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Protein

Urocortin

Gene

Ucn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451).By similarity2 Publications

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • histone deacetylase inhibitor activity Source: RGD
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • activation of protein kinase A activity Source: RGD
  • aerobic respiration Source: RGD
  • associative learning Source: RGD
  • drinking behavior Source: RGD
  • feeding behavior Source: RGD
  • female pregnancy Source: RGD
  • gastric emptying Source: RGD
  • inflammatory response Source: RGD
  • learning or memory Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of appetite Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cell death Source: RGD
  • negative regulation of cell size Source: RGD
  • negative regulation of feeding behavior Source: RGD
  • negative regulation of gastric acid secretion Source: RGD
  • negative regulation of gene expression Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • negative regulation of necrotic cell death Source: RGD
  • negative regulation of neuron death Source: RGD
  • neuron projection development Source: RGD
  • neuropeptide signaling pathway Source: RGD
  • pancreatic juice secretion Source: RGD
  • positive regulation of behavioral fear response Source: RGD
  • positive regulation of blood vessel diameter Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cAMP biosynthetic process Source: RGD
  • positive regulation of cardiac muscle contraction Source: RGD
  • positive regulation of cell growth Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of corticotropin secretion Source: RGD
  • positive regulation of DNA replication Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of peptidyl-serine phosphorylation Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of translation Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • regulation of synaptic transmission, glutamatergic Source: RGD
  • response to auditory stimulus Source: Ensembl
  • response to estradiol Source: RGD
  • response to glucocorticoid Source: RGD
  • response to oxidative stress Source: RGD
  • response to pain Source: RGD
  • sensory perception of sound Source: UniProtKB-KW
  • social behavior Source: RGD
  • startle response Source: Ensembl

Keywordsi

Molecular functionHormone
Biological processHearing

Enzyme and pathway databases

ReactomeiR-RNO-373080. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Alternative name(s):
Corticotensin
Gene namesi
Name:Ucn
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3929. Ucn.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • axon terminus Source: RGD
  • dendrite Source: RGD
  • extracellular region Source: UniProtKB-SubCell
  • neuronal cell body Source: RGD
  • perikaryon Source: RGD
  • varicosity Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000623726 – 80Add BLAST55
PeptideiPRO_000000623881 – 120UrocortinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55090.
PRIDEiP55090.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006090.
GenevisibleiP55090. RN.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Crhr1P353533EBI-9030248,EBI-9030306

GO - Molecular functioni

  • corticotropin-releasing hormone receptor 1 binding Source: RGD
  • corticotropin-releasing hormone receptor 2 binding Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi247834. 4 interactors.
IntActiP55090. 1 interactor.
STRINGi10116.ENSRNOP00000008037.

Structurei

3D structure databases

ProteinModelPortaliP55090.
SMRiP55090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55090.
OMAiLRWSPGA.
OrthoDBiEOG091G15U8.
PhylomeDBiP55090.
TreeFamiTF332956.

Family and domain databases

InterProiView protein in InterPro
IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiView protein in Pfam
PF00473. CRF. 1 hit.
PRINTSiPR01612. CRFFAMILY.
SMARTiView protein in SMART
SM00039. CRF. 1 hit.
PROSITEiView protein in PROSITE
PS00511. CRF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQRGRATLL VALLLLVQLR PESSQWSPAA AAANVVQDPN LRWNPGVRNQ
60 70 80 90 100
GGGVRALLLL LAERFPRRAG SEPAGERQRR DDPPLSIDLT FHLLRTLLEL
110 120
ARTQSQRERA EQNRIIFDSV GK
Length:122
Mass (Da):13,711
Last modified:October 1, 1996 - v1
Checksum:i9F0AF834CBFFCE74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33935 mRNA. Translation: AAA87566.1.
AF093623 Genomic DNA. Translation: AAF63153.1.
PIRiS60262.
RefSeqiNP_062023.1. NM_019150.1.
UniGeneiRn.10190.

Genome annotation databases

EnsembliENSRNOT00000008037; ENSRNOP00000008037; ENSRNOG00000006090.
GeneIDi29151.
KEGGirno:29151.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUCN1_RAT
AccessioniPrimary (citable) accession number: P55090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 10, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families