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Protein

Peroxisome biogenesis factor 2

Gene

Pex2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Somewhat implicated in the biogenesis of peroxisomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 284RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

  • bile acid biosynthetic process Source: MGI
  • cholesterol homeostasis Source: MGI
  • fatty acid beta-oxidation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of fibroblast proliferation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nervous system development Source: MGI
  • neuron migration Source: MGI
  • peroxisome organization Source: MGI
  • protein destabilization Source: MGI
  • protein import into peroxisome matrix Source: MGI
  • regulation of cholesterol biosynthetic process Source: MGI
  • very long-chain fatty acid metabolic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal membrane protein 3
Peroxisome assembly factor 1
Short name:
PAF-1
Gene namesi
Name:Pex2
Synonyms:Paf1, Pmp35, Pxmp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107486. Pex2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei140 – 159HelicalSequence analysisAdd BLAST20
Transmembranei195 – 213HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563701 – 305Peroxisome biogenesis factor 2Add BLAST305

Proteomic databases

MaxQBiP55098.
PRIDEiP55098.

PTM databases

PhosphoSitePlusiP55098.

Expressioni

Gene expression databases

CleanExiMM_PEX2.

Interactioni

Protein-protein interaction databases

IntActiP55098. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP55098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 284RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP55098.
KOiK06664.
PhylomeDBiP55098.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA
60 70 80 90 100
RFEPEVKAFL WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK
110 120 130 140 150
NQKLLYAVCT IGGRWLEERC YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE
160 170 180 190 200
LMNFLIFLQK GKFATLTERL LGIHSVFCKP QNMREVGFEY MNRELLWHGF
210 220 230 240 250
AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS GKECALCGEW
260 270 280 290 300
PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS

EVNAL
Length:305
Mass (Da):34,732
Last modified:October 1, 1996 - v1
Checksum:iFAFB6C8913F959F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 8MAAREEST → MTGKEENM in AAB91465 (PubMed:9382874).Curated8
Sequence conflicti85H → Y in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti91 – 94PNPV → LNLI in AAB91465 (PubMed:9382874).Curated4
Sequence conflicti101N → T in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti105L → W in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti114R → K in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti138C → F in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti142V → L in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti152M → I in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti225 – 227TLC → IPL in AAB91465 (PubMed:9382874).Curated3
Sequence conflicti295A → S in AAB91465 (PubMed:9382874).Curated1
Sequence conflicti298Q → E in AAB91465 (PubMed:9382874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRiI52362.
RefSeqiNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530121.1. XM_006530058.3.
XP_006530122.1. XM_006530059.2.
XP_011246442.1. XM_011248140.2.
XP_017174994.1. XM_017319505.1.
UniGeneiMm.132336.

Genome annotation databases

GeneIDi19302.
KEGGimmu:19302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRiI52362.
RefSeqiNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530121.1. XM_006530058.3.
XP_006530122.1. XM_006530059.2.
XP_011246442.1. XM_011248140.2.
XP_017174994.1. XM_017319505.1.
UniGeneiMm.132336.

3D structure databases

ProteinModelPortaliP55098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55098. 1 interactor.

PTM databases

PhosphoSitePlusiP55098.

Proteomic databases

MaxQBiP55098.
PRIDEiP55098.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19302.
KEGGimmu:19302.

Organism-specific databases

CTDi5828.
MGIiMGI:107486. Pex2.

Phylogenomic databases

HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP55098.
KOiK06664.
PhylomeDBiP55098.

Miscellaneous databases

PROiP55098.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PEX2.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPEX2_MOUSE
AccessioniPrimary (citable) accession number: P55098
Secondary accession number(s): O35467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.