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Protein

Annexin A4

Gene

Anxa4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
36 kDa zymogen granule membrane-associated protein
Short name:
ZAP36
Annexin IV
Annexin-4
Lipocortin IV
Gene namesi
Name:Anxa4
Synonyms:Anx4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621171. Anxa4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674852 – 319Annexin A4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei213N6-acetyllysineBy similarity1
Modified residuei293N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP55260.
PRIDEiP55260.

PTM databases

iPTMnetiP55260.
PhosphoSitePlusiP55260.

Interactioni

Protein-protein interaction databases

MINTiMINT-4542630.
STRINGi10116.ENSRNOP00000024436.

Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 27Combined sources12
Beta strandi28 – 31Combined sources4
Helixi34 – 41Combined sources8
Helixi46 – 60Combined sources15
Helixi64 – 71Combined sources8
Helixi74 – 84Combined sources11
Helixi87 – 99Combined sources13
Beta strandi100 – 102Combined sources3
Helixi106 – 115Combined sources10
Helixi118 – 132Combined sources15
Helixi136 – 143Combined sources8
Helixi146 – 157Combined sources12
Helixi168 – 181Combined sources14
Turni182 – 184Combined sources3
Beta strandi185 – 187Combined sources3
Helixi190 – 199Combined sources10
Helixi202 – 216Combined sources15
Helixi220 – 227Combined sources8
Helixi230 – 244Combined sources15
Helixi246 – 258Combined sources13
Beta strandi259 – 262Combined sources4
Helixi265 – 275Combined sources11
Turni276 – 278Combined sources3
Helixi280 – 291Combined sources12
Helixi295 – 302Combined sources8
Helixi305 – 315Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZHIX-ray1.58A1-319[»]
2ZHJX-ray1.35A1-319[»]
ProteinModelPortaliP55260.
SMRiP55260.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55260.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 83Annexin 1Add BLAST61
Repeati95 – 155Annexin 2Add BLAST61
Repeati179 – 239Annexin 3Add BLAST61
Repeati254 – 314Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP55260.
PhylomeDBiP55260.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKGGTVKA ASGFNATEDA QVLRKAMKGL GTDEDAIIGV LACRNTAQRQ
60 70 80 90 100
EIRTAYKSTI GRDLLEDLKS ELSSNFEQVI LGMMTPTVLY DVQELRRAMK
110 120 130 140 150
GAGTDEGCLI EILASRNPEE IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR
160 170 180 190 200
VLVSLTAGGR DEGNYLDDAL VRQDAQDLYE AGEKRWGTDE VKFLSILCSR
210 220 230 240 250
NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV KCMRNKPAYF
260 270 280 290 300
AERLYKSMKG LGTDDSTLIR VMVSRAEIDM LDIPANFKRV YGKSLYSFIK
310
GDTSGDYRKV LLILCGGDD
Length:319
Mass (Da):35,849
Last modified:January 23, 2007 - v3
Checksum:iDE4B6A3F5B173005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38224 mRNA. Translation: BAA07399.2.
UniGeneiRn.19270.

Genome annotation databases

UCSCiRGD:621171. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38224 mRNA. Translation: BAA07399.2.
UniGeneiRn.19270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZHIX-ray1.58A1-319[»]
2ZHJX-ray1.35A1-319[»]
ProteinModelPortaliP55260.
SMRiP55260.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4542630.
STRINGi10116.ENSRNOP00000024436.

PTM databases

iPTMnetiP55260.
PhosphoSitePlusiP55260.

Proteomic databases

PaxDbiP55260.
PRIDEiP55260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621171. rat.

Organism-specific databases

RGDi621171. Anxa4.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP55260.
PhylomeDBiP55260.

Miscellaneous databases

EvolutionaryTraceiP55260.
PROiP55260.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA4_RAT
AccessioniPrimary (citable) accession number: P55260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.