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P55201

- BRPF1_HUMAN

UniProt

P55201 - BRPF1_HUMAN

Protein

Peregrin

Gene

BRPF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri21 – 4727C2H2-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 32351PHD-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri386 – 40015C4-typeAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chromatin organization Source: Reactome
    2. histone H3 acetylation Source: UniProtKB
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peregrin
    Alternative name(s):
    Bromodomain and PHD finger-containing protein 1
    Protein Br140
    Gene namesi
    Name:BRPF1
    Synonyms:BR140
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14255. BRPF1.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Localization to the nucleus depends on KAT6A, ING5 and MEAF6.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. MOZ/MORF histone acetyltransferase complex Source: UniProtKB
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25424.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12141214PeregrinPRO_0000211187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei120 – 1201Phosphoserine1 Publication
    Modified residuei460 – 4601Phosphoserine3 Publications
    Modified residuei462 – 4621Phosphoserine3 Publications
    Modified residuei860 – 8601Phosphoserine1 Publication
    Modified residuei1076 – 10761Phosphoserine3 Publications
    Modified residuei1187 – 11871Phosphoserine1 Publication

    Post-translational modificationi

    Acetylated by KAT6A.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP55201.
    PaxDbiP55201.
    PRIDEiP55201.

    PTM databases

    PhosphoSiteiP55201.

    Expressioni

    Tissue specificityi

    High levels in testis.

    Gene expression databases

    ArrayExpressiP55201.
    BgeeiP55201.
    CleanExiHS_BRPF1.
    GenevestigatoriP55201.

    Organism-specific databases

    HPAiHPA003359.

    Interactioni

    Subunit structurei

    Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3).4 Publications

    Protein-protein interaction databases

    BioGridi113614. 8 interactions.
    DIPiDIP-59001N.
    IntActiP55201. 2 interactions.
    STRINGi9606.ENSP00000373340.

    Structurei

    Secondary structure

    1
    1214
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi630 – 64718
    Beta strandi652 – 6554
    Turni659 – 6613
    Helixi665 – 6684
    Helixi675 – 6839
    Helixi690 – 70718
    Helixi713 – 73725
    Beta strandi1081 – 10833
    Beta strandi1088 – 10914
    Beta strandi1099 – 11046
    Beta strandi1113 – 11153
    Beta strandi1118 – 11203
    Helixi1125 – 113713
    Beta strandi1138 – 11403
    Beta strandi1142 – 11498
    Beta strandi1154 – 11585
    Helixi1159 – 11613
    Beta strandi1162 – 11676
    Helixi1169 – 11768
    Helixi1182 – 120221

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D9ENMR-A633-740[»]
    2RS9NMR-B633-740[»]
    2X35X-ray2.00A1076-1205[»]
    2X4WX-ray1.50A1076-1205[»]
    2X4XX-ray1.85A/C/E/G1076-1205[»]
    2X4YX-ray1.70A/C/E/G/I/K/M/O1076-1205[»]
    3L42X-ray1.30A1079-1207[»]
    3MO8X-ray1.69A1079-1207[»]
    4LC2X-ray1.65A626-740[»]
    ProteinModelPortaliP55201.
    SMRiP55201. Positions 269-326, 376-452, 627-740, 1079-1205.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55201.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini645 – 71571BromoPROSITE-ProRule annotationAdd
    BLAST
    Domaini1085 – 116884PWWPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 222164Interaction with KAT6A and KAT6BAdd
    BLAST
    Regioni501 – 821321Interaction with MEAF6 and ING5Add
    BLAST
    Regioni543 – 1079537Required for RUNX1 and RUNX2 transcriptional activationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PWWP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri21 – 4727C2H2-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri273 – 32351PHD-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri386 – 40015C4-typeAdd
    BLAST

    Keywords - Domaini

    Bromodomain, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5141.
    HOGENOMiHOG000000705.
    HOVERGENiHBG004895.
    KOiK11348.
    OMAiPIPQEIF.
    OrthoDBiEOG7FBRM7.
    PhylomeDBiP55201.
    TreeFamiTF316118.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProiIPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR019542. Enhancer_polycomb-like_N.
    IPR000313. PWWP_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00439. Bromodomain. 1 hit.
    PF10513. EPL1. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    SM00249. PHD. 2 hits.
    SM00293. PWWP. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50812. PWWP. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P55201-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP     50
    PPPQQTPLRK HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE 100
    VDLHGRVHRI SIFDNLDVVS EDEEAPEEAP ENGSNKENTE TPAATPKSGK 150
    HKNKEKRKDS NHHHHHNVSA STTPKLPEVV YRELEQDTPD APPRPTSYYR 200
    YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI PQEIFEYLMD 250
    RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 300
    HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH 350
    VVCALWIPEV CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC 400
    HKANCYTAFH VTCAQQAGLY MKMEPVRETG ANGTSFSVRK TAYCDIHTPP 450
    GSARRLPALS HSEGEEDEDE EEDEGKGWSS EKVKKAKAKS RIKMKKARKI 500
    LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL HSYWTLKRQS 550
    RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 600
    ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG 650
    NIFSEPVPLS EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI 700
    VSNCLKYNAK DTIFYRAAVR LREQGGAVLR QARRQAEKMG IDFETGMHIP 750
    HSLAGDEATH HTEDAAEEER LVLLENQKHL PVEEQLKLLL ERLDEVNASK 800
    QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS SRGSLTPHPA 850
    ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK 900
    TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP 950
    SSSSDSDSDK STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD 1000
    SESSSSSSSS AASDRTSTTP SKQGRGKPSF SRGTFPEDSS EDTSGTENEA 1050
    YSVGTGRGVG HSMVRKSLGR GAGWLSEDED SPLDALDLVW AKCRGYPSYP 1100
    ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE HLYLVLFFDN 1150
    KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS 1200
    KVQGEQSSET SDSD 1214
    Length:1,214
    Mass (Da):137,499
    Last modified:October 17, 2006 - v2
    Checksum:i618F359F21F4CBF7
    GO
    Isoform 2 (identifier: P55201-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         660-660: S → SEVTELD

    Show »
    Length:1,220
    Mass (Da):138,185
    Checksum:iA4ECE0FC3638BCE5
    GO
    Isoform 3 (identifier: P55201-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         765-765: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,213
    Mass (Da):137,428
    Checksum:iC92CF66AB4788CB6
    GO
    Isoform 4 (identifier: P55201-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         873-967: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,119
    Mass (Da):127,363
    Checksum:i1DD0F0BFDF1AFDCC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51F → L in BAG57257. (PubMed:14702039)Curated
    Sequence conflicti299 – 2991A → E in AAB02119. (PubMed:7906940)Curated
    Sequence conflicti306 – 3061G → D in BAG57257. (PubMed:14702039)Curated
    Sequence conflicti341 – 3411K → R in BAG57257. (PubMed:14702039)Curated
    Sequence conflicti729 – 7291L → V in AAB02119. (PubMed:7906940)Curated
    Sequence conflicti1035 – 10351F → S in BAG57257. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1117 – 11171G → E.
    Corresponds to variant rs1042294 [ dbSNP | Ensembl ].
    VAR_028232
    Natural varianti1193 – 11931H → Q.
    Corresponds to variant rs36081837 [ dbSNP | Ensembl ].
    VAR_048430

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei660 – 6601S → SEVTELD in isoform 2. 1 PublicationVSP_037955
    Alternative sequencei765 – 7651Missing in isoform 3. 1 PublicationVSP_037956
    Alternative sequencei873 – 96795Missing in isoform 4. 1 PublicationVSP_037957Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91585 mRNA. Translation: AAB02119.1.
    AF176815 Genomic DNA. Translation: AAF19605.1.
    AK293865 mRNA. Translation: BAG57257.1.
    AL713696 mRNA. Translation: CAD28495.1.
    AC022382 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW63976.1.
    BC053851 mRNA. Translation: AAH53851.1.
    CCDSiCCDS2575.1. [P55201-1]
    CCDS33692.1. [P55201-2]
    PIRiJC2069.
    RefSeqiNP_001003694.1. NM_001003694.1. [P55201-2]
    NP_004625.2. NM_004634.2. [P55201-1]
    XP_005265508.1. XM_005265451.1. [P55201-3]
    XP_005265510.1. XM_005265453.1. [P55201-4]
    UniGeneiHs.1004.

    Genome annotation databases

    EnsembliENST00000383829; ENSP00000373340; ENSG00000156983. [P55201-2]
    ENST00000424362; ENSP00000398863; ENSG00000156983. [P55201-3]
    ENST00000433861; ENSP00000402485; ENSG00000156983. [P55201-4]
    ENST00000457855; ENSP00000410210; ENSG00000156983. [P55201-1]
    GeneIDi7862.
    KEGGihsa:7862.
    UCSCiuc003bse.3. human. [P55201-1]
    uc003bsf.3. human. [P55201-2]
    uc003bsg.3. human. [P55201-3]
    uc011ati.2. human. [P55201-4]

