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Protein

Inhibin beta C chain

Gene

INHBC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • transforming growth factor beta receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiREACT_15398. Glycoprotein hormones.
SignaLinkiP55103.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene namesi
Name:INHBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6068. INHBC.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: ProtInc
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29879.

Polymorphism and mutation databases

BioMutaiINHBC.
DMDMi1708438.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 236218Sequence AnalysisPRO_0000033730Add
BLAST
Chaini237 – 352116Inhibin beta C chainPRO_0000033731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 317By similarity
Disulfide bondi276 ↔ 349By similarity
Disulfide bondi280 ↔ 351By similarity
Disulfide bondi316 – 316InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55103.
PeptideAtlasiP55103.
PRIDEiP55103.

PTM databases

PhosphoSiteiP55103.

Expressioni

Tissue specificityi

Expressed in benign prostatic hyperplasia.1 Publication

Gene expression databases

BgeeiP55103.
CleanExiHS_INHBC.
GenevisibleiP55103. HS.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000308716.

Structurei

3D structure databases

ProteinModelPortaliP55103.
SMRiP55103. Positions 237-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278844.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP55103.
KOiK04667.
OMAiEGYAMNF.
PhylomeDBiP55103.
TreeFamiTF351791.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS
60 70 80 90 100
ILDKLHLTQR PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS
110 120 130 140 150
FAETGLSTIN QTRLDFHFSS DRTAGDREVQ QASLMFFVQL PSNTTWTLKV
160 170 180 190 200
RVLVLGPHNT NLTLATQYLL EVDASGWHQL PLGPEAQAAC SQGHLTLELV
210 220 230 240 250
LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC QGGSRMCCRQ
260 270 280 290 300
EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN
310 320 330 340 350
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG

CS
Length:352
Mass (Da):38,238
Last modified:October 1, 1996 - v1
Checksum:i496476AD82562D3E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti322 – 3221R → Q.
Corresponds to variant rs2229357 [ dbSNP | Ensembl ].
VAR_024230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82540 mRNA. Translation: CAA57890.1.
CH471054 Genomic DNA. Translation: EAW97011.1.
BC130324 mRNA. Translation: AAI30325.1.
BC130326 mRNA. Translation: AAI30327.1.
CCDSiCCDS8938.1.
PIRiJC2466.
RefSeqiNP_005529.1. NM_005538.3.
UniGeneiHs.632722.

Genome annotation databases

EnsembliENST00000309668; ENSP00000308716; ENSG00000175189.
GeneIDi3626.
KEGGihsa:3626.
UCSCiuc001snv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82540 mRNA. Translation: CAA57890.1.
CH471054 Genomic DNA. Translation: EAW97011.1.
BC130324 mRNA. Translation: AAI30325.1.
BC130326 mRNA. Translation: AAI30327.1.
CCDSiCCDS8938.1.
PIRiJC2466.
RefSeqiNP_005529.1. NM_005538.3.
UniGeneiHs.632722.

3D structure databases

ProteinModelPortaliP55103.
SMRiP55103. Positions 237-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308716.

PTM databases

PhosphoSiteiP55103.

Polymorphism and mutation databases

BioMutaiINHBC.
DMDMi1708438.

Proteomic databases

PaxDbiP55103.
PeptideAtlasiP55103.
PRIDEiP55103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309668; ENSP00000308716; ENSG00000175189.
GeneIDi3626.
KEGGihsa:3626.
UCSCiuc001snv.1. human.

Organism-specific databases

CTDi3626.
GeneCardsiGC12P057828.
HGNCiHGNC:6068. INHBC.
MIMi601233. gene.
neXtProtiNX_P55103.
PharmGKBiPA29879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278844.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiP55103.
KOiK04667.
OMAiEGYAMNF.
PhylomeDBiP55103.
TreeFamiTF351791.

Enzyme and pathway databases

ReactomeiREACT_15398. Glycoprotein hormones.
SignaLinkiP55103.

Miscellaneous databases

GeneWikiiINHBC.
GenomeRNAii3626.
NextBioi14189.
PROiP55103.
SOURCEiSearch...

Gene expression databases

BgeeiP55103.
CleanExiHS_INHBC.
GenevisibleiP55103. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain."
    Hoetten G., Neidhardt H., Schneider C., Pohl J.
    Biochem. Biophys. Res. Commun. 206:608-613(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia."
    Thomas T.Z., Chapman S.M., Hong W., Gurusingfhe C., Mellor S.L., Fletcher R., Pedersen J., Risbridger G.P.
    Prostate 34:34-43(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiINHBC_HUMAN
AccessioniPrimary (citable) accession number: P55103
Secondary accession number(s): A1L3Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.