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Protein

Annexin A4

Gene

Anxa4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
36 kDa zymogen granule membrane-associated protein
Short name:
ZAP36
Annexin IV
Annexin-4
Lipocortin IV
Gene namesi
Name:Anxa4
Synonyms:Anx4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621171. Anxa4.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 319318Annexin A4PRO_0000067485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphothreonineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei213 – 2131N6-acetyllysineBy similarity
Modified residuei293 – 2931N6-acetyllysineBy similarity
Modified residuei300 – 3001N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP55260.
PRIDEiP55260.

Interactioni

Protein-protein interaction databases

MINTiMINT-4542630.
STRINGi10116.ENSRNOP00000024436.

Structurei

Secondary structure

1
319
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 2712Combined sources
Beta strandi28 – 314Combined sources
Helixi34 – 418Combined sources
Helixi46 – 6015Combined sources
Helixi64 – 718Combined sources
Helixi74 – 8411Combined sources
Helixi87 – 9913Combined sources
Beta strandi100 – 1023Combined sources
Helixi106 – 11510Combined sources
Helixi118 – 13215Combined sources
Helixi136 – 1438Combined sources
Helixi146 – 15712Combined sources
Helixi168 – 18114Combined sources
Turni182 – 1843Combined sources
Beta strandi185 – 1873Combined sources
Helixi190 – 19910Combined sources
Helixi202 – 21615Combined sources
Helixi220 – 2278Combined sources
Helixi230 – 24415Combined sources
Helixi246 – 25813Combined sources
Beta strandi259 – 2624Combined sources
Helixi265 – 27511Combined sources
Turni276 – 2783Combined sources
Helixi280 – 29112Combined sources
Helixi295 – 3028Combined sources
Helixi305 – 31511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZHIX-ray1.58A1-319[»]
2ZHJX-ray1.35A1-319[»]
ProteinModelPortaliP55260.
SMRiP55260. Positions 5-319.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 8361Annexin 1Add
BLAST
Repeati95 – 15561Annexin 2Add
BLAST
Repeati179 – 23961Annexin 3Add
BLAST
Repeati254 – 31461Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP55260.
PhylomeDBiP55260.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKGGTVKA ASGFNATEDA QVLRKAMKGL GTDEDAIIGV LACRNTAQRQ
60 70 80 90 100
EIRTAYKSTI GRDLLEDLKS ELSSNFEQVI LGMMTPTVLY DVQELRRAMK
110 120 130 140 150
GAGTDEGCLI EILASRNPEE IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR
160 170 180 190 200
VLVSLTAGGR DEGNYLDDAL VRQDAQDLYE AGEKRWGTDE VKFLSILCSR
210 220 230 240 250
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKPAYF
260 270 280 290 300
AERLYKSMKG LGTDDSTLIR VMVSRAEIDM LDIPANFKRV YGKSLYSFIK
310
GDTSGDYRKV LLILCGGDD
Length:319
Mass (Da):35,849
Last modified:January 23, 2007 - v3
Checksum:iDE4B6A3F5B173005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38224 mRNA. Translation: BAA07399.2.
UniGeneiRn.19270.

Genome annotation databases

UCSCiRGD:621171. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38224 mRNA. Translation: BAA07399.2.
UniGeneiRn.19270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZHIX-ray1.58A1-319[»]
2ZHJX-ray1.35A1-319[»]
ProteinModelPortaliP55260.
SMRiP55260. Positions 5-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4542630.
STRINGi10116.ENSRNOP00000024436.

Proteomic databases

PaxDbiP55260.
PRIDEiP55260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621171. rat.

Organism-specific databases

RGDi621171. Anxa4.

Phylogenomic databases

eggNOGiNOG267770.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP55260.
PhylomeDBiP55260.

Miscellaneous databases

EvolutionaryTraceiP55260.
PROiP55260.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas."
    Fukuoka S., Horst K., Kazuki-Sugino R., Ikeda Y.
    Biochim. Biophys. Acta 1575:148-152(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreas.

Entry informationi

Entry nameiANXA4_RAT
AccessioniPrimary (citable) accession number: P55260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.