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Protein

Peregrin

Gene

BRPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri273 – 323PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri327 – 360C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri384 – 448PHD-type 2PROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Peregrin
Alternative name(s):
Bromodomain and PHD finger-containing protein 1
Protein Br140
Gene namesi
Name:BRPF1
Synonyms:BR140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14255. BRPF1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • MOZ/MORF histone acetyltransferase complex Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7862.
OpenTargetsiENSG00000156983.
PharmGKBiPA25424.

Chemistry databases

ChEMBLiCHEMBL3132741.
GuidetoPHARMACOLOGYi2730.

Polymorphism and mutation databases

BioMutaiBRPF1.
DMDMi116241271.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111871 – 1214PeregrinAdd BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei860PhosphoserineCombined sources1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1187PhosphoserineCombined sources1

Post-translational modificationi

Acetylated by KAT6A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP55201.
MaxQBiP55201.
PaxDbiP55201.
PeptideAtlasiP55201.
PRIDEiP55201.
TopDownProteomicsiP55201-2. [P55201-2]

PTM databases

iPTMnetiP55201.
PhosphoSitePlusiP55201.

Expressioni

Tissue specificityi

High levels in testis.

Gene expression databases

BgeeiENSG00000156983.
CleanExiHS_BRPF1.
ExpressionAtlasiP55201. baseline and differential.
GenevisibleiP55201. HS.

Organism-specific databases

HPAiHPA003359.

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HIST1H2AMP0C0S88EBI-2837428,EBI-1390628
HIST2H4BP628058EBI-2837428,EBI-302023

Protein-protein interaction databases

BioGridi113614. 24 interactors.
DIPiDIP-59001N.
IntActiP55201. 24 interactors.
STRINGi9606.ENSP00000373340.

Chemistry databases

BindingDBiP55201.

Structurei

Secondary structure

11214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni277 – 279Combined sources3
Beta strandi286 – 288Combined sources3
Beta strandi290 – 292Combined sources3
Turni294 – 296Combined sources3
Beta strandi299 – 301Combined sources3
Helixi302 – 305Combined sources4
Helixi318 – 321Combined sources4
Beta strandi324 – 326Combined sources3
Beta strandi340 – 343Combined sources4
Beta strandi348 – 350Combined sources3
Helixi351 – 356Combined sources6
Beta strandi361 – 364Combined sources4
Turni365 – 368Combined sources4
Beta strandi369 – 372Combined sources4
Helixi374 – 376Combined sources3
Helixi380 – 383Combined sources4
Turni387 – 389Combined sources3
Beta strandi392 – 395Combined sources4
Helixi411 – 416Combined sources6
Beta strandi420 – 424Combined sources5
Beta strandi439 – 443Combined sources5
Helixi625 – 627Combined sources3
Helixi630 – 646Combined sources17
Beta strandi653 – 655Combined sources3
Turni659 – 661Combined sources3
Helixi665 – 668Combined sources4
Helixi675 – 683Combined sources9
Helixi690 – 707Combined sources18
Beta strandi710 – 712Combined sources3
Helixi713 – 736Combined sources24
Beta strandi1081 – 1083Combined sources3
Beta strandi1088 – 1091Combined sources4
Beta strandi1099 – 1104Combined sources6
Beta strandi1113 – 1115Combined sources3
Beta strandi1118 – 1120Combined sources3
Helixi1125 – 1137Combined sources13
Beta strandi1138 – 1140Combined sources3
Beta strandi1142 – 1149Combined sources8
Beta strandi1154 – 1158Combined sources5
Helixi1159 – 1161Combined sources3
Beta strandi1162 – 1167Combined sources6
Helixi1169 – 1176Combined sources8
Helixi1182 – 1202Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ENMR-A633-740[»]
2RS9NMR-B633-740[»]
2X35X-ray2.00A1076-1205[»]
2X4WX-ray1.50A1076-1205[»]
2X4XX-ray1.85A/C/E/G1076-1205[»]
2X4YX-ray1.70A/C/E/G/I/K/M/O1076-1205[»]
3L42X-ray1.30A1079-1207[»]
3MO8X-ray1.69A1079-1207[»]
4LC2X-ray1.65A626-740[»]
4QYDX-ray1.94A629-742[»]
4QYLX-ray1.80A/B/C/D629-742[»]
4UYEX-ray1.65A/B622-738[»]
5C6SX-ray1.30A1079-1207[»]
5C7NX-ray1.75A626-740[»]
5C85X-ray1.70A626-740[»]
5C87X-ray1.55A626-740[»]
5C89X-ray1.65A627-740[»]
5D7XX-ray1.35A626-740[»]
5DY7X-ray1.69A626-740[»]
5DYAX-ray1.65A626-740[»]
5DYCX-ray1.65A626-740[»]
5E3DX-ray1.71A626-740[»]
5E3GX-ray1.65A626-740[»]
5EM3X-ray1.40A626-740[»]
5EPRX-ray1.65A626-740[»]
5EPSX-ray1.47A627-740[»]
5EQ1X-ray1.55A626-740[»]
5ERCX-ray2.05A274-450[»]
5ETBX-ray1.33A626-740[»]
5ETDX-ray1.40A626-740[»]
5EV9X-ray1.45A626-740[»]
5EVAX-ray1.45A626-740[»]
5EWCX-ray1.75A626-740[»]
5EWDX-ray1.58A626-740[»]
5EWHX-ray1.63A626-740[»]
5FFVX-ray1.30A/B626-740[»]
5FFWX-ray1.50A/B626-740[»]
5FFYX-ray1.55A626-740[»]
5FG4X-ray1.65A626-740[»]
5FG5X-ray1.50A/B626-740[»]
5G4RX-ray1.96A/B/C/D622-738[»]
5G4SX-ray1.60A624-738[»]
ProteinModelPortaliP55201.
SMRiP55201.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55201.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini645 – 715BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1085 – 1168PWWPPROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 222Interaction with KAT6A and KAT6B1 PublicationAdd BLAST164
Regioni501 – 821Interaction with MEAF6 and ING51 PublicationAdd BLAST321
Regioni543 – 1079Required for RUNX1 and RUNX2 transcriptional activationAdd BLAST537

