Reviewed, UniProtKB/Swiss-Prot P55245 (EGFR_MACMU)

Names and origin

Protein names

Recommended name:
    Epidermal growth factor receptor
    EC=2.7.10.1

Gene names

Name:

EGFR

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	85 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The EGF receptor mediates the biological signal of EGF, and also of TGF-alpha, amphiregulin, heparin-binding EGF, GP30 and vaccinia virus growth factor.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Binds RIPK1. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1 and MUC1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Hypothalamus.
Developmental stage	Levels in the medial basal hypothalamus and preoptic area are elevated during neonatal life (1 week-6 months), decrease during juvenile development (8-18 months) and markedly increase during the expected time of puberty (30-36 months).
Post-translational modification	Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur By similarity.
Miscellaneous	Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Isopeptide bond Ubl conjugation
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›85	›85	Epidermal growth factor receptor		PRO_0000160254
Regions
	Domain	‹1 – 77	›77	Protein kinase
Amino acid modifications
	Cross-link	37		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	78		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	85	1

Sequences

	Sequence		Length	Mass (Da)
	P55245-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D812DF47C23B3C18	FASTA	85	9,866
	10 20 30 40 50 60 HQSDVWSYGV TVWELMTFGS KPYDGIPASE ISSILEKGER LPQPPICTID VYMIMVKCWM 70 80 IDADSRPKFR ELIIEFSKMA RDPQR

References

[1]	"Developmental expression of the genes encoding transforming growth factor alpha and its receptor in the hypothalamus of female rhesus macaques." Ma Y.J., Costa M.E., Ojeda S.R. Neuroendocrinology 60:346-359(1994) [PubMed: 7545971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	S75916 mRNA. Translation: AAB33095.1.
PIR	I78540.
UniGene	Mmu.3397
3D structure databases
HSSP	HSSP built from PDB template 1M14 based on UniProtKB Q9H2C9.
SMR	P55245. Positions 1-85.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMMUG00000022394. Macaca mulatta. [Contig view]
Phylogenomic databases
HOVERGEN	P55245.
Enzyme and pathway databases
BRENDA	2.7.10.1. 1774.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. Partial match. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	P55245.

Entry information

Entry name

EGFR_MACMU

Accession

Primary (citable) accession number: P55245

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)