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Protein

Inhibin beta C chain

Gene

INHBC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-HSA-209822 Glycoprotein hormones
SignaLinkiP55103

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta C chain
Alternative name(s):
Activin beta-C chain
Gene namesi
Name:INHBC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175189.3
HGNCiHGNC:6068 INHBC
MIMi601233 gene
neXtProtiNX_P55103

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3626
OpenTargetsiENSG00000175189
PharmGKBiPA29879

Polymorphism and mutation databases

BioMutaiINHBC
DMDMi1708438

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003373019 – 236Sequence analysisAdd BLAST218
ChainiPRO_0000033731237 – 352Inhibin beta C chainAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 317By similarity
Disulfide bondi276 ↔ 349By similarity
Disulfide bondi280 ↔ 351By similarity
Disulfide bondi316InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55103
PeptideAtlasiP55103
PRIDEiP55103

PTM databases

iPTMnetiP55103
PhosphoSitePlusiP55103

Expressioni

Tissue specificityi

Expressed in benign prostatic hyperplasia.1 Publication

Gene expression databases

BgeeiENSG00000175189
CleanExiHS_INHBC
GenevisibleiP55103 HS

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308716

Structurei

3D structure databases

ProteinModelPortaliP55103
SMRiP55103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP55103
KOiK04667
OMAiYYDRDSN
OrthoDBiEOG091G09LW
PhylomeDBiP55103
TreeFamiTF351791

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001318 Inhibin_betaC
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PRINTSiPR00672 INHIBINBC
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS
60 70 80 90 100
ILDKLHLTQR PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS
110 120 130 140 150
FAETGLSTIN QTRLDFHFSS DRTAGDREVQ QASLMFFVQL PSNTTWTLKV
160 170 180 190 200
RVLVLGPHNT NLTLATQYLL EVDASGWHQL PLGPEAQAAC SQGHLTLELV
210 220 230 240 250
LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC QGGSRMCCRQ
260 270 280 290 300
EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN
310 320 330 340 350
LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG

CS
Length:352
Mass (Da):38,238
Last modified:October 1, 1996 - v1
Checksum:i496476AD82562D3E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024230322R → Q. Corresponds to variant dbSNP:rs2229357Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82540 mRNA Translation: CAA57890.1
CH471054 Genomic DNA Translation: EAW97011.1
BC130324 mRNA Translation: AAI30325.1
BC130326 mRNA Translation: AAI30327.1
CCDSiCCDS8938.1
PIRiJC2466
RefSeqiNP_005529.1, NM_005538.3
UniGeneiHs.632722

Genome annotation databases

EnsembliENST00000309668; ENSP00000308716; ENSG00000175189
GeneIDi3626
KEGGihsa:3626
UCSCiuc001snv.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiINHBC_HUMAN
AccessioniPrimary (citable) accession number: P55103
Secondary accession number(s): A1L3Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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