – 350

3

Beta strand

352 – 355

4

Helix

357 – 360

4

Turn

361 – 363

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ADAR-a) (p150) [UniParc]. Last modified November 14, 2003. Version 2. Checksum: 849D6234379277B4	FASTA	1,226	135,995
	10 20 30 40 50 60 MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ LPEAPVIGKQ 70 80 90 100 110 120 TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLG SQGLQRGFQH PSPRGRSLPQ 130 140 150 160 170 180 RGVDCLSSHF QELSIYQDQE QRILKFLEEL GEGKATTAHD LSGKLGTPKK EINRVLYSLA 190 200 210 220 230 240 KKGKLQKEAG TPPLWKIAVS TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED 250 260 270 280 290 300 LLEPFIAVSA QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 310 320 330 340 350 360 EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP PIWHLTDKKR 370 380 390 400 410 420 ERMQIKRNTN SVPETAPAAI PETRRNAEFL TCNIPTSNAS NNMVTTEKVE NGQEPVIKLE 430 440 450 460 470 480 NRQEARPEPA RLKPPVHYNG PSKAGYVDFE NGQWATDDIP DDLNSIRAAP GEFRAIMEMP 490 500 510 520 530 540 SFYSHGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV 550 560 570 580 590 600 INGREFPPAE AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 610 620 630 640 650 660 TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV AVGAQTFPSV 670 680 690 700 710 720 SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE SLDNLESMMP NKVRKIGELV 730 740 750 760 770 780 RYLNTNPVGG LLEYARSHGF AAEFKLVDQS GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG 790 800 810 820 830 840 KQEAADAALR VLIGENEKAE RMGFTEVTPV TGASLRRTML LLSRSPEAQP KTLPLTGSTF 850 860 870 880 890 900 HDQIAMLSHR CFNTLTNSFQ PSLLGRKILA AIIMKKDSED MGVVVSLGTG NRCVKGDSLS 910 920 930 940 950 960 LKGETVNDCH AEIISRRGFI RFLYSELMKY NSQTAKDSIF EPAKGGEKLQ IKKTVSFHLY 970 980 990 1000 1010 1020 ISTAPCGDGA LFDKSCSDRA MESTESRHYP VFENPKQGKL RTKVENGEGT IPVESSDIVP 1030 1040 1050 1060 1070 1080 TWDGIRLGER LRTMSCSDKI LRWNVLGLQG ALLTHFLQPI YLKSVTLGYL FSQGHLTRAI 1090 1100 1110 1120 1130 1140 CCRVTRDGSA FEDGLRHPFI VNHPKVGRVS IYDSKRQSGK TKETSVNWCL ADGYDLEILD 1150 1160 1170 1180 1190 1200 GTRGTVDGPR NELSRVSKKN IFLLFKKLCS FRYRRDLLRL SYGEAKKAAR DYETAKNYFK 1210 1220 KGLKDMGYGN WISKPQEEKN FYLCPV
	Isoform 2 (ADAR-b) [UniParc]. Checksum: 76EAF4C0E9B9AADD		1,200	133,203
