Reviewed, UniProtKB/Swiss-Prot P55200 (HRX_MOUSE)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase HRX
    EC=2.1.1.43
Alternative name(s):
    Zinc finger protein HRX
    ALL-1

Gene names

Name:	Mll
Synonyms:	All1, Hrx, Mll1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	3966 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Promotes PPP1R15A-induced apoptosis. May regulate genes involved in skeletal formation during embryonic development.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subunit structure	Interacts with SBF1 and PPP1R15A. Component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 3 A.T hook DNA-binding domains. Contains 1 bromo domain. Contains 1 CXXC-type zinc finger. Contains 3 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Repeat Zinc-finger
Ligand	DNA-binding Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	DNA methylation Inferred from mutant phenotype. Source: MGI anterior/posterior pattern formation Inferred from mutant phenotype. Source: MGI chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW embryonic hemopoiesis Inferred from mutant phenotype. Source: MGI negative regulation of cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction. Source: MGI regulation of histone H3-K4 methylation Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	histone methyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from direct assay. Source: MGI histone methyltransferase activity (H3-K4 specific) Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: MGI zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P55200-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P55200-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1603-1605: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3966	3966	Histone-lysine N-methyltransferase HRX		PRO_0000124877
Regions
	Domain	1705 – 1750	46	Bromo; divergent
	Domain	3825 – 3946	122	SET
	Domain	3950 – 3966	17	Post-SET
	DNA binding	167 – 178	12	A.T hook 1
	DNA binding	215 – 225	11	A.T hook 2
	DNA binding	299 – 307	9	A.T hook 3
	Zinc finger	1144 – 1192	49	CXXC-type
	Zinc finger	1430 – 1481	52	PHD-type 1
	Zinc finger	1478 – 1532	55	PHD-type 2
	Zinc finger	1565 – 1629	65	PHD-type 3
	Compositional bias	14 – 150	137	Gly-rich
	Compositional bias	80 – 99	20	Ser-rich
	Compositional bias	199 – 287	89	Lys-rich
	Compositional bias	443 – 491	49	Ser-rich
	Compositional bias	559 – 601	43	Pro-rich
	Compositional bias	703 – 807	105	Ser-rich
	Compositional bias	1234 – 1366	133	Pro-rich
	Compositional bias	1819 – 1867	49	Pro-rich
	Compositional bias	2185 – 2320	136	Ser-rich
Amino acid modifications
