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Protein

Growth/differentiation factor 6

Gene

GDF6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A (By similarity).By similarity

GO - Biological processi

  1. activin receptor signaling pathway Source: Ensembl
  2. apoptotic process Source: UniProtKB-KW
  3. BMP signaling pathway Source: Ensembl
  4. growth Source: InterPro
  5. pathway-restricted SMAD protein phosphorylation Source: Ensembl
  6. positive regulation of neuron differentiation Source: Ensembl
  7. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6
Short name:
GDF-6
Alternative name(s):
Bone morphogenetic protein 13
Short name:
BMP-13
Cartilage-derived morphogenetic protein 2
Short name:
CDMP-2
Gene namesi
Name:GDF6
Synonyms:BMP13, CDMP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 14

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 350328Sequence AnalysisPRO_0000425155Add
BLAST
Chaini351 – 470120Growth/differentiation factor 6PRO_0000425156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi369 ↔ 435By similarity
Disulfide bondi398 ↔ 467By similarity
Disulfide bondi402 ↔ 469By similarity
Disulfide bondi434 – 434InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP55106.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043329.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiP55106.
OMAiFTRSQRK.
OrthoDBiEOG7WMCK0.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSRVLLSA VFLISFLWDL PGFQQASISS SSSSAELGSA KGMRSRKEGR
60 70 80 90 100
MPRAPRENAT AREPLDRQEP PPRPQEEPQR RPPQQPEARE PPGRGPRVVP
110 120 130 140 150
HEYMLSIYRT YSIAEKLGIN ASFFQSSKSA NTITSFVDRG LDDLSHTPLR
160 170 180 190 200
RQKYLFDVST LSDKEELVGA ELRLFRQAPA APWGPPAGPL RLQLFACQSP
210 220 230 240 250
LLLEARSLDP QGAPRPGWEV FDVWRGLRPQ PWKQLCLELR AAWGGEPGAA
260 270 280 290 300
EDEARAPGPQ QPPPPDLRSL GFGRRVRTPQ ERALLVVFSR SQRKTLFAEM
310 320 330 340 350
REQLGSATEV VGPGGGAEGS GPPPPPPPPP PSGTPDAGLW SPSPGRRRRR
360 370 380 390 400
TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG
410 420 430 440 450
VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA
460 470
GNNVVYKQYE EMVVESCGCR
Length:470
Mass (Da):52,112
Last modified:January 22, 2014 - v2
Checksum:i6C40B980E8207A1F
GO

Sequence cautioni

The sequence AAA61416.1 differs from that shown.Several sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02039445 Genomic DNA. No translation available.
U13661 mRNA. Translation: AAA61416.1. Sequence problems.
PIRiB55452.
UniGeneiBt.29849.

Genome annotation databases

EnsembliENSBTAT00000010110; ENSBTAP00000043329; ENSBTAG00000007687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02039445 Genomic DNA. No translation available.
U13661 mRNA. Translation: AAA61416.1. Sequence problems.
PIRiB55452.
UniGeneiBt.29849.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043329.

Proteomic databases

PRIDEiP55106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010110; ENSBTAP00000043329; ENSBTAG00000007687.

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiP55106.
OMAiFTRSQRK.
OrthoDBiEOG7WMCK0.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."
    Chang S., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J.P., Kozak C.A., Reddi A.H., Moos M.
    J. Biol. Chem. 269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-470.
    Tissue: Articular cartilage.

Entry informationi

Entry nameiGDF6_BOVIN
AccessioniPrimary (citable) accession number: P55106
Secondary accession number(s): F1MD30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 22, 2014
Last modified: April 1, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.