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Protein

Putative cystathionine gamma-lyase 2

Gene

cth-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate.

Cofactori

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-cysteine from L-homocysteine and L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Putative cystathionine gamma-lyase 2 (cth-2)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-homocysteine and L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SubstrateBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei330 – 3301SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-1614558. Degradation of cysteine and homocysteine.
R-CEL-1614603. Cysteine formation from homocysteine.
UniPathwayiUPA00136; UER00202.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cystathionine gamma-lyase 2 (EC:4.4.1.1)
Alternative name(s):
Gamma-cystathionase
Gene namesi
Name:cth-2
ORF Names:ZK1127.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiZK1127.10; CE07648; WBGene00022856; cth-2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Putative cystathionine gamma-lyase 2PRO_0000114753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

EPDiP55216.
PaxDbiP55216.

2D gel databases

World-2DPAGE0011:P55216.

Interactioni

Protein-protein interaction databases

BioGridi39492. 1 interaction.
IntActiP55216. 3 interactions.
STRINGi6239.ZK1127.10.1.

Structurei

3D structure databases

ProteinModelPortaliP55216.
SMRiP55216. Positions 4-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

eggNOGiKOG0053. Eukaryota.
COG0626. LUCA.
GeneTreeiENSGT00390000000312.
HOGENOMiHOG000246415.
InParanoidiP55216.
KOiK01758.
OMAiSPIDCYL.
OrthoDBiEOG7NCV3J.
PhylomeDBiP55216.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFPHFGTA AIHVGQEPEQ WDMNQVVPPI SLSSTYKQDN PGEPKGHDYS
60 70 80 90 100
RAGNPTRDVL QKNLAALEDA KHCQVFSSGL AATSAIINLL KYGDHIVCSD
110 120 130 140 150
DVYGGTQRYI RRVAVPNHGL EVDSVDLTDV QNLEKAIKPN TKMVWFESPS
160 170 180 190 200
NPLLKVVDIA AVVQTAKKAN PEIVVVVDNT FMSPYFQRPI SLGADVVVHS
210 220 230 240 250
ITKYINGHSD VVMGAVITDN DEFQQHLFFM QLAVGAVPSP FDCFLVNRGL
260 270 280 290 300
KTLHIRMRAH YENALAVAKY LEANDRIESV LYPALPSHPQ HEVHEKQTKG
310 320 330 340 350
MSGMISFYLK GELQESRAFL SALKVFTLAE SLGGYESLAE LPSIMTHASV
360 370 380 390
PAETRIVLGI TDNLIRISVG IEDLDDLVAD LDQALKIAIP KV
Length:392
Mass (Da):43,094
Last modified:October 1, 1996 - v1
Checksum:iDA90B3353AD1004D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081697 Genomic DNA. Translation: CCD73724.1.
PIRiC88197.
RefSeqiNP_495449.1. NM_063048.5.
UniGeneiCel.9094.

Genome annotation databases

EnsemblMetazoaiZK1127.10.1; ZK1127.10.1; WBGene00022856.
ZK1127.10.2; ZK1127.10.2; WBGene00022856.
GeneIDi174155.
KEGGicel:CELE_ZK1127.10.
UCSCiZK1127.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081697 Genomic DNA. Translation: CCD73724.1.
PIRiC88197.
RefSeqiNP_495449.1. NM_063048.5.
UniGeneiCel.9094.

3D structure databases

ProteinModelPortaliP55216.
SMRiP55216. Positions 4-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39492. 1 interaction.
IntActiP55216. 3 interactions.
STRINGi6239.ZK1127.10.1.

2D gel databases

World-2DPAGE0011:P55216.

Proteomic databases

EPDiP55216.
PaxDbiP55216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1127.10.1; ZK1127.10.1; WBGene00022856.
ZK1127.10.2; ZK1127.10.2; WBGene00022856.
GeneIDi174155.
KEGGicel:CELE_ZK1127.10.
UCSCiZK1127.10.1. c. elegans.

Organism-specific databases

CTDi174155.
WormBaseiZK1127.10; CE07648; WBGene00022856; cth-2.

Phylogenomic databases

eggNOGiKOG0053. Eukaryota.
COG0626. LUCA.
GeneTreeiENSGT00390000000312.
HOGENOMiHOG000246415.
InParanoidiP55216.
KOiK01758.
OMAiSPIDCYL.
OrthoDBiEOG7NCV3J.
PhylomeDBiP55216.

Enzyme and pathway databases

UniPathwayiUPA00136; UER00202.
ReactomeiR-CEL-1614558. Degradation of cysteine and homocysteine.
R-CEL-1614603. Cysteine formation from homocysteine.

Miscellaneous databases

NextBioi882771.
PROiP55216.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCGL2_CAEEL
AccessioniPrimary (citable) accession number: P55216
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.