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Protein

Pancreatic secretory granule membrane major glycoprotein GP2

Gene

GP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic secretory granule membrane major glycoprotein GP2
Alternative name(s):
Pancreatic zymogen granule membrane protein GP-2
ZAP75
Gene namesi
Name:GP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4441. GP2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2813.
OpenTargetsiENSG00000169347.
PharmGKBiPA28822.

Polymorphism and mutation databases

BioMutaiGP2.
DMDMi215274153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004165729 – 512Pancreatic secretory granule membrane major glycoprotein GP2Add BLAST484
PropeptideiPRO_0000041658513 – 537Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi190 ↔ 200By similarity
Disulfide bondi194 ↔ 209By similarity
Disulfide bondi211 ↔ 241By similarity
Disulfide bondi229 ↔ 320By similarity
Disulfide bondi261 ↔ 284By similarity
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi401 ↔ 461PROSITE-ProRule annotationBy similarity
Disulfide bondi422 ↔ 477By similarity
Disulfide bondi466 ↔ 473By similarity
Lipidationi512GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP55259.
PeptideAtlasiP55259.
PRIDEiP55259.

PTM databases

iPTMnetiP55259.
PhosphoSitePlusiP55259.

Expressioni

Tissue specificityi

Pancreatic secretory (zymogen) granule.

Gene expression databases

BgeeiENSG00000169347.
CleanExiHS_GP2.
ExpressionAtlasiP55259. baseline and differential.
GenevisibleiP55259. HS.

Organism-specific databases

HPAiHPA015739.
HPA016668.

Interactioni

Subunit structurei

Interacts with SYCN.By similarity

Protein-protein interaction databases

BioGridi109075. 2 interactors.
IntActiP55259. 2 interactors.
STRINGi9606.ENSP00000370767.

Structurei

3D structure databases

ProteinModelPortaliP55259.
SMRiP55259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 230EGF-likeAdd BLAST45
Domaini228 – 484ZPPROSITE-ProRule annotationAdd BLAST257

Sequence similaritiesi

Contains 1 EGF-like domain.Curated
Contains 1 ZP domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IVSV. Eukaryota.
ENOG410YDU6. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000293303.
HOVERGENiHBG004349.
InParanoidiP55259.
KOiK19899.
OMAiRNQTHAI.
OrthoDBiEOG091G06RJ.
PhylomeDBiP55259.
TreeFamiTF330284.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHLMERMVG SGLLWLALVS CILTQASAVQ RGYGNPIEAS SYGLDLDCGA
60 70 80 90 100
PGTPEAHVCF DPCQNYTLLD EPFRSTENSA GSQGCDKNMS GWYRFVGEGG
110 120 130 140 150
VRMSETCVQV HRCQTDAPMW LNGTHPALGD GITNHTACAH WSGNCCFWKT
160 170 180 190 200
EVLVKACPGG YHVYRLEGTP WCNLRYCTVP RDPSTVEDKC EKACRPEEEC
210 220 230 240 250
LALNSTWGCF CRQDLNSSDV HSLQPQLDCG PREIKVKVDK CLLGGLGLGE
260 270 280 290 300
EVIAYLRDPN CSSILQTEER NWVSVTSPVQ ASACRNILER NQTHAIYKNT
310 320 330 340 350
LSLVNDFIIR DTILNINFQC AYPLDMKVSL QAALQPIVSS LNVSVDGNGE
360 370 380 390 400
FIVRMALFQD QNYTNPYEGD AVELSVESVL YVGAILEQGD TSRFNLVLRN
410 420 430 440 450
CYATPTEDKA DLVKYFIIRN SCSNQRDSTI HVEENGQSSE SRFSVQMFMF
460 470 480 490 500
AGHYDLVFLH CEIHLCDSLN EQCQPSCSRS QVRSEVPAID LARVLDLGPI
510 520 530
TRRGAQSPGV MNGTPSTAGF LVAWPMVLLT VLLAWLF
Length:537
Mass (Da):59,480
Last modified:November 25, 2008 - v3
Checksum:i8A6B6A0FC64F50B8
GO
Isoform Beta (identifier: P55259-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-178: Missing.

Show »
Length:390
Mass (Da):43,392
Checksum:i1C8EB6F39DD5CAA9
GO
Isoform Alpha (identifier: P55259-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-181: Missing.

Show »
Length:534
Mass (Da):59,128
Checksum:iA2A5F8C612E1FB02
GO
Isoform 2 (identifier: P55259-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-180: Missing.

