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P55133

- RELA_PHOAS

UniProt

P55133 - RELA_PHOAS

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Protein

GTP pyrophosphokinase

Gene

relA

Organism
Photobacterium angustum (strain S14 / CCUG 15956) (Vibrio sp. (strain S14 / CCUG 15956))
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. Plays also a role in the reductive division that occurs during the initial phase of nutrient starvation.

Catalytic activityi

ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP diphosphokinase activity Source: UniProtKB-EC
  5. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP pyrophosphokinase (EC:2.7.6.5)
Alternative name(s):
(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I
Gene namesi
Name:relA
OrganismiPhotobacterium angustum (strain S14 / CCUG 15956) (Vibrio sp. (strain S14 / CCUG 15956))
Taxonomic identifieri314292 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium

Pathology & Biotechi

Disruption phenotypei

Mutants remain rod shaped, and do not acquire the typical coccoid morphology usually seen during starvation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744GTP pyrophosphokinasePRO_0000166566Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini669 – 74476ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55133-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAVRGAHLK ENTTFELVSW VESLRQDAKV SSRIEGTYQR CIELAAEQEN
60 70 80 90 100
GPLLLWRGRE LVEILVTLSM DADTLIAALL YPLVEGGCYS TDALKEEYSG
110 120 130 140 150
TILHLVQGVE QMCAISQLKS TAEETAQAAQ VDNIRRMLLS MVDDFRCVVI
160 170 180 190 200
KLAERICNLR EVKDQPDEVR RAAAQECANI YAPLANRLGI GQLKWEIEDY
210 220 230 240 250
AFRYQHPDTY KQIAKQLSER RIDREDYITH FVDDLSDAMK ASNIRAEVQG
260 270 280 290 300
RPKHIYSIWR KMQKKSLEFD ELFDVRAVRI VAEELQDCYA ALGVVHTKYR
310 320 330 340 350
HLPKEFDDYV ANPKPNGYQS IHTVVLGPEG KTIEIQIRTK QMHEESELGV
360 370 380 390 400
AAHWKYKEGT ASGGAQSAYD EKINWLRKLL AWQEEMSDSG EMLDELRSQV
410 420 430 440 450
FDDRVYAFTP KGDVVDLPSN ATPLDFAYHI HSEVGHRCIG AKVEGRIVPF
460 470 480 490 500
TYHLQMGDQV EIITQKEPNP SRDWLNPNLG FVTSSRARAK VHAWFRKQDR
510 520 530 540 550
DKNIIAGKEI LEAELVKIHA TLKDAQYYAA KRFNVKSPEE LYAGIGSGDL
560 570 580 590 600
RINQVINHIN ALVNKPTAEE EDQQLLEKLS EASNKQATSH KKPQRDAVVV
610 620 630 640 650
EGVDNLMTHL ARCCQPIPGD DIQGFVTQGR GISVHRMDCE QLEELRHHAP
660 670 680 690 700
ERIIDTVWGG GFVGNYTITV RVTASERNGL LKELTNTLMN EKVKVAGMKS
710 720 730 740
RVDYKKQMSI MDFELELTDL EVLGRVLKRI EQVKDVAEAK RLYG
Length:744
Mass (Da):84,546
Last modified:October 1, 1996 - v1
Checksum:iB7AC772C4D47A40C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13769 Genomic DNA. Translation: AAA62208.1.

Genome annotation databases

PATRICi31352187. VBIPhoAng36222_3707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13769 Genomic DNA. Translation: AAA62208.1 .

3D structure databases

ProteinModelPortali P55133.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

PATRICi 31352187. VBIPhoAng36222_3707.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Stringent control during carbon starvation of marine Vibrio sp. strain S14: molecular cloning, nucleotide sequence, and deletion of the relA gene."
    Flaerdh K., Axberg T., Albertson N.H., Kjelleberg S.
    J. Bacteriol. 176:5949-5957(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRELA_PHOAS
AccessioniPrimary (citable) accession number: P55133
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3