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P55133

- RELA_PHOAS

UniProt

P55133 - RELA_PHOAS

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Protein
GTP pyrophosphokinase
Gene
relA
Organism
Photobacterium angustum (strain S14 / CCUG 15956) (Vibrio sp. (strain S14 / CCUG 15956))
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. Plays also a role in the reductive division that occurs during the initial phase of nutrient starvation.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. GTP diphosphokinase activity Source: UniProtKB-EC
  4. amino acid binding Source: InterPro
  5. kinase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
OrganismiPhotobacterium angustum (strain S14 / CCUG 15956) (Vibrio sp. (strain S14 / CCUG 15956))
Taxonomic identifieri314292 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Pathology & Biotechi

Disruption phenotypei

Mutants remain rod shaped, and do not acquire the typical coccoid morphology usually seen during starvation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744GTP pyrophosphokinase
PRO_0000166566Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55133.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini669 – 74476ACT
Add
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.
Contains 1 ACT domain.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55133-1 [UniParc]FASTAAdd to Basket

« Hide

MVAVRGAHLK ENTTFELVSW VESLRQDAKV SSRIEGTYQR CIELAAEQEN    50
GPLLLWRGRE LVEILVTLSM DADTLIAALL YPLVEGGCYS TDALKEEYSG 100
TILHLVQGVE QMCAISQLKS TAEETAQAAQ VDNIRRMLLS MVDDFRCVVI 150
KLAERICNLR EVKDQPDEVR RAAAQECANI YAPLANRLGI GQLKWEIEDY 200
AFRYQHPDTY KQIAKQLSER RIDREDYITH FVDDLSDAMK ASNIRAEVQG 250
RPKHIYSIWR KMQKKSLEFD ELFDVRAVRI VAEELQDCYA ALGVVHTKYR 300
HLPKEFDDYV ANPKPNGYQS IHTVVLGPEG KTIEIQIRTK QMHEESELGV 350
AAHWKYKEGT ASGGAQSAYD EKINWLRKLL AWQEEMSDSG EMLDELRSQV 400
FDDRVYAFTP KGDVVDLPSN ATPLDFAYHI HSEVGHRCIG AKVEGRIVPF 450
TYHLQMGDQV EIITQKEPNP SRDWLNPNLG FVTSSRARAK VHAWFRKQDR 500
DKNIIAGKEI LEAELVKIHA TLKDAQYYAA KRFNVKSPEE LYAGIGSGDL 550
RINQVINHIN ALVNKPTAEE EDQQLLEKLS EASNKQATSH KKPQRDAVVV 600
EGVDNLMTHL ARCCQPIPGD DIQGFVTQGR GISVHRMDCE QLEELRHHAP 650
ERIIDTVWGG GFVGNYTITV RVTASERNGL LKELTNTLMN EKVKVAGMKS 700
RVDYKKQMSI MDFELELTDL EVLGRVLKRI EQVKDVAEAK RLYG 744
Length:744
Mass (Da):84,546
Last modified:October 1, 1996 - v1
Checksum:iB7AC772C4D47A40C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13769 Genomic DNA. Translation: AAA62208.1.

Genome annotation databases

PATRICi31352187. VBIPhoAng36222_3707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13769 Genomic DNA. Translation: AAA62208.1 .

3D structure databases

ProteinModelPortali P55133.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

PATRICi 31352187. VBIPhoAng36222_3707.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stringent control during carbon starvation of marine Vibrio sp. strain S14: molecular cloning, nucleotide sequence, and deletion of the relA gene."
    Flaerdh K., Axberg T., Albertson N.H., Kjelleberg S.
    J. Bacteriol. 176:5949-5957(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRELA_PHOAS
AccessioniPrimary (citable) accession number: P55133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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