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Protein

Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic

Gene

ADG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.

Enzyme regulationi

Activated by 3'phosphoglycerate, inhibited by orthophosphate. Allosteric regulation.

Pathwayi: starch biosynthesis

This protein is involved in the pathway starch biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway starch biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glucose-1-phosphate adenylyltransferase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Nucleotidyltransferase, Transferase
Biological processStarch biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G19220-MONOMER
ARA:MONOMER-1823
MetaCyc:MONOMER-1823
SABIO-RKiP55229
UniPathwayiUPA00152

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic (EC:2.7.7.27)
Alternative name(s):
ADP-glucose pyrophosphorylase
ADP-glucose synthase
AGPase S
Alpha-D-glucose-1-phosphate adenyl transferase
Gene namesi
Name:ADG2
Synonyms:APL1
Ordered Locus Names:At5g19220
ORF Names:T24G5.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G19220
TAIRilocus:2182132 AT5G19220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 54ChloroplastSequence analysisAdd BLAST54
ChainiPRO_000001115955 – 522Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplasticAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55229
PRIDEiP55229

PTM databases

iPTMnetiP55229

Expressioni

Tissue specificityi

Leaves.

Gene expression databases

ExpressionAtlasiP55229 baseline and differential
GenevisibleiP55229 AT

Interactioni

Subunit structurei

Heterotetramer.

Protein-protein interaction databases

BioGridi17318, 1 interactor
STRINGi3702.AT5G19220.1

Structurei

3D structure databases

ProteinModelPortaliP55229
SMRiP55229
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IMYM Eukaryota
COG0448 LUCA
HOGENOMiHOG000278604
InParanoidiP55229
KOiK00975
OMAiHCVLGVR
OrthoDBiEOG093608F5
PhylomeDBiP55229

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSADCRIS LSAPSCIRSS STGLTRHIKL GSFCNGELMG KKLNLSQLPN
60 70 80 90 100
IRLRSSTNFS QKRILMSLNS VAGESKVQEL ETEKRDPRTV ASIILGGGAG
110 120 130 140 150
TRLFPLTKRR AKPAVPIGGA YRLIDVPMSN CINSGINKVY ILTQYNSASL
160 170 180 190 200
NRHLARAYNS NGLGFGDGYV EVLAATQTPG ESGKRWFQGT ADAVRQFHWL
210 220 230 240 250
FEDARSKDIE DVLILSGDHL YRMDYMDFIQ DHRQSGADIS ISCIPIDDRR
260 270 280 290 300
ASDFGLMKID DKGRVISFSE KPKGDDLKAM AVDTTILGLS KEEAEKKPYI
310 320 330 340 350
ASMGVYVFKK EILLNLLRWR FPTANDFGSE IIPFSAKEFY VNAYLFNDYW
360 370 380 390 400
EDIGTIRSFF EANLALTEHP GAFSFYDAAK PIYTSRRNLP PSKIDNSKLI
410 420 430 440 450
DSIISHGSFL TNCLIEHSIV GIRSRVGSNV QLKDTVMLGA DYYETEAEVA
460 470 480 490 500
ALLAEGNVPI GIGENTKIQE CIIDKNARVG KNVIIANSEG IQEADRSSDG
510 520
FYIRSGITVI LKNSVIKDGV VI
Length:522
Mass (Da):57,674
Last modified:July 11, 2001 - v3
Checksum:iF66CCF1A877A52C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196Q → R in BAA76362 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72290 mRNA Translation: AAB58475.1
AB022891 Genomic DNA Translation: BAA76362.1
X73367 mRNA Translation: CAA51779.2
AC069326 Genomic DNA No translation available.
CP002688 Genomic DNA Translation: AED92672.1
BT008884 mRNA Translation: AAP68323.1
AF370503 mRNA Translation: AAK43880.1
PIRiS42548
T52629
RefSeqiNP_197423.1, NM_121927.3
UniGeneiAt.31320
At.429
At.69509

Genome annotation databases

EnsemblPlantsiAT5G19220.1; AT5G19220.1; AT5G19220
GeneIDi832042
GrameneiAT5G19220.1; AT5G19220.1; AT5G19220
KEGGiath:AT5G19220

Similar proteinsi

Entry informationi

Entry nameiGLGL1_ARATH
AccessioniPrimary (citable) accession number: P55229
Secondary accession number(s): O04929, Q9SXS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: April 25, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health