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P55260

- ANXA4_RAT

UniProt

P55260 - ANXA4_RAT

Protein

Annexin A4

Gene

Anxa4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. exocytosis Source: RGD

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A4
    Alternative name(s):
    36 kDa zymogen granule membrane-associated protein
    Short name:
    ZAP36
    Annexin IV
    Annexin-4
    Lipocortin IV
    Gene namesi
    Name:Anxa4
    Synonyms:Anx4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621171. Anxa4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 319318Annexin A4PRO_0000067485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei7 – 71PhosphothreonineBy similarity
    Modified residuei213 – 2131N6-acetyllysineBy similarity
    Modified residuei293 – 2931N6-acetyllysineBy similarity
    Modified residuei300 – 3001N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP55260.
    PRIDEiP55260.

    Expressioni

    Gene expression databases

    GenevestigatoriP55260.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4542630.
    STRINGi10116.ENSRNOP00000024436.

    Structurei

    Secondary structure

    1
    319
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 2712
    Beta strandi28 – 314
    Helixi34 – 418
    Helixi46 – 6015
    Helixi64 – 718
    Helixi74 – 8411
    Helixi87 – 9913
    Beta strandi100 – 1023
    Helixi106 – 11510
    Helixi118 – 13215
    Helixi136 – 1438
    Helixi146 – 15712
    Helixi168 – 18114
    Turni182 – 1843
    Beta strandi185 – 1873
    Helixi190 – 19910
    Helixi202 – 21615
    Helixi220 – 2278
    Helixi230 – 24415
    Helixi246 – 25813
    Beta strandi259 – 2624
    Helixi265 – 27511
    Turni276 – 2783
    Helixi280 – 29112
    Helixi295 – 3028
    Helixi305 – 31511

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZHIX-ray1.58A1-319[»]
    2ZHJX-ray1.35A1-319[»]
    ProteinModelPortaliP55260.
    SMRiP55260. Positions 5-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55260.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 8361Annexin 1Add
    BLAST
    Repeati95 – 15561Annexin 2Add
    BLAST
    Repeati179 – 23961Annexin 3Add
    BLAST
    Repeati254 – 31461Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP55260.
    PhylomeDBiP55260.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002391. AnnexinIV.
    [Graphical view]
    PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55260-1 [UniParc]FASTAAdd to Basket

    « Hide

    METKGGTVKA ASGFNATEDA QVLRKAMKGL GTDEDAIIGV LACRNTAQRQ    50
    EIRTAYKSTI GRDLLEDLKS ELSSNFEQVI LGMMTPTVLY DVQELRRAMK 100
    GAGTDEGCLI EILASRNPEE IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR 150
    VLVSLTAGGR DEGNYLDDAL VRQDAQDLYE AGEKRWGTDE VKFLSILCSR 200
    NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKPAYF 250
    AERLYKSMKG LGTDDSTLIR VMVSRAEIDM LDIPANFKRV YGKSLYSFIK 300
    GDTSGDYRKV LLILCGGDD 319
    Length:319
    Mass (Da):35,849
    Last modified:January 23, 2007 - v3
    Checksum:iDE4B6A3F5B173005
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38224 mRNA. Translation: BAA07399.2.
    UniGeneiRn.19270.

    Genome annotation databases

    UCSCiRGD:621171. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38224 mRNA. Translation: BAA07399.2 .
    UniGenei Rn.19270.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZHI X-ray 1.58 A 1-319 [» ]
    2ZHJ X-ray 1.35 A 1-319 [» ]
    ProteinModelPortali P55260.
    SMRi P55260. Positions 5-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4542630.
    STRINGi 10116.ENSRNOP00000024436.

    Proteomic databases

    PaxDbi P55260.
    PRIDEi P55260.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621171. rat.

    Organism-specific databases

    RGDi 621171. Anxa4.

    Phylogenomic databases

    eggNOGi NOG267770.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P55260.
    PhylomeDBi P55260.

    Miscellaneous databases

    EvolutionaryTracei P55260.
    PROi P55260.

    Gene expression databases

    Genevestigatori P55260.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002391. AnnexinIV.
    [Graphical view ]
    PANTHERi PTHR10502:SF28. PTHR10502:SF28. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas."
      Fukuoka S., Horst K., Kazuki-Sugino R., Ikeda Y.
      Biochim. Biophys. Acta 1575:148-152(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiANXA4_RAT
    AccessioniPrimary (citable) accession number: P55260
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Seems to bind one calcium ion with high affinity.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3