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P55091

- CTRC_RAT

UniProt

P55091 - CTRC_RAT

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Protein
Chymotrypsin-C
Gene
Ctrc
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has chymotrypsin-type protease activity and hypocalcemic activity.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Charge relay system By similarity
Active sitei121 – 1211Charge relay system By similarity
Active sitei216 – 2161Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.157.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Alternative name(s):
Caldecrin
Serum calcium-decreasing factor
Gene namesi
Name:Ctrc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi1308379. Ctrc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Propeptidei17 – 2913Activation peptide
PRO_0000027715Add
BLAST
Chaini30 – 268239Chymotrypsin-C
PRO_0000027716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi17 ↔ 141 By similarity
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi59 ↔ 75 By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 222 By similarity
Disulfide bondi186 ↔ 202 By similarity
Disulfide bondi212 ↔ 243 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP55091.
PRIDEiP55091.

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

GenevestigatoriP55091.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018393.

Structurei

3D structure databases

ProteinModelPortaliP55091.
SMRiP55091. Positions 17-268.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 267238Peptidase S1
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00640000091262.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP55091.
KOiK01311.
OMAiREYPIRE.
OrthoDBiEOG75B84T.
PhylomeDBiP55091.
TreeFamiTF330455.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55091-1 [UniParc]FASTAAdd to Basket

« Hide

MLGITVLAAI LACASCCGNP AFPPNLSTRV VGGEDAVPNS WPWQVSLQYL    50
KDDTWRHTCG GSLITTSHVL TAAHCINKDF TYRVGLGKYN LTVEDEEGSV 100
YAEVDTIYVH EKWNRLFLWN DIAIIKLAEP VELSNTIQVA CIPEEGSLLP 150
QDYPCYVTGW GRLWTNGPIA EVLQQGLQPI VSHATCSRLD WWFIKVRKTM 200
VCAGGDGVIS ACNGDSGGPL NCQAEDGSWQ VHGIVSFGSS SGCNVHKKPV 250
VFTRVSAYND WINEKIQL 268
Length:268
Mass (Da):29,374
Last modified:October 1, 1996 - v1
Checksum:i33B67AF34D0F8583
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421P → A in CAA41753. 1 Publication
Sequence conflicti96 – 12025EEGSV…LFLWN → AEAPCTLRWTPSTSMRSGTD SSCGT in CAA41753. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80379 mRNA. Translation: AAB35830.1.
X59014 mRNA. Translation: CAA41753.1.
PIRiJQ1473.
RefSeqiNP_001071117.1. NM_001077649.2.
UniGeneiRn.19214.

Genome annotation databases

EnsembliENSRNOT00000018393; ENSRNOP00000018393; ENSRNOG00000013745.
GeneIDi362653.
KEGGirno:362653.
UCSCiRGD:1308379. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S80379 mRNA. Translation: AAB35830.1 .
X59014 mRNA. Translation: CAA41753.1 .
PIRi JQ1473.
RefSeqi NP_001071117.1. NM_001077649.2.
UniGenei Rn.19214.

3D structure databases

ProteinModelPortali P55091.
SMRi P55091. Positions 17-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018393.

Protein family/group databases

MEROPSi S01.157.

Proteomic databases

PaxDbi P55091.
PRIDEi P55091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018393 ; ENSRNOP00000018393 ; ENSRNOG00000013745 .
GeneIDi 362653.
KEGGi rno:362653.
UCSCi RGD:1308379. rat.

Organism-specific databases

CTDi 11330.
RGDi 1308379. Ctrc.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00640000091262.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P55091.
KOi K01311.
OMAi REYPIRE.
OrthoDBi EOG75B84T.
PhylomeDBi P55091.
TreeFami TF330455.

Miscellaneous databases

NextBioi 680758.
PROi P55091.

Gene expression databases

Genevestigatori P55091.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)."
    Tomomura A., Tomomura M., Fukushige T., Akiyama M., Kubota N., Kumaki K., Nishii Y., Noikura T., Saheki T.
    J. Biol. Chem. 270:30315-30321(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Pancreas.
  2. "Identification of cDNAs encoding two novel rat pancreatic serine proteases."
    Kang J., Wiegand U., Mueller-Hill B.
    Gene 110:181-187(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  3. "Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene."
    Yoshino-Yasuda I., Kobayashi K., Akiyama M., Itoh H., Tomomura A., Saheki T.
    J. Biochem. 123:546-554(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCTRC_RAT
AccessioniPrimary (citable) accession number: P55091
Secondary accession number(s): Q63188
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to be elastase IV.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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