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P55097

- CATK_MOUSE

UniProt

P55097 - CATK_MOUSE

Protein

Cathepsin K

Gene

Ctsk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.By similarity

    Catalytic activityi

    Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391By similarity
    Active sitei276 – 2761By similarity
    Active sitei296 – 2961By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. bone resorption Source: Ensembl
    2. intramembranous ossification Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14811.
    ReactomeiREACT_198976. Trafficking and processing of endosomal TLR.
    REACT_199000. Activation of Matrix Metalloproteinases.
    REACT_199052. Degradation of the extracellular matrix.
    REACT_199055. Collagen degradation.

    Protein family/group databases

    MEROPSiC01.036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin K (EC:3.4.22.38)
    Gene namesi
    Name:Ctsk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:107823. Ctsk.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Propeptidei16 – 11499Activation peptidePRO_0000026301Add
    BLAST
    Chaini115 – 329215Cathepsin KPRO_0000026302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 177By similarity
    Disulfide bondi170 ↔ 210By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi269 ↔ 318By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP55097.
    PRIDEiP55097.

    PTM databases

    PhosphoSiteiP55097.

    Expressioni

    Gene expression databases

    ArrayExpressiP55097.
    BgeeiP55097.
    CleanExiMM_CTSK.
    GenevestigatoriP55097.

    Interactioni

    Protein-protein interaction databases

    IntActiP55097. 1 interaction.
    MINTiMINT-3089515.

    Structurei

    3D structure databases

    ProteinModelPortaliP55097.
    SMRiP55097. Positions 16-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000230774.
    HOVERGENiHBG011513.
    InParanoidiP55097.
    KOiK01371.
    OMAiILDTQWE.
    OrthoDBiEOG786H3P.
    PhylomeDBiP55097.
    TreeFamiTF313739.

    Family and domain databases

    InterProiIPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015644. Peptidase_C1A_cathepsin-K.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF55. PTHR12411:SF55. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55097-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW    50
    EKNLKQISAH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS 100
    YSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 150
    QLKKKTGKLL ALSPQNLVDC VTENYGCGGG YMTTAFQYVQ QNGGIDSEDA 200
    YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPISVSID 250
    ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE 300
    SWGNKGYALL ARNKNNACGI TNMASFPKM 329
    Length:329
    Mass (Da):36,889
    Last modified:December 1, 2000 - v2
    Checksum:i4F4B28F664925778
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 64VFKF → GLKV in CAA64218. (PubMed:8814310)Curated
    Sequence conflicti201 – 2011Y → F in CAA64218. (PubMed:8814310)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94444 mRNA. Translation: CAA64218.1.
    AJ006033 Genomic DNA. Translation: CAA06825.1.
    BC046320 mRNA. Translation: AAH46320.1.
    CCDSiCCDS17615.1.
    PIRiS74227.
    RefSeqiNP_031828.2. NM_007802.4.
    XP_006501037.1. XM_006500974.1.
    UniGeneiMm.272085.

    Genome annotation databases

    EnsembliENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111.
    GeneIDi13038.
    KEGGimmu:13038.
    UCSCiuc008qjy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94444 mRNA. Translation: CAA64218.1 .
    AJ006033 Genomic DNA. Translation: CAA06825.1 .
    BC046320 mRNA. Translation: AAH46320.1 .
    CCDSi CCDS17615.1.
    PIRi S74227.
    RefSeqi NP_031828.2. NM_007802.4.
    XP_006501037.1. XM_006500974.1.
    UniGenei Mm.272085.

    3D structure databases

    ProteinModelPortali P55097.
    SMRi P55097. Positions 16-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P55097. 1 interaction.
    MINTi MINT-3089515.

    Chemistry

    ChEMBLi CHEMBL1075277.

    Protein family/group databases

    MEROPSi C01.036.

    PTM databases

    PhosphoSitei P55097.

    Proteomic databases

    MaxQBi P55097.
    PRIDEi P55097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015664 ; ENSMUSP00000015664 ; ENSMUSG00000028111 .
    GeneIDi 13038.
    KEGGi mmu:13038.
    UCSCi uc008qjy.1. mouse.

    Organism-specific databases

    CTDi 1513.
    MGIi MGI:107823. Ctsk.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000230774.
    HOVERGENi HBG011513.
    InParanoidi P55097.
    KOi K01371.
    OMAi ILDTQWE.
    OrthoDBi EOG786H3P.
    PhylomeDBi P55097.
    TreeFami TF313739.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14811.
    Reactomei REACT_198976. Trafficking and processing of endosomal TLR.
    REACT_199000. Activation of Matrix Metalloproteinases.
    REACT_199052. Degradation of the extracellular matrix.
    REACT_199055. Collagen degradation.

    Miscellaneous databases

    NextBioi 282924.
    PROi P55097.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55097.
    Bgeei P55097.
    CleanExi MM_CTSK.
    Genevestigatori P55097.

    Family and domain databases

    InterProi IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015644. Peptidase_C1A_cathepsin-K.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF55. PTHR12411:SF55. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development."
      Rantakokko J.A., Aro H.T., Savontaus M., Vuorio E.
      FEBS Lett. 393:307-313(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Calvaria.
    2. "Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3."
      Rantakokko J.A., Kiviranta R., Eerola R., Aro H.T., Vuorio E.
      Matrix Biol. 18:155-161(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCATK_MOUSE
    AccessioniPrimary (citable) accession number: P55097
    Secondary accession number(s): O88718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3