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P55103

- INHBC_HUMAN

UniProt

P55103 - INHBC_HUMAN

Protein

Inhibin beta C chain

Gene

INHBC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

    GO - Molecular functioni

    1. transforming growth factor beta receptor binding Source: ProtInc

    GO - Biological processi

    1. growth Source: InterPro

    Keywords - Molecular functioni

    Growth factor, Hormone

    Enzyme and pathway databases

    ReactomeiREACT_15398. Glycoprotein hormones.
    SignaLinkiP55103.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inhibin beta C chain
    Alternative name(s):
    Activin beta-C chain
    Gene namesi
    Name:INHBC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6068. INHBC.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: ProtInc
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29879.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 236218Sequence AnalysisPRO_0000033730Add
    BLAST
    Chaini237 – 352116Inhibin beta C chainPRO_0000033731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi240 ↔ 248By similarity
    Disulfide bondi247 ↔ 317By similarity
    Disulfide bondi276 ↔ 349By similarity
    Disulfide bondi280 ↔ 351By similarity
    Disulfide bondi316 – 316InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP55103.
    PeptideAtlasiP55103.
    PRIDEiP55103.

    PTM databases

    PhosphoSiteiP55103.

    Expressioni

    Tissue specificityi

    Expressed in benign prostatic hyperplasia.1 Publication

    Gene expression databases

    ArrayExpressiP55103.
    BgeeiP55103.
    CleanExiHS_INHBC.
    GenevestigatoriP55103.

    Interactioni

    Subunit structurei

    Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308716.

    Structurei

    3D structure databases

    ProteinModelPortaliP55103.
    SMRiP55103. Positions 237-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG278844.
    HOGENOMiHOG000220890.
    HOVERGENiHBG105613.
    InParanoidiP55103.
    KOiK04667.
    OMAiFREIGWH.
    PhylomeDBiP55103.
    TreeFamiTF351791.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001318. Inhibin_betaC.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00672. INHIBINBC.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55103-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS    50
    ILDKLHLTQR PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS 100
    FAETGLSTIN QTRLDFHFSS DRTAGDREVQ QASLMFFVQL PSNTTWTLKV 150
    RVLVLGPHNT NLTLATQYLL EVDASGWHQL PLGPEAQAAC SQGHLTLELV 200
    LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC QGGSRMCCRQ 250
    EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN 300
    LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG 350
    CS 352
    Length:352
    Mass (Da):38,238
    Last modified:October 1, 1996 - v1
    Checksum:i496476AD82562D3E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti322 – 3221R → Q.
    Corresponds to variant rs2229357 [ dbSNP | Ensembl ].
    VAR_024230

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82540 mRNA. Translation: CAA57890.1.
    CH471054 Genomic DNA. Translation: EAW97011.1.
    BC130324 mRNA. Translation: AAI30325.1.
    BC130326 mRNA. Translation: AAI30327.1.
    CCDSiCCDS8938.1.
    PIRiJC2466.
    RefSeqiNP_005529.1. NM_005538.3.
    UniGeneiHs.632722.

    Genome annotation databases

    EnsembliENST00000309668; ENSP00000308716; ENSG00000175189.
    GeneIDi3626.
    KEGGihsa:3626.
    UCSCiuc001snv.1. human.

    Polymorphism databases

    DMDMi1708438.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X82540 mRNA. Translation: CAA57890.1 .
    CH471054 Genomic DNA. Translation: EAW97011.1 .
    BC130324 mRNA. Translation: AAI30325.1 .
    BC130326 mRNA. Translation: AAI30327.1 .
    CCDSi CCDS8938.1.
    PIRi JC2466.
    RefSeqi NP_005529.1. NM_005538.3.
    UniGenei Hs.632722.

    3D structure databases

    ProteinModelPortali P55103.
    SMRi P55103. Positions 237-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308716.

    PTM databases

    PhosphoSitei P55103.

    Polymorphism databases

    DMDMi 1708438.

    Proteomic databases

    PaxDbi P55103.
    PeptideAtlasi P55103.
    PRIDEi P55103.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309668 ; ENSP00000308716 ; ENSG00000175189 .
    GeneIDi 3626.
    KEGGi hsa:3626.
    UCSCi uc001snv.1. human.

    Organism-specific databases

    CTDi 3626.
    GeneCardsi GC12P057828.
    HGNCi HGNC:6068. INHBC.
    MIMi 601233. gene.
    neXtProti NX_P55103.
    PharmGKBi PA29879.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278844.
    HOGENOMi HOG000220890.
    HOVERGENi HBG105613.
    InParanoidi P55103.
    KOi K04667.
    OMAi FREIGWH.
    PhylomeDBi P55103.
    TreeFami TF351791.

    Enzyme and pathway databases

    Reactomei REACT_15398. Glycoprotein hormones.
    SignaLinki P55103.

    Miscellaneous databases

    GeneWikii INHBC.
    GenomeRNAii 3626.
    NextBioi 14189.
    PROi P55103.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55103.
    Bgeei P55103.
    CleanExi HS_INHBC.
    Genevestigatori P55103.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001318. Inhibin_betaC.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00672. INHIBINBC.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new member of the TGF-beta family: a putative new activin beta C chain."
      Hoetten G., Neidhardt H., Schneider C., Pohl J.
      Biochem. Biophys. Res. Commun. 206:608-613(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia."
      Thomas T.Z., Chapman S.M., Hong W., Gurusingfhe C., Mellor S.L., Fletcher R., Pedersen J., Risbridger G.P.
      Prostate 34:34-43(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiINHBC_HUMAN
    AccessioniPrimary (citable) accession number: P55103
    Secondary accession number(s): A1L3Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3