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P55096 (ABCD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family D member 3
Alternative name(s):
68 kDa peroxisomal membrane protein
Short name=PMP68
70 kDa peroxisomal membrane protein
Short name=PMP70
Gene names
Name:Abcd3
Synonyms:Pmp70, Pxmp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer or heterodimer Potential. Interacts with PEX19 By similarity.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 659658ATP-binding cassette sub-family D member 3
PRO_0000093310

Regions

Transmembrane84 – 10421Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane313 – 33321Helical; Potential
Domain85 – 372288ABC transmembrane type-1
Domain434 – 659226ABC transporter
Nucleotide binding473 – 4808ATP Potential
Region2 – 199198Interaction with PEX19 By similarity
Region2 – 124123Targeting to peroxisomes By similarity

Amino acid modifications

Modified residue611N6-acetyllysine Ref.5
Modified residue2601N6-acetyllysine Ref.5
Modified residue3991N6-acetyllysine Ref.5
Modified residue5331N6-acetyllysine Ref.5
Modified residue6591Phosphoserine Ref.4
Glycosylation121N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict4151E → G in AAA39958. Ref.1
Sequence conflict467 – 4682AN → NH in AAA39958. Ref.1
Sequence conflict4771C → R in AAA39958. Ref.1
Sequence conflict6261R → T in AAA39958. Ref.1
Sequence conflict6281S → C in AAA39958. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P55096 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 6DF924D91B481DC4

FASTA65975,475
        10         20         30         40         50         60 
MAAFSKYLTA RNTSLAGAAF LLLCLLHKRR RALGLHGKKS GKPPLQNNEK EGKKERAVVD 

        70         80         90        100        110        120 
KVFLSRLSQI LKIMVPRTFC KETGYLLLIA VMLVSRTYCD VWMIQNGTLI ESGIIGRSSK 

       130        140        150        160        170        180 
DFKRYLFNFI AAMPLISLVN NFLKYGLNEL KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN 

       190        200        210        220        230        240 
RIANPDQLLT QDVEKFCNSV VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS 

       250        260        270        280        290        300 
GLFLTRLRRP IGKMTIMEQK YEGEYRYVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 

       310        320        330        340        350        360 
EHLHNFIFFR FSMGFIDSII AKYVATVVGY LVVSRPFLDL AHPRHLHSTH SELLEDYYQS 

       370        380        390        400        410        420 
GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD LNHGRYERTM VSQQEKGIEG 

       430        440        450        460        470        480 
AQASPLVPGA GEIINTDNII KFDHVPLATP NGDILIQDLS FEVRSGANVL ICGPNGCGKS 

       490        500        510        520        530        540 
SLFRVLGELW PLFGGRLTKP ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKRGISDQ 

       550        560        570        580        590        600 
VLKEYLDNVQ LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 

       610        620        630        640        650 
VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI TEDTVEFGS 

« Hide

References

« Hide 'large scale' references
[1]"Differential evolution and expression of murine peroxisomal membrane protein genes."
Bryant D.D., Wilson G.N.
Biochem. Mol. Med. 55:22-30(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Swiss Webster.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Peroxisomal membrane protein PMP68 of mouse liver: cloning of a cDNA encompassing the nucleotide binding fold and epitope mapping of monoclonal antibodies to the expressed protein."
Chen N., Lu Z., Land M., Ayres R., Crane D.I.
Arch. Biochem. Biophys. 321:526-530(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-647.
Tissue: Liver.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61; LYS-260; LYS-399 AND LYS-533, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28836 Genomic DNA. Translation: AAA39958.1.
AC129311 Genomic DNA. No translation available.
X89569 mRNA. Translation: CAA61748.1.
CCDSCCDS17806.1.
PIRS58009. I48716.
RefSeqNP_033017.2. NM_008991.2.
UniGeneMm.399042.

3D structure databases

ProteinModelPortalP55096.
SMRP55096. Positions 422-652.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202521. 2 interactions.
IntActP55096. 3 interactions.
MINTMINT-1861742.

PTM databases

PhosphoSiteP55096.

Proteomic databases

MaxQBP55096.
PaxDbP55096.
PRIDEP55096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029770; ENSMUSP00000029770; ENSMUSG00000028127.
GeneID19299.
KEGGmmu:19299.
UCSCuc008reg.1. mouse.

Organism-specific databases

CTD5825.
MGIMGI:1349216. Abcd3.

Phylogenomic databases

eggNOGCOG4178.
GeneTreeENSGT00390000003950.
HOGENOMHOG000206081.
HOVERGENHBG050438.
InParanoidP55096.
KOK05677.
OMASDIWMIQ.
OrthoDBEOG70ZZMP.
TreeFamTF105205.

Gene expression databases

ArrayExpressP55096.
BgeeP55096.
GenevestigatorP55096.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005283. FA_transporter.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsTIGR00954. 3a01203. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABCD3. mouse.
NextBio296245.
PROP55096.
SOURCESearch...

Entry information

Entry nameABCD3_MOUSE
AccessionPrimary (citable) accession number: P55096
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot