P55103 (INHBC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inhibin beta C chain

Alternative name(s):
Activin beta-C chain

Gene names

Name:

INHBC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subunit structure	Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed in benign prostatic hyperplasia. Ref.4
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Growth factor Hormone
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	growth Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Traceable author statement Ref.1. Source: ProtInc
Molecular_function	transforming growth factor beta receptor binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 236	218	Potential		PRO_0000033730
	Chain	237 – 352	116	Inhibin beta C chain		PRO_0000033731
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Disulfide bond	240 ↔ 248		By similarity
	Disulfide bond	247 ↔ 317		By similarity
	Disulfide bond	276 ↔ 349		By similarity
	Disulfide bond	280 ↔ 351		By similarity
	Disulfide bond	316		Interchain By similarity
Natural variations
	Natural variant	322	1	R → Q. Corresponds to variant rs2229357 [ dbSNP | Ensembl ].		VAR_024230

Sequences

	Sequence		Length	Mass (Da)
	P55103 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 496476AD82562D3E	FASTA	352	38,238
	10 20 30 40 50 60 MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR 70 80 90 100 110 120 PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS 130 140 150 160 170 180 DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL 190 200 210 220 230 240 PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC 250 260 270 280 290 300 QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN 310 320 330 340 350 LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new member of the TGF-beta family: a putative new activin beta C chain." Hoetten G., Neidhardt H., Schneider C., Pohl J. Biochem. Biophys. Res. Commun. 206:608-613(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia." Thomas T.Z., Chapman S.M., Hong W., Gurusingfhe C., Mellor S.L., Fletcher R., Pedersen J., Risbridger G.P. Prostate 34:34-43(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X82540 mRNA. Translation: CAA57890.1. CH471054 Genomic DNA. Translation: EAW97011.1. BC130324 mRNA. Translation: AAI30325.1. BC130326 mRNA. Translation: AAI30327.1.
IPI	IPI00023314.
PIR	JC2466.
RefSeq	NP_005529.1. NM_005538.2.
UniGene	Hs.632722.
3D structure databases
ProteinModelPortal	P55103.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308716.
PTM databases
PhosphoSite	P55103.
Polymorphism databases
DMDM	1708438.
Proteomic databases
PaxDb	P55103.
PeptideAtlas	P55103.
PRIDE	P55103.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309668; ENSP00000308716; ENSG00000175189.
GeneID	3626.
KEGG	hsa:3626.
UCSC	uc001snv.1. human.
Organism-specific databases
CTD	3626.
GeneCards	GC12P057828.
HGNC	HGNC:6068. INHBC.
MIM	601233. gene.
neXtProt	NX_P55103.
PharmGKB	PA29879.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278844.
HOGENOM	HOG000220890.
HOVERGEN	HBG105613.
InParanoid	P55103.
KO	K04667.
OMA	EGYAMNF.
OrthoDB	EOG4J118K.
PhylomeDB	P55103.
Enzyme and pathway databases
SignaLink	P55103.
Gene expression databases
ArrayExpress	P55103.
Bgee	P55103.
CleanEx	HS_INHBC.
Genevestigator	P55103.
GermOnline	ENSG00000175189. Homo sapiens.
Family and domain databases
InterPro	IPR001318. Inhibin_betaC. IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR00672. INHIBINBC.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3626.
NextBio	14189.
SOURCE	Search...

Entry information

Entry name

INHBC_HUMAN

Accession

Primary (citable) accession number: P55103
Secondary accession number(s): A1L3Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.