	Modified residue	134	1	Phosphoserine By similarity
	Modified residue	151	1	Phosphoserine By similarity
	Modified residue	195	1	Phosphoserine By similarity
	Modified residue	200	1	Phosphoserine By similarity
	Modified residue	277	1	Phosphoserine By similarity
	Modified residue	335	1	Phosphothreonine By similarity
	Modified residue	504	1	Phosphothreonine By similarity
	Modified residue	516	1	Phosphoserine By similarity
	Modified residue	634	1	N6-acetyllysine By similarity
	Modified residue	678	1	Phosphoserine By similarity
	Modified residue	829	1	Phosphoserine By similarity
	Modified residue	837	1	Phosphothreonine By similarity
	Modified residue	923	1	Phosphoserine By similarity
	Modified residue	1053	1	Phosphoserine By similarity
	Modified residue	1127	1	N6-acetyllysine By similarity
	Modified residue	1232	1	N6-acetyllysine By similarity
	Modified residue	1839	1	Phosphoserine By similarity
	Modified residue	1841	1	Phosphothreonine By similarity
	Modified residue	1847	1	Phosphothreonine By similarity
	Modified residue	2100	1	Phosphoserine By similarity
	Modified residue	2148	1	Phosphothreonine By similarity
	Modified residue	2152	1	Phosphoserine By similarity
	Modified residue	2154	1	Phosphothreonine By similarity
	Modified residue	2521	1	Phosphothreonine By similarity
	Modified residue	2687	1	Phosphoserine By similarity
	Modified residue	2725	1	Phosphoserine By similarity
	Modified residue	2862	1	Phosphoserine By similarity
	Modified residue	2936	1	Phosphothreonine By similarity
	Modified residue	2951	1	Phosphoserine By similarity
	Modified residue	3032	1	Phosphoserine By similarity
	Modified residue	3369	1	Phosphothreonine By similarity
	Modified residue	3510	1	Phosphoserine By similarity
	Modified residue	3514	1	Phosphoserine By similarity
	Cross-link	214		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	218		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
	Cross-link	219		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Natural variations
	Alternative sequence	1603 – 1605	3	Missing in isoform 2.		VSP_006667
	Natural variant	1597	1	K → T
Experimental info
	Sequence conflict	372	1	Q → E in BAE28820. Ref.3
	Sequence conflict	554	1	Q → K in AAA62593. Ref.2
	Sequence conflict	564	1	L → F in AAA62593. Ref.2
	Sequence conflict	797	1	P → S in BAE28820. Ref.3
	Sequence conflict	806	1	E → D in AAA62593. Ref.2
	Sequence conflict	806	1	E → D in BAE28820. Ref.3
	Sequence conflict	821	1	L → P in AAA62593. Ref.2
	Sequence conflict	821	1	L → P in BAE28820. Ref.3
	Sequence conflict	1069	1	C → Y in AAA62593. Ref.2
	Sequence conflict	1230	1	A → S in AAA62593. Ref.2
	Sequence conflict	1349	1	R → L in AAA62593. Ref.2
	Sequence conflict	1437	1	A → S in AAA62593. Ref.2
	Sequence conflict	1440	1	G → E in AAA62593. Ref.2
	Sequence conflict	1632	1	A → P in AAA62593. Ref.2
	Sequence conflict	2292	1	S → L in AAA62593. Ref.2
	Sequence conflict	3481	1	N → I in AAA62593. Ref.2
	Sequence conflict	3493	1	R → S in AAA62593. Ref.2
	Sequence conflict	3548	1	G → V in AAA62593. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: E22AE6367B5032AC	FASTA	3,966	429,649
	10 20 30 40 50 60 MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPQAGGGG PGAPPSPPAV 70 80 90 100 110 120 AAAAAGSSGA GVPGGAAAAS AASSSSASSS SSSSSSASSG PALLRVGPGF DAALQVSAAI 130 140 150 160 170 180 GTNLRRFRAV FGESGGGGGS GEDEQFLGFG SDEEVRVRSP TRSPSVKASP RKPRGRPRSG 190 200 210 220 230 240 SDRNPAILSD PSVFSPLNKS ETKSADKIKK KDSKSIEKKR GRPPTFPGVK IKITHGKDIA 250 260 270 280 290 300 ELTQGSKEDS LKKVKRTPSA MFQQATKIKK LRAGKLSPLK SKFKTGKLQI GRKGVQIVRR 310 320 330 340 350 360 RGRPPSTERI KTPSGLLINS ELEKPQKVRK DKEGTPPLTK EDKTVVRQSP RRIKPVRIIP 370 380 390 400 410 420 SCKRTDATIA KQLLQRAKKG AQKKIEKEAA QLQGRKVKTQ VKNIRQFIMP VVSAISSRII 430 440 450 460 470 480 KTPRRFIEDE DYDPPMKIAR LESTPNSRFS ATSCGSSEKS SAASQHSSQM SSDSSRSSSP 490 500 510 520 530 540 SIDTTSDSQA SEEIQALPEE RSNTPEVHTP LPISQSPENE SNDRRSRRYS MSERSFGSRA 550 560 570 580 590 600 TKKLPTLQSA PQQQTSSSPP PPLLTPPPPL QPASGISDHT PWLMPPTIPL ASPFLPASAA 610 620 630 640 650 660 PMQGKRKSIL REPTFRWTSL KHSRSEPQYF SSAKYAKEGL IRKPIFDNFR PPPLTPEDVG 670 680 690 700 710 720 FASGFSASGT AASARLFSPL HSGTRFDIHK RSPILRAPRF TPSEAHSRIF ESVTLPSNRT 730 740 750 760 770 780 SSGASSSGVS NRKRKRKVFS PIRSEPRSPS HSMRTRSGRL STSELSPLTP PSSVSSSLSI 790 800 810 820 830 840 PVSPLAASAL NPTFTFPSHS LTQSGESTEK NQRARKQTSA LAEPFSSNSP ALFPWFTPGS 850 860 870 880 890 900 QTEKGRKKDT APEELSKDRD ADKSVEKDKS RERDREREKE NKRESRKEKR KKGSDIQSSS 910 920 930 940 950 960 ALYPVGRVSK EKVAGEDVGT SSSAKKATGR KKSSSLDSGA DVAPVTLGDT TAVKAKILIK 970 980 990 1000 1010 1020 KGRGNLEKNN LDLGPAAPSL EKERTPCLSA PSSSTVKHST SSIGSMLAQA DKLPMTDKRV 1030 1040 1050 1060 1070 1080 ASLLKKAKAQ LCKIEKSKSL KQTDQPKAQG QESDSSETSV RGPRIKHVCR RAAVALGRKR 1090 1100 1110 1120 1130 1140 AVFPDDMPTL SALPWEEREK ILSSMGNDDK SSVAGSEDAE PLAPPIKPIK PVTRNKAPQE 1150 1160 1170 1180 1190 1200 PPVKKGRRSR RCGQCPGCQV PEDCGICTNC LDKPKFGGRN IKKQCCKMRK CQNLQWMPSK 1210 1220 1230 1240 1250 1260 ASLQKQTKAV KKKEKKSKTT EKKESKESTA VKSPLEPAQK AAPPPREEPA PKKSSSEPPP 1270 1280 1290 1300 1310 1320 RKPVEEKSEE GGAPAPAPAP EPKQVSAPAS RKSSKQVSQP AAVVPPQPPS TAPQKKEAPK 1330 1340 1350 1360 1370 1380 AVPSEPKKKQ PPPPEPGPEQ SKQKKVAPRP SIPVKQKPKD KEKPPPVSKQ ENAGTLNILN 1390 1400 1410 1420 1430 1440 PLSNGISSKQ KIPADGVHRI RVDFKEDCEA ENVWEMGGLG