	10 20 30 40 50 60 MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ LPEAPVIGKQ 70 80 90 100 110 120 TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLG SQGLQRGFQH PSPRGRSLPQ 130 140 150 160 170 180 RGVDCLSSHF QELSIYQDQE QRILKFLEEL GEGKATTAHD LSGKLGTPKK EINRVLYSLA 190 200 210 220 230 240 KKGKLQKEAG TPPLWKIAVS TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED 250 260 270 280 290 300 LLEPFIAVSA QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 310 320 330 340 350 360 EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP PIWHLTDKKR 370 380 390 400 410 420 ERMQIKRNTN SVPETAPAAI PETRRNAEFL TCNIPTSNAS NNMVTTEKVE NGQEPVIKLE 430 440 450 460 470 480 NRQEARPEPA RLKPPVHYNG PSKAGYVDFE NGQWATDDIP DDLNSIRAAP GEFRAIMEMP 490 500 510 520 530 540 SFYSHGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV 550 560 570 580 590 600 INGREFPPAE AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 610 620 630 640 650 660 TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV AVGAQTFPSV 670 680 690 700 710 720 SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQPEGMISE SLDNLESMMP NKVRKIGELV 730 740 750 760 770 780 RYLNTNPVGG LLEYARSHGF AAEFKLVDQS GPPHEPKFVY QAKVGGRWFP AVCAHSKKQG 790 800 810 820 830 840 KQEAADAALR VLIGENEKAE RMGFTELPLT GSTFHDQIAM LSHRCFNTLT NSFQPSLLGR 850 860 870 880 890 900 KILAAIIMKK DSEDMGVVVS LGTGNRCVKG DSLSLKGETV NDCHAEIISR RGFIRFLYSE 910 920 930 940 950 960 LMKYNSQTAK DSIFEPAKGG EKLQIKKTVS FHLYISTAPC GDGALFDKSC SDRAMESTES 970 980 990 1000 1010 1020 RHYPVFENPK QGKLRTKVEN GEGTIPVESS DIVPTWDGIR LGERLRTMSC SDKILRWNVL 1030 1040 1050 1060 1070 1080 GLQGALLTHF LQPIYLKSVT LGYLFSQGHL TRAICCRVTR DGSAFEDGLR HPFIVNHPKV 1090 1100 1110 1120 1130 1140 GRVSIYDSKR QSGKTKETSV NWCLADGYDL EILDGTRGTV DGPRNELSRV SKKNIFLLFK 1150 1160 1170 1180 1190 1200 KLCSFRYRRD LLRLSYGEAK KAARDYETAK NYFKKGLKDM GYGNWISKPQ EEKNFYLCPV
	Isoform 3 (ADAR-c) [UniParc]. Checksum: 329A03A0DC702D56		1,181	131,099
	10 20 30 40 50 60 MNPRQGYSLS GYYTHPFQGY EHRQLRYQQP GPGSSPSSFL LKQIEFLKGQ LPEAPVIGKQ 70 80 90 100 110 120 TPSLPPSLPG LRPRFPVLLA SSTRGRQVDI RGVPRGVHLG SQGLQRGFQH PSPRGRSLPQ 130 140 150 160 170 180 RGVDCLSSHF QELSIYQDQE QRILKFLEEL GEGKATTAHD LSGKLGTPKK EINRVLYSLA 190 200 210 220 230 240 KKGKLQKEAG TPPLWKIAVS TQAWNQHSGV VRPDGHSQGA PNSDPSLEPE DRNSTSVSED 250 260 270 280 290 300 LLEPFIAVSA QAWNQHSGVV RPDSHSQGSP NSDPGLEPED SNSTSALEDP LEFLDMAEIK 310 320 330 340 350 360 EKICDYLFNV SDSSALNLAK NIGLTKARDI NAVLIDMERQ GDVYRQGTTP PIWHLTDKKR 370 380 390 400 410 420 ERMQIKRNTN SVPETAPAAI PETRRNAEFL TCNIPTSNAS NNMVTTEKVE NGQEPVIKLE 430 440 450 460 470 480 NRQEARPEPA RLKPPVHYNG PSKAGYVDFE NGQWATDDIP DDLNSIRAAP GEFRAIMEMP 490 500 510 520 530 540 SFYSHGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE FNMIEQSGPP HEPRFKFQVV 550 560 570 580 590 600 INGREFPPAE AGSKKVAKQD AAMKAMTILL EEAKAKDSGK SEESSHYSTE KESEKTAESQ 610 620 630 640 650 660 TPTPSATSFF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP AHEPKFQYCV AVGAQTFPSV 670 680 690 700 710 720 SAPSKKVAKQ MAAEEAMKAL HGEATNSMAS DNQVRKIGEL VRYLNTNPVG GLLEYARSHG 730 740 750 760 770 780 FAAEFKLVDQ SGPPHEPKFV YQAKVGGRWF PAVCAHSKKQ GKQEAADAAL RVLIGENEKA 790 800 810 820 830 840 ERMGFTELPL TGSTFHDQIA MLSHRCFNTL TNSFQPSLLG RKILAAIIMK KDSEDMGVVV 850 860 870 880 890 900 SLGTGNRCVK GDSLSLKGET VNDCHAEIIS RRGFIRFLYS ELMKYNSQTA KDSIFEPAKG 910 920 930 940 950 960 GEKLQIKKTV SFHLYISTAP CGDGALFDKS CSDRAMESTE SRHYPVFENP KQGKLRTKVE 970 980 990 1000 1010 1020 NGEGTIPVES SDIVPTWDGI RLGERLRTMS CSDKILRWNV LGLQGALLTH FLQPIYLKSV 1030 1040 1050 1060 1070 1080 TLGYLFSQGH LTRAICCRVT RDGSAFEDGL RHPFIVNHPK VGRVSIYDSK RQSGKTKETS 1090 1100 1110 1120 1130 1140 VNWCLADGYD LEILDGTRGT VDGPRNELSR VSKKNIFLLF KKLCSFRYRR DLLRLSYGEA 1150 1160 1170 1180 KKAARDYETA KNYFKKGLKD MGYGNWISKP QEEKNFYLCP V
	Isoform 4 [UniParc]. Checksum: A3E6EA1355DEF005		1,269	140,767
	10 20 30 40 50 60 MMSPICDQTI DSRLKVEKAT WWGRVGGGSR PHWQPPGVRP CPEEVQDPGY SLSGYYTHPF 70 80 90 100 110 120 QGYEHRQLRY QQPGPGSSPS SFLLKQIEFL KGQLPEAPVI GKQTPSLPPS LPGLRPRFPV 130 140 150 160 170 180 LLASSTRGRQ VDIRGVPRGV HLGSQGLQRG FQHPSPRGRS LPQRGVDCLS SHFQELSIYQ 190 200 210 220 230 240 DQEQRILKFL EELGEGKATT AHDLSGKLGT PKKEINRVLY SLAKKGKLQK EAGTPPLWKI 250 260 270 280 290 300 AVSTQAWNQH SGVVRPDGHS QGAPNSDPSL EPEDRNSTSV SEDLLEPFIA VSAQAWNQHS 310 320 330 340 350 360 GVVRPDSHSQ GSPNSDPGLE PEDSNSTSAL EDPLEFLDMA EIKEKICDYL FNVSDSSALN 370 380 390 400 410 420 LAKNIGLTKA RDINAVLIDM ERQGDVYRQG TTPPIWHLTD KKRERMQIKR NTNSVPETAP 430 440 450 460 470 480 AAIPETRRNA EFLTCNIPTS NASNNMVTTE KVENGQEPVI KLENRQEARP EPARLKPPVH 490 500 510 520 530 540 YNGPSKAGYV DFENGQWATD DIPDDLNSIR AAPGEFRAIM EMPSFYSHGL PRCSPYKKLT 550 560 570 580 590 600 ECQLKNPISG LLEYAQFASQ TCEFNMIEQS GPPHEPRFKF QVVINGREFP PAEAGSKKVA 610 620 630 640 650 660 KQDAAMKAMT ILLEEAKAKD SGKSEESSHY STEKESEKTA ESQTPTPSAT SFFSGKSPVT 670 680 690 700 710 720 TLLECMHKLG NSCEFRLLSK EGPAHEPKFQ YCVAVGAQTF PSVSAPSKKV AKQMAAEEAM 730 740 750 760 770 780 KALHGEATNS MASDNQPEGM ISESLDNLES MMPNKVRKIG ELVRYLNTNP VGGLLEYARS 790 800 810 820 830 840 HGFAAEFKLV DQSGPPHEPK FVYQAKVGGR WFPAVCAHSK KQGKQEAADA ALRVLIGENE 850 860 870 880 890 900 KAERMGFTEV TPVTGASLRR TMLLLSRSPE AQPKTLPLTG STFHDQIAML SHRCFNTLTN 910 920 930 940 950 960 SFQPSLLGRK ILAAIIMKKD SEDMGVVVSL GTGNRCVKGD SLSLKGETVN DCHAEIISRR 970 980 990 1000 1010 1020 GFIRFLYSEL MKYNSQTAKD SIFEPAKGGE KLQIKKTVSF HLYISTAPCG DGALFDKSCS 1030 1040 1050 1060 1070 1080 DRAMESTESR HYPVFENPKQ GKLRTKVENG EGTIPVESSD IVPTWDGIRL GERLRTMSCS 1090 1100 1110 1120 1130 1140 DKILRWNVLG LQGALLTHFL QPIYLKSVTL GYLFSQGHLT RAICCRVTRD GSAFEDGLRH 1150 1160 1170 1180 1190 1200 PFIVNHPKVG RVSIYDSKRQ SGKTKETSVN WCLADGYDLE ILDGTRGTVD GPRNELSRVS 1210 1220 1230 1240 1250 1260 KKNIFLLFKK LCSFRYRRDL LRLSYGEAKK AARDYETAKN YFKKGLKDMG YGNWISKPQE EKNFYLCPV
