UniProtKB - P55097 (CATK_MOUSE)
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Protein
Cathepsin K
Gene
Ctsk
Organism
Mus musculus (Mouse)
Status
Functioni
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).By similarity
Catalytic activityi
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 139 | By similarity | 1 | |
Active sitei | 276 | By similarity | 1 | |
Active sitei | 296 | By similarity | 1 |
GO - Molecular functioni
- collagen binding Source: MGI
- cysteine-type endopeptidase activity Source: MGI
- fibronectin binding Source: MGI
- proteoglycan binding Source: MGI
GO - Biological processi
- bone resorption Source: Ensembl
- collagen catabolic process Source: MGI
- intramembranous ossification Source: Ensembl
- positive regulation of protein targeting to mitochondrion Source: MGI
- proteolysis involved in cellular protein catabolic process Source: MGI
- regulation of autophagy of mitochondrion Source: MGI
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
BioCyci | MetaCyc:MONOMER-14811 |
Reactomei | R-MMU-1442490 Collagen degradation R-MMU-1474228 Degradation of the extracellular matrix R-MMU-1592389 Activation of Matrix Metalloproteinases R-MMU-1679131 Trafficking and processing of endosomal TLR R-MMU-2132295 MHC class II antigen presentation R-MMU-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
Protein family/group databases
MEROPSi | I29.007 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Ctsk |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107823 Ctsk |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
PropeptideiPRO_0000026301 | 16 – 114 | Activation peptideAdd BLAST | 99 | |
ChainiPRO_0000026302 | 115 – 329 | Cathepsin KAdd BLAST | 215 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 136 ↔ 177 | By similarity | ||
Disulfide bondi | 170 ↔ 210 | By similarity | ||
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 269 ↔ 318 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
PaxDbi | P55097 |
PeptideAtlasi | P55097 |
PRIDEi | P55097 |
PTM databases
iPTMneti | P55097 |
PhosphoSitePlusi | P55097 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028111 |
CleanExi | MM_CTSK |
ExpressionAtlasi | P55097 baseline and differential |
Genevisiblei | P55097 MM |
Interactioni
GO - Molecular functioni
- fibronectin binding Source: MGI
- proteoglycan binding Source: MGI
Protein-protein interaction databases
IntActi | P55097 1 interactor. |
MINTi | P55097 |
STRINGi | 10090.ENSMUSP00000015664 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Turni | 121 – 125 | Combined sources | 5 | |
Helixi | 139 – 156 | Combined sources | 18 | |
Helixi | 164 – 170 | Combined sources | 7 | |
Helixi | 176 – 178 | Combined sources | 3 | |
Helixi | 182 – 192 | Combined sources | 11 | |
Beta strandi | 195 – 197 | Combined sources | 3 | |
Turni | 198 – 200 | Combined sources | 3 | |
Helixi | 214 – 216 | Combined sources | 3 | |
Beta strandi | 217 – 219 | Combined sources | 3 | |
Beta strandi | 224 – 226 | Combined sources | 3 | |
Helixi | 232 – 241 | Combined sources | 10 | |
Beta strandi | 244 – 249 | Combined sources | 6 | |
Helixi | 254 – 257 | Combined sources | 4 | |
Beta strandi | 261 – 264 | Combined sources | 4 | |
Beta strandi | 271 – 273 | Combined sources | 3 | |
Beta strandi | 276 – 286 | Combined sources | 11 | |
Beta strandi | 289 – 295 | Combined sources | 7 | |
Beta strandi | 307 – 311 | Combined sources | 5 | |
Beta strandi | 313 – 316 | Combined sources | 4 | |
Helixi | 317 – 319 | Combined sources | 3 | |
Turni | 320 – 323 | Combined sources | 4 | |
Beta strandi | 325 – 327 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5T6U | X-ray | 2.90 | A | 115-329 | [»] | |
ProteinModelPortali | P55097 | |||||
SMRi | P55097 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1543 Eukaryota COG4870 LUCA |
GeneTreei | ENSGT00900000140823 |
HOGENOMi | HOG000230774 |
HOVERGENi | HBG011513 |
InParanoidi | P55097 |
KOi | K01371 |
OMAi | KGNKHWI |
OrthoDBi | EOG091G0AKT |
PhylomeDBi | P55097 |
TreeFami | TF313739 |
Family and domain databases
InterProi | View protein in InterPro IPR000169 Pept_cys_AS IPR025660 Pept_his_AS IPR013128 Peptidase_C1A IPR000668 Peptidase_C1A_C IPR015644 Peptidase_C1A_cathepsin-K IPR013201 Prot_inhib_I29 |
PANTHERi | PTHR12411 PTHR12411, 1 hit PTHR12411:SF55 PTHR12411:SF55, 1 hit |
Pfami | View protein in Pfam PF08246 Inhibitor_I29, 1 hit PF00112 Peptidase_C1, 1 hit |
PRINTSi | PR00705 PAPAIN |
SMARTi | View protein in SMART SM00848 Inhibitor_I29, 1 hit SM00645 Pept_C1, 1 hit |
PROSITEi | View protein in PROSITE PS00139 THIOL_PROTEASE_CYS, 1 hit PS00639 THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P55097-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW
60 70 80 90 100
EKNLKQISAH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS
110 120 130 140 150
YSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG
160 170 180 190 200
QLKKKTGKLL ALSPQNLVDC VTENYGCGGG YMTTAFQYVQ QNGGIDSEDA
210 220 230 240 250
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPISVSID
260 270 280 290 300
ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE
310 320
SWGNKGYALL ARNKNNACGI TNMASFPKM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 – 6 | VFKF → GLKV in CAA64218 (PubMed:8814310).Curated | 4 | |
Sequence conflicti | 201 | Y → F in CAA64218 (PubMed:8814310).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X94444 mRNA Translation: CAA64218.1 AJ006033 Genomic DNA Translation: CAA06825.1 BC046320 mRNA Translation: AAH46320.1 |
CCDSi | CCDS17615.1 |
PIRi | S74227 |
RefSeqi | NP_031828.2, NM_007802.4 XP_006501037.1, XM_006500974.3 |
UniGenei | Mm.272085 |
Genome annotation databases
Ensembli | ENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111 |
GeneIDi | 13038 |
KEGGi | mmu:13038 |
UCSCi | uc008qjy.2 mouse |
Similar proteinsi
Entry informationi
Entry namei | CATK_MOUSE | |
Accessioni | P55097Primary (citable) accession number: P55097 Secondary accession number(s): O88718 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | February 28, 2018 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |