Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-type natriuretic peptide

Gene

Nppc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: RGD
  • protein homodimerization activity Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • animal organ development Source: RGD
  • cGMP biosynthetic process Source: RGD
  • growth plate cartilage chondrocyte differentiation Source: UniProtKB
  • growth plate cartilage chondrocyte proliferation Source: UniProtKB
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of DNA metabolic process Source: RGD
  • negative regulation of meiotic cell cycle Source: RGD
  • negative regulation of oocyte maturation Source: RGD
  • ossification Source: UniProtKB-KW
  • positive regulation of blood vessel diameter Source: RGD
  • positive regulation of cGMP biosynthetic process Source: RGD
  • positive regulation of mast cell degranulation Source: UniProtKB
  • positive regulation of osteoblast differentiation Source: RGD
  • positive regulation of uterine smooth muscle relaxation Source: UniProtKB
  • post-embryonic development Source: RGD
  • protein folding Source: RGD
  • receptor guanylyl cyclase signaling pathway Source: MGI
  • regulation of cAMP metabolic process Source: RGD
  • regulation of cGMP metabolic process Source: RGD
  • regulation of multicellular organism growth Source: RGD
  • regulation of smooth muscle cell proliferation Source: RGD
  • reproductive process Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to hypoxia Source: RGD

Keywordsi

Molecular functionHormone, Vasoactive
Biological processOsteogenesis

Enzyme and pathway databases

ReactomeiR-RNO-5578768 Physiological factors

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:Nppc
Synonyms:Cnp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620850 Nppc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000156524 – 73Add BLAST50
PeptideiPRO_000000156674 – 126CNP-53Add BLAST53
PeptideiPRO_000000156798 – 126CNP-29By similarityAdd BLAST29
PeptideiPRO_0000001568105 – 126CNP-22Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP55207
PRIDEiP55207

PTM databases

iPTMnetiP55207
PhosphoSitePlusiP55207

Expressioni

Tissue specificityi

Expressed exclusively in brain.

Gene expression databases

BgeeiENSRNOG00000018854
GenevisibleiP55207 RN

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD
  • hormone receptor binding Source: RGD
  • peptide hormone receptor binding Source: RGD
  • protein homodimerization activity Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025582

Structurei

3D structure databases

SMRiP55207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBQ Eukaryota
ENOG410YUR4 LUCA
GeneTreeiENSGT00390000015492
HOGENOMiHOG000010304
HOVERGENiHBG004229
InParanoidiP55207
KOiK12336
OMAiGMWARLL
OrthoDBiEOG091G14FZ
PhylomeDBiP55207
TreeFamiTF106305

Family and domain databases

InterProiView protein in InterPro
IPR002406 C_natriurtcpep
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00713 CNATPEPTIDE
PR00710 NATPEPTIDES
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL AEPQAAGGNQ
60 70 80 90 100
KKGDKTPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,314
Last modified:October 1, 1996 - v1
Checksum:i0957A0DB5BC82E08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90219 mRNA Translation: BAA14250.1
PIRiS12988
RefSeqiNP_446202.1, NM_053750.1
UniGeneiRn.10637

Genome annotation databases

EnsembliENSRNOT00000025582; ENSRNOP00000025582; ENSRNOG00000018854
GeneIDi114593
KEGGirno:114593
UCSCiRGD:620850 rat

Similar proteinsi

Entry informationi

Entry nameiANFC_RAT
AccessioniPrimary (citable) accession number: P55207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health