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Protein

Tachykinin-3

Gene

Tac3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Alternative name(s):
Neurokinin B-like protein Zneurok1
Preprotachykinin-B
Short name:
PPT-B
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:Tac3
Synonyms:Nknb, Tac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:98476. Tac2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003356821 – 79Add BLAST59
PeptideiPRO_000003356982 – 91Neurokinin-B10
PropeptideiPRO_000003357095 – 116Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55099.
PRIDEiP55099.

PTM databases

PhosphoSitePlusiP55099.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025400.
CleanExiMM_TAC2.
GenevisibleiP55099. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026466.

Structurei

3D structure databases

ProteinModelPortaliP55099.
SMRiP55099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH. Eukaryota.
ENOG4111D7S. LUCA.
GeneTreeiENSGT00390000000335.
HOGENOMiHOG000154597.
HOVERGENiHBG016587.
InParanoidiP55099.
KOiK05240.
OMAiKRNIQPD.
OrthoDBiEOG091G0X8Y.
PhylomeDBiP55099.
TreeFamiTF337038.

Family and domain databases

InterProiIPR003635. Neurokinin-B/TAC3.
IPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PANTHERiPTHR15536. PTHR15536. 1 hit.
PfamiPF03823. Neurokinin_B. 1 hit.
[Graphical view]
PIRSFiPIRSF001843. Neurokinin. 1 hit.
PRINTSiPR01828. NEUROKININB.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSAMLFAAV LALSLAWTFG AVCEEPQGQG GRLSKDSDLY QLPPSLLRRL
60 70 80 90 100
YDSRPVSLEG LLKVLSKASV GPKETSLPQK RDMHDFFVGL MGKRNSQPDT
110
PTDVVEENTP SFGILK
Length:116
Mass (Da):12,737
Last modified:May 10, 2004 - v2
Checksum:iBD4C8B171C2213CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28G → E in BAA03316 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14423 mRNA. Translation: BAA03316.1.
AF186116 mRNA. Translation: AAF01434.1.
BC051476 mRNA. Translation: AAH51476.1.
CCDSiCCDS24248.1.
PIRiI65342.
RefSeqiNP_001186900.1. NM_001199971.1.
NP_033338.2. NM_009312.2.
UniGeneiMm.2374.

Genome annotation databases

EnsembliENSMUST00000026466; ENSMUSP00000026466; ENSMUSG00000025400.
ENSMUST00000179960; ENSMUSP00000136622; ENSMUSG00000025400.
GeneIDi21334.
KEGGimmu:21334.
UCSCiuc007hkj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14423 mRNA. Translation: BAA03316.1.
AF186116 mRNA. Translation: AAF01434.1.
BC051476 mRNA. Translation: AAH51476.1.
CCDSiCCDS24248.1.
PIRiI65342.
RefSeqiNP_001186900.1. NM_001199971.1.
NP_033338.2. NM_009312.2.
UniGeneiMm.2374.

3D structure databases

ProteinModelPortaliP55099.
SMRiP55099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026466.

PTM databases

PhosphoSitePlusiP55099.

Proteomic databases

PaxDbiP55099.
PRIDEiP55099.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026466; ENSMUSP00000026466; ENSMUSG00000025400.
ENSMUST00000179960; ENSMUSP00000136622; ENSMUSG00000025400.
GeneIDi21334.
KEGGimmu:21334.
UCSCiuc007hkj.2. mouse.

Organism-specific databases

CTDi21334.
MGIiMGI:98476. Tac2.

Phylogenomic databases

eggNOGiENOG410J2QH. Eukaryota.
ENOG4111D7S. LUCA.
GeneTreeiENSGT00390000000335.
HOGENOMiHOG000154597.
HOVERGENiHBG016587.
InParanoidiP55099.
KOiK05240.
OMAiKRNIQPD.
OrthoDBiEOG091G0X8Y.
PhylomeDBiP55099.
TreeFamiTF337038.

Enzyme and pathway databases

ReactomeiR-MMU-380095. Tachykinin receptors bind tachykinins.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP55099.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025400.
CleanExiMM_TAC2.
GenevisibleiP55099. MM.

Family and domain databases

InterProiIPR003635. Neurokinin-B/TAC3.
IPR013055. Tachy_Neuro_lke_CS.
[Graphical view]
PANTHERiPTHR15536. PTHR15536. 1 hit.
PfamiPF03823. Neurokinin_B. 1 hit.
[Graphical view]
PIRSFiPIRSF001843. Neurokinin. 1 hit.
PRINTSiPR01828. NEUROKININB.
PROSITEiPS00267. TACHYKININ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTKNK_MOUSE
AccessioniPrimary (citable) accession number: P55099
Secondary accession number(s): Q9QXS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.