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P55205

- GUC2G_RAT

UniProt

P55205 - GUC2G_RAT

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Protein
Guanylate cyclase 2G
Gene
Gucy2g, Ksgc
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to a yet not identified ligand.
Possible role in processes such as water and electrolyte balance, and muscle contraction.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. guanylate cyclase activity Source: RGD
  4. protein kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Receptor

Keywords - Biological processi

cGMP biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclase 2G (EC:4.6.1.2)
Alternative name(s):
Guanylyl cyclase receptor G
Short name:
GC-G
Kinase-like domain-containing soluble guanylyl cyclase
Short name:
ksGC
Gene namesi
Name:Gucy2g
Synonyms:Ksgc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621853. Gucy2g.

Subcellular locationi

Isoform 2 : Cytoplasm Reviewed prediction

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini44 – 481438Extracellular Reviewed prediction
Add
BLAST
Transmembranei482 – 50221Helical; Reviewed prediction
Add
BLAST
Topological domaini503 – 1100598Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343 Reviewed prediction
Add
BLAST
Chaini44 – 11001057Guanylate cyclase 2G
PRO_0000042179Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55205.
PRIDEiP55205.

Expressioni

Tissue specificityi

Expressed in lung, kidney and skeletal muscle. Low levels in intestine.1 Publication

Gene expression databases

GenevestigatoriP55205.

Interactioni

Subunit structurei

Homodimer or heterodimer with NPR1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP55205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini549 – 826278Protein kinase
Add
BLAST
Domaini901 – 1031131Guanylate cyclase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
HOGENOMiHOG000293307.
HOVERGENiHBG051862.
InParanoidiP55205.
PhylomeDBiP55205.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR001170. Ntpep_rcpt.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00255. NATPEPTIDER.
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55205-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASRARSEPP LEHRFYGGAE SHAGHSSLVL TLFVVMLMTC LEAAKLTVGF     50
HAPWNISHPF SVQRLGAGLQ IAVDKLNSEP VGPGNLSWEF TYTNATCNAK 100
ESLAAFIDQV QREHISVLIG PACPEAAEVI GLLASEWDIP LFDFVGQMTA 150
LEDHFWCDTC VTLVPPKQEI GTVLRESLQY LGWEYIGVFG GSSAGSSWGE 200
VNELWKAVED ELQLHFTITA RVRYSSGHSD LLQEGLRSMS SVARVIILIC 250
SSEDAKHILQ AAEDLGLNSG EFVFLLLQQL EDSFWKEVLA EDKVTRFPKV 300
YESVFLIAPS TYGGSAGDDD FRKQVYQRLR RPPFQSSISS EDQVSPYSAY 350
LHDALLLYAQ TVEEMMKAEK DFRDGRQLIS TLRADQVTLQ GITGPVLLDA 400
QGKRHMDYSV YALQKSGNGS RFLPFLHYDS FQKVIRPWRD DLNASGPHGS 450
HPEYKPDCGF HEDLCRTKPP TGAGMTASVT AVIPTVTLLV VASAAAITGL 500
MLWRLRGKVQ NHPGDTWWQI HYDSITLLPQ HKPSHRGTPM SRCNVSNAST 550
VKISADCGSF AKTHQDEELF YAPVGLYQGN HVALCYIGEE AEARIKKPTV 600
LREVWLMCEL KHENIVPFFG VCTEPPNICI VTQYCKKGSL KDVLRNSDHE 650
MDWIFKLSFV YDIVNGMLFL HGSPLRSHGN LKPSNCLVDS HMQLKLAGFG 700
LWEFKHGSTC RIYNQEATDH SELYWTAPEL LRLRELPWSG TPQGDVYSFA 750
ILLRDLIHQQ AHGPFEDLEA APEEIISCIK DPRAPVPLRP SLLEDKGDER 800
IVALVRACWA ESPEQRPAFP SIKKTLREAS PRGRVSILDS MMGKLEMYAS 850
HLEEVVEERT CQLVAEKRKV EKLLSTMLPS FVGEQLIAGK SVEPEHFESV 900
TIFFSDIVGF TKLCSLSSPL QVVKLLNDLY SLFDHTIQTH DVYKVETIGD 950
AYMVASGLPI RNGAQHADEI ATMSLHLLSV TTNFQIGHMP EERLKLRIGL 1000
HTGPVVAGVV GITMPRYCLF GDTVNMASRM ESSSLPLRIH VSQSTARALL 1050
VAGGYHLQKR GTISVKGKGE QTTFWLTGKD GFAVPLPEFT EEEAKVPEIL 1100
Length:1,100
Mass (Da):122,497
Last modified:September 27, 2005 - v2
Checksum:iE487701031EF9965
GO
Isoform 2 (identifier: P55205-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-666: Missing.

Show »
Length:434
Mass (Da):48,319
Checksum:iB4829C053CEFAE31
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 666666Missing in isoform 2.
VSP_015787Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti738 – 7447WSGTPQG → GPAPRR in AAC52417. 1 Publication
Sequence conflicti782 – 7821P → S in AAC52417. 1 Publication
Sequence conflicti786 – 7861V → F in AAC52417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024622 mRNA. Translation: AAC01752.1.
U33847 mRNA. Translation: AAC52417.1.
PIRiT42260.
UniGeneiRn.10198.

Genome annotation databases

UCSCiRGD:621853. rat. [P55205-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF024622 mRNA. Translation: AAC01752.1 .
U33847 mRNA. Translation: AAC52417.1 .
PIRi T42260.
UniGenei Rn.10198.

3D structure databases

ProteinModelPortali P55205.
ModBasei Search...

Proteomic databases

PaxDbi P55205.
PRIDEi P55205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621853. rat. [P55205-1 ]

Organism-specific databases

RGDi 621853. Gucy2g.

Phylogenomic databases

eggNOGi COG2114.
HOGENOMi HOG000293307.
HOVERGENi HBG051862.
InParanoidi P55205.
PhylomeDBi P55205.

Miscellaneous databases

NextBioi 623135.

Gene expression databases

Genevestigatori P55205.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR001170. Ntpep_rcpt.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00255. NATPEPTIDER.
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression."
    Kojima M., Hisaki K., Matsuo H., Kangawa K.
    Biochem. Biophys. Res. Commun. 217:993-1000(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  2. "The cloning and expression of a new guanylyl cyclase orphan receptor."
    Schulz S., Wedel B.J., Matthews A., Garbers D.L.
    J. Biol. Chem. 273:1032-1037(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).

Entry informationi

Entry nameiGUC2G_RAT
AccessioniPrimary (citable) accession number: P55205
Secondary accession number(s): O54884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 27, 2005
Last modified: April 16, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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