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 47C2H2-typePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri273 – 323PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri327 – 360C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri384 – 448PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiP55201.
KOiK11348.
OMAiSPSREVM.
OrthoDBiEOG091G00VK.
PhylomeDBiP55201.
TreeFamiTF316118.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVDFDVKTF CHNLRATKPP YECPVETCRK VYKSYSGIEY HLYHYDHDNP
60 70 80 90 100
PPPQQTPLRK HKKKGRQSRP ANKQSPSPSE VSQSPGREVM SYAQAQRMVE
110 120 130 140 150
VDLHGRVHRI SIFDNLDVVS EDEEAPEEAP ENGSNKENTE TPAATPKSGK
160 170 180 190 200
HKNKEKRKDS NHHHHHNVSA STTPKLPEVV YRELEQDTPD APPRPTSYYR
210 220 230 240 250
YIEKSAEELD EEVEYDMDEE DYIWLDIMNE RRKTEGVSPI PQEIFEYLMD
260 270 280 290 300
RLEKESYFES HNKGDPNALV DEDAVCCICN DGECQNSNVI LFCDMCNLAV
310 320 330 340 350
HQECYGVPYI PEGQWLCRRC LQSPSRAVDC ALCPNKGGAF KQTDDGRWAH
360 370 380 390 400
VVCALWIPEV CFANTVFLEP IDSIEHIPPA RWKLTCYICK QRGSGACIQC
410 420 430 440 450
HKANCYTAFH VTCAQQAGLY MKMEPVRETG ANGTSFSVRK TAYCDIHTPP
460 470 480 490 500
GSARRLPALS HSEGEEDEDE EEDEGKGWSS EKVKKAKAKS RIKMKKARKI
510 520 530 540 550
LAEKRAAAPV VSVPCIPPHR LSKITNRLTI QRKSQFMQRL HSYWTLKRQS
560 570 580 590 600
RNGVPLLRRL QTHLQSQRNC DQVGRDSEDK NWALKEQLKS WQRLRHDLER
610 620 630 640 650
ARLLVELIRK REKLKRETIK VQQIAMEMQL TPFLILLRKT LEQLQEKDTG
660 670 680 690 700
NIFSEPVPLS EVPDYLDHIK KPMDFFTMKQ NLEAYRYLNF DDFEEDFNLI
710 720 730 740 750
VSNCLKYNAK DTIFYRAAVR LREQGGAVLR QARRQAEKMG IDFETGMHIP
760 770 780 790 800
HSLAGDEATH HTEDAAEEER LVLLENQKHL PVEEQLKLLL ERLDEVNASK
810 820 830 840 850
QSVGRSRRAK MIKKEMTALR RKLAHQRETG RDGPERHGPS SRGSLTPHPA
860 870 880 890 900
ACDKDGQTDS AAEESSSQET SKGLGPNMSS TPAHEVGRRT SVLFSKKNPK
910 920 930 940 950
TAGPPKRPGR PPKNRESQMT PSHGGSPVGP PQLPIMSSLR QRKRGRSPRP
960 970 980 990 1000
SSSSDSDSDK STEDPPMDLP ANGFSGGNQP VKKSFLVYRN DCSLPRSSSD
1010 1020 1030 1040 1050
SESSSSSSSS AASDRTSTTP SKQGRGKPSF SRGTFPEDSS EDTSGTENEA
1060 1070 1080 1090 1100
YSVGTGRGVG HSMVRKSLGR GAGWLSEDED SPLDALDLVW AKCRGYPSYP
1110 1120 1130 1140 1150
ALIIDPKMPR EGMFHHGVPI PVPPLEVLKL GEQMTQEARE HLYLVLFFDN
1160 1170 1180 1190 1200
KRTWQWLPRT KLVPLGVNQD LDKEKMLEGR KSNIRKSVQI AYHRALQHRS
1210
KVQGEQSSET SDSD
Length:1,214
Mass (Da):137,499
Last modified:October 17, 2006 - v2
Checksum:i618F359F21F4CBF7
GO
Isoform 2 (identifier: P55201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     660-660: S → SEVTELD

Show »
Length:1,220
Mass (Da):138,185
Checksum:iA4ECE0FC3638BCE5
GO
Isoform 3 (identifier: P55201-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-765: Missing.

Note: No experimental confirmation available.
Show »
Length:1,213
Mass (Da):137,428
Checksum:iC92CF66AB4788CB6
GO
Isoform 4 (identifier: P55201-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     873-967: Missing.

Note: No experimental confirmation available.
Show »
Length:1,119
Mass (Da):127,363
Checksum:i1DD0F0BFDF1AFDCC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5F → L in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti299A → E in AAB02119 (PubMed:7906940).Curated1
Sequence conflicti306G → D in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti341K → R in BAG57257 (PubMed:14702039).Curated1
Sequence conflicti729L → V in AAB02119 (PubMed:7906940).Curated1
Sequence conflicti1035F → S in BAG57257 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0282321117G → E.Corresponds to variant rs1042294dbSNPEnsembl.1
Natural variantiVAR_0484301193H → Q.Corresponds to variant rs36081837dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037955660S → SEVTELD in isoform 2. 1 Publication1
Alternative sequenceiVSP_037956765Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_037957873 – 967Missing in isoform 4. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91585 mRNA. Translation: AAB02119.1.
AF176815 Genomic DNA. Translation: AAF19605.1.
AK293865 mRNA. Translation: BAG57257.1.
AL713696 mRNA. Translation: CAD28495.1.
AC022382 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63976.1.
BC053851 mRNA. Translation: AAH53851.1.
CCDSiCCDS2575.1. [P55201-1]
CCDS33692.1. [P55201-2]
CCDS82729.1. [P55201-4]
CCDS82730.1. [P55201-3]
PIRiJC2069.
RefSeqiNP_001003694.1. NM_001003694.1. [P55201-2]
NP_001305978.1. NM_001319049.1. [P55201-4]
NP_001305979.1. NM_001319050.1. [P55201-3]
NP_004625.2. NM_004634.2. [P55201-1]
UniGeneiHs.1004.

