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Protein

Transaldolase

Gene

tal

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:tal
Ordered Locus Names:ML0582
ORF Names:B1496_F2_65/B1496_F1_27, MLCL536.39
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0582.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001736351 – 375TransaldolaseAdd BLAST375

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0582.

Structurei

3D structure databases

ProteinModelPortaliP55193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 2 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0176. LUCA.
HOGENOMiHOG000226074.
KOiK00616.
OMAiWLDNITR.
OrthoDBiPOG091H05PS.

Family and domain databases

CDDicd00955. Transaldolase_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00493. Transaldolase_2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004732. Transaldolase_2.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
PIRSFiPIRSF036915. Trnald_Bac_Plnt. 1 hit.
TIGRFAMsiTIGR00876. tal_mycobact. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKIQNPNL AALSAAGVSV WLDDLSRDRL QSGNLQKLID TKSVVGVTTN
60 70 80 90 100
PSIFQKAFAN GHAYDAQIAE LAKRGANVDV TVRTVTTDDV RHACDVLACE
110 120 130 140 150
WEASHGKDGR VSIEVDPRLA HDTDKTIAQA VELWRIVDHP NLFIKIPATK
160 170 180 190 200
AGLPAITAVL AEGISVNVTL IFSVQRHREV IDAYLAGIEK AAEAGRDLSK
210 220 230 240 250
IVSVASFFVS RVDTEIDKRL EKLGSEQALA LRGQAGVANA RLAYAAYQKA
260 270 280 290 300
FEGGQRYQTL MARGAQVQRP LWASTGVKNP DYADTLYVTE LVAPNTVNTM
310 320 330 340 350
PETTIDAVAD HGVIRGDTIS GTTLSSQKVF DSLVAVGVDL IDVFAVLEHE
360 370
GVQKFVKSWN ELLKETQEQL DSVAK
Length:375
Mass (Da):40,588
Last modified:May 30, 2000 - v2
Checksum:i10FCFB4765D665AB
GO

Sequence cautioni

The sequence AAA17140 differs from that shown. Reason: Frameshift at position 155.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155A → G (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17145.1. Frameshift.
U00013 Genomic DNA. Translation: AAA17140.1. Frameshift.
Z99125 Genomic DNA. Translation: CAB16183.1.
AL583919 Genomic DNA. Translation: CAC30090.1.
PIRiT11020.
RefSeqiNP_301493.1. NC_002677.1.
WP_010907817.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30090; CAC30090; CAC30090.
GeneIDi910135.
KEGGimle:ML0582.
PATRICi18052138. VBIMycLep78757_1016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00013 Genomic DNA. Translation: AAA17145.1. Frameshift.
U00013 Genomic DNA. Translation: AAA17140.1. Frameshift.
Z99125 Genomic DNA. Translation: CAB16183.1.
AL583919 Genomic DNA. Translation: CAC30090.1.
PIRiT11020.
RefSeqiNP_301493.1. NC_002677.1.
WP_010907817.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP55193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30090; CAC30090; CAC30090.
GeneIDi910135.
KEGGimle:ML0582.
PATRICi18052138. VBIMycLep78757_1016.

Organism-specific databases

LepromaiML0582.

Phylogenomic databases

eggNOGiCOG0176. LUCA.
HOGENOMiHOG000226074.
KOiK00616.
OMAiWLDNITR.
OrthoDBiPOG091H05PS.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.

Family and domain databases

CDDicd00955. Transaldolase_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00493. Transaldolase_2. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR004732. Transaldolase_2.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. TAL_FSA. 1 hit.
[Graphical view]
PIRSFiPIRSF036915. Trnald_Bac_Plnt. 1 hit.
TIGRFAMsiTIGR00876. tal_mycobact. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_MYCLE
AccessioniPrimary (citable) accession number: P55193
Secondary accession number(s): O65930, Q49698, Q49705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: October 5, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.