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P55106

- GDF6_BOVIN

UniProt

P55106 - GDF6_BOVIN

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Protein

Growth/differentiation factor 6

Gene

GDF6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A (By similarity).By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. growth Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6
Short name:
GDF-6
Alternative name(s):
Bone morphogenetic protein 13
Short name:
BMP-13
Cartilage-derived morphogenetic protein 2
Short name:
CDMP-2
Gene namesi
Name:GDF6
Synonyms:BMP13, CDMP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 350328Sequence AnalysisPRO_0000425155Add
BLAST
Chaini351 – 470120Growth/differentiation factor 6PRO_0000425156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi369 ↔ 435By similarity
Disulfide bondi398 ↔ 467By similarity
Disulfide bondi402 ↔ 469By similarity
Disulfide bondi434 – 434InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP55106.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043329.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG317866.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiP55106.
OMAiFTRSQRK.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55106-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTSRVLLSA VFLISFLWDL PGFQQASISS SSSSAELGSA KGMRSRKEGR
60 70 80 90 100
MPRAPRENAT AREPLDRQEP PPRPQEEPQR RPPQQPEARE PPGRGPRVVP
110 120 130 140 150
HEYMLSIYRT YSIAEKLGIN ASFFQSSKSA NTITSFVDRG LDDLSHTPLR
160 170 180 190 200
RQKYLFDVST LSDKEELVGA ELRLFRQAPA APWGPPAGPL RLQLFACQSP
210 220 230 240 250
LLLEARSLDP QGAPRPGWEV FDVWRGLRPQ PWKQLCLELR AAWGGEPGAA
260 270 280 290 300
EDEARAPGPQ QPPPPDLRSL GFGRRVRTPQ ERALLVVFSR SQRKTLFAEM
310 320 330 340 350
REQLGSATEV VGPGGGAEGS GPPPPPPPPP PSGTPDAGLW SPSPGRRRRR
360 370 380 390 400
TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG
410 420 430 440 450
VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA
460 470
GNNVVYKQYE EMVVESCGCR
Length:470
Mass (Da):52,112
Last modified:January 22, 2014 - v2
Checksum:i6C40B980E8207A1F
GO

Sequence cautioni

The sequence AAA61416.1 differs from that shown. Reason: Several sequencing errors.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02039445 Genomic DNA. No translation available.
U13661 mRNA. Translation: AAA61416.1. Sequence problems.
PIRiB55452.
UniGeneiBt.29849.

Genome annotation databases

EnsembliENSBTAT00000010110; ENSBTAP00000043329; ENSBTAG00000007687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02039445 Genomic DNA. No translation available.
U13661 mRNA. Translation: AAA61416.1 . Sequence problems.
PIRi B55452.
UniGenei Bt.29849.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000043329.

Proteomic databases

PRIDEi P55106.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000010110 ; ENSBTAP00000043329 ; ENSBTAG00000007687 .

Phylogenomic databases

eggNOGi NOG317866.
GeneTreei ENSGT00760000118883.
HOGENOMi HOG000231514.
HOVERGENi HBG107938.
InParanoidi P55106.
OMAi FTRSQRK.
TreeFami TF316134.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."
    Chang S., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J.P., Kozak C.A., Reddi A.H., Moos M.
    J. Biol. Chem. 269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-470.
    Tissue: Articular cartilage.

Entry informationi

Entry nameiGDF6_BOVIN
AccessioniPrimary (citable) accession number: P55106
Secondary accession number(s): F1MD30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 22, 2014
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3