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Protein

Growth/differentiation factor 10

Gene

Gdf10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: GO_Central
  • cell development Source: GO_Central
  • cerebellum development Source: RGD
  • negative regulation of osteoblast differentiation Source: UniProtKB
  • osteoblast differentiation Source: RGD
  • ovulation cycle Source: RGD
  • positive regulation of osteoblast differentiation Source: RGD
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • regulation of ossification Source: RGD
  • response to transforming growth factor beta Source: RGD
  • SMAD protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Bone-inducing protein
Short name:
BIP
Gene namesi
Name:Gdf10Imported
Synonyms:Bmp3b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621512. Gdf10.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000003384830 – 366Sequence analysisAdd BLAST337
ChainiPRO_0000033849367 – 476Growth/differentiation factor 10Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi374 ↔ 441By similarity
Disulfide bondi403 ↔ 473By similarity
Disulfide bondi407 ↔ 475By similarity
Disulfide bondi440InterchainBy similarity
Glycosylationi467N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP55108.

Expressioni

Tissue specificityi

Costa, costicartilage, femur, calvaria, trachea, aorta and brain. Predominantly in the cerebellum.1 Publication

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4542496.

Structurei

3D structure databases

ProteinModelPortaliP55108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP55108.
KOiK05496.
PhylomeDBiP55108.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGLARISL RSQLLPLVPL LLLLRGAGCG HRVPSWSSLP SAADSVQRDR
60 70 80 90 100
DLQQSPGDAA AALGPGAQDI VAVHMLRLYE KYNRRGAPPG GGNTVRSFRA
110 120 130 140 150
RLDVIDQKPV YFFNLTSMQD SEMILTATFH FYSEPPRWPR AREVFCKPRA
160 170 180 190 200
KNASCRLLTP GLPARLHLIF RSLSQNTATQ GLLRGAMALT PPPRGLWQAK
210 220 230 240 250
DISSIIKAAR RDGELLLSAQ LDSGEKDLGV PRPSSHMPYI LVYANDLAIS
260 270 280 290 300
EPNSVAVTLQ RYDPFPAGDF EPGAAPNSSA DPRVRRAAQV SKPLQDNELP
310 320 330 340 350
GLDERPAPAL HAQHFHKHEF WSSPFRALKP RTGRKDRKKK DQDTFTPSSS
360 370 380 390 400
QVLDFDEKTM QKARRRQWDE PRVCSRRYLK VDFADIGWNE WIISPKSFDA
410 420 430 440 450
YYCAGACEFP MPKIVRPSNH ATIQSIVRAV GIVPGIPEPC CVPDKMNSLG
460 470
VLFLDENRNV VLKVYPNMSV ETCACR
Length:476
Mass (Da):52,961
Last modified:October 1, 1996 - v1
Checksum:i873F4D4150C625EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49494 mRNA. Translation: BAA08454.1.
PIRiJC4646.
RefSeqiNP_077351.1. NM_024375.1.
UniGeneiRn.8707.

Genome annotation databases

GeneIDi79216.
KEGGirno:79216.
UCSCiRGD:621512. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49494 mRNA. Translation: BAA08454.1.
PIRiJC4646.
RefSeqiNP_077351.1. NM_024375.1.
UniGeneiRn.8707.

3D structure databases

ProteinModelPortaliP55108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4542496.

Proteomic databases

PRIDEiP55108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79216.
KEGGirno:79216.
UCSCiRGD:621512. rat.

Organism-specific databases

CTDi2662.
RGDi621512. Gdf10.

Phylogenomic databases

HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP55108.
KOiK05496.
PhylomeDBiP55108.

Miscellaneous databases

PROiP55108.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDF10_RAT
AccessioniPrimary (citable) accession number: P55108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.