Ctsk

Functionⁱ

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).By similarity

Catalytic activityⁱ

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	139	By similarity	1
Active siteⁱ	276	By similarity	1
Active siteⁱ	296	By similarity	1

GO - Molecular functionⁱ

collagen binding Source: MGI
cysteine-type endopeptidase activity Source: MGI
fibronectin binding Source: MGI
proteoglycan binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone resorption Source: Ensembl
collagen catabolic process Source: MGI
intramembranous ossification Source: Ensembl
positive regulation of protein targeting to mitochondrion Source: MGI
proteolysis involved in cellular protein catabolic process Source: MGI
regulation of autophagy of mitochondrion Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-14811
Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1592389 Activation of Matrix Metalloproteinases R-MMU-1679131 Trafficking and processing of endosomal TLR R-MMU-2132295 MHC class II antigen presentation R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I29.007

MEROPSⁱ

I29.007

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cathepsin K (EC:3.4.22.38)
Gene namesⁱ	Name:Ctsk
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:107823 Ctsk

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL1075277

ChEMBLⁱ

CHEMBL1075277

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 15	Sequence analysisAdd BLAST	15
PropeptideⁱPRO_0000026301	16 – 114	Activation peptideAdd BLAST	99
ChainⁱPRO_0000026302	115 – 329	Cathepsin KAdd BLAST	215

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	103	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	136 ↔ 177	By similarity
Disulfide bondⁱ	170 ↔ 210	By similarity
Glycosylationⁱ	213	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	269 ↔ 318	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbⁱ	P55097
PeptideAtlas More...PeptideAtlasⁱ	P55097
PRIDEⁱ	P55097

PTM databases

iPTMnetⁱ	P55097
PhosphoSitePlusⁱ	P55097

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028111
CleanExⁱ	MM_CTSK
ExpressionAtlasⁱ	P55097 baseline and differential
Genevisibleⁱ	P55097 MM

Interactionⁱ

GO - Molecular functionⁱ

fibronectin binding Source: MGI
proteoglycan binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P55097 1 interactor.
Molecular INTeraction database More...MINTⁱ	P55097
STRINGⁱ	10090.ENSMUSP00000015664

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	121 – 125	Combined sources	5
Helixⁱ	139 – 156	Combined sources	18
Helixⁱ	164 – 170	Combined sources	7
Helixⁱ	176 – 178	Combined sources	3
Helixⁱ	182 – 192	Combined sources	11
Beta strandⁱ	195 – 197	Combined sources	3
Turnⁱ	198 – 200	Combined sources	3
Helixⁱ	214 – 216	Combined sources	3
Beta strandⁱ	217 – 219	Combined sources	3
Beta strandⁱ	224 – 226	Combined sources	3
Helixⁱ	232 – 241	Combined sources	10
Beta strandⁱ	244 – 249	Combined sources	6
Helixⁱ	254 – 257	Combined sources	4
Beta strandⁱ	261 – 264	Combined sources	4
Beta strandⁱ	271 – 273	Combined sources	3
Beta strandⁱ	276 – 286	Combined sources	11
Beta strandⁱ	289 – 295	Combined sources	7
Beta strandⁱ	307 – 311	Combined sources	5
Beta strandⁱ	313 – 316	Combined sources	4
Helixⁱ	317 – 319	Combined sources	3
Turnⁱ	320 – 323	Combined sources	4
Beta strandⁱ	325 – 327	Combined sources	3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5T6U	X-ray	2.90	A	115-329	[»]
ProteinModelPortalⁱ	P55097
SMRⁱ	P55097
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140823
HOGENOMⁱ	HOG000230774
HOVERGENⁱ	HBG011513
InParanoidⁱ	P55097
KEGG Orthology (KO) More...KOⁱ	K01371
OMAⁱ	KGNKHWI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AKT
PhylomeDBⁱ	P55097
TreeFamⁱ	TF313739

Family and domain databases

InterProⁱ	View protein in InterPro IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C IPR015644 Peptidase_C1A_cathepsin-K IPR013201 Prot_inhib_I29
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit PTHR12411:SF55 PTHR12411:SF55, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P55097-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW 
        60         70         80         90        100
EKNLKQISAH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS 
       110        120        130        140        150
YSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 
       160        170        180        190        200
QLKKKTGKLL ALSPQNLVDC VTENYGCGGG YMTTAFQYVQ QNGGIDSEDA 
       210        220        230        240        250
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPISVSID 
       260        270        280        290        300
ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE 
       310        320 
SWGNKGYALL ARNKNNACGI TNMASFPKM

Length:329

Mass (Da):36,889

Last modified:December 1, 2000 - v2

Checksum:ⁱ4F4B28F664925778

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	3 – 6	VFKF → GLKV in CAA64218 (PubMed:8814310).Curated		4
Sequence conflictⁱ	201	Y → F in CAA64218 (PubMed:8814310).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X94444 mRNA Translation: CAA64218.1 AJ006033 Genomic DNA Translation: CAA06825.1 BC046320 mRNA Translation: AAH46320.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17615.1
PIRⁱ	S74227
NCBI Reference Sequences More...RefSeqⁱ	NP_031828.2, NM_007802.4 XP_006501037.1, XM_006500974.3
UniGeneⁱ	Mm.272085

Genome annotation databases

Ensemblⁱ	ENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111
GeneIDⁱ	13038
KEGGⁱ	mmu:13038
UCSC genome browser More...UCSCⁱ	uc008qjy.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P55097	Q545T0 UPI000957C7BB	Mus musculus (Mouse)	329	UniRef100_P55097	Cluster: Cathepsin K	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P55097	Q545T0 UPI000957C7BB UPI0007DA81B5 UPI000454B18F UPI00022F410B UPI00038C07DE A0A1U7QR43 UPI000A324328 O35186 UPI000A30CBB1 +2	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Microtus ochrogaster (Prairie vole) Mesocricetus auratus (Golden hamster) Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mus caroli (Ryukyu mouse) (Ricefield mouse) Peromyscus maniculatus bairdii (Prairie deer mouse)	329	UniRef90_P55097	Cluster: Cathepsin K	13

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P55097	Q545T0 UPI000957C7BB UPI0007DA81B5 UPI000454B18F UPI00022F410B UPI00038C07DE UPI000A30CBB1 O35186 A0A1U7QR43 UPI000A324328 +54	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Microtus ochrogaster (Prairie vole) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Rattus norvegicus (Rat) Mesocricetus auratus (Golden hamster) Mus caroli (Ryukyu mouse) (Ricefield mouse) Peromyscus maniculatus bairdii (Prairie deer mouse) Anolis carolinensis (Green anole) (American chameleon) Chelonia mydas (Green sea-turtle) (Chelonia agassizi) And more	329	UniRef50_P55097	Cluster: Cathepsin K	65

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X94444 mRNA Translation: CAA64218.1 AJ006033 Genomic DNA Translation: CAA06825.1 BC046320 mRNA Translation: AAH46320.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17615.1
PIRⁱ	S74227
NCBI Reference Sequences More...RefSeqⁱ	NP_031828.2, NM_007802.4 XP_006501037.1, XM_006500974.3
UniGeneⁱ	Mm.272085

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5T6U	X-ray	2.90	A	115-329	[»]
ProteinModelPortalⁱ	P55097
SMRⁱ	P55097
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P55097 1 interactor.
Molecular INTeraction database More...MINTⁱ	P55097
STRINGⁱ	10090.ENSMUSP00000015664

Chemistry databases

ChEMBLⁱ	CHEMBL1075277

ChEMBLⁱ

CHEMBL1075277

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I29.007

MEROPSⁱ

I29.007

PTM databases

iPTMnetⁱ	P55097
PhosphoSitePlusⁱ	P55097

Proteomic databases

PaxDbⁱ	P55097
PeptideAtlas More...PeptideAtlasⁱ	P55097
PRIDEⁱ	P55097

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111
GeneIDⁱ	13038
KEGGⁱ	mmu:13038
UCSC genome browser More...UCSCⁱ	uc008qjy.2 mouse

Organism-specific databases

CTDⁱ	1513
MGIⁱ	MGI:107823 Ctsk

Phylogenomic databases

eggNOGⁱ	KOG1543 Eukaryota COG4870 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140823
HOGENOMⁱ	HOG000230774
HOVERGENⁱ	HBG011513
InParanoidⁱ	P55097
KEGG Orthology (KO) More...KOⁱ	K01371
OMAⁱ	KGNKHWI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AKT
PhylomeDBⁱ	P55097
TreeFamⁱ	TF313739

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-14811
Reactomeⁱ	R-MMU-1442490 Collagen degradation R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1592389 Activation of Matrix Metalloproteinases R-MMU-1679131 Trafficking and processing of endosomal TLR R-MMU-2132295 MHC class II antigen presentation R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P55097
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028111
CleanExⁱ	MM_CTSK
ExpressionAtlasⁱ	P55097 baseline and differential
Genevisibleⁱ	P55097 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C IPR015644 Peptidase_C1A_cathepsin-K IPR013201 Prot_inhib_I29
PANTHERⁱ	PTHR12411 PTHR12411, 1 hit PTHR12411:SF55 PTHR12411:SF55, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit
PRINTSⁱ	PR00705 PAPAIN
SMARTⁱ	View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CATK_MOUSE
Accessionⁱ	P55097Primary (citable) accession number: P55097 Secondary accession number(s): O88718
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	December 1, 2000
	Last modified:	February 28, 2018
	This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P55097 (CATK_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cathepsin K

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Extracellular region or secreted

Lysosome

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