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Protein

Inhibin beta C chain

Gene

Inhbc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene namesi
Name:Inhbc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:105932. Inhbc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 236218Sequence analysisPRO_0000033732Add
BLAST
Chaini237 – 352116Inhibin beta C chainPRO_0000033733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 317By similarity
Disulfide bondi276 ↔ 349By similarity
Disulfide bondi280 ↔ 351By similarity
Disulfide bondi316 – 316InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP55104.
PaxDbiP55104.
PRIDEiP55104.

PTM databases

PhosphoSiteiP55104.

Expressioni

Tissue specificityi

Mainly expressed in the adult liver.

Gene expression databases

BgeeiP55104.
CleanExiMM_INHBC.
GenevisibleiP55104. MM.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026472.

Structurei

3D structure databases

ProteinModelPortaliP55104.
SMRiP55104. Positions 237-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP55104.
KOiK04667.
OMAiEGYAMNF.
OrthoDBiEOG74R1Q4.
PhylomeDBiP55104.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLLLALL FLTPTTVVNP KTEGPCPACW GAIFDLESQR ELLLDLAKKS
60 70 80 90 100
ILDKLHLSQR PILSRPVSRG ALKTALQRLR GPRRETLLEH DQRQEEYEII
110 120 130 140 150
SFADTDLSSI NQTRLEFHFS GRMASGMEVR QTRFMFFVQF PHNATQTMNI
160 170 180 190 200
RVLVLRPYDT NLTLTSQYVV QVNASGWYQL LLGPEAQAAC SQGHLTLELV
210 220 230 240 250
PESQVAHSSL ILGWFSHRPF VAAQVRVEGK HRVRRRGIDC QGASRMCCRQ
260 270 280 290 300
EFFVDFREIG WNDWIIQPEG YAMNFCTGQC PLHVAGMPGI SASFHTAVLN
310 320 330 340 350
LLKANAAAGT TGRGSCCVPT SRRPLSLLYY DRDSNIVKTD IPDMVVEACG

CS
Length:352
Mass (Da):39,401
Last modified:November 1, 1997 - v2
Checksum:i220812FD73717185
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431A → G in CAA62347 (PubMed:8838799).Curated
Sequence conflicti243 – 2431A → G in CAA62333 (PubMed:8838799).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90841, X90842 Genomic DNA. Translation: CAA62347.1.
X90819 mRNA. Translation: CAA62333.1.
U40773, U40772 Genomic DNA. Translation: AAC52723.1.
U95962 mRNA. Translation: AAC53164.1.
BC026140 mRNA. Translation: AAH26140.1.
CCDSiCCDS24240.1.
PIRiJC5366.
S70580.
RefSeqiNP_034695.1. NM_010565.3.
UniGeneiMm.2594.

Genome annotation databases

EnsembliENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405.
GeneIDi16325.
KEGGimmu:16325.
UCSCiuc007hjj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90841, X90842 Genomic DNA. Translation: CAA62347.1.
X90819 mRNA. Translation: CAA62333.1.
U40773, U40772 Genomic DNA. Translation: AAC52723.1.
U95962 mRNA. Translation: AAC53164.1.
BC026140 mRNA. Translation: AAH26140.1.
CCDSiCCDS24240.1.
PIRiJC5366.
S70580.
RefSeqiNP_034695.1. NM_010565.3.
UniGeneiMm.2594.

3D structure databases

ProteinModelPortaliP55104.
SMRiP55104. Positions 237-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026472.

PTM databases

PhosphoSiteiP55104.

Proteomic databases

MaxQBiP55104.
PaxDbiP55104.
PRIDEiP55104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405.
GeneIDi16325.
KEGGimmu:16325.
UCSCiuc007hjj.2. mouse.

Organism-specific databases

CTDi3626.
MGIiMGI:105932. Inhbc.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP55104.
KOiK04667.
OMAiEGYAMNF.
OrthoDBiEOG74R1Q4.
PhylomeDBiP55104.
TreeFamiTF351791.

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Miscellaneous databases

NextBioi289398.
PROiP55104.
SOURCEiSearch...

Gene expression databases

BgeeiP55104.
CleanExiMM_INHBC.
GenevisibleiP55104. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene."
    Schmitt J., Hoetten G., Jenkins N.A., Gilbert D.J., Copeland N.G., Pohl J., Schrewe H.
    Genomics 32:358-366(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129.
    Tissue: Liver.
  2. "Structural analysis of the mouse activin beta C gene."
    Lau A.L., Nishimori K., Matzuk M.M.
    Biochim. Biophys. Acta 1307:145-148(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues."
    Fang J., Wang S.Q., Smiley E., Bonadio J.
    Biochem. Biophys. Res. Commun. 231:655-661(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiINHBC_MOUSE
AccessioniPrimary (citable) accession number: P55104
Secondary accession number(s): Q61452
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.