    Polymorphism databases

    DMDMi116241271.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91585 mRNA. Translation: AAB02119.1 .
    AF176815 Genomic DNA. Translation: AAF19605.1 .
    AK293865 mRNA. Translation: BAG57257.1 .
    AL713696 mRNA. Translation: CAD28495.1 .
    AC022382 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW63976.1 .
    BC053851 mRNA. Translation: AAH53851.1 .
    CCDSi CCDS2575.1. [P55201-1 ]
    CCDS33692.1. [P55201-2 ]
    PIRi JC2069.
    RefSeqi NP_001003694.1. NM_001003694.1. [P55201-2 ]
    NP_004625.2. NM_004634.2. [P55201-1 ]
    XP_005265508.1. XM_005265451.1. [P55201-3 ]
    XP_005265510.1. XM_005265453.1. [P55201-4 ]
    UniGenei Hs.1004.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D9E NMR - A 633-740 [» ]
    2RS9 NMR - B 633-740 [» ]
    2X35 X-ray 2.00 A 1076-1205 [» ]
    2X4W X-ray 1.50 A 1076-1205 [» ]
    2X4X X-ray 1.85 A/C/E/G 1076-1205 [» ]
    2X4Y X-ray 1.70 A/C/E/G/I/K/M/O 1076-1205 [» ]
    3L42 X-ray 1.30 A 1079-1207 [» ]
    3MO8 X-ray 1.69 A 1079-1207 [» ]
    4LC2 X-ray 1.65 A 626-740 [» ]
    ProteinModelPortali P55201.
    SMRi P55201. Positions 269-326, 376-452, 627-740, 1079-1205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113614. 8 interactions.
    DIPi DIP-59001N.
    IntActi P55201. 2 interactions.
    STRINGi 9606.ENSP00000373340.

    PTM databases

    PhosphoSitei P55201.

    Polymorphism databases

    DMDMi 116241271.

    Proteomic databases

    MaxQBi P55201.
    PaxDbi P55201.
    PRIDEi P55201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383829 ; ENSP00000373340 ; ENSG00000156983 . [P55201-2 ]
    ENST00000424362 ; ENSP00000398863 ; ENSG00000156983 . [P55201-3 ]
    ENST00000433861 ; ENSP00000402485 ; ENSG00000156983 . [P55201-4 ]
    ENST00000457855 ; ENSP00000410210 ; ENSG00000156983 . [P55201-1 ]
    GeneIDi 7862.
    KEGGi hsa:7862.
    UCSCi uc003bse.3. human. [P55201-1 ]
    uc003bsf.3. human. [P55201-2 ]
    uc003bsg.3. human. [P55201-3 ]
    uc011ati.2. human. [P55201-4 ]

    Organism-specific databases

    CTDi 7862.
    GeneCardsi GC03P009781.
    HGNCi HGNC:14255. BRPF1.
    HPAi HPA003359.
    MIMi 602410. gene.
    neXtProti NX_P55201.
    PharmGKBi PA25424.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5141.
    HOGENOMi HOG000000705.
    HOVERGENi HBG004895.
    KOi K11348.
    OMAi PIPQEIF.
    OrthoDBi EOG7FBRM7.
    PhylomeDBi P55201.
    TreeFami TF316118.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    EvolutionaryTracei P55201.
    GenomeRNAii 7862.
    NextBioi 30302.
    PROi P55201.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55201.
    Bgeei P55201.
    CleanExi HS_BRPF1.
    Genevestigatori P55201.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.30.40.10. 1 hit.
    InterProi IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR019542. Enhancer_polycomb-like_N.
    IPR000313. PWWP_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 1 hit.
    PF10513. EPL1. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    SM00249. PHD. 2 hits.
    SM00293. PWWP. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS50812. PWWP. 1 hit.
    PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    PS50157. ZINC_FINGER_C2H2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID."
      Thompson K.A., Wang B., Argraves W.S., Giancotti F.G., Schranck D.P., Ruoslahti E.
      Biochem. Biophys. Res. Commun. 198:1143-1152(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Sequencing and analyzing of BAC DNA on 3p26."
      Hu S.N., Dong W., Zeng Y.X., Yu J., Yang H.M.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Cerebellum.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Eye.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
      Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
      Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX.
    10. Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX, INTERACTION WITH ING5; MEAF6; KAT6A AND KAT6B, SUBCELLULAR LOCATION, ACETYLATION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-1187, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462 AND SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462; SER-860 AND SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Solution structure of the bromodomain of peregrin."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 633-740.
    17. Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1076-1205 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.
    18. "Structural and histone binding ability characterizations of human PWWP domains."
      Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
      PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 1079-1207 IN COMPLEX WITH TRIMETHYLATED HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.

    Entry informationi

    Entry nameiBRPF1_HUMAN
    AccessioniPrimary (citable) accession number: P55201
    Secondary accession number(s): B4DEZ6
    , Q7Z6E0, Q8TCM6, Q9UHI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3