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P55106 (GDF6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 6

Short name=GDF-6
Alternative name(s):
Cartilage-derived morphogenetic protein 2
Short name=CDMP-2
Gene names
Name:GDF6
Synonyms:CDMP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the TGF-beta family.

Sequence caution

The sequence AAA61416.1 differs from that shown. Reason: Several sequencing errors.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

growth

Inferred from electronic annotation. Source: InterPro

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 350328 Potential
PRO_0000425155
Chain351 – 470120Growth/differentiation factor 6
PRO_0000425156

Amino acid modifications

Glycosylation1201N-linked (GlcNAc...) Potential
Disulfide bond369 ↔ 435 By similarity
Disulfide bond398 ↔ 467 By similarity
Disulfide bond402 ↔ 469 By similarity
Disulfide bond434Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P55106 [UniParc].

Last modified January 22, 2014. Version 2.
Checksum: 6C40B980E8207A1F

FASTA47052,112
        10         20         30         40         50         60 
MDTSRVLLSA VFLISFLWDL PGFQQASISS SSSSAELGSA KGMRSRKEGR MPRAPRENAT 

        70         80         90        100        110        120 
AREPLDRQEP PPRPQEEPQR RPPQQPEARE PPGRGPRVVP HEYMLSIYRT YSIAEKLGIN 

       130        140        150        160        170        180 
ASFFQSSKSA NTITSFVDRG LDDLSHTPLR RQKYLFDVST LSDKEELVGA ELRLFRQAPA 

       190        200        210        220        230        240 
APWGPPAGPL RLQLFACQSP LLLEARSLDP QGAPRPGWEV FDVWRGLRPQ PWKQLCLELR 

       250        260        270        280        290        300 
AAWGGEPGAA EDEARAPGPQ QPPPPDLRSL GFGRRVRTPQ ERALLVVFSR SQRKTLFAEM 

       310        320        330        340        350        360 
REQLGSATEV VGPGGGAEGS GPPPPPPPPP PSGTPDAGLW SPSPGRRRRR TAFASRHGKR 

       370        380        390        400        410        420 
HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT 

       430        440        450        460        470 
LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE EMVVESCGCR 

« Hide

References

« Hide 'large scale' references
[1]"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.
Genome Biol. 10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]"Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."
Chang S., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J.P., Kozak C.A., Reddi A.H., Moos M.
J. Biol. Chem. 269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-470.
Tissue: Articular cartilage.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DAAA02039445 Genomic DNA. No translation available.
U13661 mRNA. Translation: AAA61416.1. Sequence problems.
PIRB55452.
UniGeneBt.29849.

3D structure databases

ProteinModelPortalP55106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000043329.

Proteomic databases

PRIDEP55106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000010110; ENSBTAP00000043329; ENSBTAG00000007687.

Phylogenomic databases

eggNOGNOG317866.
GeneTreeENSGT00730000110209.
HOGENOMHOG000231514.
HOVERGENHBG107938.
InParanoidP55106.
TreeFamTF316134.

Family and domain databases

InterProIPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGDF6_BOVIN
AccessionPrimary (citable) accession number: P55106
Secondary accession number(s): F1MD30
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 22, 2014
Last modified: March 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families