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P55096

- ABCD3_MOUSE

UniProt

P55096 - ABCD3_MOUSE

Protein

ATP-binding cassette sub-family D member 3

Gene

Abcd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi473 – 4808ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. fatty acid beta-oxidation Source: Ensembl
    2. peroxisome organization Source: Ensembl
    3. very long-chain fatty acid catabolic process Source: Ensembl

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family D member 3
    Alternative name(s):
    68 kDa peroxisomal membrane protein
    Short name:
    PMP68
    70 kDa peroxisomal membrane protein
    Short name:
    PMP70
    Gene namesi
    Name:Abcd3
    Synonyms:Pmp70, Pxmp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1349216. Abcd3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrion Source: MGI
    4. peroxisomal matrix Source: Ensembl
    5. peroxisomal membrane Source: MGI
    6. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 659658ATP-binding cassette sub-family D member 3PRO_0000093310Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis
    Modified residuei61 – 611N6-acetyllysine1 Publication
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Modified residuei260 – 2601N6-acetyllysine1 Publication
    Modified residuei399 – 3991N6-acetyllysine1 Publication
    Modified residuei533 – 5331N6-acetyllysine1 Publication
    Modified residuei659 – 6591Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP55096.
    PaxDbiP55096.
    PRIDEiP55096.

    PTM databases

    PhosphoSiteiP55096.

    Expressioni

    Gene expression databases

    ArrayExpressiP55096.
    BgeeiP55096.
    GenevestigatoriP55096.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer Potential. Interacts with PEX19 By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi202521. 2 interactions.
    IntActiP55096. 3 interactions.
    MINTiMINT-1861742.

    Structurei

    3D structure databases

    ProteinModelPortaliP55096.
    SMRiP55096. Positions 422-652.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei126 – 14621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei224 – 24421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei313 – 33321HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 372288ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 659226ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 199198Interaction with PEX19By similarityAdd
    BLAST
    Regioni2 – 124123Targeting to peroxisomesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4178.
    GeneTreeiENSGT00390000003950.
    HOGENOMiHOG000206081.
    HOVERGENiHBG050438.
    InParanoidiP55096.
    KOiK05677.
    OMAiSDIWMIQ.
    OrthoDBiEOG70ZZMP.
    TreeFamiTF105205.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005283. FA_transporter.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsiTIGR00954. 3a01203. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55096-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFSKYLTA RNTSLAGAAF LLLCLLHKRR RALGLHGKKS GKPPLQNNEK    50
    EGKKERAVVD KVFLSRLSQI LKIMVPRTFC KETGYLLLIA VMLVSRTYCD 100
    VWMIQNGTLI ESGIIGRSSK DFKRYLFNFI AAMPLISLVN NFLKYGLNEL 150
    KLCFRVRLTR YLYEEYLQAF TYYKMGNLDN RIANPDQLLT QDVEKFCNSV 200
    VDLYSNLSKP FLDIVLYIFK LTSAIGAQGP ASMMAYLLVS GLFLTRLRRP 250
    IGKMTIMEQK YEGEYRYVNS RLITNSEEIA FYNGNKREKQ TIHSVFRKLV 300
    EHLHNFIFFR FSMGFIDSII AKYVATVVGY LVVSRPFLDL AHPRHLHSTH 350
    SELLEDYYQS GRMLLRMSQA LGRIVLAGRE MTRLAGFTAR ITELMQVLKD 400
    LNHGRYERTM VSQQEKGIEG AQASPLVPGA GEIINTDNII KFDHVPLATP 450
    NGDILIQDLS FEVRSGANVL ICGPNGCGKS SLFRVLGELW PLFGGRLTKP 500
    ERGKLFYVPQ RPYMTLGTLR DQVIYPDGKE DQKKRGISDQ VLKEYLDNVQ 550
    LGHILEREGG WDSVQDWMDV LSGGEKQRMA MARLFYHKPQ FAILDECTSA 600
    VSVDVEDYIY SHCRKVGITL FTVSHRKSLW KHHEYYLHMD GRGNYEFKKI 650
    TEDTVEFGS 659
    Length:659
    Mass (Da):75,475
    Last modified:June 28, 2011 - v2
    Checksum:i6DF924D91B481DC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti415 – 4151E → G in AAA39958. (PubMed:7551822)Curated
    Sequence conflicti467 – 4682AN → NH in AAA39958. (PubMed:7551822)Curated
    Sequence conflicti477 – 4771C → R in AAA39958. (PubMed:7551822)Curated
    Sequence conflicti626 – 6261R → T in AAA39958. (PubMed:7551822)Curated
    Sequence conflicti628 – 6281S → C in AAA39958. (PubMed:7551822)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28836 Genomic DNA. Translation: AAA39958.1.
    AC129311 Genomic DNA. No translation available.
    X89569 mRNA. Translation: CAA61748.1.
    CCDSiCCDS17806.1.
    PIRiI48716. S58009.
    RefSeqiNP_033017.2. NM_008991.2.
    UniGeneiMm.399042.

    Genome annotation databases

    EnsembliENSMUST00000029770; ENSMUSP00000029770; ENSMUSG00000028127.
    GeneIDi19299.
    KEGGimmu:19299.
    UCSCiuc008reg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28836 Genomic DNA. Translation: AAA39958.1 .
    AC129311 Genomic DNA. No translation available.
    X89569 mRNA. Translation: CAA61748.1 .
    CCDSi CCDS17806.1.
    PIRi I48716. S58009.
    RefSeqi NP_033017.2. NM_008991.2.
    UniGenei Mm.399042.

    3D structure databases

    ProteinModelPortali P55096.
    SMRi P55096. Positions 422-652.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202521. 2 interactions.
    IntActi P55096. 3 interactions.
    MINTi MINT-1861742.

    PTM databases

    PhosphoSitei P55096.

    Proteomic databases

    MaxQBi P55096.
    PaxDbi P55096.
    PRIDEi P55096.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029770 ; ENSMUSP00000029770 ; ENSMUSG00000028127 .
    GeneIDi 19299.
    KEGGi mmu:19299.
    UCSCi uc008reg.1. mouse.

    Organism-specific databases

    CTDi 5825.
    MGIi MGI:1349216. Abcd3.

    Phylogenomic databases

    eggNOGi COG4178.
    GeneTreei ENSGT00390000003950.
    HOGENOMi HOG000206081.
    HOVERGENi HBG050438.
    InParanoidi P55096.
    KOi K05677.
    OMAi SDIWMIQ.
    OrthoDBi EOG70ZZMP.
    TreeFami TF105205.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    ChiTaRSi ABCD3. mouse.
    NextBioi 296245.
    PROi P55096.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55096.
    Bgeei P55096.
    Genevestigatori P55096.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR005283. FA_transporter.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    TIGRFAMsi TIGR00954. 3a01203. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential evolution and expression of murine peroxisomal membrane protein genes."
      Bryant D.D., Wilson G.N.
      Biochem. Mol. Med. 55:22-30(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Swiss Webster.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Peroxisomal membrane protein PMP68 of mouse liver: cloning of a cDNA encompassing the nucleotide binding fold and epitope mapping of monoclonal antibodies to the expressed protein."
      Chen N., Lu Z., Land M., Ayres R., Crane D.I.
      Arch. Biochem. Biophys. 321:526-530(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-647.
      Tissue: Liver.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-61; LYS-260; LYS-399 AND LYS-533, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiABCD3_MOUSE
    AccessioniPrimary (citable) accession number: P55096
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3