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Reviewed, UniProtKB/Swiss-Prot P55104 (INHBC_MOUSE)

Last modified December 15, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Inhibin beta C chain
Alternative name(s):
    Activin beta-C chain
Gene names
Name: Inhbc
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Mainly expressed in the adult liver.

Sequence similarities

Belongs to the TGF-beta family.

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Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
Hormone
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongrowth factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

hormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 236218 Potential
PRO_0000033732
Chain237 – 352116Inhibin beta C chain
PRO_0000033733

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Disulfide bond240 ↔ 248 By similarity
Disulfide bond247 ↔ 317 By similarity
Disulfide bond276 ↔ 349 By similarity
Disulfide bond280 ↔ 351 By similarity
Disulfide bond316Interchain By similarity

Experimental info

Sequence conflict2431A → G in CAA62347. Ref.1
Sequence conflict2431A → G in CAA62333. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P55104-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 220812FD73717185

FASTA35239,401
        10         20         30         40         50         60 
MASSLLLALL FLTPTTVVNP KTEGPCPACW GAIFDLESQR ELLLDLAKKS ILDKLHLSQR 

        70         80         90        100        110        120 
PILSRPVSRG ALKTALQRLR GPRRETLLEH DQRQEEYEII SFADTDLSSI NQTRLEFHFS 

       130        140        150        160        170        180 
GRMASGMEVR QTRFMFFVQF PHNATQTMNI RVLVLRPYDT NLTLTSQYVV QVNASGWYQL 

       190        200        210        220        230        240 
LLGPEAQAAC SQGHLTLELV PESQVAHSSL ILGWFSHRPF VAAQVRVEGK HRVRRRGIDC 

       250        260        270        280        290        300 
QGASRMCCRQ EFFVDFREIG WNDWIIQPEG YAMNFCTGQC PLHVAGMPGI SASFHTAVLN 

       310        320        330        340        350 
LLKANAAAGT TGRGSCCVPT SRRPLSLLYY DRDSNIVKTD IPDMVVEACG CS

« Hide

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References

« Hide 'large scale' references
[1]"Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene."
Schmitt J., Hoetten G., Jenkins N.A., Gilbert D.J., Copeland N.G., Pohl J., Schrewe H.
Genomics 32:358-366(1996) [PubMed: 8838799] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129.
Tissue: Liver.
[2]"Structural analysis of the mouse activin beta C gene."
Lau A.L., Nishimori K., Matzuk M.M.
Biochim. Biophys. Acta 1307:145-148(1996) [PubMed: 8679697] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues."
Fang J., Wang S.Q., Smiley E., Bonadio J.
Biochem. Biophys. Res. Commun. 231:655-661(1997) [PubMed: 9070865] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X90841, X90842 Genomic DNA. Translation: CAA62347.1.
X90819 mRNA. Translation: CAA62333.1.
U40773, U40772 Genomic DNA. Translation: AAC52723.1.
U95962 mRNA. Translation: AAC53164.1.
BC026140 mRNA. Translation: AAH26140.1.
IPIIPI00136513.
PIRJC5366.
S70580.
RefSeqNP_034695.1.
UniGeneMm.2594

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP55104.

Proteomic databases

PRIDEP55104.

Genome annotation databases

EnsemblENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405; Mus musculus. [Genome view]
GeneID16325.
KEGGmmu:16325.
UCSCuc007hjj.1. mouse.

Organism-specific databases

CTD16325.
MGIMGI:105932. Inhbc.

Phylogenomic databases

HOGENOMHBG446695.
HOVERGENP55104.
InParanoidP55104.
OMAWIIQPEG.
OrthoDBEOG9PZMSK.

Gene expression databases

ArrayExpressP55104.
BgeeP55104.
CleanExMM_INHBC.
GenevestigatorP55104.
GermOnlineENSMUSG00000025405. Mus musculus.

Family and domain databases

InterProIPR001318. Inhibin_betaC.
IPR001839. TGFb.
IPR017948. TGFb_CS.
IPR015615. TGFbeta.
[Graphical view]
PANTHERPTHR11848. TGFbeta. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSPR00672. INHIBINBC.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio289398.
SOURCESearch...

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Entry information

Entry nameINHBC_MOUSE
AccessionPrimary (citable) accession number: P55104
Secondary accession number(s): Q61452
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: December 15, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents