ID   EGFR_MACMU              Reviewed;          85 AA.
AC   P55245;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 75.
DE   RecName: Full=Epidermal growth factor receptor;
DE            EC=2.7.10.1;
DE   Flags: Fragment;
GN   Name=EGFR;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RX   MEDLINE=95124501; PubMed=7545971;
RA   Ma Y.J., Costa M.E., Ojeda S.R.;
RT   "Developmental expression of the genes encoding transforming growth
RT   factor alpha and its receptor in the hypothalamus of female rhesus
RT   macaques.";
RL   Neuroendocrinology 60:346-359(1994).
CC   -!- FUNCTION: The EGF receptor mediates the biological signal of EGF,
CC       and also of TGF-alpha, amphiregulin, heparin-binding EGF, GP30 and
CC       vaccinia virus growth factor.
CC   -!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
CC       [protein]-L-tyrosine phosphate.
CC   -!- SUBUNIT: Binds RIPK1. Part of a complex with ERBB2 and either
CC       PIK3C2A or PIK3C2B. The autophosphorylated form interacts with
CC       PIK3C2B, maybe indirectly. Interacts with PELP1 and MUC1 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Hypothalamus.
CC   -!- DEVELOPMENTAL STAGE: Levels in the medial basal hypothalamus and
CC       preoptic area are elevated during neonatal life (1 week-6 months),
CC       decrease during juvenile development (8-18 months) and markedly
CC       increase during the expected time of puberty (30-36 months).
CC   -!- PTM: Monoubiquitinated and polyubiquitinated upon EGF stimulation;
CC       which does not affect tyrosine kinase activity or signaling
CC       capacity but may play a role in lysosomal targeting. Polyubiquitin
CC       linkage is mainly through 'Lys-63', but linkage through 'Lys-48',
CC       'Lys-11' and 'Lys-29' also occur (By similarity).
CC   -!- MISCELLANEOUS: Binding of EGF to the receptor leads to
CC       dimerization, internalization of the EGF-receptor complex,
CC       induction of the tyrosine kinase activity, stimulation of cell DNA
CC       synthesis, and cell proliferation.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. EGF receptor subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; S75916; AAB33095.1; -; mRNA.
DR   PIR; I78540; I78540.
DR   UniGene; Mmu.3397; -.
DR   HSSP; Q9H2C9; 1M14.
DR   SMR; P55245; 1-85.
DR   Ensembl; ENSMMUG00000022394; Macaca mulatta.
DR   HOVERGEN; P55245; -.
DR   BRENDA; 2.7.10.1; 1774.
DR   BindingDB; P55245; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kin...; IEA:EC.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   InterPro; IPR008266; Tyr_pkinase_AS.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; PARTIAL.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; PARTIAL.
PE   2: Evidence at transcript level;
KW   ATP-binding; Isopeptide bond; Kinase; Membrane; Nucleotide-binding;
KW   Receptor; Transferase; Tyrosine-protein kinase; Ubl conjugation.
FT   CHAIN        <1    >85       Epidermal growth factor receptor.
FT                                /FTId=PRO_0000160254.
FT   DOMAIN       <1     77       Protein kinase.
FT   CROSSLNK     37     37       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin) (By
FT                                similarity).
FT   CROSSLNK     78     78       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin) (By
FT                                similarity).
FT   NON_TER       1      1
FT   NON_TER      85     85
SQ   SEQUENCE   85 AA;  9866 MW;  D812DF47C23B3C18 CRC64;
     HQSDVWSYGV TVWELMTFGS KPYDGIPASE ISSILEKGER LPQPPICTID VYMIMVKCWM
     IDADSRPKFR ELIIEFSKMA RDPQR
//