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P55201

- BRPF1_HUMAN

UniProt

P55201 - BRPF1_HUMAN

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Protein

Peregrin

Gene
BRPF1, BR140
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 4727C2H2-typeAdd
BLAST
Zinc fingeri273 – 32351PHD-typeAdd
BLAST
Zinc fingeri386 – 40015C4-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. chromatin organization Source: Reactome
  2. histone H3 acetylation Source: UniProtKB
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Peregrin
Alternative name(s):
Bromodomain and PHD finger-containing protein 1
Protein Br140
Gene namesi
Name:BRPF1
Synonyms:BR140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14255. BRPF1.

Subcellular locationi

Nucleus. Cytoplasm
Note: Localization to the nucleus depends on KAT6A, ING5 and MEAF6.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. MOZ/MORF histone acetyltransferase complex Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25424.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12141214PeregrinPRO_0000211187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Phosphoserine1 Publication
Modified residuei460 – 4601Phosphoserine3 Publications
Modified residuei462 – 4621Phosphoserine3 Publications
Modified residuei860 – 8601Phosphoserine1 Publication
Modified residuei1076 – 10761Phosphoserine3 Publications
Modified residuei1187 – 11871Phosphoserine1 Publication

Post-translational modificationi

Acetylated by KAT6A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP55201.
PaxDbiP55201.
PRIDEiP55201.

PTM databases

PhosphoSiteiP55201.

Expressioni

Tissue specificityi

High levels in testis.

Gene expression databases

ArrayExpressiP55201.
BgeeiP55201.
CleanExiHS_BRPF1.
GenevestigatoriP55201.

Organism-specific databases

HPAiHPA003359.

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3).4 Publications

Protein-protein interaction databases

BioGridi113614. 8 interactions.
DIPiDIP-59001N.
IntActiP55201. 2 interactions.
STRINGi9606.ENSP00000373340.

Structurei

Secondary structure

1
1214
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi630 – 64718
Beta strandi652 – 6554
Turni659 – 6613
Helixi665 – 6684
Helixi675 – 6839
Helixi690 – 70718
Helixi713 – 73725
Beta strandi1081 – 10833
Beta strandi1088 – 10914
Beta strandi1099 – 11046
Beta strandi1113 – 11153
Beta strandi1118 – 11203
Helixi1125 – 113713
Beta strandi1138 – 11403
Beta strandi1142 – 11498
Beta strandi1154 – 11585
Helixi1159 – 11613
Beta strandi1162 – 11676
Helixi1169 – 11768
Helixi1182 – 120221

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D9ENMR-A633-740[»]
2RS9NMR-B633-740[»]
2X35X-ray2.00A1076-1205[»]
2X4WX-ray1.50A1076-1205[»]
2X4XX-ray1.85A/C/E/G1076-1205[»]
2X4YX-ray1.70A/C/E/G/I/K/M/O1076-1205[»]
3L42X-ray1.30A1079-1207[»]
3MO8X-ray1.69A1079-1207[»]
4LC2X-ray1.65A626-740[»]
ProteinModelPortaliP55201.
SMRiP55201. Positions 269-326, 376-452, 627-740, 1079-1205.

Miscellaneous databases

EvolutionaryTraceiP55201.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini645 – 71571BromoAdd
BLAST
Domaini1085 – 116884PWWPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 222164Interaction with KAT6A and KAT6BAdd
BLAST
Regioni501 – 821321Interaction with MEAF6 and ING5Add
BLAST
Regioni543 – 1079537Required for RUNX1 and RUNX2 transcriptional activationAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.
Contains 1 PWWP domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 4727C2H2-typeAdd
BLAST
Zinc fingeri273 – 32351PHD-typeAdd
BLAST
Zinc fingeri386 – 40015C4-typeAdd
BLAST

