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Protein

Peroxisome biogenesis factor 2

Gene

Pex2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Somewhat implicated in the biogenesis of peroxisomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • bile acid biosynthetic process Source: MGI
  • cholesterol homeostasis Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nervous system development Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • protein destabilization Source: MGI
  • protein import into peroxisome matrix Source: MGI
  • protein polyubiquitination Source: GO_Central
  • regulation of cholesterol biosynthetic process Source: MGI
  • very long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal membrane protein 3
Peroxisome assembly factor 1
Short name:
PAF-1
Gene namesi
Name:Pex2
Synonyms:Paf1, Pmp35, Pxmp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107486. Pex2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei140 – 15920HelicalSequence AnalysisAdd
BLAST
Transmembranei195 – 21319HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Peroxisome biogenesis factor 2PRO_0000056370Add
BLAST

Proteomic databases

MaxQBiP55098.
PaxDbiP55098.
PRIDEiP55098.

PTM databases

PhosphoSiteiP55098.

Expressioni

Gene expression databases

CleanExiMM_PEX2.
GenevisibleiP55098. MM.

Interactioni

Protein-protein interaction databases

IntActiP55098. 1 interaction.
STRINGi10090.ENSMUSP00000059415.

Structurei

3D structure databases

ProteinModelPortaliP55098.
SMRiP55098. Positions 241-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG245402.
HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP55098.
KOiK06664.
PhylomeDBiP55098.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA
60 70 80 90 100
RFEPEVKAFL WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK
110 120 130 140 150
NQKLLYAVCT IGGRWLEERC YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE
160 170 180 190 200
LMNFLIFLQK GKFATLTERL LGIHSVFCKP QNMREVGFEY MNRELLWHGF
210 220 230 240 250
AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS GKECALCGEW
260 270 280 290 300
PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS

EVNAL
Length:305
Mass (Da):34,732
Last modified:October 1, 1996 - v1
Checksum:iFAFB6C8913F959F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 88MAAREEST → MTGKEENM in AAB91465 (PubMed:9382874).Curated
Sequence conflicti85 – 851H → Y in AAB91465 (PubMed:9382874).Curated
Sequence conflicti91 – 944PNPV → LNLI in AAB91465 (PubMed:9382874).Curated
Sequence conflicti101 – 1011N → T in AAB91465 (PubMed:9382874).Curated
Sequence conflicti105 – 1051L → W in AAB91465 (PubMed:9382874).Curated
Sequence conflicti114 – 1141R → K in AAB91465 (PubMed:9382874).Curated
Sequence conflicti138 – 1381C → F in AAB91465 (PubMed:9382874).Curated
Sequence conflicti142 – 1421V → L in AAB91465 (PubMed:9382874).Curated
Sequence conflicti152 – 1521M → I in AAB91465 (PubMed:9382874).Curated
Sequence conflicti225 – 2273TLC → IPL in AAB91465 (PubMed:9382874).Curated
Sequence conflicti295 – 2951A → S in AAB91465 (PubMed:9382874).Curated
Sequence conflicti298 – 2981Q → E in AAB91465 (PubMed:9382874).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRiI52362.
RefSeqiNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530121.1. XM_006530058.2.
XP_006530122.1. XM_006530059.2.
UniGeneiMm.132336.

Genome annotation databases

GeneIDi19302.
KEGGimmu:19302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRiI52362.
RefSeqiNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530121.1. XM_006530058.2.
XP_006530122.1. XM_006530059.2.
UniGeneiMm.132336.

3D structure databases

ProteinModelPortaliP55098.
SMRiP55098. Positions 241-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55098. 1 interaction.
STRINGi10090.ENSMUSP00000059415.

PTM databases

PhosphoSiteiP55098.

Proteomic databases

MaxQBiP55098.
PaxDbiP55098.
PRIDEiP55098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19302.
KEGGimmu:19302.

Organism-specific databases

CTDi5828.
MGIiMGI:107486. Pex2.

Phylogenomic databases

eggNOGiNOG245402.
HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP55098.
KOiK06664.
PhylomeDBiP55098.

Miscellaneous databases

NextBioi296257.
PROiP55098.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PEX2.
GenevisibleiP55098. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes."
    Wilson G.N., Bryant D.D.
    Biochem. Med. Metab. Biol. 51:140-148(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Swiss Webster.
    Tissue: Liver.
  2. "Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder."
    Faust P.L., Hatten M.E.
    J. Cell Biol. 139:1293-1305(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Cerebellum.

Entry informationi

Entry nameiPEX2_MOUSE
AccessioniPrimary (citable) accession number: P55098
Secondary accession number(s): O35467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 24, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.