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P55098

- PEX2_MOUSE

UniProt

P55098 - PEX2_MOUSE

Protein

Peroxisome biogenesis factor 2

Gene

Pex2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Somewhat implicated in the biogenesis of peroxisomes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. bile acid biosynthetic process Source: MGI
    2. cholesterol homeostasis Source: MGI
    3. nervous system development Source: MGI
    4. neuron migration Source: MGI
    5. peroxisome organization Source: UniProtKB-KW
    6. regulation of cholesterol biosynthetic process Source: MGI

    Keywords - Biological processi

    Peroxisome biogenesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome biogenesis factor 2
    Alternative name(s):
    Peroxin-2
    Peroxisomal membrane protein 3
    Peroxisome assembly factor 1
    Short name:
    PAF-1
    Gene namesi
    Name:Pex2
    Synonyms:Paf1, Pmp35, Pxmp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107486. Pex2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. peroxisomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Peroxisome biogenesis factor 2PRO_0000056370Add
    BLAST

    Proteomic databases

    MaxQBiP55098.
    PaxDbiP55098.
    PRIDEiP55098.

    PTM databases

    PhosphoSiteiP55098.

    Expressioni

    Gene expression databases

    CleanExiMM_PEX2.
    GenevestigatoriP55098.

    Interactioni

    Protein-protein interaction databases

    IntActiP55098. 1 interaction.
    STRINGi10090.ENSMUSP00000059415.

    Structurei

    3D structure databases

    ProteinModelPortaliP55098.
    SMRiP55098. Positions 239-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei140 – 15920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21319HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pex2/pex10/pex12 family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG245402.
    HOGENOMiHOG000294074.
    HOVERGENiHBG000416.
    InParanoidiP55098.
    KOiK06664.
    PhylomeDBiP55098.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR006845. Pex_N.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF04757. Pex2_Pex12. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55098-1 [UniParc]FASTAAdd to Basket

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    MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA    50
    RFEPEVKAFL WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK 100
    NQKLLYAVCT IGGRWLEERC YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE 150
    LMNFLIFLQK GKFATLTERL LGIHSVFCKP QNMREVGFEY MNRELLWHGF 200
    AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS GKECALCGEW 250
    PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS 300
    EVNAL 305
    Length:305
    Mass (Da):34,732
    Last modified:October 1, 1996 - v1
    Checksum:iFAFB6C8913F959F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 88MAAREEST → MTGKEENM in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti85 – 851H → Y in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti91 – 944PNPV → LNLI in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti101 – 1011N → T in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti105 – 1051L → W in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti114 – 1141R → K in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti138 – 1381C → F in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti142 – 1421V → L in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti152 – 1521M → I in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti225 – 2273TLC → IPL in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti295 – 2951A → S in AAB91465. (PubMed:9382874)Curated
    Sequence conflicti298 – 2981Q → E in AAB91465. (PubMed:9382874)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27842 Genomic DNA. Translation: AAA21742.1.
    AF031128 mRNA. Translation: AAB91465.1.
    PIRiI52362.
    RefSeqiNP_001156773.1. NM_001163301.2.
    NP_001156774.1. NM_001163302.2.
    NP_001156777.1. NM_001163305.2.
    NP_001156778.1. NM_001163306.2.
    NP_001254643.1. NM_001267714.1.
    NP_001254644.1. NM_001267715.1.
    NP_033020.2. NM_008994.4.
    XP_006530120.1. XM_006530057.1.
    XP_006530121.1. XM_006530058.1.
    XP_006530122.1. XM_006530059.1.
    UniGeneiMm.132336.

    Genome annotation databases

    GeneIDi19302.
    KEGGimmu:19302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27842 Genomic DNA. Translation: AAA21742.1 .
    AF031128 mRNA. Translation: AAB91465.1 .
    PIRi I52362.
    RefSeqi NP_001156773.1. NM_001163301.2.
    NP_001156774.1. NM_001163302.2.
    NP_001156777.1. NM_001163305.2.
    NP_001156778.1. NM_001163306.2.
    NP_001254643.1. NM_001267714.1.
    NP_001254644.1. NM_001267715.1.
    NP_033020.2. NM_008994.4.
    XP_006530120.1. XM_006530057.1.
    XP_006530121.1. XM_006530058.1.
    XP_006530122.1. XM_006530059.1.
    UniGenei Mm.132336.

    3D structure databases

    ProteinModelPortali P55098.
    SMRi P55098. Positions 239-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P55098. 1 interaction.
    STRINGi 10090.ENSMUSP00000059415.

    PTM databases

    PhosphoSitei P55098.

    Proteomic databases

    MaxQBi P55098.
    PaxDbi P55098.
    PRIDEi P55098.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19302.
    KEGGi mmu:19302.

    Organism-specific databases

    CTDi 5828.
    MGIi MGI:107486. Pex2.

    Phylogenomic databases

    eggNOGi NOG245402.
    HOGENOMi HOG000294074.
    HOVERGENi HBG000416.
    InParanoidi P55098.
    KOi K06664.
    PhylomeDBi P55098.

    Miscellaneous databases

    NextBioi 296257.
    PROi P55098.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PEX2.
    Genevestigatori P55098.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR006845. Pex_N.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF04757. Pex2_Pex12. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes."
      Wilson G.N., Bryant D.D.
      Biochem. Med. Metab. Biol. 51:140-148(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Swiss Webster.
      Tissue: Liver.
    2. "Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder."
      Faust P.L., Hatten M.E.
      J. Cell Biol. 139:1293-1305(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiPEX2_MOUSE
    AccessioniPrimary (citable) accession number: P55098
    Secondary accession number(s): O35467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3