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P55103 (INHBC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene names
Name:INHBC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subunit structure

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in benign prostatic hyperplasia. Ref.4

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionGrowth factor
Hormone
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgrowth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functiontransforming growth factor beta receptor binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 236218 Potential
PRO_0000033730
Chain237 – 352116Inhibin beta C chain
PRO_0000033731

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Disulfide bond240 ↔ 248 By similarity
Disulfide bond247 ↔ 317 By similarity
Disulfide bond276 ↔ 349 By similarity
Disulfide bond280 ↔ 351 By similarity
Disulfide bond316Interchain By similarity

Natural variations

Natural variant3221R → Q.
Corresponds to variant rs2229357 [ dbSNP | Ensembl ].
VAR_024230

Sequences

Sequence LengthMass (Da)Tools
P55103 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 496476AD82562D3E

FASTA35238,238
        10         20         30         40         50         60 
MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR 

        70         80         90        100        110        120 
PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS 

       130        140        150        160        170        180 
DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL 

       190        200        210        220        230        240 
PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC 

       250        260        270        280        290        300 
QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN 

       310        320        330        340        350 
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new member of the TGF-beta family: a putative new activin beta C chain."
Hoetten G., Neidhardt H., Schneider C., Pohl J.
Biochem. Biophys. Res. Commun. 206:608-613(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia."
Thomas T.Z., Chapman S.M., Hong W., Gurusingfhe C., Mellor S.L., Fletcher R., Pedersen J., Risbridger G.P.
Prostate 34:34-43(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X82540 mRNA. Translation: CAA57890.1.
CH471054 Genomic DNA. Translation: EAW97011.1.
BC130324 mRNA. Translation: AAI30325.1.
BC130326 mRNA. Translation: AAI30327.1.
CCDSCCDS8938.1.
PIRJC2466.
RefSeqNP_005529.1. NM_005538.3.
UniGeneHs.632722.

3D structure databases

ProteinModelPortalP55103.
SMRP55103. Positions 237-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308716.

PTM databases

PhosphoSiteP55103.

Polymorphism databases

DMDM1708438.

Proteomic databases

PaxDbP55103.
PeptideAtlasP55103.
PRIDEP55103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309668; ENSP00000308716; ENSG00000175189.
GeneID3626.
KEGGhsa:3626.
UCSCuc001snv.1. human.

Organism-specific databases

CTD3626.
GeneCardsGC12P057828.
HGNCHGNC:6068. INHBC.
MIM601233. gene.
neXtProtNX_P55103.
PharmGKBPA29879.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278844.
HOGENOMHOG000220890.
HOVERGENHBG105613.
InParanoidP55103.
KOK04667.
OMAFREIGWH.
PhylomeDBP55103.
TreeFamTF351791.

Enzyme and pathway databases

SignaLinkP55103.

Gene expression databases

ArrayExpressP55103.
BgeeP55103.
CleanExHS_INHBC.
GenevestigatorP55103.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00672. INHIBINBC.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiINHBC.
GenomeRNAi3626.
NextBio14189.
PROP55103.
SOURCESearch...

Entry information

Entry nameINHBC_HUMAN
AccessionPrimary (citable) accession number: P55103
Secondary accession number(s): A1L3Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM