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P55096

- ABCD3_MOUSE

UniProt

P55096 - ABCD3_MOUSE

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Protein

ATP-binding cassette sub-family D member 3

Gene

Abcd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi473 – 4808ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid beta-oxidation Source: Ensembl
  2. peroxisome organization Source: Ensembl
  3. very long-chain fatty acid catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 3
Alternative name(s):
68 kDa peroxisomal membrane protein
Short name:
PMP68
70 kDa peroxisomal membrane protein
Short name:
PMP70
Gene namesi
Name:Abcd3
Synonyms:Pmp70, Pxmp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1349216. Abcd3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
  4. peroxisomal matrix Source: Ensembl
  5. peroxisomal membrane Source: MGI
  6. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 659658ATP-binding cassette sub-family D member 3PRO_0000093310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
Modified residuei61 – 611N6-acetyllysine1 Publication
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Modified residuei260 – 2601N6-acetyllysine1 Publication
Modified residuei399 – 3991N6-acetyllysine1 Publication
Modified residuei533 – 5331N6-acetyllysine1 Publication
Modified residuei659 – 6591Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP55096.
PaxDbiP55096.
PRIDEiP55096.

PTM databases

PhosphoSiteiP55096.

Expressioni

Gene expression databases

BgeeiP55096.
ExpressionAtlasiP55096. baseline and differential.
GenevestigatoriP55096.

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). Interacts with PEX19 (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi202521. 2 interactions.
IntActiP55096. 3 interactions.
MINTiMINT-1861742.

Structurei

3D structure databases

ProteinModelPortaliP55096.
SMRiP55096. Positions 422-652.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei126 – 14621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei224 – 24421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei313 – 33321HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 372288ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 659226ABC transporterPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 199198Interaction with PEX19By similarityAdd
BLAST
Regioni2 – 124123Targeting to peroxisomesBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4178.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiP55096.
KOiK05677.
OMAiSDIWMIQ.
OrthoDBiEOG70ZZMP.
TreeFamiTF105205.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR00954. 3a01203. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55096-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFSKYLTA RNTSLAGAAF LLLCLLHKRR RALGLHGKKS GKPPLQNNEK
60 70 80 90 100
EGKKERAVVD KVFLSRLSQI LKIMVPRTFC KETGYLLLIA VMLVSRTYCD
110 120 130 140 150
VWMIQNGTLI ESGIIGRSSK DFKRYLFNFI AAMPLISLVN NFLKYGLNEL
160 170 180 190 200
KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN RIANPDQLLT QDVEKFCNSV
210 220 230 240 250
VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS GLFLTRLRRP
260 270 280 290 300
IGKMTIMEQK YEGEYRYVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV
310 320 330 340 350
EHLHNFIFFR FSMGFIDSII AKYVATVVGY LVVSRPFLDL AHPRHLHSTH
360 370 380 390 400
SELLEDYYQS GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD
410 420 430 440 450
LNHGRYERTM VSQQEKGIEG AQASPLVPGA GEIINTDNII KFDHVPLATP
460 470 480 490 500
NGDILIQDLS FEVRSGANVL ICGPNGCGKS SLFRVLGELW PLFGGRLTKP
510 520 530 540 550
ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKRGISDQ VLKEYLDNVQ
560 570 580 590 600
LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA
610 620 630 640 650
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI

TEDTVEFGS
Length:659
Mass (Da):75,475
Last modified:June 28, 2011 - v2
Checksum:i6DF924D91B481DC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti415 – 4151E → G in AAA39958. (PubMed:7551822)Curated
Sequence conflicti467 – 4682AN → NH in AAA39958. (PubMed:7551822)Curated
Sequence conflicti477 – 4771C → R in AAA39958. (PubMed:7551822)Curated
Sequence conflicti626 – 6261R → T in AAA39958. (PubMed:7551822)Curated
Sequence conflicti628 – 6281S → C in AAA39958. (PubMed:7551822)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28836 Genomic DNA. Translation: AAA39958.1.
AC129311 Genomic DNA. No translation available.
X89569 mRNA. Translation: CAA61748.1.
CCDSiCCDS17806.1.
PIRiI48716. S58009.
RefSeqiNP_033017.2. NM_008991.2.
UniGeneiMm.399042.

Genome annotation databases

EnsembliENSMUST00000029770; ENSMUSP00000029770; ENSMUSG00000028127.
GeneIDi19299.
KEGGimmu:19299.
UCSCiuc008reg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28836 Genomic DNA. Translation: AAA39958.1 .
AC129311 Genomic DNA. No translation available.
X89569 mRNA. Translation: CAA61748.1 .
CCDSi CCDS17806.1.
PIRi I48716. S58009.
RefSeqi NP_033017.2. NM_008991.2.
UniGenei Mm.399042.

3D structure databases

ProteinModelPortali P55096.
SMRi P55096. Positions 422-652.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202521. 2 interactions.
IntActi P55096. 3 interactions.
MINTi MINT-1861742.

PTM databases

PhosphoSitei P55096.

Proteomic databases

MaxQBi P55096.
PaxDbi P55096.
PRIDEi P55096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029770 ; ENSMUSP00000029770 ; ENSMUSG00000028127 .
GeneIDi 19299.
KEGGi mmu:19299.
UCSCi uc008reg.1. mouse.

Organism-specific databases

CTDi 5825.
MGIi MGI:1349216. Abcd3.

Phylogenomic databases

eggNOGi COG4178.
GeneTreei ENSGT00390000003950.
HOGENOMi HOG000206081.
HOVERGENi HBG050438.
InParanoidi P55096.
KOi K05677.
OMAi SDIWMIQ.
OrthoDBi EOG70ZZMP.
TreeFami TF105205.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSi ABCD3. mouse.
NextBioi 296245.
PROi P55096.
SOURCEi Search...

Gene expression databases

Bgeei P55096.
ExpressionAtlasi P55096. baseline and differential.
Genevestigatori P55096.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsi TIGR00954. 3a01203. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential evolution and expression of murine peroxisomal membrane protein genes."
    Bryant D.D., Wilson G.N.
    Biochem. Mol. Med. 55:22-30(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Swiss Webster.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Peroxisomal membrane protein PMP68 of mouse liver: cloning of a cDNA encompassing the nucleotide binding fold and epitope mapping of monoclonal antibodies to the expressed protein."
    Chen N., Lu Z., Land M., Ayres R., Crane D.I.
    Arch. Biochem. Biophys. 321:526-530(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-647.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61; LYS-260; LYS-399 AND LYS-533, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABCD3_MOUSE
AccessioniPrimary (citable) accession number: P55096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3