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P55091 (CTRC_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chymotrypsin-C

EC=3.4.21.2
Alternative name(s):
Caldecrin
Serum calcium-decreasing factor
Gene names
Name:Ctrc
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has chymotrypsin-type protease activity and hypocalcemic activity.

Catalytic activity

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Tissue specificity

Pancreas.

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

Contains 1 peptidase S1 domain.

Caution

Was originally (Ref.2) thought to be elastase IV.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Propeptide17 – 2913Activation peptide
PRO_0000027715
Chain30 – 268239Chymotrypsin-C
PRO_0000027716

Regions

Domain30 – 267238Peptidase S1

Sites

Active site741Charge relay system By similarity
Active site1211Charge relay system By similarity
Active site2161Charge relay system By similarity

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Disulfide bond17 ↔ 141 By similarity
Disulfide bond59 ↔ 75 By similarity
Disulfide bond155 ↔ 222 By similarity
Disulfide bond186 ↔ 202 By similarity
Disulfide bond212 ↔ 243 By similarity

Experimental info

Sequence conflict421P → A in CAA41753. Ref.2
Sequence conflict96 – 12025EEGSV…LFLWN → AEAPCTLRWTPSTSMRSGTD SSCGT in CAA41753. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55091 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 33B67AF34D0F8583

FASTA26829,374
        10         20         30         40         50         60 
MLGITVLAAI LACASCCGNP AFPPNLSTRV VGGEDAVPNS WPWQVSLQYL KDDTWRHTCG 

        70         80         90        100        110        120 
GSLITTSHVL TAAHCINKDF TYRVGLGKYN LTVEDEEGSV YAEVDTIYVH EKWNRLFLWN 

       130        140        150        160        170        180 
DIAIIKLAEP VELSNTIQVA CIPEEGSLLP QDYPCYVTGW GRLWTNGPIA EVLQQGLQPI 

       190        200        210        220        230        240 
VSHATCSRLD WWFIKVRKTM VCAGGDGVIS ACNGDSGGPL NCQAEDGSWQ VHGIVSFGSS 

       250        260 
SGCNVHKKPV VFTRVSAYND WINEKIQL 

« Hide

References

[1]"Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)."
Tomomura A., Tomomura M., Fukushige T., Akiyama M., Kubota N., Kumaki K., Nishii Y., Noikura T., Saheki T.
J. Biol. Chem. 270:30315-30321(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Pancreas.
[2]"Identification of cDNAs encoding two novel rat pancreatic serine proteases."
Kang J., Wiegand U., Mueller-Hill B.
Gene 110:181-187(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[3]"Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."
Yoshino-Yasuda I., Kobayashi K., Akiyama M., Itoh H., Tomomura A., Saheki T.
J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S80379 mRNA. Translation: AAB35830.1.
X59014 mRNA. Translation: CAA41753.1.
PIRJQ1473.
RefSeqNP_001071117.1. NM_001077649.2.
UniGeneRn.19214.

3D structure databases

ProteinModelPortalP55091.
SMRP55091. Positions 17-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018393.

Protein family/group databases

MEROPSS01.157.

Proteomic databases

PaxDbP55091.
PRIDEP55091.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018393; ENSRNOP00000018393; ENSRNOG00000013745.
GeneID362653.
KEGGrno:362653.
UCSCRGD:1308379. rat.

Organism-specific databases

CTD11330.
RGD1308379. Ctrc.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00640000091262.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP55091.
KOK01311.
OMAREYPIRE.
OrthoDBEOG75B84T.
PhylomeDBP55091.
TreeFamTF330455.

Gene expression databases

GenevestigatorP55091.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio680758.
PROP55091.

Entry information

Entry nameCTRC_RAT
AccessionPrimary (citable) accession number: P55091
Secondary accession number(s): Q63188
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries