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Protein

Growth/differentiation factor 10

Gene

GDF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: ProtInc
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processOsteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 10
Short name:
GDF-10
Alternative name(s):
Bone morphogenetic protein 3B
Short name:
BMP-3B
Bone-inducing protein
Short name:
BIP
Gene namesi
Name:GDF10Imported
Synonyms:BMP3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:4215. GDF10.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2662.
OpenTargetsiENSG00000266524.
PharmGKBiPA28630.

Polymorphism and mutation databases

BioMutaiGDF10.
DMDMi1705471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
PropeptideiPRO_000003384434 – 368Sequence analysisAdd BLAST335
ChainiPRO_0000033845369 – 478Growth/differentiation factor 10Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 443By similarity
Disulfide bondi405 ↔ 475By similarity
Disulfide bondi409 ↔ 477By similarity
Disulfide bondi442InterchainBy similarity
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55107.
PeptideAtlasiP55107.
PRIDEiP55107.

PTM databases

iPTMnetiP55107.
PhosphoSitePlusiP55107.

Expressioni

Tissue specificityi

Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.1 Publication

Gene expression databases

BgeeiENSG00000107623.
CleanExiHS_GDF10.
GenevisibleiP55107. HS.

Organism-specific databases

HPAiHPA015498.

Interactioni

Subunit structurei

Homodimer or heterodimer. Can form a non-covalent complex of the mature region and the pro-region.By similarity

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: ProtInc
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi108931. 7 interactors.
IntActiP55107. 1 interactor.
STRINGi9606.ENSP00000224605.

Structurei

3D structure databases

ProteinModelPortaliP55107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP55107.
KOiK05496.
OMAiTSMQDSE.
OrthoDBiEOG091G0WGP.
PhylomeDBiP55107.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVPARTSP GPGPQLLLLL LPLFLLLLRD VAGSHRAPAW SALPAAADGL
60 70 80 90 100
QGDRDLQRHP GDAAATLGPS AQDMVAVHMH RLYEKYSRQG ARPGGGNTVR
110 120 130 140 150
SFRARLEVVD QKAVYFFNLT SMQDSEMILT ATFHFYSEPP RWPRALEVLC
160 170 180 190 200
KPRAKNASGR PLPLGPPTRQ HLLFRSLSQN TATQGLLRGA MALAPPPRGL
210 220 230 240 250
WQAKDISPIV KAARRDGELL LSAQLDSEER DPGVPRPSPY APYILVYAND
260 270 280 290 300
LAISEPNSVA VTLQRYDPFP AGDPEPRAAP NNSADPRVRR AAQATGPLQD
310 320 330 340 350
NELPGLDERP PRAHAQHFHK HQLWPSPFRA LKPRPGRKDR RKKGQEVFMA
360 370 380 390 400
ASQVLDFDEK TMQKARRKQW DEPRVCSRRY LKVDFADIGW NEWIISPKSF
410 420 430 440 450
DAYYCAGACE FPMPKIVRPS NHATIQSIVR AVGIIPGIPE PCCVPDKMNS
460 470
LGVLFLDENR NVVLKVYPNM SVDTCACR
Length:478
Mass (Da):53,122
Last modified:October 1, 1996 - v1
Checksum:i80AE0FA4C50B23A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49493 Genomic DNA. Translation: BAA08453.1.
D49492 mRNA. Translation: BAA08452.1.
AL731561 Genomic DNA. No translation available.
CH471251 Genomic DNA. Translation: EAW50661.1.
L42113 mRNA. Translation: AAL77527.1.
CCDSiCCDS73117.1.
PIRiJC4838.
RefSeqiNP_004953.1. NM_004962.4.
UniGeneiHs.2171.

Genome annotation databases

EnsembliENST00000580279; ENSP00000464145; ENSG00000266524.
GeneIDi2662.
KEGGihsa:2662.
UCSCiuc001jfb.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGDF10_HUMAN
AccessioniPrimary (citable) accession number: P55107
Secondary accession number(s): Q5VSQ8, Q9UCX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 7, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families