Ctsk

Functionⁱ

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity).By similarity

Catalytic activityⁱ

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Sites

Feature key	Position(s)	Length	Description
Active siteⁱ	139 – 139	1	By similarity
Active siteⁱ	276 – 276	1	By similarity
Active siteⁱ	296 – 296	1	By similarity

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-14811.
Reactomeⁱ	R-MMU-1442490. Collagen degradation. R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-1592389. Activation of Matrix Metalloproteinases. R-MMU-1679131. Trafficking and processing of endosomal TLR.

Protein family/group databases

MEROPSⁱ	I29.007.

MEROPSⁱ

I29.007.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cathepsin K (EC:3.4.22.38)
Gene namesⁱ	Name:Ctsk
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 3

Organism-specific databases

MGIⁱ	MGI:107823. Ctsk.

Subcellular locationⁱ

Lysosome By similarity

GO - Cellular componentⁱ

extracellular space Source: MGI
lysosome Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Chemistry

ChEMBLⁱ	CHEMBL1075277.

ChEMBLⁱ

CHEMBL1075277.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Feature identifier	Actions
Signal peptideⁱ	1 – 15	15	Sequence analysis		Add BLAST
Propeptideⁱ	16 – 114	99	Activation peptide	PRO_0000026301	Add BLAST
Chainⁱ	115 – 329	215	Cathepsin K	PRO_0000026302	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Glycosylationⁱ	103 – 103	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	136 ↔ 177		By similarity
Disulfide bondⁱ	170 ↔ 210		By similarity
Glycosylationⁱ	213 – 213	1	N-linked (GlcNAc...)Sequence analysis
Disulfide bondⁱ	269 ↔ 318		By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbⁱ	P55097.
PeptideAtlasⁱ	P55097.
PRIDEⁱ	P55097.

PTM databases

iPTMnetⁱ	P55097.
PhosphoSiteⁱ	P55097.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028111.
CleanExⁱ	MM_CTSK.
ExpressionAtlasⁱ	P55097. baseline and differential.
Genevisibleⁱ	P55097. MM.

Interactionⁱ

GO - Molecular functionⁱ

collagen binding Source: MGI
fibronectin binding Source: MGI
proteoglycan binding Source: MGI

Protein-protein interaction databases

IntActⁱ	P55097. 1 interaction.
MINTⁱ	MINT-3089515.
STRINGⁱ	10090.ENSMUSP00000015664.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P55097.
SMRⁱ	P55097. Positions 16-329.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
HOGENOMⁱ	HOG000230774.
HOVERGENⁱ	HBG011513.
InParanoidⁱ	P55097.
KOⁱ	K01371.
OMAⁱ	LTHRREY.
OrthoDBⁱ	EOG091G0AKT.
PhylomeDBⁱ	P55097.
TreeFamⁱ	TF313739.

Family and domain databases

InterProⁱ	IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit. PTHR12411:SF55. PTHR12411:SF55. 1 hit.
Pfamⁱ	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITEⁱ	PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P55097-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWVFKFLLLP MVSFALSPEE MLDTQWELWK KTHQKQYNSK VDEISRRLIW 
        60         70         80         90        100
EKNLKQISAH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLRIPPSRS 
       110        120        130        140        150
YSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 
       160        170        180        190        200
QLKKKTGKLL ALSPQNLVDC VTENYGCGGG YMTTAFQYVQ QNGGIDSEDA 
       210        220        230        240        250
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPISVSID 
       260        270        280        290        300
ASLASFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGSK HWIIKNSWGE 
       310        320 
SWGNKGYALL ARNKNNACGI TNMASFPKM

Length:329

Mass (Da):36,889

Last modified:December 1, 2000 - v2

Checksum:ⁱ4F4B28F664925778

GO

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Sequence conflictⁱ	3 – 6	4	VFKF → GLKV in CAA64218 (PubMed:8814310).Curated
Sequence conflictⁱ	201 – 201	1	Y → F in CAA64218 (PubMed:8814310).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X94444 mRNA. Translation: CAA64218.1. AJ006033 Genomic DNA. Translation: CAA06825.1. BC046320 mRNA. Translation: AAH46320.1.
CCDSⁱ	CCDS17615.1.
PIRⁱ	S74227.
RefSeqⁱ	NP_031828.2. NM_007802.4. XP_006501037.1. XM_006500974.2.
UniGeneⁱ	Mm.272085.

Genome annotation databases

Ensemblⁱ	ENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111.
GeneIDⁱ	13038.
KEGGⁱ	mmu:13038.
UCSCⁱ	uc008qjy.2. mouse.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X94444 mRNA. Translation: CAA64218.1. AJ006033 Genomic DNA. Translation: CAA06825.1. BC046320 mRNA. Translation: AAH46320.1.
CCDSⁱ	CCDS17615.1.
PIRⁱ	S74227.
RefSeqⁱ	NP_031828.2. NM_007802.4. XP_006501037.1. XM_006500974.2.
UniGeneⁱ	Mm.272085.

3D structure databases

ProteinModelPortalⁱ	P55097.
SMRⁱ	P55097. Positions 16-329.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P55097. 1 interaction.
MINTⁱ	MINT-3089515.
STRINGⁱ	10090.ENSMUSP00000015664.

Chemistry

ChEMBLⁱ	CHEMBL1075277.

ChEMBLⁱ

CHEMBL1075277.

Protein family/group databases

MEROPSⁱ	I29.007.

MEROPSⁱ

I29.007.

PTM databases

iPTMnetⁱ	P55097.
PhosphoSiteⁱ	P55097.

Proteomic databases

PaxDbⁱ	P55097.
PeptideAtlasⁱ	P55097.
PRIDEⁱ	P55097.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000015664; ENSMUSP00000015664; ENSMUSG00000028111.
GeneIDⁱ	13038.
KEGGⁱ	mmu:13038.
UCSCⁱ	uc008qjy.2. mouse.

Organism-specific databases

CTDⁱ	1513.
MGIⁱ	MGI:107823. Ctsk.

Phylogenomic databases

eggNOGⁱ	KOG1543. Eukaryota. COG4870. LUCA.
HOGENOMⁱ	HOG000230774.
HOVERGENⁱ	HBG011513.
InParanoidⁱ	P55097.
KOⁱ	K01371.
OMAⁱ	LTHRREY.
OrthoDBⁱ	EOG091G0AKT.
PhylomeDBⁱ	P55097.
TreeFamⁱ	TF313739.

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-14811.
Reactomeⁱ	R-MMU-1442490. Collagen degradation. R-MMU-1474228. Degradation of the extracellular matrix. R-MMU-1592389. Activation of Matrix Metalloproteinases. R-MMU-1679131. Trafficking and processing of endosomal TLR.

Miscellaneous databases

PROⁱ	P55097.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028111.
CleanExⁱ	MM_CTSK.
ExpressionAtlasⁱ	P55097. baseline and differential.
Genevisibleⁱ	P55097. MM.

Family and domain databases

InterProⁱ	IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR015644. Peptidase_C1A_cathepsin-K. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHERⁱ	PTHR12411. PTHR12411. 1 hit. PTHR12411:SF55. PTHR12411:SF55. 1 hit.
Pfamⁱ	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTSⁱ	PR00705. PAPAIN.
SMARTⁱ	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITEⁱ	PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

CATK_MOUSE

Accessionⁱ

Primary (citable) accession number: P55097
Secondary accession number(s): O88718

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 1, 2000
Last modified:	September 7, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P55097 (CATK_MOUSE)

UniProt

P55097 - CATK_MOUSE

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Cathepsin K

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