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Protein

Microsomal triglyceride transfer protein large subunit

Gene

MTTP

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal triglyceride transfer protein large subunit
Gene namesi
Name:MTTP
Synonyms:MTP
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000004159419 – 895Microsomal triglyceride transfer protein large subunitAdd BLAST877

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI). Interacts with APOB.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP55158.
SMRiP55158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 659VitellogeninPROSITE-ProRule annotationAdd BLAST632

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006416.
OrthoDBiEOG091G0BRK.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR037594. Lipovitellin-like_superhlx.
IPR011030. Lipovitellin_superhlx_dom.
IPR015816. Vitellinogen_b-sht_N.
PfamiView protein in Pfam
PF01347. Vitellogenin_N. 1 hit.
SMARTiView protein in SMART
SM00638. LPD_N. 1 hit.
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 1 hit.
PROSITEiView protein in PROSITE
PS51211. VITELLOGENIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLAVLFLC FFSSYSASVK GHTTGLSLNN ERLYKLTYST EVFLDGGKGK
60 70 80 90 100
LKDSVGYRIS SDVDVVLLWR NPDGDDDQLI QVTITAVNVE NVNQQRGEKS
110 120 130 140 150
IFKGKTTPKI IGKDNLEALQ RPVLLHLVRG KVKEFYSYEN EPVGIENLKR
160 170 180 190 200
GLASLFQMQL SSGTTNEVDI SGDCKVTYQA QQDKVVKTKA LDTCKIERSG
210 220 230 240 250
FTTVNQVLGV SSKATSVTTY KIEDSFVTAV HAEETRDFSL NFLQAIAGKI
260 270 280 290 300
VSKQKLELKT TEAGPRMVPG KQVAGVIKAL DSKYTAIPIV GQVLQSACQG
310 320 330 340 350
CPSLAEHWQS IRKHLEPENL SNAKAVSSFL AFIQHLRTAR REEILQILKA
360 370 380 390 400
EKKEVLPQLV DAVTSAQTPD SLEAILDFLD FKSDSSIVLQ ERFLYACGFA
410 420 430 440 450
SHPDEELLRA LLSKFKGSFA SNDIRETVMI IIGALVRKLC QNEGCKLKAV
460 470 480 490 500
VEAKKLILGG LEKPEKKEDT TMYLLALKNA LLPEGIPLLL KYAEAGEGPV
510 520 530 540 550
SHLATTVLQR YDVSFITDEV KKTLNRIYHQ NRKIHEKTVR TTAAAVILKS
560 570 580 590 600
NPSYMDVKNI LLSIGELPKE MNKYMLTFVR DILNFEMPSS KMIRRVLKEM
610 620 630 640 650
VAHNYDRFSK SGSSSAYTGY IERSPHAAST YSLDMLYSGS GILRRSNLNV
660 670 680 690 700
FQYLGKAGLH GSQVVIEAQG LESLIAATPD EGEENLDSYA GMSAILFDVQ
710 720 730 740 750
LRPVTFFNGY SDLMSKMLSA SGDPVSVVKG LILLIDHSQD IQLQSGLKAN
760 770 780 790 800
MEIQGGLAID ISGSMEFSLW YRESKTRVKN RVAVVIDSAV TVDSSFVKAG
810 820 830 840 850
LESRAETEAG LEFISTVQFS QYPFLVCMQM DRAEAPFRQF ETKYERLSTG
860 870 880 890
RGYVSRRRKE SLVSGYELPL HQENSEMCNM VFPPQPESDN SGGWF
Length:895
Mass (Da):99,388
Last modified:October 1, 1996 - v1
Checksum:i841062179548059D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14995 mRNA. Translation: AAA53143.1.
PIRiA55413.
RefSeqiNP_001268537.1. NM_001281608.1.

Genome annotation databases

GeneIDi101836921.

Similar proteinsi

Entry informationi

Entry nameiMTP_MESAU
AccessioniPrimary (citable) accession number: P55158
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 31, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome