Reviewed, UniProtKB/Swiss-Prot P55196 (AFAD_HUMAN)

Names and origin

Protein names

Recommended name:
    Afadin
Alternative name(s):
    Protein AF-6

Gene names

Name:	MLLT4
Synonyms:	AF6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1816 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
Subunit structure	Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1 and RIT2 By similarity. Interacts with NRXN1 and BCR.
Subcellular location	Cell junction › adherens junction. Note= Not found at cell-matrix AJs.
Domain	The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin.
Involvement in disease	A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
Sequence similarities	Contains 1 dilute domain. Contains 1 FHA domain. Contains 1 PDZ (DHR) domain. Contains 2 Ras-associating domains.
Sequence caution	The sequence CAB82312.1 differs from that shown. Reason: Frameshift at positions 1492, 1495 and 1684.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cell adhesion Traceable author statement. Source: ProtInc cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cell-cell junction Traceable author statement. Source: ProtInc
Molecular function	protein C-terminus binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAG	P61981	1	EBI-365875,EBI-359832

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P55196-1)

Also known as: l-afadin;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P55196-2)

Also known as: s-afadin;

The sequence of this isoform differs from the canonical sequence as follows:
     1031-1031: D → DV
     1588-1611: LQDEERRRQQQLEEMRKREAEDRA → VKGGVLWLCPSVVPILASACFPWG
     1612-1816: Missing.

Isoform 3 (identifier: P55196-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1666-1743: LCRPPLPRDY...SSTRKSHGDL → PNSYPGSTGA...TELENELNTK
     1744-1816: Missing.

Isoform 4 (identifier: P55196-4)

The sequence of this isoform differs from the canonical sequence as follows:
     137-137: P → PK
     391-391: P → PGRRNHFAYYNYHTYE
     1031-1031: D → DV
     1730-1816: QDKYSSTRKS...KRVTNQLSLS → PNSYPGSTGA...TELENELNTK

Isoform 5 (identifier: P55196-5)

The sequence of this isoform differs from the canonical sequence as follows:
     391-391: P → PGRRNHFAYYNYHTYE
     1031-1031: D → DV
     1587-1587: R → RTAMPAISVLDL
     1730-1816: QDKYSSTRKS...KRVTNQLSLS → PNSYPGSTGA...TELENELNTK

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1816

1816

Afadin

PRO_0000215918

Regions

Domain

39 – 133

95

Ras-associating 1

Domain

245 – 347

103

Ras-associating 2

Domain

425 – 491

67

FHA

Domain

652 – 892

241

Dilute

Domain

991 – 1076

86

PDZ

Coiled coil

145 – 184

40

Potential

Coiled coil

1391 – 1431

41

Potential

Coiled coil

1506 – 1650

145

Potential

Compositional bias

162 – 174

13

Glu/Lys-rich

Compositional bias

1329 – 1375

47

Pro-rich

Compositional bias

1561 – 1571

11

Asp/Glu-rich (acidic)

Compositional bias

1661 – 1691

31

Pro-rich

Sites

Site

26

1

Breakpoint for translocation to form MLL-MLLT4

Amino acid modifications

Modified residue

94

1

Phosphotyrosine

Modified residue

215

1

Phosphoserine

Modified residue

541

1

Phosphoserine By similarity

Modified residue

1090

1

Phosphoserine

Modified residue

1155

1

Phosphoserine

Modified residue

1156

1

Phosphoserine

Modified residue

1165

1

Phosphoserine

Modified residue

1184

1

Phosphoserine

Modified residue

1213

1

Phosphotyrosine By similarity

Modified residue

1215

1

Phosphothreonine

Modified residue

1258

1

Phosphoserine By similarity

Modified residue

1313

1

Phosphothreonine By similarity

Modified residue

1317

1

Phosphothreonine By similarity

Modified residue

1679

1

Phosphoserine

Modified residue

1681

1

Phosphoserine

Modified residue

1704

1

Phosphoserine

Natural variations

Alternative sequence

137

1

P → PK in isoform 4.

VSP_019254

Alternative sequence

391

1

P → PGRRNHFAYYNYHTYE in isoform 4 and isoform 5.

VSP_019255

Alternative sequence

1031

1

D → DV in isoform 1, isoform 4 and isoform 5.

VSP_019256

Alternative sequence

1587

1

R → RTAMPAISVLDL in isoform 5.

VSP_019257

Alternative sequence

1588 – 1611

24

LQDEE…AEDRA → VKGGVLWLCPSVVPILASAC FPWG in isoform 1.

VSP_000217

Alternative sequence

1612 – 1816

205

Missing in isoform 1.

VSP_000218

Alternative sequence

1666 – 1743

78

LCRPP…SHGDL → PNSYPGSTGAAVGAHDACRD AKEKRSKSQDADSPGSSGAP ENLTFKERQRLFSQGQDVSN KVKASRKLTELENELNTK in isoform 3.

VSP_000219

Alternative sequence

1730 – 1816

87

QDKYS…QLSLS → PNSYPGSTGAAVGAHDACRD AKEKRSKSQDADSPGSSGAP ENLTFKERQRLFSQGQDVSN KVKASRKLTELENELNTK in isoform 4 and isoform 5.

VSP_019258

Alternative sequence

1744 – 1816

73

Missing in isoform 3.

VSP_000220

Experimental info

Sequence conflict

373

1

G → V in AAC50059. Ref.1

Sequence conflict

1408

1

R → P in AAC50059. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1816

Helix Strand Turn

Details...

