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Protein

Urocortin

Gene

Ucn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451).By similarity2 Publications

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • histone deacetylase inhibitor activity Source: RGD

GO - Biological processi

  • activation of protein kinase A activity Source: RGD
  • aerobic respiration Source: RGD
  • associative learning Source: RGD
  • drinking behavior Source: RGD
  • feeding behavior Source: RGD
  • female pregnancy Source: RGD
  • gastric emptying Source: RGD
  • inflammatory response Source: RGD
  • learning or memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of appetite Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of cell size Source: RGD
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • negative regulation of necrotic cell death Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuron projection development Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • pancreatic juice secretion Source: RGD
  • positive regulation of behavioral fear response Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of cardiac muscle contraction Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of corticotropin secretion Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of translation Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • positive regulation of vasodilation Source: RGD
  • regulation of synaptic transmission, glutamatergic Source: RGD
  • response to auditory stimulus Source: Ensembl
  • response to estradiol Source: RGD
  • response to glucocorticoid Source: RGD
  • response to oxidative stress Source: RGD
  • response to pain Source: RGD
  • sensory perception of sound Source: UniProtKB-KW
  • social behavior Source: RGD
  • startle response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Alternative name(s):
Corticotensin
Gene namesi
Name:Ucn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3929. Ucn.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • axon terminus Source: RGD
  • dendrite Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • perikaryon Source: RGD
  • varicosity Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 8055PRO_0000006237Add
BLAST
Peptidei81 – 12040UrocortinPRO_0000006238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei120 – 1201Valine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55090.
PRIDEiP55090.

Expressioni

Gene expression databases

GenevisibleiP55090. RN.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Crhr1P353533EBI-9030248,EBI-9030306

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

BioGridi247834. 4 interactions.
IntActiP55090. 1 interaction.
STRINGi10116.ENSRNOP00000008037.

Structurei

3D structure databases

ProteinModelPortaliP55090.
SMRiP55090. Positions 81-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55090.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP55090.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ
60 70 80 90 100
GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL
110 120
ARTQSQRERA EQNRIIFDSV GK
Length:122
Mass (Da):13,711
Last modified:October 1, 1996 - v1
Checksum:i9F0AF834CBFFCE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33935 mRNA. Translation: AAA87566.1.
AF093623 Genomic DNA. Translation: AAF63153.1.
PIRiS60262.
RefSeqiNP_062023.1. NM_019150.1.
UniGeneiRn.10190.

Genome annotation databases

EnsembliENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090.
GeneIDi29151.
KEGGirno:29151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33935 mRNA. Translation: AAA87566.1.
AF093623 Genomic DNA. Translation: AAF63153.1.
PIRiS60262.
RefSeqiNP_062023.1. NM_019150.1.
UniGeneiRn.10190.

3D structure databases

ProteinModelPortaliP55090.
SMRiP55090. Positions 81-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247834. 4 interactions.
IntActiP55090. 1 interaction.
STRINGi10116.ENSRNOP00000008037.

Proteomic databases

PaxDbiP55090.
PRIDEiP55090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090.
GeneIDi29151.
KEGGirno:29151.

Organism-specific databases

CTDi7349.
RGDi3929. Ucn.

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55090.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP55090.
TreeFamiTF332956.

Miscellaneous databases

PROiP55090.

Gene expression databases

GenevisibleiP55090. RN.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor."
    Vaughan J.M., Donaldson C.J., Bittencourt J., Perrin M.H., Lewis K.A., Sutton S.W., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J.E., Sawchenko P., Vale W.W.
    Nature 378:287-292(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Sprague-Dawley.
  2. "Detection of rat urocortin in lymphoid tissues: implications for the functional assessment of urocortin as a novel neuro-immunomodulatory peptide."
    Park J.H., Lee Y.J., Kim K.L.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Lewis.
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiUCN1_RAT
AccessioniPrimary (citable) accession number: P55090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.