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Protein

G1/S-specific cyclin-D1

Gene

CCND1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin-D1
Gene namesi
Name:CCND1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804341 – 292G1/S-specific cyclin-D1Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).By similarity
Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP55169

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012203

Structurei

3D structure databases

ProteinModelPortaliP55169
SMRiP55169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin D subfamily.Curated

Phylogenomic databases

eggNOGiKOG0656 Eukaryota
ENOG410XRKC LUCA
HOGENOMiHOG000008182
HOVERGENiHBG050837
InParanoidiP55169
KOiK04503
PhylomeDBiP55169

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015451 Cyclin_D
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF67 PTHR10177:SF67, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P55169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHQLQCCEV ETIRRAYLDA NLLNDRVLQT MLKAEETCSP SVSYFKCVQK
60 70 80 90 100
EILPYMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS FEPLKKSRLQ
110 120 130 140 150
LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLQM ELLLVNKLKW
160 170 180 190 200
NLAAMTPHDF IEHFLTKMPL AEDTKQIIRK HAQTFVALCA TDVKFISNPP
210 220 230 240 250
SMIAAGSVVA AVQGLHLGNT NTFLSYQCLT HFLSQVIKCD PDCLRACQEQ
260 270 280 290
IESLLESSLR QAQQHNVSSE TKTVEDEADL SCTPTDVRDV NI
Length:292
Mass (Da):33,264
Last modified:October 1, 1996 - v1
Checksum:i7B543029DB45A67D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40844 mRNA Translation: AAA83271.1
RefSeqiNP_990712.1, NM_205381.1
UniGeneiGga.3039

Genome annotation databases

GeneIDi396341
KEGGigga:396341

Similar proteinsi

Entry informationi

Entry nameiCCND1_CHICK
AccessioniPrimary (citable) accession number: P55169
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health