ILTSVPITPR VVCFLCASSG 1450 1460 1470 1480 1490 1500 HVEFVYCQVC CEPFHKFCLE ENERPLEDQL ENWCCRRCKF CHVCGRQHQA TKQLLECNKC 1510 1520 1530 1540 1550 1560 RNSYHPECLG PNYPTKPTKK KKVWICTKCV RCKSCGSTTP GKGWDAQWSH DFSLCHDCAK 1570 1580 1590 1600 1610 1620 LFAKGNFCPL CDKCYDDDDY ESKMMQCGKC DRWVHSKCES LSGTEDEMYE ILSNLPESVA 1630 1640 1650 1660 1670 1680 YTCVNCTERH PAEWRLALEK ELQASLKQVL TALLNSRTTS HLLRYRQAAK PPDLNPETEE 1690 1700 1710 1720 1730 1740 SIPSRSSPEG PDPPVLTEVS KQDEQQPLDL EGVKKRMDQG SYVSVLEFSD DIVKIIQAAI 1750 1760 1770 1780 1790 1800 NSDGGQPEIK KANSMVKSFF IRQMERVFPW FSVKKSRFWE PNKVSNNSGM LPNAVLPPSL 1810 1820 1830 1840 1850 1860 DHNYAQWQER EESSHTEQPP LMKKIIPAPK PKGPGEPDSP TPLHPPTPPI LSTDRSREDS 1870 1880 1890 1900 1910 1920 PELNPPPGID DNRQCALCLM YGDDSANDAG RLLYIGQNEW THVNCALWSA EVFEDDDGSL 1930 1940 1950 1960 1970 1980 KNVHMAVIRG KQLRCEFCQK PGATVGCCLT SCTSNYHFMC SRAKNCVFLD DKKVYCQRHR 1990 2000 2010 2020 2030 2040 DLIKGEVVPE NGFEVFRRVF VDFEGISLRR KFLNGLEPEN IHMMIGSMTI DCLGILNDLS 2050 2060 2070 2080 2090 2100 DCEDKLFPIG YQCSRVYWST TDARKRCVYT CKIMECRPPV VEPDINSTVE HDDNRTIAHS 2110 2120 2130 2140 2150 2160 PSSFIDASCK DSQSTAAILS PPSPDRPHSQ TSGSCYYHVI SKVPRIRTPS YSPTQRSPGC 2170 2180 2190 2200 2210 2220 RPLPSAGSPT PTTHEIVTVG DPLLSSGLRS IGSRRHSTSS LSPLRSKLRI MSPVRTGSAY 2230 2240 2250 2260 2270 2280 SRSSVSSVPS LGTATDPEAS AKASDRGGLL SSSANLGHSA PPSSSSQRTV GGSKTSHLDG 2290 2300 2310 2320 2330 2340 SSPSEVKRCS ASDLVPKGSL VKGEKNRTSS SKSTDGSAHS TAYPGIPKLT PQVHNATPGE 2350 2360 2370 2380 2390 2400 LNISKIGSFA EPSTVPFSSK DTVSYPQLHL RGQRSDRDQH MDPSQSVKPS PNEDGEIKTL 2410 2420 2430 2440 2450 2460 KLPGMGHRPS ILHEHIGSSS RDRRQKGKKS SKETCKEKHS SKSYLEPGQV TTGEEGNLKP 2470 2480 2490 2500 2510 2520 EFADEVLTPG FLGQRPCNNV SSEKIGDKVL PLSGVPKGQS TQVEGSSKEL QAPRKCSVKV 2530 2540 2550 2560 2570 2580 TPLKMEGENQ SKNTQKESGP GSPAHIESVC PAEPVSASRS PGAGPGVQPS PNNTLSQDPQ 2590 2600 2610 2620 2630 2640 SNNYQNLPEQ DRNLMIPDGP KPQEDGSFKR RYPRRSARAR SNMFFGLTPL YGVRSYGEED 2650 2660 2670 2680 2690 2700 IPFYSNSTGK KRGKRSAEGQ VDGADDLSTS DEDDLYYYNF TRTVISSGGE ERLASHNLFR 2710 2720 2730 2740 2750 2760 EEEQCDLPKI SQLDGVDDGT ESDTSVTATS RKSSQIPKRN GKENGTENLK IDRPEDAGEK 2770 2780 2790 2800 2810 2820 EHVIKSAVGH KNEPKLDNCH SVSRVKAQGQ DSLEAQLSSL ESSRRVHTST PSDKNLLDTY 2830 2840 2850 2860 2870 2880 NAELLKSDSD NNNSDDCGNI LPSDIMDFVL KNTPSMQALG ESPESSSSEL LTLGEGLGLD 2890 2900 2910 2920 2930 2940 SNREKDIGLF EVFSQQLPAT EPVDSSVSSS ISAEEQFELP LELPSDLSVL TTRSPTVPSQ 2950 2960 2970 2980 2990 3000 NPSRLAVISD SGEKRVTITE KSVASSEGDP ALLSPGVDPA PEGHMTPDHF IQGHMDADHI 3010 3020 3030 3040 3050 3060 SSPPCGSVEQ GHGNSQDLTR NSGTPGLQVP VSPTVPVQNQ KYVPSSTDSP GPSQISNAAV 3070 3080 3090 3100 