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P55106

- GDF6_BOVIN

UniProt

P55106 - GDF6_BOVIN

Protein

Growth/differentiation factor 6

Gene

GDF6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (22 Jan 2014)
      Previous versions | rss
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    Functioni

    Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. May signal through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. growth Source: InterPro
    3. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 6
    Short name:
    GDF-6
    Alternative name(s):
    Bone morphogenetic protein 13
    Short name:
    BMP-13
    Cartilage-derived morphogenetic protein 2
    Short name:
    CDMP-2
    Gene namesi
    Name:GDF6
    Synonyms:BMP13, CDMP2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 350328Sequence AnalysisPRO_0000425155Add
    BLAST
    Chaini351 – 470120Growth/differentiation factor 6PRO_0000425156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi369 ↔ 435By similarity
    Disulfide bondi398 ↔ 467By similarity
    Disulfide bondi402 ↔ 469By similarity
    Disulfide bondi434 – 434InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP55106.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000043329.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG317866.
    GeneTreeiENSGT00730000110209.
    HOGENOMiHOG000231514.
    HOVERGENiHBG107938.
    InParanoidiP55106.
    OMAiFTRSQRK.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55106-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSRVLLSA VFLISFLWDL PGFQQASISS SSSSAELGSA KGMRSRKEGR    50
    MPRAPRENAT AREPLDRQEP PPRPQEEPQR RPPQQPEARE PPGRGPRVVP 100
    HEYMLSIYRT YSIAEKLGIN ASFFQSSKSA NTITSFVDRG LDDLSHTPLR 150
    RQKYLFDVST LSDKEELVGA ELRLFRQAPA APWGPPAGPL RLQLFACQSP 200
    LLLEARSLDP QGAPRPGWEV FDVWRGLRPQ PWKQLCLELR AAWGGEPGAA 250
    EDEARAPGPQ QPPPPDLRSL GFGRRVRTPQ ERALLVVFSR SQRKTLFAEM 300
    REQLGSATEV VGPGGGAEGS GPPPPPPPPP PSGTPDAGLW SPSPGRRRRR 350
    TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG 400
    VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA 450
    GNNVVYKQYE EMVVESCGCR 470
    Length:470
    Mass (Da):52,112
    Last modified:January 22, 2014 - v2
    Checksum:i6C40B980E8207A1F
    GO

    Sequence cautioni

    The sequence AAA61416.1 differs from that shown. Reason: Several sequencing errors.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02039445 Genomic DNA. No translation available.
    U13661 mRNA. Translation: AAA61416.1. Sequence problems.
    PIRiB55452.
    UniGeneiBt.29849.

    Genome annotation databases

    EnsembliENSBTAT00000010110; ENSBTAP00000043329; ENSBTAG00000007687.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02039445 Genomic DNA. No translation available.
    U13661 mRNA. Translation: AAA61416.1 . Sequence problems.
    PIRi B55452.
    UniGenei Bt.29849.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000043329.

    Proteomic databases

    PRIDEi P55106.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010110 ; ENSBTAP00000043329 ; ENSBTAG00000007687 .

    Phylogenomic databases

    eggNOGi NOG317866.
    GeneTreei ENSGT00730000110209.
    HOGENOMi HOG000231514.
    HOVERGENi HBG107938.
    InParanoidi P55106.
    OMAi FTRSQRK.
    TreeFami TF316134.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. "Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development."
      Chang S., Hoang B., Thomas J.T., Vukicevic S., Luyten F.P., Ryba N.J.P., Kozak C.A., Reddi A.H., Moos M.
      J. Biol. Chem. 269:28227-28234(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-470.
      Tissue: Articular cartilage.

    Entry informationi

    Entry nameiGDF6_BOVIN
    AccessioniPrimary (citable) accession number: P55106
    Secondary accession number(s): F1MD30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 22, 2014
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3