	Isoform 5 [UniParc]. Checksum: 976C613CD94308C7		931	103,670
	10 20 30 40 50 60 MAEIKEKICD YLFNVSDSSA LNLAKNIGLT KARDINAVLI DMERQGDVYR QGTTPPIWHL 70 80 90 100 110 120 TDKKRERMQI KRNTNSVPET APAAIPETRR NAEFLTCNIP TSNASNNMVT TEKVENGQEP 130 140 150 160 170 180 VIKLENRQEA RPEPARLKPP VHYNGPSKAG YVDFENGQWA TDDIPDDLNS IRAAPGEFRA 190 200 210 220 230 240 IMEMPSFYSH GLPRCSPYKK LTECQLKNPI SGLLEYAQFA SQTCEFNMIE QSGPPHEPRF 250 260 270 280 290 300 KFQVVINGRE FPPAEAGSKK VAKQDAAMKA MTILLEEAKA KDSGKSEESS HYSTEKESEK 310 320 330 340 350 360 TAESQTPTPS ATSFFSGKSP VTTLLECMHK LGNSCEFRLL SKEGPAHEPK FQYCVAVGAQ 370 380 390 400 410 420 TFPSVSAPSK KVAKQMAAEE AMKALHGEAT NSMASDNQPE GMISESLDNL ESMMPNKVRK 430 440 450 460 470 480 IGELVRYLNT NPVGGLLEYA RSHGFAAEFK LVDQSGPPHE PKFVYQAKVG GRWFPAVCAH 490 500 510 520 530 540 SKKQGKQEAA DAALRVLIGE NEKAERMGFT EVTPVTGASL RRTMLLLSRS PEAQPKTLPL 550 560 570 580 590 600 TGSTFHDQIA MLSHRCFNTL TNSFQPSLLG RKILAAIIMK KDSEDMGVVV SLGTGNRCVK 610 620 630 640 650 660 GDSLSLKGET VNDCHAEIIS RRGFIRFLYS ELMKYNSQTA KDSIFEPAKG GEKLQIKKTV 670 680 690 700 710 720 SFHLYISTAP CGDGALFDKS CSDRAMESTE SRHYPVFENP KQGKLRTKVE NGEGTIPVES 730 740 750 760 770 780 SDIVPTWDGI RLGERLRTMS CSDKILRWNV LGLQGALLTH FLQPIYLKSV TLGYLFSQGH 790 800 810 820 830 840 LTRAICCRVT RDGSAFEDGL RHPFIVNHPK VGRVSIYDSK RQSGKTKETS VNWCLADGYD 850 860 870 880 890 900 LEILDGTRGT VDGPRNELSR VSKKNIFLLF KKLCSFRYRR DLLRLSYGEA KKAARDYETA 910 920 930 KNYFKKGLKD MGYGNWISKP QEEKNFYLCP V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing." Kim U., Wang Y., Sanford T., Zeng Y., Nishikura K. Proc. Natl. Acad. Sci. U.S.A. 91:11457-11461(1994) [PubMed: 7972084] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
[2]	"Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase." Patterson J.B., Samuel C.E. Mol. Cell. Biol. 15:5376-5388(1995) [PubMed: 7565688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[3]	"Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase." Liu Y., George C.X., Patterson J.B., Samuel C.E. J. Biol. Chem. 272:4419-4428(1997) [PubMed: 9020165] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Placenta.
[4]	"The gene coding for the interferon-inducible human dsRNA adenosine deaminase is transcribed into several messengers specifying different proteins." Deblandre G., Marinx O., Nols C., Defrance P., Berr P., Huez G., Caput D. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Cervix carcinoma.
[5]	The German cDNA consortium Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: