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P55260 (ANXA4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A4
Alternative name(s):
36 kDa zymogen granule membrane-associated protein
Short name=ZAP36
Annexin IV
Annexin-4
Lipocortin IV
Gene names
Name:Anxa4
Synonyms:Anx4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Miscellaneous

Seems to bind one calcium ion with high affinity By similarity.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 319318Annexin A4
PRO_0000067485

Regions

Repeat23 – 8361Annexin 1
Repeat95 – 15561Annexin 2
Repeat179 – 23961Annexin 3
Repeat254 – 31461Annexin 4

Amino acid modifications

Modified residue71Phosphothreonine By similarity
Modified residue2131N6-acetyllysine By similarity
Modified residue2931N6-acetyllysine By similarity
Modified residue3001N6-acetyllysine By similarity

Secondary structure

............................................... 319
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55260 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: DE4B6A3F5B173005

FASTA31935,849
        10         20         30         40         50         60 
METKGGTVKA ASGFNATEDA QVLRKAMKGL GTDEDAIIGV LACRNTAQRQ EIRTAYKSTI 

        70         80         90        100        110        120 
GRDLLEDLKS ELSSNFEQVI LGMMTPTVLY DVQELRRAMK GAGTDEGCLI EILASRNPEE 

       130        140        150        160        170        180 
IRRINQTYQQ QYGRSLEEDI CSDTSFMFQR VLVSLTAGGR DEGNYLDDAL VRQDAQDLYE 

       190        200        210        220        230        240 
AGEKRWGTDE VKFLSILCSR NRNHLLHVFD EYKRISQKDI EQSIKSETSG SFEDALLAIV 

       250        260        270        280        290        300 
KCMRNKPAYF AERLYKSMKG LGTDDSTLIR VMVSRAEIDM LDIPANFKRV YGKSLYSFIK 

       310 
GDTSGDYRKV LLILCGGDD 

« Hide

References

[1]"Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas."
Fukuoka S., Horst K., Kazuki-Sugino R., Ikeda Y.
Biochim. Biophys. Acta 1575:148-152(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D38224 mRNA. Translation: BAA07399.2.
UniGeneRn.19270.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZHIX-ray1.58A1-319[»]
2ZHJX-ray1.35A1-319[»]
ProteinModelPortalP55260.
SMRP55260. Positions 5-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4542630.
STRING10116.ENSRNOP00000024436.

Proteomic databases

PaxDbP55260.
PRIDEP55260.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621171. rat.

Organism-specific databases

RGD621171. Anxa4.

Phylogenomic databases

eggNOGNOG267770.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidP55260.
PhylomeDBP55260.

Gene expression databases

GenevestigatorP55260.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55260.
PROP55260.

Entry information

Entry nameANXA4_RAT
AccessionPrimary (citable) accession number: P55260
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references