P55107 (BMP3B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 3B
Short name=BMP-3B

Alternative name(s):
Bone-inducing protein
Short name=BIP
Growth/differentiation factor 10
Short name=GDF-10

Gene names

Name:	GDF10
Synonyms:	BMP3B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Homodimer or heterodimer Potential.
Subcellular location	Secreted.
Tissue specificity	Expressed in femur, brain, lung, skeletal muscle, pancreas and testis. Ref.1
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	growth Inferred from electronic annotation. Source: InterPro skeletal system development Traceable author statement Ref.1. Source: ProtInc transforming growth factor beta receptor signaling pathway Traceable author statement Ref.4. Source: ProtInc
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	growth factor activity Traceable author statement Ref.4. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Propeptide	34 – 368	335	Potential		PRO_0000033844
	Chain	369 – 478	110	Bone morphogenetic protein 3B		PRO_0000033845
Amino acid modifications
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	156	1	N-linked (GlcNAc...) Potential
	Glycosylation	281	1	N-linked (GlcNAc...) Potential
	Glycosylation	469	1	N-linked (GlcNAc...) Potential
	Disulfide bond	376 ↔ 443		By similarity
	Disulfide bond	405 ↔ 475		By similarity
	Disulfide bond	409 ↔ 477		By similarity
	Disulfide bond	442		Interchain By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55107 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 80AE0FA4C50B23A9	FASTA	478	53,122
	10 20 30 40 50 60 MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL QGDRDLQRHP 70 80 90 100 110 120 GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR SFRARLEVVD QKAVYFFNLT 130 140 150 160 170 180 SMQDSEMILT ATFHFYSEPP RWPRALEVLC KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN 190 200 210 220 230 240 TATQGLLRGA MALAPPPRGL WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY 250 260 270 280 290 300 APYILVYAND LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD 310 320 330 340 350 360 NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA ASQVLDFDEK 370 380 390 400 410 420 TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF DAYYCAGACE FPMPKIVRPS 430 440 450 460 470 NHATIQSIVR AVGIIPGIPE PCCVPDKMNS LGVLFLDENR NVVLKVYPNM SVDTCACR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b)." Hino J., Takao M., Takeshita N., Konno Y., Nishizawa T., Matsuo H., Kangawa K. Biochem. Biophys. Res. Commun. 223:304-310(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Tissue: Femur.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3." Cunningham N.S., Jenkins N.A., Gilbert D.J., Copeland N.G., Reddi A.H., Lee S.-J. Growth Factors 12:99-109(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 360-478. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49493 Genomic DNA. Translation: BAA08453.1. D49492 mRNA. Translation: BAA08452.1. AL731561 Genomic DNA. Translation: CAH74047.1. CH471251 Genomic DNA. Translation: EAW50661.1. L42113 mRNA. Translation: AAL77527.1.
IPI	IPI00023315.
PIR	JC4838.
RefSeq	NP_004953.1. NM_004962.3.
UniGene	Hs.2171.
3D structure databases
ProteinModelPortal	P55107.
ModBase	Search...
Protein-protein interaction databases
IntAct	P55107. 1 interaction.
STRING	9606.ENSP00000224605.
PTM databases
PhosphoSite	P55107.
Polymorphism databases
DMDM	1705471.
Proteomic databases
PaxDb	P55107.
PRIDE	P55107.
Protocols and materials databases
DNASU	2662.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000224605; ENSP00000224605; ENSG00000107623. ENST00000580279; ENSP00000464145; ENSG00000266524.
GeneID	2662.
KEGG	hsa:2662.
UCSC	uc001jfb.3. human.
Organism-specific databases
CTD	2662.
GeneCards	GC10M048425.
HGNC	HGNC:4215. GDF10.
HPA	HPA015498.
MIM	601361. gene.
neXtProt	NX_P55107.
PharmGKB	PA28630.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303392.
HOGENOM	HOG000232003.
HOVERGEN	HBG004857.
InParanoid	P55107.
KO	K05496.
OMA	TSMQDSE.
PhylomeDB	P55107.
Gene expression databases
ArrayExpress	P55107.
Bgee	P55107.
CleanEx	HS_GDF10.
Genevestigator	P55107.
GermOnline	ENSG00000107623. Homo sapiens.
Family and domain databases
InterPro	IPR017197. BMP3/GDF10. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PIRSF	PIRSF037403. BMP3/GDF10. 1 hit.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2662.
NextBio	10508.
SOURCE	Search...

Entry information

Entry name

BMP3B_HUMAN

Accession

Primary (citable) accession number: P55107
Secondary accession number(s): Q5VSQ8, Q9UCX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.