P55133 (RELA_PHOAS) Reviewed, UniProtKB/Swiss-Prot
Last modified October 16, 2013. Version 76. History...
Names and origin
|Protein names||Recommended name:|
ppGpp synthase I
|Organism||Photobacterium angustum (strain S14 / CCUG 15956) (Vibrio sp. (strain S14 / CCUG 15956))|
|Taxonomic identifier||314292 [NCBI]|
|Taxonomic lineage||Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium ›|
|Sequence length||744 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. Plays also a role in the reductive division that occurs during the initial phase of nutrient starvation.
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
Mutants remain rod shaped, and do not acquire the typical coccoid morphology usually seen during starvation. Ref.1
Belongs to the RelA/SpoT family.
Contains 1 ACT domain.
|Gene Ontology (GO)|
|Biological_process||guanosine tetraphosphate biosynthetic process|
Inferred from electronic annotation. Source: UniProtKB-UniPathway
Inferred from electronic annotation. Source: UniProtKB-KWGTP binding
Inferred from electronic annotation. Source: UniProtKB-KWGTP diphosphokinase activity
Inferred from electronic annotation. Source: UniProtKB-ECamino acid binding
Inferred from electronic annotation. Source: InterProkinase activity
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|||"Stringent control during carbon starvation of marine Vibrio sp. strain S14: molecular cloning, nucleotide sequence, and deletion of the relA gene."|
Flaerdh K., Axberg T., Albertson N.H., Kjelleberg S.
J. Bacteriol. 176:5949-5957(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.
|U13769 Genomic DNA. Translation: AAA62208.1.|
3D structure databases
Protocols and materials databases
Genome annotation databases
|PATRIC||31352187. VBIPhoAng36222_3707. |
Enzyme and pathway databases
Family and domain databases
|Gene3D||22.214.171.124. 1 hit. |
|InterPro||IPR026020. (p)ppGpp_Synthase. |
|PANTHER||PTHR21262:SF1. PTHR21262:SF1. 1 hit. |
|Pfam||PF01842. ACT. 1 hit. |
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
|SMART||SM00954. RelA_SpoT. 1 hit. |
|SUPFAM||SSF81271. SSF81271. 1 hit. |
|TIGRFAMs||TIGR00691. spoT_relA. 1 hit. |
|PROSITE||PS51671. ACT. 1 hit. |
|Accession||Primary (citable) accession number: P55133|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Prokaryotic Protein Annotation Program|