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Protein

C-type natriuretic peptide

Gene

Nppc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • peptide hormone receptor binding Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • cGMP biosynthetic process Source: RGD
  • growth plate cartilage chondrocyte differentiation Source: UniProtKB
  • growth plate cartilage chondrocyte proliferation Source: UniProtKB
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of DNA metabolic process Source: RGD
  • negative regulation of meiotic cell cycle Source: Ensembl
  • negative regulation of oocyte maturation Source: Ensembl
  • ossification Source: UniProtKB-KW
  • positive regulation of cGMP biosynthetic process Source: RGD
  • positive regulation of osteoblast differentiation Source: RGD
  • positive regulation of vasodilation Source: RGD
  • post-embryonic development Source: Ensembl
  • receptor guanylyl cyclase signaling pathway Source: UniProtKB
  • regulation of cAMP metabolic process Source: Ensembl
  • regulation of multicellular organism growth Source: Ensembl
  • regulation of smooth muscle cell proliferation Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to hypoxia Source: RGD
  • single organism reproductive process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Keywords - Biological processi

Osteogenesis

Enzyme and pathway databases

ReactomeiR-RNO-5578768. Physiological factors.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type natriuretic peptide
Cleaved into the following 3 chains:
Gene namesi
Name:Nppc
Synonyms:Cnp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620850. Nppc.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 7350PRO_0000001565Add
BLAST
Peptidei74 – 12653CNP-53PRO_0000001566Add
BLAST
Peptidei98 – 12629CNP-29By similarityPRO_0000001567Add
BLAST
Peptidei105 – 12622CNP-22PRO_0000001568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 126By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP55207.
PRIDEiP55207.

Expressioni

Tissue specificityi

Expressed exclusively in brain.

Gene expression databases

GenevisibleiP55207. RN.

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD
  • peptide hormone receptor binding Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025582.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBQ. Eukaryota.
ENOG410YUR4. LUCA.
GeneTreeiENSGT00390000015492.
HOGENOMiHOG000010304.
HOVERGENiHBG004229.
InParanoidiP55207.
KOiK12336.
OMAiGMWARLL.
OrthoDBiEOG79CZ1S.
PhylomeDBiP55207.
TreeFamiTF106305.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSQLIACA LLLALLSLRP SEAKPGTPPK VPRTPPGEEL AEPQAAGGNQ
60 70 80 90 100
KKGDKTPGGG GANLKGDRSR LLRDLRVDTK SRAAWARLLH EHPNARKYKG
110 120
GNKKGLSKGC FGLKLDRIGS MSGLGC
Length:126
Mass (Da):13,314
Last modified:October 1, 1996 - v1
Checksum:i0957A0DB5BC82E08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90219 mRNA. Translation: BAA14250.1.
PIRiS12988.
RefSeqiNP_446202.1. NM_053750.1.
UniGeneiRn.10637.

Genome annotation databases

EnsembliENSRNOT00000025582; ENSRNOP00000025582; ENSRNOG00000018854.
GeneIDi114593.
KEGGirno:114593.
UCSCiRGD:620850. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90219 mRNA. Translation: BAA14250.1.
PIRiS12988.
RefSeqiNP_446202.1. NM_053750.1.
UniGeneiRn.10637.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025582.

Proteomic databases

PaxDbiP55207.
PRIDEiP55207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025582; ENSRNOP00000025582; ENSRNOG00000018854.
GeneIDi114593.
KEGGirno:114593.
UCSCiRGD:620850. rat.

Organism-specific databases

CTDi4880.
RGDi620850. Nppc.

Phylogenomic databases

eggNOGiENOG410IZBQ. Eukaryota.
ENOG410YUR4. LUCA.
GeneTreeiENSGT00390000015492.
HOGENOMiHOG000010304.
HOVERGENiHBG004229.
InParanoidiP55207.
KOiK12336.
OMAiGMWARLL.
OrthoDBiEOG79CZ1S.
PhylomeDBiP55207.
TreeFamiTF106305.

Enzyme and pathway databases

ReactomeiR-RNO-5578768. Physiological factors.

Miscellaneous databases

NextBioi618753.
PROiP55207.

Gene expression databases

GenevisibleiP55207. RN.

Family and domain databases

InterProiIPR002406. C_natriurtcpep.
IPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00713. CNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP)."
    Kojima M., Minamino N., Kangawa K., Matsuo H.
    FEBS Lett. 276:209-213(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiANFC_RAT
AccessioniPrimary (citable) accession number: P55207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 16, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.