Keywords - Domaini

Bromodomain, Zinc-finger

Phylogenomic databases

eggNOGiCOG5141.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
KOiK11348.
OMAiPIPQEIF.
OrthoDBiEOG7FBRM7.
PhylomeDBiP55201.
TreeFamiTF316118.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P55201-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP     50
PPPQQTPLRK HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE 100
VDLHGRVHRI SIFDNLDVVS EDEEAPEEAP ENGSNKENTE TPAATPKSGK 150
HKNKEKRKDS NHHHHHNVSA STTPKLPEVV YRELEQDTPD APPRPTSYYR 200
YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI PQEIFEYLMD 250
RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV 300
HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH 350
VVCALWIPEV CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC 400
HKANCYTAFH VTCAQQAGLY MKMEPVRETG ANGTSFSVRK TAYCDIHTPP 450
GSARRLPALS HSEGEEDEDE EEDEGKGWSS EKVKKAKAKS RIKMKKARKI 500
LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL HSYWTLKRQS 550
RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER 600
ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG 650
NIFSEPVPLS EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI 700
VSNCLKYNAK DTIFYRAAVR LREQGGAVLR QARRQAEKMG IDFETGMHIP 750
HSLAGDEATH HTEDAAEEER LVLLENQKHL PVEEQLKLLL ERLDEVNASK 800
QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS SRGSLTPHPA 850
ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK 900
TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP 950
SSSSDSDSDK STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD 1000
SESSSSSSSS AASDRTSTTP SKQGRGKPSF SRGTFPEDSS EDTSGTENEA 1050
YSVGTGRGVG HSMVRKSLGR GAGWLSEDED SPLDALDLVW AKCRGYPSYP 1100
ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE HLYLVLFFDN 1150
KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS 1200
KVQGEQSSET SDSD 1214
Length:1,214
Mass (Da):137,499
Last modified:October 17, 2006 - v2
Checksum:i618F359F21F4CBF7
GO
Isoform 2 (identifier: P55201-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-660: S → SEVTELD

Show »
Length:1,220
Mass (Da):138,185
Checksum:iA4ECE0FC3638BCE5
GO
Isoform 3 (identifier: P55201-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-765: Missing.

Note: No experimental confirmation available.

Show »
Length:1,213
Mass (Da):137,428
Checksum:iC92CF66AB4788CB6
GO
Isoform 4 (identifier: P55201-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     873-967: Missing.

Note: No experimental confirmation available.

Show »
Length:1,119
Mass (Da):127,363
Checksum:i1DD0F0BFDF1AFDCC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1117 – 11171G → E.
Corresponds to variant rs1042294 [ dbSNP | Ensembl ].
VAR_028232
Natural varianti1193 – 11931H → Q.
Corresponds to variant rs36081837 [ dbSNP | Ensembl ].
VAR_048430

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei660 – 6601S → SEVTELD in isoform 2. VSP_037955
Alternative sequencei765 – 7651Missing in isoform 3. VSP_037956
Alternative sequencei873 – 96795Missing in isoform 4. VSP_037957Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51F → L in BAG57257. 1 Publication
Sequence conflicti299 – 2991A → E in AAB02119. 1 Publication
Sequence conflicti306 – 3061G → D in BAG57257. 1 Publication
Sequence conflicti341 – 3411K → R in BAG57257. 1 Publication
Sequence conflicti729 – 7291L → V in AAB02119. 1 Publication
Sequence conflicti1035 – 10351F → S in BAG57257. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91585 mRNA. Translation: AAB02119.1.
AF176815 Genomic DNA. Translation: AAF19605.1.
AK293865 mRNA. Translation: BAG57257.1.
AL713696 mRNA. Translation: CAD28495.1.
AC022382 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63976.1.
BC053851 mRNA. Translation: AAH53851.1.
CCDSiCCDS2575.1. [P55201-1]
CCDS33692.1. [P55201-2]
PIRiJC2069.
RefSeqiNP_001003694.1. NM_001003694.1. [P55201-2]
NP_004625.2. NM_004634.2. [P55201-1]
XP_005265508.1. XM_005265451.1. [P55201-3]
XP_005265510.1. XM_005265453.1. [P55201-4]
UniGeneiHs.1004.

Genome annotation databases

EnsembliENST00000302054; ENSP00000306297; ENSG00000156983. [P55201-1]
ENST00000383829; ENSP00000373340; ENSG00000156983. [P55201-2]
ENST00000424362; ENSP00000398863; ENSG00000156983. [P55201-3]
ENST00000433861; ENSP00000402485; ENSG00000156983. [P55201-4]
ENST00000457855; ENSP00000410210; ENSG00000156983. [P55201-1]
GeneIDi7862.
KEGGihsa:7862.
UCSCiuc003bse.3. human. [P55201-1]
uc003bsf.3. human. [P55201-2]
uc003bsg.3. human. [P55201-3]
uc011ati.2. human. [P55201-4]

