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P55097

- CATK_MOUSE

UniProt

P55097 - CATK_MOUSE

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Protein

Cathepsin K

Gene
Ctsk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activityi

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391 By similarity
Active sitei276 – 2761 By similarity
Active sitei296 – 2961 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. bone resorption Source: Ensembl
  2. intramembranous ossification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14811.
ReactomeiREACT_198976. Trafficking and processing of endosomal TLR.
REACT_199000. Activation of Matrix Metalloproteinases.
REACT_199052. Degradation of the extracellular matrix.
REACT_199055. Collagen degradation.

Protein family/group databases

MEROPSiC01.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin K (EC:3.4.22.38)
Gene namesi
Name:Ctsk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:107823. Ctsk.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed predictionAdd
BLAST
Propeptidei16 – 11499Activation peptidePRO_0000026301Add
BLAST
Chaini115 – 329215Cathepsin KPRO_0000026302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 177 By similarity
Disulfide bondi170 ↔ 210 By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi269 ↔ 318 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP55097.
PRIDEiP55097.

PTM databases

PhosphoSiteiP55097.

Expressioni

Gene expression databases

ArrayExpressiP55097.
BgeeiP55097.
CleanExiMM_CTSK.
GenevestigatoriP55097.

Interactioni

Protein-protein interaction databases

IntActiP55097. 1 interaction.
MINTiMINT-3089515.

Structurei

3D structure databases

ProteinModelPortaliP55097.
SMRiP55097. Positions 16-329.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiP55097.
KOiK01371.
OMAiILDTQWE.
OrthoDBiEOG786H3P.
PhylomeDBiP55097.
TreeFamiTF313739.

Family and domain databases

InterProiIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55097-1 [UniParc]FASTAAdd to Basket

« Hide

MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW    50
EKNLKQISAH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS 100
YSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 150
QLKKKTGKLL ALSPQNLVDC VTENYGCGGG YMTTAFQYVQ QNGGIDSEDA 200
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPISVSID 250
ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE 300
SWGNKGYALL ARNKNNACGI TNMASFPKM 329
Length:329
Mass (Da):36,889
Last modified:December 1, 2000 - v2
Checksum:i4F4B28F664925778
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 64VFKF → GLKV in CAA64218. 1 Publication
Sequence conflicti201 – 2011Y → F in CAA64218. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94444 mRNA. Translation: CAA64218.1.
AJ006033 Genomic DNA. Translation: CAA06825.1.
BC046320 mRNA. Translation: AAH46320.1.
CCDSiCCDS17615.1.
PIRiS74227.
RefSeqiNP_031828.2. NM_007802.4.
XP_006501037.1. XM_006500974.1.
UniGeneiMm.272085.

Genome annotation databases

EnsembliENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111.
GeneIDi13038.
KEGGimmu:13038.
UCSCiuc008qjy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94444 mRNA. Translation: CAA64218.1 .
AJ006033 Genomic DNA. Translation: CAA06825.1 .
BC046320 mRNA. Translation: AAH46320.1 .
CCDSi CCDS17615.1.
PIRi S74227.
RefSeqi NP_031828.2. NM_007802.4.
XP_006501037.1. XM_006500974.1.
UniGenei Mm.272085.

3D structure databases

ProteinModelPortali P55097.
SMRi P55097. Positions 16-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P55097. 1 interaction.
MINTi MINT-3089515.

Chemistry

ChEMBLi CHEMBL1075277.

Protein family/group databases

MEROPSi C01.036.

PTM databases

PhosphoSitei P55097.

Proteomic databases

MaxQBi P55097.
PRIDEi P55097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015664 ; ENSMUSP00000015664 ; ENSMUSG00000028111 .
GeneIDi 13038.
KEGGi mmu:13038.
UCSCi uc008qjy.1. mouse.

Organism-specific databases

CTDi 1513.
MGIi MGI:107823. Ctsk.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000230774.
HOVERGENi HBG011513.
InParanoidi P55097.
KOi K01371.
OMAi ILDTQWE.
OrthoDBi EOG786H3P.
PhylomeDBi P55097.
TreeFami TF313739.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-14811.
Reactomei REACT_198976. Trafficking and processing of endosomal TLR.
REACT_199000. Activation of Matrix Metalloproteinases.
REACT_199052. Degradation of the extracellular matrix.
REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi 282924.
PROi P55097.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55097.
Bgeei P55097.
CleanExi MM_CTSK.
Genevestigatori P55097.

Family and domain databases

InterProi IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development."
    Rantakokko J.A., Aro H.T., Savontaus M., Vuorio E.
    FEBS Lett. 393:307-313(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Calvaria.
  2. "Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3."
    Rantakokko J.A., Kiviranta R., Eerola R., Aro H.T., Vuorio E.
    Matrix Biol. 18:155-161(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCATK_MOUSE
AccessioniPrimary (citable) accession number: P55097
Secondary accession number(s): O88718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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