Beta strand

990 – 997

8

Beta strand

999 – 1001

3

Beta strand

1004 – 1009

6

Beta strand

1018 – 1024

7

Helix

1029 – 1032

4

Beta strand

1037 – 1044

8

Helix

1054 – 1062

9

Beta strand

1066 – 1074

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (l-afadin) [UniParc]. Last modified January 11, 2001. Version 2. Checksum: EB1FE7F04879CE8F	FASTA	1,816	205,605
	10 20 30 40 50 60 MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 70 80 90 100 110 120 RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 130 140 150 160 170 180 DREGRFVLKN ENDAIPPKAQ SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS 190 200 210 220 230 240 DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD 250 260 270 280 290 300 GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN PKDYCIARVM 310 320 330 340 350 360 LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF QLKRRPPDHI PKKTKKHLEG 370 380 390 400 410 420 KTPKGKERAD GSGYGSTLPP EKLPYLVELS PDGSDSRDKP KLYRLQLSVT EVGTEKLDDN 430 440 450 460 470 480 SIQLFGPGIQ PHHCDLTNMD GVVTVTPRSM DAETYVEGQR ISETTMLQSG MKVQFGASHV 490 500 510 520 530 540 FKFVDPSQDH ALAKRSVDGG LMVKGPRHKP GIVQETTFDL GGDIHSGTAL PTSKSTTRLD 550 560 570 580 590 600 SDRVSSASST AERGMVKPMI RVEQQPDYRR QESRTQDASG PELILPASIE FRESSEDSFL 610 620 630 640 650 660 SAIINYTNSS TVHFKLSPTY VLYMACRYVL SNQYRPDISP TERTHKVIAV VNKMVSMMEG 670 680 690 700 710 720 VIQKQKNIAG ALAFWMANAS ELLNFIKQDR DLSRITLDAQ DVLAHLVQMA FKYLVHCLQS 730 740 750 760 770 780 ELNNYMPAFL DDPEENSLQR PKIDDVLHTL TGAMSLLRRC RVNAALTIQL FSQLFHFINM 790 800 810 820 830 840 WLFNRLVTDP DSGLCSHYWG AIIRQQLGHI EAWAEKQGLE LAADCHLSRI VQATTLLTMD 850 860 870 880 890 900 KYAPDDIPNI NSTCFKLNSL QLQALLQNYH CAPDEPFIPT DLIENVVTVA ENTADELARS 910 920 930 940 950 960 DGREVQLEED PDLQLPFLLP EDGYSCDVVR NIPNGLQEFL DPLCQRGFCR LIPHTRSPGT 970 980 990 1000 1010 1020 WTIYFEGADY ESHLLRENTE LAQPLRKEPE IITVTLKKQN GMGLSIVAAK GAGQDKLGIY 1030 1040 1050 1060 1070 1080 VKSVVKGGAA DDGRLAAGDQ LLSVDGRSLV GLSQERAAEL MTRTSSVVTL EVAKQGAIYH 1090 1100 1110 1120 1130 1140 GLATLLNQPS PMMQRISDRR GSGKPRPKSE GFELYNNSTQ NGSPESPQLP WAEYSEPKKL 1150 1160 1170 1180 1190 1200 PGDDRLMKNR ADHRSSPNVA NQPPSPGGKS AYASGTTAKI TSVSTGNLCT EEQTPPPRPE 1210 1220 1230 1240 1250 1260 AYPIPTQTYT REYFTFPASK SQDRMAPPQN QWPNYEEKPH MHTDSNHSSI AIQRVTRSQE 1270 1280 1290 1300 1310 1320 ELREDKAYQL ERHRIEAAMD RKSDSDMWIN QSSSLDSSTS SQEHLNHSSK SVTPASTLTK 1330 1340 1350 1360 1370 1380 SGPGRWKTPA AIPATPVAVS QPIRTDLPPP PPPPPVHYAG DFDGMSMDLP LPPPPSANQI 1390 1400 1410 1420 1430 1440 GLPSAQVAAA ERRKREEHQR WYEKEKARLE EERERKRREQ ERKLGQMRTQ SLNPAPFSPL 1450 1460 1470 1480 1490 1500 TAQQMKPEKP STLQRPQETV IRELQPQQQP RTIERRDLQY ITVSKEELSS GDSLSPDPWK 1510 1520 1530 1540 1550 1560 RDAKEKLEKQ QQMHIVDMLS KEIQELQSKP DRSAEESDRL RKLMLEWQFQ KRLQESKQKD 1570 1580 1590 1600 1610 1620 EDDEEEEDDD VDTMLIMQRL EAERRARLQD EERRRQQQLE EMRKREAEDR ARQEEERRRQ 1630 1640 1650 1660 1670 1680 EEERTKRDAE EKRRQEEGYY SRLEAERRRQ HDEAARRLLE PEAPGLCRPP LPRDYEPPSP 1690 1700 1710 1720 1730 1740 SPAPGAPPPP PQRNASYLKT QVLSPDSLFT AKFVAYNEEE EEEDCSLAGQ DKYSSTRKSH 1750 1760 1770 1780 1790 1800 GDLLPAPLKP RPPPCQPRPA SDGVFLSNSF QPPSAKANST AHKKGQPLPP PKKSSSYHPS 1810 HCKGRGKRVT NQLSLS
	Isoform 1 (s-afadin) [UniParc]. Checksum: 202D7BEC1E825AB6		1,612	182,000
	10 20 30 40 50 60 MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 70 80 90 100 110 120 RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 130 140 150 160 170 180 DREGRFVLKN ENDAIPPKAQ SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS 190 200 210 220 230 240 DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD 250 260 270 280 290 300 GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN PKDYCIARVM 310 320 330 340 350 360 LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF QLKRRPPDHI PKKTKKHLEG 370 380 390 400 410 420 KTPKGKERAD GSGYGSTLPP EKLPYLVELS PDGSDSRDKP KLYRLQLSVT EVGTEKLDDN 430 440 450 460 470 480 SIQLFGPGIQ PHHCDLTNMD GVVTVTPRSM DAETYVEGQR ISETTMLQSG MKVQFGASHV 490 500 510 520 530 540 FKFVDPSQDH ALAKRSVDGG LMVKGPRHKP GIVQETTFDL GGDIHSGTAL PTSKSTTRLD 550 560 570 580 590 600 SDRVSSASST AERGMVKPMI RVEQQPDYRR QESRTQDASG PELILPASIE FRESSEDSFL 610 620 630 640 650 660 SAIINYTNSS TVHFKLSPTY VLYMACRYVL SNQYRPDISP TERTHKVIAV VNKMVSMMEG 670 680 690 700 710 720 VIQKQKNIAG ALAFWMANAS ELLNFIKQDR DLSRITLDAQ DVLAHLVQMA FKYLVHCLQS 730 740 750 760 770 780 ELNNYMPAFL DDPEENSLQR PKIDDVLHTL TGAMSLLRRC RVNAALTIQL FSQLFHFINM 790 800 810 820 830 840 WLFNRLVTDP DSGLCSHYWG AIIRQQLGHI EAWAEKQGLE LAADCHLSRI VQATTLLTMD 850 860 870 880 890 900 KYAPDDIPNI NSTCFKLNSL QLQALLQNYH CAPDEPFIPT DLIENVVTVA ENTADELARS 910 920 930 940 950 960 DGREVQLEED PDLQLPFLLP EDGYSCDVVR NIPNGLQEFL DPLCQRGFCR LIPHTRSPGT 970 980 990 1000 1010 1020 WTIYFEGADY ESHLLRENTE LAQPLRKEPE IITVTLKKQN GMGLSIVAAK GAGQDKLGIY 1030 1040 1050 1060 1070 1080 VKSVVKGGAA DVDGRLAAGD QLLSVDGRSL VGLSQERAAE LMTRTSSVVT LEVAKQGAIY 1090 1100 1110 1120 1130 1140 HGLATLLNQP SPMMQRISDR RGSGKPRPKS EGFELYNNST QNGSPESPQL PWAEYSEPKK 1150 1160 1170 1180 1190 1200 LPGDDRLMKN RADHRSSPNV ANQPPSPGGK SAYASGTTAK ITSVSTGNLC TEEQTPPPRP 1210 1220 1230 1240 1250 1260 EAYPIPTQTY TREYFTFPAS KSQDRMAPPQ NQWPNYEEKP HMHTDSNHSS IAIQRVTRSQ 1270 1280 1290 1300 1310 1320 EELREDKAYQ LERHRIEAAM DRKSDSDMWI NQSSSLDSST SSQEHLNHSS KSVTPASTLT 1330 1340 1350 1360 1370 1380 KSGPGRWKTP AAIPATPVAV SQPIRTDLPP PPPPPPVHYA GDFDGMSMDL PLPPPPSANQ 1390 1400 1410 1420 1430 1440 IGLPSAQVAA AERRKREEHQ RWYEKEKARL EEERERKRRE QERKLGQMRT QSLNPAPFSP 1450 1460 1470 1480 1490 1500 LTAQQMKPEK PSTLQRPQET VIRELQPQQQ PRTIERRDLQ YITVSKEELS SGDSLSPDPW 1510 1520 1530 1540 1550 1560 KRDAKEKLEK QQQMHIVDML SKEIQELQSK PDRSAEESDR LRKLMLEWQF QKRLQESKQK 1570 1580 1590 1600 1610 DEDDEEEEDD DVDTMLIMQR LEAERRARVK GGVLWLCPSV VPILASACFP WG
	Isoform 3 [UniParc]. Checksum: ECCDE46AD8C401B9		1,743	197,653
	10 20 30 40 50 60 MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 70 80 90 100 110 120 RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 130 140 150 160 170 180 DREGRFVLKN ENDAIPPKAQ SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS 190 200 210 220 230 240 DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD 250 260 270 280 290 300 GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN PKDYCIARVM 310 320 330 340 350 360 LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF QLKRRPPDHI PKKTKKHLEG 370 380 390 400 410 420 KTPKGKERAD GSGYGSTLPP EKLPYLVELS PDGSDSRDKP KLYRLQLSVT EVGTEKLDDN 430 440 450 460 470 480 SIQLFGPGIQ PHHCDLTNMD GVVTVTPRSM DAETYVEGQR ISETTMLQSG MKVQFGASHV 490 500 510 520 530 540 FKFVDPSQDH ALAKRSVDGG LMVKGPRHKP GIVQETTFDL GGDIHSGTAL PTSKSTTRLD 550 560 570 580 590 600 SDRVSSASST AERGMVKPMI RVEQQPDYRR QESRTQDASG PELILPASIE FRESSEDSFL 610 620 630 640 650 660 SAIINYTNSS TVHFKLSPTY VLYMACRYVL SNQYRPDISP TERTHKVIAV VNKMVSMMEG 670 680 690 700 710 720 VIQKQKNIAG ALAFWMANAS ELLNFIKQDR DLSRITLDAQ DVLAHLVQMA FKYLVHCLQS 730 740 750 760 770 780 ELNNYMPAFL DDPEENSLQR PKIDDVLHTL TGAMSLLRRC RVNAALTIQL FSQLFHFINM 790 800 810 820 830 840 WLFNRLVTDP DSGLCSHYWG AIIRQQLGHI EAWAEKQGLE LAADCHLSRI VQATTLLTMD 850 860 870 880 890 900 KYAPDDIPNI NSTCFKLNSL QLQALLQNYH CAPDEPFIPT DLIENVVTVA ENTADELARS 910 920 930 940 950 960 DGREVQLEED PDLQLPFLLP EDGYSCDVVR NIPNGLQEFL DPLCQRGFCR LIPHTRSPGT 970 980 990 1000 1010 1020 WTIYFEGADY ESHLLRENTE LAQPLRKEPE IITVTLKKQN GMGLSIVAAK GAGQDKLGIY 1030 1040 1050 1060 1070 1080 VKSVVKGGAA DDGRLAAGDQ LLSVDGRSLV GLSQERAAEL MTRTSSVVTL EVAKQGAIYH 1090 1100 1110 1120 1130 1140 GLATLLNQPS PMMQRISDRR GSGKPRPKSE GFELYNNSTQ NGSPESPQLP WAEYSEPKKL 1150 1160 1170 1180 1190 1200 PGDDRLMKNR ADHRSSPNVA NQPPSPGGKS AYASGTTAKI TSVSTGNLCT EEQTPPPRPE 1210 1220 1230 1240 1250 1260 AYPIPTQTYT REYFTFPASK SQDRMAPPQN QWPNYEEKPH MHTDSNHSSI AIQRVTRSQE 1270 1280 1290 1300 1310 1320 ELREDKAYQL ERHRIEAAMD RKSDSDMWIN QSSSLDSSTS SQEHLNHSSK SVTPASTLTK 1330 1340 1350 1360 1370 1380 SGPGRWKTPA AIPATPVAVS QPIRTDLPPP PPPPPVHYAG DFDGMSMDLP LPPPPSANQI 1390 1400 1410 1420 1430 1440 GLPSAQVAAA ERRKREEHQR WYEKEKARLE