P55201 (BRPF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peregrin

Alternative name(s):
Bromodomain and PHD finger-containing protein 1
Protein Br140

Gene names

Name:	BRPF1
Synonyms:	BR140

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1214 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2. Ref.10 Ref.11
Subunit structure	Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
Subcellular location	Nucleus. Cytoplasm. Note: Localization to the nucleus depends on KAT6A, ING5 and MEAF6. Ref.11
Tissue specificity	High levels in testis.
Post-translational modification	Acetylated by KAT6A.
Sequence similarities	Contains 1 bromo domain. Contains 1 C2H2-type zinc finger. Contains 1 PHD-type zinc finger. Contains 1 PWWP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Chromatin regulator
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histone H3 acetylation Inferred from direct assay Ref.10. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.11. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MOZ/MORF histone acetyltransferase complex Inferred from direct assay Ref.10Ref.11. Source: UniProtKB cytoplasm Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55201-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55201-2)

The sequence of this isoform differs from the canonical sequence as follows:
     660-660: S → SEVTELD

Isoform 3 (identifier: P55201-3)

The sequence of this isoform differs from the canonical sequence as follows:
     765-765: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: P55201-4)

The sequence of this isoform differs from the canonical sequence as follows:
     873-967: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1214

1214

Peregrin

PRO_0000211187

Regions

Domain

645 – 715

71

Bromo

Domain

1085 – 1168

84

PWWP

Zinc finger

21 – 47

27

C2H2-type

Zinc finger

273 – 323

51

PHD-type

Zinc finger

386 – 400

15

C4-type

Region

59 – 222

164

Interaction with KAT6A and KAT6B

Region

501 – 821

321

Interaction with MEAF6 and ING5

Region

543 – 1079

537

Required for RUNX1 and RUNX2 transcriptional activation

Amino acid modifications

Modified residue

120

1

Phosphoserine Ref.12

Modified residue

238

1

Phosphoserine Ref.8

Modified residue

460

1

Phosphoserine Ref.9

Modified residue

462

1

Phosphoserine Ref.9

Modified residue

922

1

Phosphoserine Ref.9

Modified residue

1076

1

Phosphoserine Ref.13

Modified residue

1187

1

Phosphoserine Ref.12

Natural variations

Alternative sequence

660

1

S → SEVTELD in isoform 2.

VSP_037955

Alternative sequence

765

1

Missing in isoform 3.

VSP_037956

Alternative sequence

873 – 967

95

Missing in isoform 4.

VSP_037957

Natural variant

1117

1

G → E.
Corresponds to variant rs1042294 [ dbSNP | Ensembl ].

VAR_028232

Natural variant

1193

1

H → Q.
Corresponds to variant rs36081837 [ dbSNP | Ensembl ].

VAR_048430

Experimental info

Sequence conflict

5

1

F → L in BAG57257. Ref.3

Sequence conflict

299

1

A → E in AAB02119. Ref.1

Sequence conflict

306

1

G → D in BAG57257. Ref.3

Sequence conflict

341

1

K → R in BAG57257. Ref.3

Sequence conflict

729

1

L → V in AAB02119. Ref.1

Sequence conflict

1035

1

F → S in BAG57257. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1214

Helix Strand Turn

Details...

Helix

633 – 647

15

Beta strand

652 – 655

4

Turn

659 – 661

3

Helix

665 – 668

4

Helix

675 – 683

9

Helix

690 – 707

18

Helix

713 – 738

26

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 618F359F21F4CBF7	FASTA	1,214	137,499
	10 20 30 40 50 60 MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK 70 80 90 100 110 120 HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 130 140 150 160 170 180 EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV 190 200 210 220 230 240 YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI 250 260 270 280 290 300 PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 310 320 330 340 350 360 HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV 370 380 390 400 410 420 CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY 430 440 450 460 470 480 MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS 490 500 510 520 530 540 EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL 550 560 570 580 590 600 HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 610 620 630 640 650 660 ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS 670 680 690 700 710 720 EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI VSNCLKYNAK DTIFYRAAVR 730 740 750 760 770 780 LREQGGAVLR QARRQAEKMG IDFETGMHIP HSLAGDEATH HTEDAAEEER LVLLENQKHL 790 800 810 820 830 840 PVEEQLKLLL ERLDEVNASK QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS 850 860 870 880 890 900 SRGSLTPHPA ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK 910 920 930 940 950 960 TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP SSSSDSDSDK 970 980 990 1000 1010 1020 STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD SESSSSSSSS AASDRTSTTP 1030 1040 1050 1060 1070 1080 SKQGRGKPSF SRGTFPEDSS EDTSGTENEA YSVGTGRGVG HSMVRKSLGR GAGWLSEDED 1090 1100 1110 1120 1130 1140 SPLDALDLVW AKCRGYPSYP ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE 1150 1160 1170 1180 1190 1200 HLYLVLFFDN KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS 1210 KVQGEQSSET SDSD
	Isoform 2 [UniParc]. Checksum: A4ECE0FC3638BCE5	FASTA	1,220	138,185
	10 20 30 40 50 60 MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK 70 80 90 100 110 120 HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 130 140 150 160 170 180 EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV 190 200 210 220 230 240 YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI 250 260 270 280 290 300 PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 310 320 330 340 350 360 HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV 370 380 390 400 410 420 CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY 430 440 450 460 470 480 MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS 490 500 510 520 530 540 EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL 550 560 570 580 590 600 HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 610 620 630 640 650 660 ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS 670 680 690 700 710 720 EVTELDEVPD YLDHIKKPMD FFTMKQNLEA YRYLNFDDFE EDFNLIVSNC LKYNAKDTIF 730 740 750 760 770 780 YRAAVRLREQ GGAVLRQARR QAEKMGIDFE TGMHIPHSLA GDEATHHTED AAEEERLVLL 790 800 810 820 830 840 ENQKHLPVEE QLKLLLERLD EVNASKQSVG RSRRAKMIKK EMTALRRKLA HQRETGRDGP 850 860 870 880 890 900 ERHGPSSRGS LTPHPAACDK DGQTDSAAEE SSSQETSKGL GPNMSSTPAH EVGRRTSVLF 910 920 930 940 950 960 SKKNPKTAGP PKRPGRPPKN RESQMTPSHG GSPVGPPQLP IMSSLRQRKR GRSPRPSSSS 970 980 990 1000 1010 1020 DSDSDKSTED PPMDLPANGF SGGNQPVKKS FLVYRNDCSL PRSSSDSESS SSSSSSAASD 1030 1040 1050 1060 1070 1080 RTSTTPSKQG RGKPSFSRGT FPEDSSEDTS GTENEAYSVG TGRGVGHSMV RKSLGRGAGW 1090 1100 1110 1120 1130 1140 LSEDEDSPLD ALDLVWAKCR GYPSYPALII DPKMPREGMF HHGVPIPVPP LEVLKLGEQM 1150 1160 1170 1180 1190 1200 TQEAREHLYL VLFFDNKRTW QWLPRTKLVP LGVNQDLDKE KMLEGRKSNI RKSVQIAYHR 1210 1220 ALQHRSKVQG EQSSETSDSD
	Isoform 3 [UniParc]. Checksum: C92CF66AB4788CB6	FASTA	1,213	137,428
	10 20 30 40 50 60 MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK 70 80 90 100 110 120 HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 130 140 150 160 170 180 EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV 190 200 210 220 230 240 YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI 250 260 270 280 290 300 PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 310 320 330 340 350 360 HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV 370 380 390 400 410 420 CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY 430 440 450 460 470 480 MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS 490 500 510 520 530 540 EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL 550 560 570 580 590 600 HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 610 620 630 640 650 660 ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS 670 680 690 700 710 720 EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI VSNCLKYNAK DTIFYRAAVR 730 740 750 760 770 780 LREQGGAVLR QARRQAEKMG IDFETGMHIP HSLAGDEATH HTEDAEEERL VLLENQKHLP 790 800 810 820 830 840 VEEQLKLLLE RLDEVNASKQ SVGRSRRAKM IKKEMTALRR KLAHQRETGR DGPERHGPSS 850 860 870 880 890 900 RGSLTPHPAA CDKDGQTDSA AEESSSQETS KGLGPNMSST PAHEVGRRTS VLFSKKNPKT 910 920 930 940 950 960 AGPPKRPGRP PKNRESQMTP SHGGSPVGPP QLPIMSSLRQ RKRGRSPRPS SSSDSDSDKS 970 980 990 1000 1010 1020 TEDPPMDLPA NGFSGGNQPV KKSFLVYRND CSLPRSSSDS ESSSSSSSSA ASDRTSTTPS 1030 1040 1050 1060 1070 1080 KQGRGKPSFS RGTFPEDSSE DTSGTENEAY SVGTGRGVGH SMVRKSLGRG AGWLSEDEDS 1090 1100 1110 1120 1130 1140 PLDALDLVWA KCRGYPSYPA LIIDPKMPRE GMFHHGVPIP VPPLEVLKLG EQMTQEAREH 1150 1160 1170 1180 1190 1200 LYLVLFFDNK RTWQWLPRTK LVPLGVNQDL DKEKMLEGRK SNIRKSVQIA YHRALQHRSK 1210 VQGEQSSETS DSD
	Isoform 4 [UniParc]. Checksum: 1DD0F0BFDF1AFDCC	FASTA	1,119	127,363
	10 20 30 40 50 60 MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK 70 80 90 100 110 120 HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 130 140 150 160 170 180 EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV 190 200 210 220 230 240 YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI 250 260 270 280 290 300 PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 310 320 330 340 350 360 HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV 370 380 390 400 410 420 CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY 430 440 450 460 470 480 MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS 490 500 510 520 530 540 EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL 550 560 570 580 590 600 HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 610 620 630 640 650 660 ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS 670 680 690 700 710 720 EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI VSNCLKYNAK DTIFYRAAVR 730 740 750 760 770 780 LREQGGAVLR QARRQAEKMG IDFETGMHIP HSLAGDEATH HTEDAAEEER LVLLENQKHL 790 800 810 820 830 840 PVEEQLKLLL ERLDEVNASK QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS 850 860 870 880 890 900 SRGSLTPHPA ACDKDGQTDS AAEESSSQET SKDLPANGFS GGNQPVKKSF LVYRNDCSLP 910 920 930 940 950 960 RSSSDSESSS SSSSSAASDR TSTTPSKQGR GKPSFSRGTF PEDSSEDTSG TENEAYSVGT 970 980 990 1000 1010 1020 GRGVGHSMVR KSLGRGAGWL SEDEDSPLDA LDLVWAKCRG YPSYPALIID PKMPREGMFH 1030 1040 1050 1060 1070 1080 HGVPIPVPPL EVLKLGEQMT QEAREHLYLV LFFDNKRTWQ WLPRTKLVPL GVNQDLDKEK 1090 1100 1110 MLEGRKSNIR KSVQIAYHRA LQHRSKVQGE QSSETSDSD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID." Thompson K.A., Wang B., Argraves W.S., Giancotti F.G., Schranck D.P., Ruoslahti E. Biochem. Biophys. Res. Commun. 198:1143-1152(1994) [PubMed: 7906940] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Sequencing and analyzing of BAC DNA on 3p26." Hu S.N., Dong W., Zeng Y.X., Yu J., Yang H.M. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Cerebellum.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[8]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462 AND SER-922, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J. Mol. Cell 21:51-64(2006) [PubMed: 16387653] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX.
[11]	"Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes." Ullah M., Pelletier N., Xiao L., Zhao S.P., Wang K., Degerny C., Tahmasebi S., Cayrou C., Doyon Y., Goh S.-L., Champagne N., Cote J., Yang X.-J. Mol. Cell. Biol. 28:6828-6843(2008) [PubMed: 18794358] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX, INTERACTION WITH ING5; MEAF6; KAT6A AND KAT6B, SUBCELLULAR LOCATION, ACETYLATION.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-1187, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Solution structure of the bromodomain of peregrin." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 633-740.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M91585 mRNA. Translation: AAB02119.1.
AF176815 Genomic DNA. Translation: AAF19605.1.
AK293865 mRNA. Translation: BAG57257.1.
AL713696 mRNA. Translation: CAD28495.1.
AC022382 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63976.1.
BC053851 mRNA. Translation: AAH53851.1.

IPI

IPI00023856.
IPI00456620.
IPI00925976.
IPI00926602.

PIR

JC2069.

RefSeq

NP_001003694.1. NM_001003694.1.
NP_004625.2. NM_004634.2.

UniGene

Hs.1004.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D9E	NMR	-	A	633-740	[»]
2X35	X-ray	2.00	A	1076-1205	[»]
2X4W	X-ray	1.50	A	1076-1205	[»]
2X4X	X-ray	1.85	A/C/E/G	1076-1205	[»]
2X4Y	X-ray	1.70	A/C/E/G/I/K/M/O	1076-1205	[»]
3L42	X-ray	1.30	A	1079-1207	[»]
3MO8	X-ray	1.69	A	1079-1207	[»]

ProteinModelPortal

P55201.

SMR

P55201. Positions 269-326, 633-740, 1079-1205.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59001N.

IntAct

P55201. 2 interactions.

STRING

P55201.

PTM databases

PhosphoSite

P55201.

Polymorphism databases

DMDM

116241271.

Proteomic databases

PRIDE

P55201.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000302054; ENSP00000306297; ENSG00000156983.
ENST00000383829; ENSP00000373340; ENSG00000156983.
ENST00000433861; ENSP00000402485; ENSG00000156983.
ENST00000457855; ENSP00000410210; ENSG00000156983.

GeneID

7862.

KEGG

hsa:7862.

UCSC

uc003bse.1. human.

Organism-specific databases

CTD

7862.

GeneCards

GC03P009777.

HGNC

HGNC:14255. BRPF1.

HPA

HPA003359.

MIM

602410. gene.

neXtProt

NX_P55201.

PharmGKB

PA25424.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG04477.

GeneTree

ENSGT00600000084089.

HOGENOM

HBG717256.

HOVERGEN

HBG004895.

OMA

VETCRKV.

OrthoDB

EOG42Z4PD.

PhylomeDB

P55201.

Gene expression databases

ArrayExpress

P55201.

Bgee

P55201.

CleanEx

HS_BRPF1.

Genevestigator

P55201.

GermOnline

ENSG00000156983. Homo sapiens.

Family and domain databases

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Gene3D

G3DSA:1.20.920.10. Bromodomain. 1 hit.
G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.

KO

K11348.

Pfam

PF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]

SUPFAM

SSF47370. Bromodomain. 1 hit.
SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

30302.

SOURCE

Search...

Entry information

Entry name

BRPF1_HUMAN

Accession

Primary (citable) accession number: P55201
Secondary accession number(s): B4DEZ6 , Q7Z6E0, Q8TCM6, Q9UHI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 17, 2006
Last modified:	January 25, 2012
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.