Polymorphism databases

DMDMi116241271.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91585 mRNA. Translation: AAB02119.1 .
AF176815 Genomic DNA. Translation: AAF19605.1 .
AK293865 mRNA. Translation: BAG57257.1 .
AL713696 mRNA. Translation: CAD28495.1 .
AC022382 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63976.1 .
BC053851 mRNA. Translation: AAH53851.1 .
CCDSi CCDS2575.1. [P55201-1 ]
CCDS33692.1. [P55201-2 ]
PIRi JC2069.
RefSeqi NP_001003694.1. NM_001003694.1. [P55201-2 ]
NP_004625.2. NM_004634.2. [P55201-1 ]
XP_005265508.1. XM_005265451.1. [P55201-3 ]
XP_005265510.1. XM_005265453.1. [P55201-4 ]
UniGenei Hs.1004.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D9E NMR - A 633-740 [» ]
2RS9 NMR - B 633-740 [» ]
2X35 X-ray 2.00 A 1076-1205 [» ]
2X4W X-ray 1.50 A 1076-1205 [» ]
2X4X X-ray 1.85 A/C/E/G 1076-1205 [» ]
2X4Y X-ray 1.70 A/C/E/G/I/K/M/O 1076-1205 [» ]
3L42 X-ray 1.30 A 1079-1207 [» ]
3MO8 X-ray 1.69 A 1079-1207 [» ]
4LC2 X-ray 1.65 A 626-740 [» ]
ProteinModelPortali P55201.
SMRi P55201. Positions 269-326, 376-452, 627-740, 1079-1205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113614. 8 interactions.
DIPi DIP-59001N.
IntActi P55201. 2 interactions.
STRINGi 9606.ENSP00000373340.

PTM databases

PhosphoSitei P55201.

Polymorphism databases

DMDMi 116241271.

Proteomic databases

MaxQBi P55201.
PaxDbi P55201.
PRIDEi P55201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302054 ; ENSP00000306297 ; ENSG00000156983 . [P55201-1 ]
ENST00000383829 ; ENSP00000373340 ; ENSG00000156983 . [P55201-2 ]
ENST00000424362 ; ENSP00000398863 ; ENSG00000156983 . [P55201-3 ]
ENST00000433861 ; ENSP00000402485 ; ENSG00000156983 . [P55201-4 ]
ENST00000457855 ; ENSP00000410210 ; ENSG00000156983 . [P55201-1 ]
GeneIDi 7862.
KEGGi hsa:7862.
UCSCi uc003bse.3. human. [P55201-1 ]
uc003bsf.3. human. [P55201-2 ]
uc003bsg.3. human. [P55201-3 ]
uc011ati.2. human. [P55201-4 ]

Organism-specific databases

CTDi 7862.
GeneCardsi GC03P009781.
HGNCi HGNC:14255. BRPF1.
HPAi HPA003359.
MIMi 602410. gene.
neXtProti NX_P55201.
PharmGKBi PA25424.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5141.
HOGENOMi HOG000000705.
HOVERGENi HBG004895.
KOi K11348.
OMAi PIPQEIF.
OrthoDBi EOG7FBRM7.
PhylomeDBi P55201.
TreeFami TF316118.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

EvolutionaryTracei P55201.
GenomeRNAii 7862.
NextBioi 30302.
PROi P55201.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55201.
Bgeei P55201.
CleanExi HS_BRPF1.
Genevestigatori P55201.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProi IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID."
    Thompson K.A., Wang B., Argraves W.S., Giancotti F.G., Schranck D.P., Ruoslahti E.
    Biochem. Biophys. Res. Commun. 198:1143-1152(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Sequencing and analyzing of BAC DNA on 3p26."
    Hu S.N., Dong W., Zeng Y.X., Yu J., Yang H.M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-462, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."
    Doyon Y., Cayrou C., Ullah M., Landry A.-J., Cote V., Selleck W., Lane W.S., Tan S., Yang X.-J., Cote J.
    Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX.
  10. Cited for: FUNCTION, IDENTIFICATION IN THE MOZ/MORF COMPLEX, INTERACTION WITH ING5; MEAF6; KAT6A AND KAT6B, SUBCELLULAR LOCATION, ACETYLATION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-1187, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462 AND SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460; SER-462; SER-860 AND SER-1076, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Solution structure of the bromodomain of peregrin."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 633-740.
  17. Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1076-1205 IN COMPLEX WITH HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.
  18. "Structural and histone binding ability characterizations of human PWWP domains."
    Wu H., Zeng H., Lam R., Tempel W., Amaya M.F., Xu C., Dombrovski L., Qiu W., Wang Y., Min J.
    PLoS ONE 6:E18919-E18919(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 1079-1207 IN COMPLEX WITH TRIMETHYLATED HISTONE H3 PEPTIDE, INTERACTION WITH HISTONE H3.

Entry informationi

Entry nameiBRPF1_HUMAN
AccessioniPrimary (citable) accession number: P55201
Secondary accession number(s): B4DEZ6
, Q7Z6E0, Q8TCM6, Q9UHI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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