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P55098

- PEX2_MOUSE

UniProt

P55098 - PEX2_MOUSE

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Protein

Peroxisome biogenesis factor 2

Gene

Pex2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Somewhat implicated in the biogenesis of peroxisomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. bile acid biosynthetic process Source: MGI
  2. cholesterol homeostasis Source: MGI
  3. nervous system development Source: MGI
  4. neuron migration Source: MGI
  5. peroxisome organization Source: UniProtKB-KW
  6. regulation of cholesterol biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 2
Alternative name(s):
Peroxin-2
Peroxisomal membrane protein 3
Peroxisome assembly factor 1
Short name:
PAF-1
Gene namesi
Name:Pex2
Synonyms:Paf1, Pmp35, Pxmp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107486. Pex2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Peroxisome biogenesis factor 2PRO_0000056370Add
BLAST

Proteomic databases

MaxQBiP55098.
PaxDbiP55098.
PRIDEiP55098.

PTM databases

PhosphoSiteiP55098.

Expressioni

Gene expression databases

CleanExiMM_PEX2.
GenevestigatoriP55098.

Interactioni

Protein-protein interaction databases

IntActiP55098. 1 interaction.
STRINGi10090.ENSMUSP00000059415.

Structurei

3D structure databases

ProteinModelPortaliP55098.
SMRiP55098. Positions 239-288.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei140 – 15920HelicalSequence AnalysisAdd
BLAST
Transmembranei195 – 21319HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the pex2/pex10/pex12 family.Curated
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 28441RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG245402.
HOGENOMiHOG000294074.
HOVERGENiHBG000416.
InParanoidiP55098.
KOiK06664.
PhylomeDBiP55098.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55098-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA
60 70 80 90 100
RFEPEVKAFL WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK
110 120 130 140 150
NQKLLYAVCT IGGRWLEERC YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE
160 170 180 190 200
LMNFLIFLQK GKFATLTERL LGIHSVFCKP QNMREVGFEY MNRELLWHGF
210 220 230 240 250
AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS GKECALCGEW
260 270 280 290 300
PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS

EVNAL
Length:305
Mass (Da):34,732
Last modified:October 1, 1996 - v1
Checksum:iFAFB6C8913F959F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 88MAAREEST → MTGKEENM in AAB91465. (PubMed:9382874)Curated
Sequence conflicti85 – 851H → Y in AAB91465. (PubMed:9382874)Curated
Sequence conflicti91 – 944PNPV → LNLI in AAB91465. (PubMed:9382874)Curated
Sequence conflicti101 – 1011N → T in AAB91465. (PubMed:9382874)Curated
Sequence conflicti105 – 1051L → W in AAB91465. (PubMed:9382874)Curated
Sequence conflicti114 – 1141R → K in AAB91465. (PubMed:9382874)Curated
Sequence conflicti138 – 1381C → F in AAB91465. (PubMed:9382874)Curated
Sequence conflicti142 – 1421V → L in AAB91465. (PubMed:9382874)Curated
Sequence conflicti152 – 1521M → I in AAB91465. (PubMed:9382874)Curated
Sequence conflicti225 – 2273TLC → IPL in AAB91465. (PubMed:9382874)Curated
Sequence conflicti295 – 2951A → S in AAB91465. (PubMed:9382874)Curated
Sequence conflicti298 – 2981Q → E in AAB91465. (PubMed:9382874)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1.
AF031128 mRNA. Translation: AAB91465.1.
PIRiI52362.
RefSeqiNP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530120.1. XM_006530057.1.
XP_006530121.1. XM_006530058.1.
XP_006530122.1. XM_006530059.1.
UniGeneiMm.132336.

Genome annotation databases

GeneIDi19302.
KEGGimmu:19302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L27842 Genomic DNA. Translation: AAA21742.1 .
AF031128 mRNA. Translation: AAB91465.1 .
PIRi I52362.
RefSeqi NP_001156773.1. NM_001163301.2.
NP_001156774.1. NM_001163302.2.
NP_001156777.1. NM_001163305.2.
NP_001156778.1. NM_001163306.2.
NP_001254643.1. NM_001267714.1.
NP_001254644.1. NM_001267715.1.
NP_033020.2. NM_008994.4.
XP_006530120.1. XM_006530057.1.
XP_006530121.1. XM_006530058.1.
XP_006530122.1. XM_006530059.1.
UniGenei Mm.132336.

3D structure databases

ProteinModelPortali P55098.
SMRi P55098. Positions 239-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P55098. 1 interaction.
STRINGi 10090.ENSMUSP00000059415.

PTM databases

PhosphoSitei P55098.

Proteomic databases

MaxQBi P55098.
PaxDbi P55098.
PRIDEi P55098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 19302.
KEGGi mmu:19302.

Organism-specific databases

CTDi 5828.
MGIi MGI:107486. Pex2.

Phylogenomic databases

eggNOGi NOG245402.
HOGENOMi HOG000294074.
HOVERGENi HBG000416.
InParanoidi P55098.
KOi K06664.
PhylomeDBi P55098.

Miscellaneous databases

NextBioi 296257.
PROi P55098.
SOURCEi Search...

Gene expression databases

CleanExi MM_PEX2.
Genevestigatori P55098.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR006845. Pex_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF04757. Pex2_Pex12. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of mammalian peroxisome assembly factor-1 (PMP35) genes."
    Wilson G.N., Bryant D.D.
    Biochem. Med. Metab. Biol. 51:140-148(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Swiss Webster.
    Tissue: Liver.
  2. "Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder."
    Faust P.L., Hatten M.E.
    J. Cell Biol. 139:1293-1305(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Cerebellum.

Entry informationi

Entry nameiPEX2_MOUSE
AccessioniPrimary (citable) accession number: P55098
Secondary accession number(s): O35467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3