Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P55091

- CTRC_RAT

UniProt

P55091 - CTRC_RAT

Protein

Chymotrypsin-C

Gene

Ctrc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has chymotrypsin-type protease activity and hypocalcemic activity.

    Catalytic activityi

    Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Charge relay systemBy similarity
    Active sitei121 – 1211Charge relay systemBy similarity
    Active sitei216 – 2161Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.157.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chymotrypsin-C (EC:3.4.21.2)
    Alternative name(s):
    Caldecrin
    Serum calcium-decreasing factor
    Gene namesi
    Name:Ctrc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1308379. Ctrc.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Propeptidei17 – 2913Activation peptidePRO_0000027715Add
    BLAST
    Chaini30 – 268239Chymotrypsin-CPRO_0000027716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi17 ↔ 141PROSITE-ProRule annotation
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
    Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
    Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP55091.
    PRIDEiP55091.

    Expressioni

    Tissue specificityi

    Pancreas.

    Gene expression databases

    GenevestigatoriP55091.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018393.

    Structurei

    3D structure databases

    ProteinModelPortaliP55091.
    SMRiP55091. Positions 17-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 267238Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00640000091262.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP55091.
    KOiK01311.
    OMAiREYPIRE.
    OrthoDBiEOG75B84T.
    PhylomeDBiP55091.
    TreeFamiTF330455.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGITVLAAI LACASCCGNP AFPPNLSTRV VGGEDAVPNS WPWQVSLQYL    50
    KDDTWRHTCG GSLITTSHVL TAAHCINKDF TYRVGLGKYN LTVEDEEGSV 100
    YAEVDTIYVH EKWNRLFLWN DIAIIKLAEP VELSNTIQVA CIPEEGSLLP 150
    QDYPCYVTGW GRLWTNGPIA EVLQQGLQPI VSHATCSRLD WWFIKVRKTM 200
    VCAGGDGVIS ACNGDSGGPL NCQAEDGSWQ VHGIVSFGSS SGCNVHKKPV 250
    VFTRVSAYND WINEKIQL 268
    Length:268
    Mass (Da):29,374
    Last modified:October 1, 1996 - v1
    Checksum:i33B67AF34D0F8583
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421P → A in CAA41753. (PubMed:1537555)Curated
    Sequence conflicti96 – 12025EEGSV…LFLWN → AEAPCTLRWTPSTSMRSGTD SSCGT in CAA41753. (PubMed:1537555)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80379 mRNA. Translation: AAB35830.1.
    X59014 mRNA. Translation: CAA41753.1.
    PIRiJQ1473.
    RefSeqiNP_001071117.1. NM_001077649.2.
    UniGeneiRn.19214.

    Genome annotation databases

    EnsembliENSRNOT00000018393; ENSRNOP00000018393; ENSRNOG00000013745.
    GeneIDi362653.
    KEGGirno:362653.
    UCSCiRGD:1308379. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80379 mRNA. Translation: AAB35830.1 .
    X59014 mRNA. Translation: CAA41753.1 .
    PIRi JQ1473.
    RefSeqi NP_001071117.1. NM_001077649.2.
    UniGenei Rn.19214.

    3D structure databases

    ProteinModelPortali P55091.
    SMRi P55091. Positions 17-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018393.

    Protein family/group databases

    MEROPSi S01.157.

    Proteomic databases

    PaxDbi P55091.
    PRIDEi P55091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018393 ; ENSRNOP00000018393 ; ENSRNOG00000013745 .
    GeneIDi 362653.
    KEGGi rno:362653.
    UCSCi RGD:1308379. rat.

    Organism-specific databases

    CTDi 11330.
    RGDi 1308379. Ctrc.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00640000091262.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P55091.
    KOi K01311.
    OMAi REYPIRE.
    OrthoDBi EOG75B84T.
    PhylomeDBi P55091.
    TreeFami TF330455.

    Miscellaneous databases

    NextBioi 680758.
    PROi P55091.

    Gene expression databases

    Genevestigatori P55091.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)."
      Tomomura A., Tomomura M., Fukushige T., Akiyama M., Kubota N., Kumaki K., Nishii Y., Noikura T., Saheki T.
      J. Biol. Chem. 270:30315-30321(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Pancreas.
    2. "Identification of cDNAs encoding two novel rat pancreatic serine proteases."
      Kang J., Wiegand U., Mueller-Hill B.
      Gene 110:181-187(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    3. "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."
      Yoshino-Yasuda I., Kobayashi K., Akiyama M., Itoh H., Tomomura A., Saheki T.
      J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiCTRC_RAT
    AccessioniPrimary (citable) accession number: P55091
    Secondary accession number(s): Q63188
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be elastase IV.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3