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P55098 (PEX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisome biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal membrane protein 3
Peroxisome assembly factor 1
Short name=PAF-1
Gene names
Name:Pex2
Synonyms:Paf1, Pmp35, Pxmp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Somewhat implicated in the biogenesis of peroxisomes.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the pex2/pex10/pex12 family.

Contains 1 RING-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Peroxisome biogenesis factor 2
PRO_0000056370

Regions

Transmembrane140 – 15920Helical; Potential
Transmembrane195 – 21319Helical; Potential
Zinc finger244 – 28441RING-type

Experimental info

Sequence conflict1 – 88MAAREEST → MTGKEENM in AAB91465. Ref.2
Sequence conflict851H → Y in AAB91465. Ref.2
Sequence conflict91 – 944PNPV → LNLI in AAB91465. Ref.2
Sequence conflict1011N → T in AAB91465. Ref.2
Sequence conflict1051L → W in AAB91465. Ref.2
Sequence conflict1141R → K in AAB91465. Ref.2
Sequence conflict1381C → F in AAB91465. Ref.2
Sequence conflict1421V → L in AAB91465. Ref.2
Sequence conflict1521M → I in AAB91465. Ref.2
Sequence conflict225 – 2273TLC → IPL in AAB91465. Ref.2
Sequence conflict2951A → S in AAB91465. Ref.2
Sequence conflict2981Q → E in AAB91465. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55098 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: FAFB6C8913F959F0

FASTA30534,732
        10         20         30         40         50         60 
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL 

        70         80         90        100        110        120 
WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK NQKLLYAVCT IGGRWLEERC 

       130        140        150        160        170        180 
YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE LMNFLIFLQK GKFATLTERL LGIHSVFCKP 

       190        200        210        220        230        240 
QNMREVGFEY MNRELLWHGF AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS 

       250        260        270        280        290        300 
GKECALCGEW PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS 


EVNAL 

« Hide

References

[1]"Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes."
Wilson G.N., Bryant D.D.
Biochem. Med. Metab. Biol. 51:140-148(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Swiss Webster.
Tissue: Liver.
[2]"Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder."
Faust P.L., Hatten M.E.
J. Cell Biol. 139:1293-1305(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRI52362.
RefSeqNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530120.1. XM_006530057.1.
XP_006530121.1. XM_006530058.1.
XP_006530122.1. XM_006530059.1.
UniGeneMm.132336.

3D structure databases

ProteinModelPortalP55098.
SMRP55098. Positions 238-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP55098. 1 interaction.
STRING10090.ENSMUSP00000059415.

PTM databases

PhosphoSiteP55098.

Proteomic databases

PaxDbP55098.
PRIDEP55098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19302.
KEGGmmu:19302.

Organism-specific databases

CTD5828.
MGIMGI:107486. Pex2.

Phylogenomic databases

eggNOGNOG245402.
HOGENOMHOG000294074.
HOVERGENHBG000416.
InParanoidP55098.
KOK06664.
PhylomeDBP55098.

Gene expression databases

CleanExMM_PEX2.
GenevestigatorP55098.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296257.
PROP55098.
SOURCESearch...

Entry information

Entry namePEX2_MOUSE
AccessionPrimary (citable) accession number: P55098
Secondary accession number(s): O35467
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot