Peregrin - Homo sapiens (Human)

Sequence

>sp|P55201|BRPF1_HUMAN Peregrin OS=Homo sapiens GN=BRPF1 PE=1 SV=2 MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRK HKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVS EDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDSNHHHHHNVSASTTPKLPEVV YRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPI PQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAV HQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEV CFANTVFLEPIDSIEHIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLY MKMEPVRETGANGTSFSVRKTAYCDIHTPPGSARRLPALSHSEGEEDEDEEEDEGKGWSS EKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQRL HSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLER ARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLS EVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVR LREQGGAVLRQARRQAEKMGIDFETGMHIPHSLAGDEATHHTEDAAEEERLVLLENQKHL PVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPS SRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDK STEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTP SKQGRGKPSFSRGTFPEDSSEDTSGTENEAYSVGTGRGVGHSMVRKSLGRGAGWLSEDED SPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEARE HLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS KVQGEQSSETSDSD

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Reviewed, UniProtKB/Swiss-Prot P55201 (BRPF1_HUMAN)

Last modified June 16, 2009. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Peregrin
Alternative name(s):
    Bromodomain and PHD finger-containing protein 1
    BR140 protein

Gene names

Name:	BRPF1
Synonyms:	BR140

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	1214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Subunit structure	Component of the MOZ/MORF composed at least of ING5, MYST3/MOZ, MYST4/MORF and one of BRPF1, BRD1/BRPF2 and BRPF3.
Subcellular location	Nucleus Probable.
Tissue specificity	High levels in testis.
Sequence similarities	Contains 1 bromo domain. Contains 1 C2H2-type zinc finger. Contains 1 PHD-type zinc finger. Contains 1 PWWP domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Bromodomain Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Ref.1 Traceable author statement. Source: ProtInc
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1214

1214

Peregrin

PRO_0000211187

Regions

Domain

645 – 715

Bromo

Domain

1085 – 1168

PWWP

Zinc finger

21 – 47

C2H2-type

Zinc finger

273 – 323

PHD-type

Zinc finger

386 – 400

C4-type

Amino acid modifications

Modified residue

120

Phosphoserine Ref.6

Modified residue

238

Phosphoserine Ref.3

Modified residue

460

Phosphoserine Ref.4

Modified residue

462

Phosphoserine Ref.4

Modified residue

922

Phosphoserine Ref.4

Modified residue

1187

Phosphoserine Ref.6

Natural variations

Natural variant

1117

G → E: dbSNP rs1042294.

VAR_028232

Natural variant

1193

H → Q: dbSNP rs36081837.

VAR_048430

Experimental info

Sequence conflict

299

A → E in AAB02119. Ref.1

Sequence conflict

729

L → V in AAB02119. Ref.1

Secondary structure

1214

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P55201-1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 618F359F21F4CBF7
Show »

FASTA

1,214

137,499

        10         20         30         40         50         60 
MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP PPPQQTPLRK 

        70         80         90        100        110        120 
HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE VDLHGRVHRI SIFDNLDVVS 

       130        140        150        160        170        180 
EDEEAPEEAP ENGSNKENTE TPAATPKSGK HKNKEKRKDS NHHHHHNVSA STTPKLPEVV 

       190        200        210        220        230        240 
YRELEQDTPD APPRPTSYYR YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI 

       250        260        270        280        290        300 
PQEIFEYLMD RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 

       310        320        330        340        350        360 
HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH VVCALWIPEV 

       370        380        390        400        410        420 
CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC HKANCYTAFH VTCAQQAGLY 

       430        440        450        460        470        480 
MKMEPVRETG ANGTSFSVRK TAYCDIHTPP GSARRLPALS HSEGEEDEDE EEDEGKGWSS 

       490        500        510        520        530        540 
EKVKKAKAKS RIKMKKARKI LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL 

       550        560        570        580        590        600 
HSYWTLKRQS RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 

       610        620        630        640        650        660 
ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG NIFSEPVPLS 

       670        680        690        700        710        720 
EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI VSNCLKYNAK DTIFYRAAVR 

       730        740        750        760        770        780 
LREQGGAVLR QARRQAEKMG IDFETGMHIP HSLAGDEATH HTEDAAEEER LVLLENQKHL 

       790        800        810        820        830        840 
PVEEQLKLLL ERLDEVNASK QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS 

       850        860        870        880        890        900 
SRGSLTPHPA ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK 

       910        920        930        940        950        960 
TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP SSSSDSDSDK 

       970        980        990       1000       1010       1020 
STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD SESSSSSSSS AASDRTSTTP 

      1030       1040       1050       1060       1070       1080 
SKQGRGKPSF SRGTFPEDSS EDTSGTENEA YSVGTGRGVG HSMVRKSLGR GAGWLSEDED 

      1090       1100       1110       1120       1130       1140 
SPLDALDLVW AKCRGYPSYP ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE 

      1150       1160       1170       1180       1190       1200 
HLYLVLFFDN KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS 

      1210 
KVQGEQSSET SDSD

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID." Thompson K.A., Wang B., Argraves W.S., Giancotti F.G., Schranck D.P., Ruoslahti E. Biochem. Biophys. Res. Commun. 198:1143-1152(1994) [PubMed: 7906940] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequencing and analyzing of BAC DNA on 3p26." Hu S.N., Dong W., Zeng Y.X., Yu J., Yang H.M. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462 AND SER-922, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation." Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J. Mol. Cell 21:51-64(2006) [PubMed: 16387653] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-1187, MASS SPECTROMETRY.
[7]	"Solution structure of the bromodomain of peregrin." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 633-740.

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Cross-references

Sequence databases

M91585 mRNA. Translation: AAB02119.1.
AF176815 Genomic DNA. Translation: AAF19605.1.

IPI

IPI00023856.

RefSeq

NP_004625.2.

UniGene

Hs.1004

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D9E	NMR	-	A	633-740	[»]

ModBase

Search...

PTM databases

PhosphoSite

P55201.

Proteomic databases

PRIDE

P55201.

Genome annotation databases

Ensembl

ENSG00000156983. Homo sapiens. [Contig view]

GeneID

7862.

Organism-specific databases

GeneCards

GC03P009748.

H-InvDB

HIX0003030.

HGNC

HGNC:14255. BRPF1.

HPA

HPA003359.

MIM

602410. gene.

PharmGKB

PA25424.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P55201.

Gene expression databases

ArrayExpress

P55201.

Bgee

P55201.

CleanEx

HS_BRPF1.

GermOnline

ENSG00000156983. Homo sapiens.

Family and domain databases

InterPro

IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_of_polycomb-like.
IPR000313. PWWP.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
[Graphical view]

Gene3D

G3DSA:1.20.920.10. Bromodomain. 1 hit.

Pfam

PF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00628. PHD. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]

PRINTS

PR00503. BROMODOMAIN.

SMART

SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]

PROSITE

PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

30302.

SOURCE

Search...

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Entry information

Entry name

BRPF1_HUMAN

Accession

Primary (citable) accession number: P55201
Secondary accession number(s): Q9UHI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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