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P55250

- FUMH_RHIOR

UniProt

P55250 - FUMH_RHIOR

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Protein

Fumarate hydratase, mitochondrial

Gene

FUMR

Organism
Rhizopus oryzae (Mucormycosis agent) (Rhizopus arrhizus var. delemar)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate = fumarate + H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301SubstrateBy similarity

GO - Molecular functioni

  1. fumarate hydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fumarate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase, mitochondrial (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:FUMR
OrganismiRhizopus oryzae (Mucormycosis agent) (Rhizopus arrhizus var. delemar)
Taxonomic identifieri64495 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. tricarboxylic acid cycle enzyme complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1515MitochondrionSequence AnalysisAdd
BLAST
Chaini16 – 494479Fumarate hydratase, mitochondrialPRO_0000010331Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55250.
SMRiP55250. Positions 33-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 1624B siteBy similarity
Regioni169 – 1713Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRASATRFL SQAKNMNNSP RLFSSASAAL QKFRAERDTF GDLQVPADRY
60 70 80 90 100
WGAQTQRSLQ NFDIGGPTER MPEPLIRAFG VLKKAAATVN MTYGLDPKVG
110 120 130 140 150
EAIQKAADEV IDGSLIDHFP LVVWQTGSGT QTKMNVNEVI SNRAIELLGG
160 170 180 190 200
ELGSKAPVHP NDHVNMSQSS NDTFPTAMHV AAVVEIHGRL IPALTTLRDA
210 220 230 240 250
LQAKSAEFEH IIKIGRTHLQ DATPLTLGQE FSGYTQQLTY GIARVQGTLE
260 270 280 290 300
RLYNLAQGGT AVGTGLNTRK GFDAKVAEAI ASITGLPFKT APNKFEALAA
310 320 330 340 350
HDALVEAHGA LNTVACSLMK IANDIRYLGS GPRCGLGELS LPENEPGSSI
360 370 380 390 400
MPGKVNPTQC EAMTMVCAQV MGNNTAISVA GSNGQFELNV FKPVMIKNLI
410 420 430 440 450
QSIRLISDAS ISFTKNCVVG IEANEKKISS IMNESLMLVT ALNPHIGYDK
460 470 480 490
AAKCAKKAHK EGTTLKEAAL SLGYLTSEEF DQWVRPEDMI SAKD
Length:494
Mass (Da):53,157
Last modified:October 1, 1996 - v1
Checksum:i8FDB9D323A9146EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78576 Genomic DNA. Translation: CAA55314.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78576 Genomic DNA. Translation: CAA55314.1 .

3D structure databases

ProteinModelPortali P55250.
SMRi P55250. Positions 33-493.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
HAMAPi MF_00743. FumaraseC.
InterProi IPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00979. fumC_II. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The fumR gene encoding fumarase in the filamentous fungus Rhizopus oryzae: cloning, structure and expression."
    Friedberg D., Peleg Y., Monsonego A., Maissi S., Battat E., Rokem J.S., Goldberg I.
    Gene 163:139-144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10260 / CBS 329.47 / DSM 905 / NRRL 1526.

Entry informationi

Entry nameiFUMH_RHIOR
AccessioniPrimary (citable) accession number: P55250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors (By similarity).By similarity

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3