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Protein

Zinc metalloproteinase nas-4

Gene

nas-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease, which may be involved in digestion.

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc; catalyticPROSITE-ProRule annotation
Active sitei188 – 1881PROSITE-ProRule annotation
Metal bindingi191 – 1911Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi197 – 1971Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A19.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-4 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 4
Gene namesi
Name:nas-4
ORF Names:C05D11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC05D11.6a; CE37080; WBGene00003523; nas-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 315295Zinc metalloproteinase nas-4PRO_0000028909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP55112.
PaxDbiP55112.

Expressioni

Tissue specificityi

Digestive tract. Found in the pharynx cells of the procorpus, metacorpus, isthmus and terminal bulb, and in the terminal bulb lumen.1 Publication

Gene expression databases

ExpressionAtlasiP55112. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.C05D11.6b.

Structurei

3D structure databases

ProteinModelPortaliP55112.
SMRiP55112. Positions 101-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000267150.
InParanoidiP55112.
PhylomeDBiP55112.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTIQRYSLV FCAIFATCWT ASVVNNKQVI DTSVPQTETT LNDADFHSDL
60 70 80 90 100
HQRYDLQTLG IKVKDDPTIG NYSEGDILLE SPKKFVEENN KLGRNAIKQI
110 120 130 140 150
YRRWPNNEIP YTLSSQYGSY ARSVIANAMN EYHTKTCVKF VARDPSKHHD
160 170 180 190 200
YLWIHPDEGC YSLVGKTGGK QPVSLDSGCI QVGTIVHELM HAVGFFHEQS
210 220 230 240 250
RQDRDSYIDV VWQNVMNGAD DQFEKYNLNV ISHLDEPYDY ASIMHYGPYA
260 270 280 290 300
FSGSGKKTLV PKKSGSERMG QRVKFSDIDV RKINKLYNCP GVSGNNNNNN
310
NNQINSNSIV NHPQV
Length:315
Mass (Da):35,743
Last modified:February 1, 2005 - v4
Checksum:i0EBC9A73BDF3FCDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080365 Genomic DNA. Translation: CCD63195.1.
AJ561201 mRNA. Translation: CAD99204.1.
PIRiB88482.
RefSeqiNP_001254939.1. NM_001268010.1.
UniGeneiCel.39459.

Genome annotation databases

EnsemblMetazoaiC05D11.6a; C05D11.6a; WBGene00003523.
GeneIDi182259.
UCSCiC05D11.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080365 Genomic DNA. Translation: CCD63195.1.
AJ561201 mRNA. Translation: CAD99204.1.
PIRiB88482.
RefSeqiNP_001254939.1. NM_001268010.1.
UniGeneiCel.39459.

3D structure databases

ProteinModelPortaliP55112.
SMRiP55112. Positions 101-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C05D11.6b.

Protein family/group databases

MEROPSiM12.A19.

Proteomic databases

EPDiP55112.
PaxDbiP55112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC05D11.6a; C05D11.6a; WBGene00003523.
GeneIDi182259.
UCSCiC05D11.6. c. elegans.

Organism-specific databases

CTDi182259.
WormBaseiC05D11.6a; CE37080; WBGene00003523; nas-4.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000267150.
InParanoidiP55112.
PhylomeDBiP55112.

Miscellaneous databases

NextBioi916948.
PROiP55112.

Gene expression databases

ExpressionAtlasiP55112. baseline and differential.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The astacin protein family in Caenorhabditis elegans."
    Moehrlen F., Hutter H., Zwilling R.
    Eur. J. Biochem. 270:4909-4920(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-244, TISSUE SPECIFICITY.
    Strain: Bristol N2.

Entry informationi

Entry nameiNAS4_CAEEL
AccessioniPrimary (citable) accession number: P55112
Secondary accession number(s): Q7Z0N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 1, 2005
Last modified: March 16, 2016
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.