Genome annotation databases

EnsembliENST00000383829; ENSP00000373340; ENSG00000156983. [P55201-2]
ENST00000424362; ENSP00000398863; ENSG00000156983. [P55201-3]
ENST00000433861; ENSP00000402485; ENSG00000156983. [P55201-4]
ENST00000457855; ENSP00000410210; ENSG00000156983. [P55201-1]
GeneIDi7862.
KEGGihsa:7862.
UCSCiuc003bsf.4. human. [P55201-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91585 mRNA. Translation: AAB02119.1.
AF176815 Genomic DNA. Translation: AAF19605.1.
AK293865 mRNA. Translation: BAG57257.1.
AL713696 mRNA. Translation: CAD28495.1.
AC022382 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63976.1.
BC053851 mRNA. Translation: AAH53851.1.
CCDSiCCDS2575.1. [P55201-1]
CCDS33692.1. [P55201-2]
CCDS82729.1. [P55201-4]
CCDS82730.1. [P55201-3]
PIRiJC2069.
RefSeqiNP_001003694.1. NM_001003694.1. [P55201-2]
NP_001305978.1. NM_001319049.1. [P55201-4]
NP_001305979.1. NM_001319050.1. [P55201-3]
NP_004625.2. NM_004634.2. [P55201-1]
UniGeneiHs.1004.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ENMR-A633-740[»]
2RS9NMR-B633-740[»]
2X35X-ray2.00A1076-1205[»]
2X4WX-ray1.50A1076-1205[»]
2X4XX-ray1.85A/C/E/G1076-1205[»]
2X4YX-ray1.70A/C/E/G/I/K/M/O1076-1205[»]
3L42X-ray1.30A1079-1207[»]
3MO8X-ray1.69A1079-1207[»]
4LC2X-ray1.65A626-740[»]
4QYDX-ray1.94A629-742[»]
4QYLX-ray1.80A/B/C/D629-742[»]
4UYEX-ray1.65A/B622-738[»]
5C6SX-ray1.30A1079-1207[»]
5C7NX-ray1.75A626-740[»]
5C85X-ray1.70A626-740[»]
5C87X-ray1.55A626-740[»]
5C89X-ray1.65A627-740[»]
5D7XX-ray1.35A626-740[»]
5DY7X-ray1.69A626-740[»]
5DYAX-ray1.65A626-740[»]
5DYCX-ray1.65A626-740[»]
5E3DX-ray1.71A626-740[»]
5E3GX-ray1.65A626-740[»]
5EM3X-ray1.40A626-740[»]
5EPRX-ray1.65A626-740[»]
5EPSX-ray1.47A627-740[»]
5EQ1X-ray1.55A626-740[»]
5ERCX-ray2.05A274-450[»]
5ETBX-ray1.33A626-740[»]
5ETDX-ray1.40A626-740[»]
5EV9X-ray1.45A626-740[»]
5EVAX-ray1.45A626-740[»]
5EWCX-ray1.75A626-740[»]
5EWDX-ray1.58A626-740[»]
5EWHX-ray1.63A626-740[»]
5FFVX-ray1.30A/B626-740[»]
5FFWX-ray1.50A/B626-740[»]
5FFYX-ray1.55A626-740[»]
5FG4X-ray1.65A626-740[»]
5FG5X-ray1.50A/B626-740[»]
5G4RX-ray1.96A/B/C/D622-738[»]
5G4SX-ray1.60A624-738[»]
ProteinModelPortaliP55201.
SMRiP55201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113614. 24 interactors.
DIPiDIP-59001N.
IntActiP55201. 24 interactors.
STRINGi9606.ENSP00000373340.

Chemistry databases

BindingDBiP55201.
ChEMBLiCHEMBL3132741.
GuidetoPHARMACOLOGYi2730.

PTM databases

iPTMnetiP55201.
PhosphoSitePlusiP55201.

Polymorphism and mutation databases

BioMutaiBRPF1.
DMDMi116241271.

Proteomic databases

EPDiP55201.
MaxQBiP55201.
PaxDbiP55201.
PeptideAtlasiP55201.
PRIDEiP55201.
TopDownProteomicsiP55201-2. [P55201-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383829; ENSP00000373340; ENSG00000156983. [P55201-2]
ENST00000424362; ENSP00000398863; ENSG00000156983. [P55201-3]
ENST00000433861; ENSP00000402485; ENSG00000156983. [P55201-4]
ENST00000457855; ENSP00000410210; ENSG00000156983. [P55201-1]
GeneIDi7862.
KEGGihsa:7862.
UCSCiuc003bsf.4. human. [P55201-1]

Organism-specific databases

CTDi7862.
DisGeNETi7862.
GeneCardsiBRPF1.
HGNCiHGNC:14255. BRPF1.
HPAiHPA003359.
MIMi602410. gene.
neXtProtiNX_P55201.
OpenTargetsiENSG00000156983.
PharmGKBiPA25424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiP55201.
KOiK11348.
OMAiSPSREVM.
OrthoDBiEOG091G00VK.
PhylomeDBiP55201.
TreeFamiTF316118.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Miscellaneous databases

ChiTaRSiBRPF1. human.
EvolutionaryTraceiP55201.
GenomeRNAii7862.
PROiP55201.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156983.
CleanExiHS_BRPF1.
ExpressionAtlasiP55201. baseline and differential.
GenevisibleiP55201. HS.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR007087. Znf_C2H2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRPF1_HUMAN
AccessioniPrimary (citable) accession number: P55201
Secondary accession number(s): B4DEZ6
, Q7Z6E0, Q8TCM6, Q9UHI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.