3110 3120 QTTPPHLKPA TEKLIVVNQN MQPLYVLQTL PNGVTQKIQL TSPVSSTPSV METNTSVLGP 3130 3140 3150 3160 3170 3180 MGSGLTLTTG LNPSLPPSPS LFPPASKGLL SVPHHQHLHS FPAAAQSSFP PNISSPPSGL 3190 3200 3210 3220 3230 3240 LIGVQPPPDP QLLGSEANQR TDLTTTVATP SSGLKKRPIS RLHTRKNKKL APSSAPSNIA 3250 3260 3270 3280 3290 3300 PSDVVSNMTL INFTPSQLSN HPSLLDLGSL NPSSHRTVPN IIKRSKSGIM YFEQAPLLPP 3310 3320 3330 3340 3350 3360 QSVGGTAATA AGSSTISQDT SHLTSGPVSA LASGSSVLNV VSMQTTAAPT SSTSVPGHVT 3370 3380 3390 3400 3410 3420 LANQRLLGTP DIGSISHLLI KASHQSLGIQ DQPVALPPSS GMFPQLGTSQ TPSAAAMTAA 3430 3440 3450 3460 3470 3480 SSICVLPSSQ TAGMTAASPP GEAEEHYKLQ RGNQLLAGKT GTLTSQRDRD PDSAPGTQPS 3490 3500 3510 3520 3530 3540 NFTQTAEAPN GVRLEQNKTL PSAKPASSAS PGSSPSSGQQ SGSSSVPGPT KPKPKAKRIQ 3550 3560 3570 3580 3590 3600 LPLDKGSGKK HKVSHLRTSS EAHIPHRDTD PAPQPSVTRT PRANREQQDA AGVEQPSQKE 3610 3620 3630 3640 3650 3660 CGQPAGPVAA LPEVQATQNP ANEQENAEPK AMEEEESGFS SPLMLWLQQE QKRKESITER 3670 3680 3690 3700 3710 3720 KPKKGLVFEI SSDDGFQICA ESIEDAWKSL TDKVQEARSN ARLKQLSFAG VNGLRMLGIL 3730 3740 3750 3760 3770 3780 HDAVVFLIEQ LAGAKHCRNY KFRFHKPEEA NEPPLNPHGS ARAEVHLRKS AFDMFNFLAS 3790 3800 3810 3820 3830 3840 KHRQPPEYNP NDEEEEEVQL KSARRATSMD LPMPMRFRHL KKTSKEAVGV YRSPIHGRGL 3850 3860 3870 3880 3890 3900 FCKRNIDAGE MVIEYAGNVI RSIQTDKREK YYDSKGIGCY MFRIDDSEVV DATMHGNAAR 3910 3920 3930 3940 3950 3960 FINHSCEPNC YSRVINIDGQ KHIVIFAMRK IYRGEELTYD YKFPIEDASN KLPCNCGAKK CRKFLN
	Isoform 2. Checksum: 56E75279720ABEDB	FASTA	3,963	429,362
	10 20 30 40 50 60 MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPQAGGGG PGAPPSPPAV 70 80 90 100 110 120 AAAAAGSSGA GVPGGAAAAS AASSSSASSS SSSSSSASSG PALLRVGPGF DAALQVSAAI 130 140 150 160 170 180 GTNLRRFRAV FGESGGGGGS GEDEQFLGFG SDEEVRVRSP TRSPSVKASP RKPRGRPRSG 190 200 210 220 230 240 SDRNPAILSD PSVFSPLNKS ETKSADKIKK KDSKSIEKKR GRPPTFPGVK IKITHGKDIA 250 260 270 280 290 300 ELTQGSKEDS LKKVKRTPSA MFQQATKIKK LRAGKLSPLK SKFKTGKLQI GRKGVQIVRR 310 320 330 340 350 360 RGRPPSTERI KTPSGLLINS ELEKPQKVRK DKEGTPPLTK EDKTVVRQSP RRIKPVRIIP 370 380 390 400 410 420 SCKRTDATIA KQLLQRAKKG AQKKIEKEAA QLQGRKVKTQ VKNIRQFIMP VVSAISSRII 430 440 450 460 470 480 KTPRRFIEDE DYDPPMKIAR LESTPNSRFS ATSCGSSEKS SAASQHSSQM SSDSSRSSSP 490 500 510 520 530 540 SIDTTSDSQA SEEIQALPEE RSNTPEVHTP LPISQSPENE SNDRRSRRYS MSERSFGSRA 550 560 570 580 590 600 TKKLPTLQSA PQQQTSSSPP PPLLTPPPPL QPASGISDHT PWLMPPTIPL ASPFLPASAA 610 620 630 640 650 660 PMQGKRKSIL REPTFRWTSL KHSRSEPQYF SSAKYAKEGL IRKPIFDNFR PPPLTPEDVG 670 680 690 700 710 720 FASGFSASGT AASARLFSPL HSGTRFDIHK RSPILRAPRF TPSEAHSRIF ESVTLPSNRT 730 740 750 760 770 780 SSGASSSGVS NRKRKRKVFS PIRSEPRSPS HSMRTRSGRL STSELSPLTP PSSVSSSLSI 790 800 810 820 830 840 PVSPLAASAL NPTFTFPSHS LTQSGESTEK NQRARKQTSA LAEPFSSNSP ALFPWFTPGS 850 860 870 880 890 900 QTEKGRKKDT APEELSKDRD ADKSVEKDKS RERDREREKE NKRESRKEKR KKGSDIQSSS 910 920 930 940 950 960 ALYPVGRVSK EKVAGEDVGT SSSAKKATGR KKSSSLDSGA DVAPVTLGDT TAVKAKILIK 970 980 990 1000 1010 1020 KGRGNLEKNN LDLGPAAPSL EKERTPCLSA PSSSTVKHST SSIGSMLAQA DKLPMTDKRV 1030 1040 1050 1060 1070 1080 ASLLKKAKAQ LCKIEKSKSL KQTDQPKAQG QESDSSETSV RGPRIKHVCR RAAVALGRKR 1090 1100 1110 1120 1130 1140 AVFPDDMPTL SALPWEEREK ILSSMGNDDK SSVAGSEDAE PLAPPIKPIK PVTRNKAPQE 1150 1160 1170 1180 1190 1200 PPVKKGRRSR RCGQCPGCQV PEDCGICTNC LDKPKFGGRN IKKQCCKMRK CQNLQWMPSK 1210 1220 1230 1240 1250 1260 ASLQKQTKAV KKKEKKSKTT EKKESKESTA VKSPLEPAQK AAPPPREEPA PKKSSSEPPP 1270 1280 1290 1300 1310 1320 RKPVEEKSEE GGAPAPAPAP EPKQVSAPAS RKSSKQVSQP AAVVPPQPPS TAPQKKEAPK 1330 1340 1350 1360 1370 1380 AVPSEPKKKQ PPPPEPGPEQ SKQKKVAPRP SIPVKQKPKD KEKPPPVSKQ ENAGTLNILN 1390 1400 1410 1420 1430 1440 PLSNGISSKQ KIPADGVHRI RVDFKEDCEA ENVWEMGGLG ILTSVPITPR VVCFLCASSG 1450 1460 1470 1480 1490 1500 HVEFVYCQVC CEPFHKFCLE ENERPLEDQL ENWCCRRCKF CHVCGRQHQA TKQLLECNKC 1510 1520 1530 1540 1550 1560 RNSYHPECLG PNYPTKPTKK KKVWICTKCV RCKSCGSTTP GKGWDAQWSH DFSLCHDCAK 1570 1580 1590 1600 1610 1620 LFAKGNFCPL CDKCYDDDDY ESKMMQCGKC DRWVHSKCES LSDEMYEILS NLPESVAYTC 1630 1640 1650 1660 1670 1680 VNCTERHPAE WRLALEKELQ ASLKQVLTAL LNSRTTSHLL RYRQAAKPPD LNPETEESIP 1690 1700 1710 1720 1730 1740 SRSSPEGPDP PVLTEVSKQD EQQPLDLEGV KKRMDQGSYV SVLEFSDDIV KIIQAAINSD 1750 1760 1770 1780 1790 1800 GGQPEIKKAN SMVKSFFIRQ MERVFPWFSV KKSRFWEPNK VSNNSGMLPN AVLPPSLDHN 1810 1820 1830 1840 1850 1860 YAQWQEREES SHTEQPPLMK KIIPAPKPKG PGEPDSPTPL HPPTPPILST DRSREDSPEL 1870 1880 1890 1900 1910 1920 NPPPGIDDNR QCALCLMYGD DSANDAGRLL YIGQNEWTHV NCALWSAEVF EDDDGSLKNV 1930 1940 1950 1960 1970 1980 HMAVIRGKQL RCEFCQKPGA TVGCCLTSCT SNYHFMCSRA KNCVFLDDKK VYCQRHRDLI 1990 2000 2010 2020 2030 2040 KGEVVPENGF EVFRRVFVDF EGISLRRKFL NGLEPENIHM MIGSMTIDCL GILNDLSDCE 2050 2060 2070 2080 2090 2100 DKLFPIGYQC SRVYWSTTDA RKRCVYTCKI MECRPPVVEP DINSTVEHDD NRTIAHSPSS 2110 2120 2130 2140 2150 2160 FIDASCKDSQ STAAILSPPS PDRPHSQTSG SCYYHVISKV PRIRTPSYSP TQRSPGCRPL 2170 2180 2190 2200 2210 2220 PSAGSPTPTT HEIVTVGDPL LSSGLRSIGS RRHSTSSLSP LRSKLRIMSP VRTGSAYSRS 2230 2240 2250 2260 2270 2280 SVSSVPSLGT ATDPEASAKA SDRGGLLSSS ANLGHSAPPS SSSQRTVGGS KTSHLDGSSP 2290 2300 2310 2320 2330 2340 SEVKRCSASD LVPKGSLVKG EKNRTSSSKS TDGSAHSTAY PGIPKLTPQV HNATPGELNI 2350 2360 2370 2380 2390 2400 SKIGSFAEPS TVPFSSKDTV SYPQLHLRGQ RSDRDQHMDP SQSVKPSPNE DGEIKTLKLP 2410 2420 2430 2440 2450 2460 GMGHRPSILH EHIGSSSRDR RQKGKKSSKE TCKEKHSSKS YLEPGQVTTG EEGNLKPEFA 2470 2480 2490 2500 2510 2520 DEVLTPGFLG QRPCNNVSSE KIGDKVLPLS GVPKGQSTQV EGSSKELQAP RKCSVKVTPL 2530 2540 2550 2560 2570 2580 KMEGENQSKN TQKESGPGSP AHIESVCPAE PVSASRSPGA GPGVQPSPNN TLSQDPQSNN 2590 2600 2610 2620 2630 2640 YQNLPEQDRN LMIPDGPKPQ EDGSFKRRYP RRSARARSNM FFGLTPLYGV RSYGEEDIPF 2650 2660 2670 2680 2690 2700 YSNSTGKKRG KRSAEGQVDG ADDLSTSDED DLYYYNFTRT VISSGGEERL ASHNLFREEE 2710 2720 2730 2740 2750 2760 QCDLPKISQL DGVDDGTESD TSVTATSRKS SQIPKRNGKE NGTENLKIDR PEDAGEKEHV 2770 2780 2790 2800 2810 2820 IKSAVGHKNE PKLDNCHSVS RVKAQGQDSL EAQLSSLESS RRVHTSTPSD KNLLDTYNAE 2830 2840 2850 2860 2870 2880 LLKSDSDNNN SDDCGNILPS DIMDFVLKNT PSMQALGESP ESSSSELLTL GEGLGLDSNR 2890 2900 2910 2920 2930 2940 EKDIGLFEVF SQQLPATEPV DSSVSSSISA EEQFELPLEL PSDLSVLTTR SPTVPSQNPS 2950 2960 2970 2980 2990 3000 RLAVISDSGE KRVTITEKSV ASSEGDPALL SPGVDPAPEG HMTPDHFIQG HMDADHISSP 3010 3020 3030 3040 3050 3060 PCGSVEQGHG NSQDLTRNSG TPGLQVPVSP TVPVQNQKYV PSSTDSPGPS QISNAAVQTT 3070 3080 3090 3100 3110 3120 PPHLKPATEK LIVVNQNMQP LYVLQTLPNG VTQKIQLTSP VSSTPSVMET NTSVLGPMGS 3130 3140 3150 3160 3170 3180 GLTLTTGLNP SLPPSPSLFP PASKGLLSVP HHQHLHSFPA AAQSSFPPNI SSPPSGLLIG 3190 3200 3210 3220 3230 3240 VQPPPDPQLL GSEANQRTDL TTTVATPSSG LKKRPISRLH TRKNKKLAPS SAPSNIAPSD 3250 3260 3270 3280 3290 3300 VVSNMTLINF TPSQLSNHPS LLDLGSLNPS SHRTVPNIIK RSKSGIMYFE QAPLLPPQSV 3310 3320 3330 3340 3350 3360 GGTAATAAGS STISQDTSHL TSGPVSALAS GSSVLNVVSM QTTAAPTSST SVPGHVTLAN 3370 3380 3390 3400 3410 3420 QRLLGTPDIG SISHLLIKAS HQSLGIQDQP VALPPSSGMF PQLGTSQTPS AAAMTAASSI 3430 3440 3450 3460 3470 3480 CVLPSSQTAG MTAASPPGEA EEHYKLQRGN QLLAGKTGTL TSQRDRDPDS APGTQPSNFT 3490 3500 3510 3520 3530 3540 QTAEAPNGVR LEQNKTLPSA KPASSASPGS SPSSGQQSGS SSVPGPTKPK PKAKRIQLPL 3550 3560 3570 3580 3590 3600 DKGSGKKHKV SHLRTSSEAH IPHRDTDPAP QPSVTRTPRA NREQQDAAGV EQPSQKECGQ 3610 3620 3630 3640 3650 3660 PAGPVAALPE VQATQNPANE QENAEPKAME EEESGFSSPL MLWLQQEQKR KESITERKPK 3670 3680 3690 3700 3710 3720 KGLVFEISSD DGFQICAESI EDAWKSLTDK VQEARSNARL KQLSFAGVNG LRMLGILHDA 3730 3740 3750 3760 3770 3780 VVFLIEQLAG AKHCRNYKFR FHKPEEANEP PLNPHGSARA EVHLRKSAFD MFNFLASKHR 3790 3800 3810 3820 3830 3840 QPPEYNPNDE EEEEVQLKSA RRATSMDLPM PMRFRHLKKT SKEAVGVYRS PIHGRGLFCK 3850 3860 3870 3880 3890 3900 RNIDAGEMVI EYAGNVIRSI QTDKREKYYD SKGIGCYMFR IDDSEVVDAT MHGNAARFIN 3910 3920 3930 3940 3950 3960 HSCEPNCYSR VINIDGQKHI VIFAMRKIYR GEELTYDYKF PIEDASNKLP CNCGAKKCRK FLN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases." Ma Q., Alder H., Nelson K.K., Chatterjee D., Gu Y., Nakamura T., Canaani E., Croce C.M., Siracusa L.D., Buchberg A.M. Proc. Natl. Acad. Sci. U.S.A. 90:6350-6354(1993) [PubMed: 8327517] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 101-3966 (ISOFORMS 1 AND 2). Strain: C57BL/6 X CBA and C57BL/6J. Tissue: Lung and Spleen.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 372-1517 (ISOFORM 1). Strain: C57BL/6J. Tissue: Medulla oblongata and Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC061963 Genomic DNA. No translation available. AC142113 Genomic DNA. No translation available. L17069 mRNA. Translation: AAA62593.1. AK140439 mRNA. Translation: BAE24386.1. Different initiation. AK149341 mRNA. Translation: BAE28820.1.
IPI	IPI00230024. IPI00315032.
UniGene	Mm.2389
3D structure databases
SMR	P55200. Positions 1143-1211.
ModBase	Search...
Protein-protein interaction databases
STRING	P55200.
PTM databases
PhosphoSite	P55200.
Proteomic databases
PRIDE	P55200.
Genome annotation databases
Ensembl	ENSMUST00000002095; ENSMUSP00000002095; ENSMUSG00000002028; Mus musculus. [Genome view] ENSMUST00000114689; ENSMUSP00000110337; ENSMUSG00000002028; Mus musculus. [Genome view]
UCSC	uc009pep.1. mouse. uc009peq.1. mouse.
Organism-specific databases
MGI	MGI:96995. Mll1.
Phylogenomic databases
HOGENOM	P55200.
HOVERGEN	P55200.
Gene expression databases
ArrayExpress	P55200.
Bgee	P55200.
CleanEx	MM_MLL1.
Genevestigator	P55200.
GermOnline	ENSMUSG00000002028. Mus musculus.
Family and domain databases
InterPro	IPR017956. AT_hook_DNA-bd_motif. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR003889. FYrich_C. IPR018516. FYrich_C_sg. IPR003888. FYrich_N. IPR018518. FYrich_N_sg. IPR016569. MeTrfase_trithorax. IPR003616. Post-SET_Zn_bd. IPR001214. SET. IPR019786. Zinc_finger_PHD-type_CS. IPR002857. Znf_CXXC. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF02178. AT_hook. 1 hit. PF05965. FYRC. 1 hit. PF05964. FYRN. 1 hit. PF00628. PHD. 3 hits. PF00856. SET. 1 hit. PF02008. zf-CXXC. 1 hit. [Graphical view]
PIRSF	PIRSF010354. Methyltransferase_trithorax. 1 hit.
SMART	SM00384. AT_hook. 3 hits. SM00297. BROMO. 1 hit. SM00542. FYRC. 1 hit. SM00541. FYRN. 1 hit. SM00249. PHD. 4 hits. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS00633. BROMODOMAIN_1. False negative. PS50014. BROMODOMAIN_2. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS51058. ZF_CXXC. 1 hit. PS01359. ZF_PHD_1. 3 hits. PS50016. ZF_PHD_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

HRX_MOUSE

Accession

Primary (citable) accession number: P55200
Secondary accession number(s): Q3UEU1, Q3USE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 9, 2007
Last modified:	October 13, 2009
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)