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Protein

Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplastic

Gene

APL3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.

Enzyme regulationi

Activated by 3'phosphoglycerate, inhibited by orthophosphate. Allosteric regulation.

Pathwayi: starch biosynthesis

This protein is involved in the pathway starch biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway starch biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glucose-1-phosphate adenylyltransferase activity Source: TAIR

GO - Biological processi

  • glycogen biosynthetic process Source: InterPro
  • starch biosynthetic process Source: TAIR

Keywordsi

Molecular functionAllosteric enzyme, Nucleotidyltransferase, Transferase
Biological processStarch biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.27 399
SABIO-RKP55231
UniPathwayiUPA00152

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplastic (EC:2.7.7.27)
Alternative name(s):
ADP-glucose pyrophosphorylase
ADP-glucose synthase
AGPase S
Alpha-D-glucose-1-phosphate adenyl transferase
Gene namesi
Name:APL3
Ordered Locus Names:At4g39210
ORF Names:T22F8.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G39210
TAIRilocus:2136358 AT4G39210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61ChloroplastCuratedAdd BLAST61
ChainiPRO_000001116162 – 521Glucose-1-phosphate adenylyltransferase large subunit 3, chloroplasticAdd BLAST460

Proteomic databases

PaxDbiP55231
PRIDEiP55231

PTM databases

iPTMnetiP55231

Expressioni

Tissue specificityi

Probably are expressed in roots, flowers and/or seeds.

Gene expression databases

ExpressionAtlasiP55231 baseline and differential
GenevisibleiP55231 AT

Interactioni

Subunit structurei

Heterotetramer.

Protein-protein interaction databases

STRINGi3702.AT4G39210.1

Structurei

3D structure databases

ProteinModelPortaliP55231
SMRiP55231
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IMYM Eukaryota
COG0448 LUCA
HOGENOMiHOG000278604
InParanoidiP55231
KOiK00975
OMAiVNIDRSG
OrthoDBiEOG093608F5
PhylomeDBiP55231

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55231-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSCCNFSLG TKTVLAKDSF KNVENKFLGE KIKGSVLKPF SSDLSSKKFR
60 70 80 90 100
NRKLRPGVAY AIATSKNAKE ALKNQPSMFE RRRADPKNVA AIILGGGDGA
110 120 130 140 150
KLFPLTKRAA TPAVPVGGCY RMIDIPMSNC INSCINKIFV LTQFNSASLN
160 170 180 190 200
RHLARTYFGN GINFGDGFVE VLAATQTPGE AGKKWFQGTA DAVRKFLWVF
210 220 230 240 250
EDAKNRNIEN IIILSGDHLY RMNYMDFVQH HVDSKADITL SCAPVDESRA
260 270 280 290 300
SEYGLVNIDR SGRVVHFSEK PTGIDLKSMQ TDTTMHGLSH QEAAKSPYIA
310 320 330 340 350
SMGVYCFKTE ALLKLLTWRY PSSNDFGSEI IPAAIKDHNV QGYIYRDYWE
360 370 380 390 400
DIGTIKSFYE ANIALVEEHP KFEFYDQNTP FYTSPRFLPP TKTEKCRIVN
410 420 430 440 450
SVISHGCFLG ECSIQRSIIG ERSRLDYGVE LQDTLMLGAD SYQTESEIAS
460 470 480 490 500
LLAEGNVPIG IGRDTKIRKC IIDKNAKIGK NVVIMNKDDV KEADRPEEGF
510 520
YIRSGITVVV EKATIKDGTV I
Length:521
Mass (Da):58,029
Last modified:December 5, 2001 - v2
Checksum:i2E6AAE91F9E6E367
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296S → Y (PubMed:8292792).Curated1
Sequence conflicti301S → G in CAA51776 (PubMed:8292792).Curated1
Sequence conflicti362N → S in CAA51776 (PubMed:8292792).Curated1
Sequence conflicti448 – 450IAS → SR in CAA51776 (PubMed:8292792).Curated3
Sequence conflicti477K → R in CAA51776 (PubMed:8292792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18432 Genomic DNA Translation: CAA77173.1
AL050351 Genomic DNA Translation: CAB43636.1
AL161594 Genomic DNA Translation: CAB80584.1
CP002687 Genomic DNA Translation: AEE87038.1
CP002687 Genomic DNA Translation: ANM66846.1
AY059862 mRNA Translation: AAL24344.1
BT010378 mRNA Translation: AAQ56821.1
X73364 mRNA Translation: CAA51776.1
PIRiT08569
RefSeqiNP_001328715.1, NM_001342527.1
NP_195632.1, NM_120081.2
UniGeneiAt.75

Genome annotation databases

EnsemblPlantsiAT4G39210.1; AT4G39210.1; AT4G39210
AT4G39210.2; AT4G39210.2; AT4G39210
GeneIDi830076
GrameneiAT4G39210.1; AT4G39210.1; AT4G39210
AT4G39210.2; AT4G39210.2; AT4G39210
KEGGiath:AT4G39210

Similar proteinsi

Entry informationi

Entry nameiGLGL3_ARATH
AccessioniPrimary (citable) accession number: P55231
Secondary accession number(s): Q9ZR38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 5, 2001
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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