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P55097 (CATK_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cathepsin K
EC=3.4.22.38
Gene names
Name:Ctsk
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activity

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbone resorption

Inferred from electronic annotation. Source: Ensembl

intramembranous ossification

Inferred from electronic annotation. Source: Ensembl

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

lysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Propeptide16 – 11499Activation peptide
PRO_0000026301
Chain115 – 329215Cathepsin K
PRO_0000026302

Sites

Active site1391 By similarity
Active site2761 By similarity
Active site2961 By similarity

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Disulfide bond136 ↔ 177 By similarity
Disulfide bond170 ↔ 210 By similarity
Disulfide bond269 ↔ 318 By similarity

Experimental info

Sequence conflict3 – 64VFKF → GLKV in CAA64218. Ref.1
Sequence conflict2011Y → F in CAA64218. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P55097 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 4F4B28F664925778

FASTA32936,889
        10         20         30         40         50         60 
MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW EKNLKQISAH 

        70         80         90        100        110        120 
NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS YSNDTLYTPE WEGRVPDSID 

       130        140        150        160        170        180 
YRKKGYVTPV KNQGQCGSCW AFSSAGALEG QLKKKTGKLL ALSPQNLVDC VTENYGCGGG 

       190        200        210        220        230        240 
YMTTAFQYVQ QNGGIDSEDA YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA 

       250        260        270        280        290        300 
RVGPISVSID ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE 

       310        320 
SWGNKGYALL ARNKNNACGI TNMASFPKM

« Hide

References

« Hide 'large scale' references
[1]"Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development."
Rantakokko J.A., Aro H.T., Savontaus M., Vuorio E.
FEBS Lett. 393:307-313(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Calvaria.
[2]"Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3."
Rantakokko J.A., Kiviranta R., Eerola R., Aro H.T., Vuorio E.
Matrix Biol. 18:155-161(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94444 mRNA. Translation: CAA64218.1.
AJ006033 Genomic DNA. Translation: CAA06825.1.
BC046320 mRNA. Translation: AAH46320.1.
IPIIPI00316575.
PIRS74227.
RefSeqNP_031828.2. NM_007802.4.
UniGeneMm.272085.

3D structure databases

ProteinModelPortalP55097.
SMRP55097. Positions 16-329.
ModBaseSearch...

Protein-protein interaction databases

IntActP55097. 1 interaction.
MINTMINT-3089515.

Protein family/group databases

MEROPSC01.036.

PTM databases

PhosphoSiteP55097.

Proteomic databases

PRIDEP55097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111.
GeneID13038.
KEGGmmu:13038.
UCSCuc008qjy.1. mouse.

Organism-specific databases

CTD1513.
MGIMGI:107823. Ctsk.

Phylogenomic databases

eggNOGCOG4870.
HOGENOMHOG000230774.
HOVERGENHBG011513.
InParanoidP55097.
KOK01371.
OMALKVPPSH.
OrthoDBEOG786H3P.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-14811.

Gene expression databases

ArrayExpressP55097.
BgeeP55097.
CleanExMM_CTSK.
GenevestigatorP55097.

Family and domain databases

InterProIPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. False negative.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL1075277.
NextBio282924.
PROP55097.
SOURCESearch...

Entry information

Entry nameCATK_MOUSE
AccessionPrimary (citable) accession number: P55097
Secondary accession number(s): O88718
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: November 13, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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