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Protein

Chymotrypsin-C

Gene

Ctrc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has chymotrypsin-type protease activity and hypocalcemic activity.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Protein family/group databases

MEROPSiS01.157.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Alternative name(s):
Caldecrin
Serum calcium-decreasing factor
Gene namesi
Name:Ctrc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308379. Ctrc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002771517 – 29Activation peptideAdd BLAST13
ChainiPRO_000002771630 – 268Chymotrypsin-CAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi17 ↔ 141PROSITE-ProRule annotation
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP55091.
PRIDEiP55091.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSRNOG00000013745.
ExpressionAtlasiP55091. baseline and differential.
GenevisibleiP55091. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018393.

Structurei

3D structure databases

ProteinModelPortaliP55091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP55091.
KOiK01311.
OMAiWNDIAII.
OrthoDBiEOG091G0DF7.
PhylomeDBiP55091.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGITVLAAI LACASCCGNP AFPPNLSTRV VGGEDAVPNS WPWQVSLQYL
60 70 80 90 100
KDDTWRHTCG GSLITTSHVL TAAHCINKDF TYRVGLGKYN LTVEDEEGSV
110 120 130 140 150
YAEVDTIYVH EKWNRLFLWN DIAIIKLAEP VELSNTIQVA CIPEEGSLLP
160 170 180 190 200
QDYPCYVTGW GRLWTNGPIA EVLQQGLQPI VSHATCSRLD WWFIKVRKTM
210 220 230 240 250
VCAGGDGVIS ACNGDSGGPL NCQAEDGSWQ VHGIVSFGSS SGCNVHKKPV
260
VFTRVSAYND WINEKIQL
Length:268
Mass (Da):29,374
Last modified:October 1, 1996 - v1
Checksum:i33B67AF34D0F8583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42P → A in CAA41753 (PubMed:1537555).Curated1
Sequence conflicti96 – 120EEGSV…LFLWN → AEAPCTLRWTPSTSMRSGTD SSCGT in CAA41753 (PubMed:1537555).CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80379 mRNA. Translation: AAB35830.1.
X59014 mRNA. Translation: CAA41753.1.
PIRiJQ1473.
RefSeqiNP_001071117.1. NM_001077649.2.
UniGeneiRn.19214.

Genome annotation databases

EnsembliENSRNOT00000018393; ENSRNOP00000018393; ENSRNOG00000013745.
GeneIDi362653.
KEGGirno:362653.
UCSCiRGD:1308379. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80379 mRNA. Translation: AAB35830.1.
X59014 mRNA. Translation: CAA41753.1.
PIRiJQ1473.
RefSeqiNP_001071117.1. NM_001077649.2.
UniGeneiRn.19214.

3D structure databases

ProteinModelPortaliP55091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018393.

Protein family/group databases

MEROPSiS01.157.

Proteomic databases

PaxDbiP55091.
PRIDEiP55091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018393; ENSRNOP00000018393; ENSRNOG00000013745.
GeneIDi362653.
KEGGirno:362653.
UCSCiRGD:1308379. rat.

Organism-specific databases

CTDi11330.
RGDi1308379. Ctrc.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP55091.
KOiK01311.
OMAiWNDIAII.
OrthoDBiEOG091G0DF7.
PhylomeDBiP55091.
TreeFamiTF330455.

Enzyme and pathway databases

ReactomeiR-RNO-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

PROiP55091.

Gene expression databases

BgeeiENSRNOG00000013745.
ExpressionAtlasiP55091. baseline and differential.
GenevisibleiP55091. RN.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRC_RAT
AccessioniPrimary (citable) accession number: P55091
Secondary accession number(s): Q63188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be elastase IV.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.