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Protein

Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic

Gene

ADG2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.

Enzyme regulationi

Activated by 3'phosphoglycerate, inhibited by orthophosphate. Allosteric regulation.

Pathwayi: starch biosynthesis

This protein is involved in the pathway starch biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway starch biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glucose-1-phosphate adenylyltransferase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Starch biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT5G19220-MONOMER.
MetaCyc:MONOMER-1823.
SABIO-RKP55229.
UniPathwayiUPA00152.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic (EC:2.7.7.27)
Alternative name(s):
ADP-glucose pyrophosphorylase
ADP-glucose synthase
AGPase S
Alpha-D-glucose-1-phosphate adenyl transferase
Gene namesi
Name:ADG2
Synonyms:APL1
Ordered Locus Names:At5g19220
ORF Names:T24G5.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G19220.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • chloroplast stroma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5454ChloroplastSequence analysisAdd
BLAST
Chaini55 – 522468Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplasticPRO_0000011159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei428 – 4281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55229.
PRIDEiP55229.

PTM databases

iPTMnetiP55229.

Expressioni

Tissue specificityi

Leaves.

Gene expression databases

GenevisibleiP55229. AT.

Interactioni

Subunit structurei

Heterotetramer.

Protein-protein interaction databases

BioGridi17318. 1 interaction.
STRINGi3702.AT5G19220.1.

Structurei

3D structure databases

ProteinModelPortaliP55229.
SMRiP55229. Positions 101-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IMYM. Eukaryota.
COG0448. LUCA.
HOGENOMiHOG000278604.
InParanoidiP55229.
KOiK00975.
OMAiGCFLDNC.
OrthoDBiEOG093608F5.
PhylomeDBiP55229.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiPS00808. ADP_GLC_PYROPHOSPH_1. 1 hit.
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55229-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSADCRIS LSAPSCIRSS STGLTRHIKL GSFCNGELMG KKLNLSQLPN
60 70 80 90 100
IRLRSSTNFS QKRILMSLNS VAGESKVQEL ETEKRDPRTV ASIILGGGAG
110 120 130 140 150
TRLFPLTKRR AKPAVPIGGA YRLIDVPMSN CINSGINKVY ILTQYNSASL
160 170 180 190 200
NRHLARAYNS NGLGFGDGYV EVLAATQTPG ESGKRWFQGT ADAVRQFHWL
210 220 230 240 250
FEDARSKDIE DVLILSGDHL YRMDYMDFIQ DHRQSGADIS ISCIPIDDRR
260 270 280 290 300
ASDFGLMKID DKGRVISFSE KPKGDDLKAM AVDTTILGLS KEEAEKKPYI
310 320 330 340 350
ASMGVYVFKK EILLNLLRWR FPTANDFGSE IIPFSAKEFY VNAYLFNDYW
360 370 380 390 400
EDIGTIRSFF EANLALTEHP GAFSFYDAAK PIYTSRRNLP PSKIDNSKLI
410 420 430 440 450
DSIISHGSFL TNCLIEHSIV GIRSRVGSNV QLKDTVMLGA DYYETEAEVA
460 470 480 490 500
ALLAEGNVPI GIGENTKIQE CIIDKNARVG KNVIIANSEG IQEADRSSDG
510 520
FYIRSGITVI LKNSVIKDGV VI
Length:522
Mass (Da):57,674
Last modified:July 11, 2001 - v3
Checksum:iF66CCF1A877A52C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961Q → R in BAA76362 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72290 mRNA. Translation: AAB58475.1.
AB022891 Genomic DNA. Translation: BAA76362.1.
X73367 mRNA. Translation: CAA51779.2.
AC069326 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92672.1.
BT008884 mRNA. Translation: AAP68323.1.
AF370503 mRNA. Translation: AAK43880.1.
PIRiS42548.
T52629.
RefSeqiNP_197423.1. NM_121927.3.
UniGeneiAt.31320.
At.429.
At.69509.

Genome annotation databases

EnsemblPlantsiAT5G19220.1; AT5G19220.1; AT5G19220.
GeneIDi832042.
GrameneiAT5G19220.1; AT5G19220.1; AT5G19220.
KEGGiath:AT5G19220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72290 mRNA. Translation: AAB58475.1.
AB022891 Genomic DNA. Translation: BAA76362.1.
X73367 mRNA. Translation: CAA51779.2.
AC069326 Genomic DNA. No translation available.
CP002688 Genomic DNA. Translation: AED92672.1.
BT008884 mRNA. Translation: AAP68323.1.
AF370503 mRNA. Translation: AAK43880.1.
PIRiS42548.
T52629.
RefSeqiNP_197423.1. NM_121927.3.
UniGeneiAt.31320.
At.429.
At.69509.

3D structure databases

ProteinModelPortaliP55229.
SMRiP55229. Positions 101-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17318. 1 interaction.
STRINGi3702.AT5G19220.1.

PTM databases

iPTMnetiP55229.

Proteomic databases

PaxDbiP55229.
PRIDEiP55229.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G19220.1; AT5G19220.1; AT5G19220.
GeneIDi832042.
GrameneiAT5G19220.1; AT5G19220.1; AT5G19220.
KEGGiath:AT5G19220.

Organism-specific databases

TAIRiAT5G19220.

Phylogenomic databases

eggNOGiENOG410IMYM. Eukaryota.
COG0448. LUCA.
HOGENOMiHOG000278604.
InParanoidiP55229.
KOiK00975.
OMAiGCFLDNC.
OrthoDBiEOG093608F5.
PhylomeDBiP55229.

Enzyme and pathway databases

UniPathwayiUPA00152.
BioCyciARA:AT5G19220-MONOMER.
MetaCyc:MONOMER-1823.
SABIO-RKP55229.

Miscellaneous databases

PROiP55229.

Gene expression databases

GenevisibleiP55229. AT.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005836. ADP_Glu_pyroP_CS.
IPR011831. GlgC.
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
SSF53448. SSF53448. 2 hits.
TIGRFAMsiTIGR02091. glgC. 1 hit.
PROSITEiPS00808. ADP_GLC_PYROPHOSPH_1. 1 hit.
PS00809. ADP_GLC_PYROPHOSPH_2. 1 hit.
PS00810. ADP_GLC_PYROPHOSPH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLGL1_ARATH
AccessioniPrimary (citable) accession number: P55229
Secondary accession number(s): O04929, Q9SXS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 11, 2001
Last modified: September 7, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.