P55106F1MD30GDF6_BOVINGrowth/differentiation factor 6GDF-6Bone morphogenetic protein 13BMP-13Cartilage-derived morphogenetic protein 2CDMP-2GDF6BMP13CDMP2Bos taurusBovineEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBosA whole-genome assembly of the domestic cow, Bos taurus.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.NUCLEOTIDE SEQUENCE [MRNA] OF 32-470Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.Homodimer; disulfide-linked.SecretedBelongs to the TGF-beta family.Several sequencing errors.ApoptosisCleavage on pair of basic residuesCytokineDevelopmental proteinDisulfide bondGlycoproteinGrowth factorReference proteomeSecretedSignalMDTSRVLLSAVFLISFLWDLPGFQQASISSSSSSAELGSAKGMRSRKEGRMPRAPRENATAREPLDRQEPPPRPQEEPQRRPPQQPEAREPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHTPLRRQKYLFDVSTLSDKEELVGAELRLFRQAPAAPWGPPAGPLRLQLFACQSPLLLEARSLDPQGAPRPGWEVFDVWRGLRPQPWKQLCLELRAAWGGEPGAAEDEARAPGPQQPPPPDLRSLGFGRRVRTPQERALLVVFSRSQRKTLFAEMREQLGSATEVVGPGGGAEGSGPPPPPPPPPPSGTPDAGLWSPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEEMVVESCGCR
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