Show »
Length:387
Mass (Da):43,039
Checksum:i5EFE625C031A3A42
GO

Sequence cautioni

The sequence AAB19240 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189K → KK in BAA07400 (Ref. 5) Curated1
Sequence conflicti243L → Q in BAA07400 (Ref. 5) Curated1
Sequence conflicti248L → F in BAA07400 (Ref. 5) Curated1
Sequence conflicti505A → G in BAA07400 (Ref. 5) Curated1
Sequence conflicti535 – 537WLF → LAV in BAA07400 (Ref. 5) Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03574931 – 180Missing in isoform 2. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_00694832 – 178Missing in isoform Beta. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_035750179 – 181Missing in isoform Alpha. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36221 mRNA. Translation: AAB19240.1. Different initiation.
AC106796 Genomic DNA. No translation available.
CH471186 Genomic DNA. Translation: EAW50311.1.
AB035541 mRNA. Translation: BAA88166.1.
AB035542 mRNA. Translation: BAA88167.1.
D38225 mRNA. Translation: BAA07400.1.
CCDSiCCDS10582.2. [P55259-3]
CCDS42128.1. [P55259-1]
CCDS45432.1. [P55259-4]
CCDS45433.1. [P55259-2]
PIRiG02091.
RefSeqiNP_001007241.2. NM_001007240.2. [P55259-1]
NP_001493.2. NM_001502.3. [P55259-3]
UniGeneiHs.53985.

Genome annotation databases

EnsembliENST00000302555; ENSP00000304044; ENSG00000169347. [P55259-3]
ENST00000341642; ENSP00000343861; ENSG00000169347. [P55259-4]
ENST00000381360; ENSP00000370765; ENSG00000169347. [P55259-2]
ENST00000381362; ENSP00000370767; ENSG00000169347. [P55259-1]
GeneIDi2813.
KEGGihsa:2813.
UCSCiuc002dgv.4. human. [P55259-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36221 mRNA. Translation: AAB19240.1. Different initiation.
AC106796 Genomic DNA. No translation available.
CH471186 Genomic DNA. Translation: EAW50311.1.
AB035541 mRNA. Translation: BAA88166.1.
AB035542 mRNA. Translation: BAA88167.1.
D38225 mRNA. Translation: BAA07400.1.
CCDSiCCDS10582.2. [P55259-3]
CCDS42128.1. [P55259-1]
CCDS45432.1. [P55259-4]
CCDS45433.1. [P55259-2]
PIRiG02091.
RefSeqiNP_001007241.2. NM_001007240.2. [P55259-1]
NP_001493.2. NM_001502.3. [P55259-3]
UniGeneiHs.53985.

3D structure databases

ProteinModelPortaliP55259.
SMRiP55259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109075. 2 interactors.
IntActiP55259. 2 interactors.
STRINGi9606.ENSP00000370767.

PTM databases

iPTMnetiP55259.
PhosphoSitePlusiP55259.

Polymorphism and mutation databases

BioMutaiGP2.
DMDMi215274153.

Proteomic databases

PaxDbiP55259.
PeptideAtlasiP55259.
PRIDEiP55259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302555; ENSP00000304044; ENSG00000169347. [P55259-3]
ENST00000341642; ENSP00000343861; ENSG00000169347. [P55259-4]
ENST00000381360; ENSP00000370765; ENSG00000169347. [P55259-2]
ENST00000381362; ENSP00000370767; ENSG00000169347. [P55259-1]
GeneIDi2813.
KEGGihsa:2813.
UCSCiuc002dgv.4. human. [P55259-1]

Organism-specific databases

CTDi2813.
DisGeNETi2813.
GeneCardsiGP2.
HGNCiHGNC:4441. GP2.
HPAiHPA015739.
HPA016668.
MIMi602977. gene.
neXtProtiNX_P55259.
OpenTargetsiENSG00000169347.
PharmGKBiPA28822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVSV. Eukaryota.
ENOG410YDU6. LUCA.
GeneTreeiENSGT00530000063244.
HOGENOMiHOG000293303.
HOVERGENiHBG004349.
InParanoidiP55259.
KOiK19899.
OMAiRNQTHAI.
OrthoDBiEOG091G06RJ.
PhylomeDBiP55259.
TreeFamiTF330284.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169347-MONOMER.

Miscellaneous databases

GeneWikiiGP2_(gene).
GenomeRNAii2813.
PROiP55259.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169347.
CleanExiHS_GP2.
ExpressionAtlasiP55259. baseline and differential.
GenevisibleiP55259. HS.

Family and domain databases

InterProiIPR001507. ZP_dom.
IPR017977. ZP_dom_CS.
[Graphical view]
PfamiPF00100. Zona_pellucida. 1 hit.
[Graphical view]
PRINTSiPR00023. ZPELLUCIDA.
SMARTiSM00241. ZP. 1 hit.
[Graphical view]
PROSITEiPS00682. ZP_1. 1 hit.
PS51034. ZP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP2_HUMAN
AccessioniPrimary (citable) accession number: P55259
Secondary accession number(s): A6NFM9
, A6NJA8, Q13338, Q9UIF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.