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Protein

Urocortin

Gene

Ucn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451).By similarity2 Publications

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • histone deacetylase inhibitor activity Source: RGD
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • activation of protein kinase A activity Source: RGD
  • aerobic respiration Source: RGD
  • associative learning Source: RGD
  • drinking behavior Source: RGD
  • feeding behavior Source: RGD
  • female pregnancy Source: RGD
  • gastric emptying Source: RGD
  • inflammatory response Source: RGD
  • learning or memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of appetite Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of cell size Source: RGD
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • negative regulation of necrotic cell death Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuron projection development Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • pancreatic juice secretion Source: RGD
  • positive regulation of behavioral fear response Source: RGD
  • positive regulation of blood vessel diameter Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cAMP-mediated signaling Source: RGD
  • positive regulation of cardiac muscle contraction Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of corticotropin secretion Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • positive regulation of translation Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • regulation of synaptic transmission, glutamatergic Source: RGD
  • response to auditory stimulus Source: RGD
  • response to estradiol Source: RGD
  • response to glucocorticoid Source: RGD
  • response to oxidative stress Source: RGD
  • response to pain Source: RGD
  • sensory perception of sound Source: UniProtKB-KW
  • social behavior Source: RGD
  • startle response Source: RGD

Keywordsi

Molecular functionHormone
Biological processHearing

Enzyme and pathway databases

ReactomeiR-RNO-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Alternative name(s):
Corticotensin
Gene namesi
Name:Ucn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3929 Ucn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000623726 – 80Add BLAST55
PeptideiPRO_000000623881 – 120UrocortinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55090
PRIDEiP55090

Expressioni

Gene expression databases

BgeeiENSRNOG00000006090
GenevisibleiP55090 RN

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Crhr1P353533EBI-9030248,EBI-9030306

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi247834, 4 interactors
IntActiP55090, 1 interactor
STRINGi10116.ENSRNOP00000008037

Structurei

3D structure databases

ProteinModelPortaliP55090
SMRiP55090
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ Eukaryota
ENOG410Y0J4 LUCA
GeneTreeiENSGT00510000049284
HOGENOMiHOG000121779
HOVERGENiHBG036241
InParanoidiP55090
OMAiLRWSPGA
OrthoDBiEOG091G15U8
PhylomeDBiP55090
TreeFamiTF332956

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ
60 70 80 90 100
GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL
110 120
ARTQSQRERA EQNRIIFDSV GK
Length:122
Mass (Da):13,711
Last modified:October 1, 1996 - v1
Checksum:i9F0AF834CBFFCE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33935 mRNA Translation: AAA87566.1
AF093623 Genomic DNA Translation: AAF63153.1
PIRiS60262
RefSeqiNP_062023.1, NM_019150.1
UniGeneiRn.10190

Genome annotation databases

EnsembliENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090
GeneIDi29151
KEGGirno:29151

Similar proteinsi

Entry informationi

Entry nameiUCN1_RAT
AccessioniPrimary (citable) accession number: P55090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health