EERERKRREQ ERKLGQMRTQ SLNPAPFSPL 1450 1460 1470 1480 1490 1500 TAQQMKPEKP STLQRPQETV IRELQPQQQP RTIERRDLQY ITVSKEELSS GDSLSPDPWK 1510 1520 1530 1540 1550 1560 RDAKEKLEKQ QQMHIVDMLS KEIQELQSKP DRSAEESDRL RKLMLEWQFQ KRLQESKQKD 1570 1580 1590 1600 1610 1620 EDDEEEEDDD VDTMLIMQRL EAERRARLQD EERRRQQQLE EMRKREAEDR ARQEEERRRQ 1630 1640 1650 1660 1670 1680 EEERTKRDAE EKRRQEEGYY SRLEAERRRQ HDEAARRLLE PEAPGPNSYP GSTGAAVGAH 1690 1700 1710 1720 1730 1740 DACRDAKEKR SKSQDADSPG SSGAPENLTF KERQRLFSQG QDVSNKVKAS RKLTELENEL NTK
	Isoform 4 [UniParc]. Checksum: 51486232F183A3BA		1,824	206,804
	10 20 30 40 50 60 MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 70 80 90 100 110 120 RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 130 140 150 160 170 180 DREGRFVLKN ENDAIPPKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KREKEALRQA 190 200 210 220 230 240 SDKDDRPFQG EDVENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS 250 260 270 280 290 300 DGRPDSGGTL RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV 310 320 330 340 350 360 MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDH IPKKTKKHLE 370 380 390 400 410 420 GKTPKGKERA DGSGYGSTLP PEKLPYLVEL SPGRRNHFAY YNYHTYEDGS DSRDKPKLYR 430 440 450 460 470 480 LQLSVTEVGT EKLDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRSMDAET YVEGQRISET 490 500 510 520 530 540 TMLQSGMKVQ FGASHVFKFV DPSQDHALAK RSVDGGLMVK GPRHKPGIVQ ETTFDLGGDI 550 560 570 580 590 600 HSGTALPTSK STTRLDSDRV SSASSTAERG MVKPMIRVEQ QPDYRRQESR TQDASGPELI 610 620 630 640 650 660 LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSNQY RPDISPTERT 670 680 690 700 710 720 HKVIAVVNKM VSMMEGVIQK QKNIAGALAF WMANASELLN FIKQDRDLSR ITLDAQDVLA 730 740 750 760 770 780 HLVQMAFKYL VHCLQSELNN YMPAFLDDPE ENSLQRPKID DVLHTLTGAM SLLRRCRVNA 790 800 810 820 830 840 ALTIQLFSQL FHFINMWLFN RLVTDPDSGL CSHYWGAIIR QQLGHIEAWA EKQGLELAAD 850 860 870 880 890 900 CHLSRIVQAT TLLTMDKYAP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE 910 920 930 940 950 960 NVVTVAENTA DELARSDGRE VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN GLQEFLDPLC 970 980 990 1000 1010 1020 QRGFCRLIPH TRSPGTWTIY FEGADYESHL LRENTELAQP LRKEPEIITV TLKKQNGMGL 1030 1040 1050 1060 1070 1080 SIVAAKGAGQ DKLGIYVKSV VKGGAADVDG RLAAGDQLLS VDGRSLVGLS QERAAELMTR 1090 1100 1110 1120 1130 1140 TSSVVTLEVA KQGAIYHGLA TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSTQNGS 1150 1160 1170 1180 1190 1200 PESPQLPWAE YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKSAYA SGTTAKITSV 1210 1220 1230 1240 1250 1260 STGNLCTEEQ TPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQNQWP NYEEKPHMHT 1270 1280 1290 1300 1310 1320 DSNHSSIAIQ RVTRSQEELR EDKAYQLERH RIEAAMDRKS DSDMWINQSS SLDSSTSSQE 1330 1340 1350 1360 1370 1380 HLNHSSKSVT PASTLTKSGP GRWKTPAAIP ATPVAVSQPI RTDLPPPPPP PPVHYAGDFD 1390 1400 1410 1420 1430 1440 GMSMDLPLPP PPSANQIGLP SAQVAAAERR KREEHQRWYE KEKARLEEER ERKRREQERK 1450 1460 1470 1480 1490 1500 LGQMRTQSLN PAPFSPLTAQ QMKPEKPSTL QRPQETVIRE LQPQQQPRTI ERRDLQYITV 1510 1520 1530 1540 1550 1560 SKEELSSGDS LSPDPWKRDA KEKLEKQQQM HIVDMLSKEI QELQSKPDRS AEESDRLRKL 1570 1580 1590 1600 1610 1620 MLEWQFQKRL QESKQKDEDD EEEEDDDVDT MLIMQRLEAE RRARLQDEER RRQQQLEEMR 1630 1640 1650 1660 1670 1680 KREAEDRARQ EEERRRQEEE RTKRDAEEKR RQEEGYYSRL EAERRRQHDE AARRLLEPEA 1690 1700 1710 1720 1730 1740 PGLCRPPLPR DYEPPSPSPA PGAPPPPPQR NASYLKTQVL SPDSLFTAKF VAYNEEEEEE 1750 1760 1770 1780 1790 1800 DCSLAGPNSY PGSTGAAVGA HDACRDAKEK RSKSQDADSP GSSGAPENLT FKERQRLFSQ 1810 1820 GQDVSNKVKA SRKLTELENE LNTK
	Isoform 5 [UniParc]. Checksum: 3D57FDBD6A521DFD		1,834	207,788
	10 20 30 40 50 60 MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 70 80 90 100 110 120 RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 130 140 150 160 170 180 DREGRFVLKN ENDAIPPKAQ SNGPEKQEKE GVIQNFKRTL SKKEKKEKKK REKEALRQAS 190 200 210 220 230 240 DKDDRPFQGE DVENSRLAAE VYKDMPETSF TRTISNPEVV MKRRRQQKLE KRMQEFRSSD 250 260 270 280 290 300 GRPDSGGTLR IYADSLKPNI PYKTILLSTT DPADFAVAEA LEKYGLEKEN PKDYCIARVM 310 320 330 340 350 360 LPPGAQHSDE KGAKEIILDD DECPLQIFRE WPSDKGILVF QLKRRPPDHI PKKTKKHLEG 370 380 390 400 410 420 KTPKGKERAD GSGYGSTLPP EKLPYLVELS PGRRNHFAYY NYHTYEDGSD SRDKPKLYRL 430 440 450 460 470 480 QLSVTEVGTE KLDDNSIQLF GPGIQPHHCD LTNMDGVVTV TPRSMDAETY VEGQRISETT 490 500 510 520 530 540 MLQSGMKVQF GASHVFKFVD PSQDHALAKR SVDGGLMVKG PRHKPGIVQE TTFDLGGDIH 550 560 570 580 590 600 SGTALPTSKS TTRLDSDRVS SASSTAERGM VKPMIRVEQQ PDYRRQESRT QDASGPELIL 610 620 630 640 650 660 PASIEFRESS EDSFLSAIIN YTNSSTVHFK LSPTYVLYMA CRYVLSNQYR PDISPTERTH 670 680 690 700 710 720 KVIAVVNKMV SMMEGVIQKQ KNIAGALAFW MANASELLNF IKQDRDLSRI TLDAQDVLAH 730 740 750 760 770 780 LVQMAFKYLV HCLQSELNNY MPAFLDDPEE NSLQRPKIDD VLHTLTGAMS LLRRCRVNAA 790 800 810 820 830 840 LTIQLFSQLF HFINMWLFNR LVTDPDSGLC SHYWGAIIRQ QLGHIEAWAE KQGLELAADC 850 860 870 880 890 900 HLSRIVQATT LLTMDKYAPD DIPNINSTCF KLNSLQLQAL LQNYHCAPDE PFIPTDLIEN 910 920 930 940 950 960 VVTVAENTAD ELARSDGREV QLEEDPDLQL PFLLPEDGYS CDVVRNIPNG LQEFLDPLCQ 970 980 990 1000 1010 1020 RGFCRLIPHT RSPGTWTIYF EGADYESHLL RENTELAQPL RKEPEIITVT LKKQNGMGLS 1030 1040 1050 1060 1070 1080 IVAAKGAGQD KLGIYVKSVV KGGAADVDGR LAAGDQLLSV DGRSLVGLSQ ERAAELMTRT 1090 1100 1110 1120 1130 1140 SSVVTLEVAK QGAIYHGLAT LLNQPSPMMQ RISDRRGSGK PRPKSEGFEL YNNSTQNGSP 1150 1160 1170 1180</