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Protein

Urocortin

Gene

UCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).By similarity1 Publication

Miscellaneous

Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processHearing

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.
SIGNORiP55089.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:UCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163794.6.
HGNCiHGNC:12516. UCN.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116R → A: Reduced affinity for CRHR1. 1 Publication1
Mutagenesisi118I → A: Reduced affinity for CRHR2. 1 Publication1
Mutagenesisi119F → A: Strongly reduced affinity for CRHR2. 1 Publication1
Mutagenesisi122V → A: Reduced affinity for CRHR2. 1 Publication1

Organism-specific databases

DisGeNETi7349.
OpenTargetsiENSG00000163794.
PharmGKBiPA37163.

Polymorphism and mutation databases

BioMutaiUCN.
DMDMi1718059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000623326 – 82Add BLAST57
PeptideiPRO_000000623483 – 122UrocortinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55089.
PeptideAtlasiP55089.
PRIDEiP55089.

Expressioni

Tissue specificityi

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications

Gene expression databases

BgeeiENSG00000163794.
CleanExiHS_UCN.
GenevisibleiP55089. HS.

Organism-specific databases

HPAiCAB010911.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113196. 4 interactors.
STRINGi9606.ENSP00000296099.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi108 – 121Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089.
SMRiP55089.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55089.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55089.
OMAiLRWSPGA.
PhylomeDBiP55089.
TreeFamiTF332956.

Family and domain databases

InterProiView protein in InterPro
IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiView protein in Pfam
PF00473. CRF. 1 hit.
PRINTSiPR01612. CRFFAMILY.
SMARTiView protein in SMART
SM00039. CRF. 1 hit.
PROSITEiView protein in PROSITE
PS00511. CRF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG
60 70 80 90 100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL
110 120
ELARTQSQRE RAEQNRIIFD SVGK
Length:124
Mass (Da):13,458
Last modified:October 1, 1996 - v1
Checksum:i4F765DA75DDD4A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSiCCDS1747.1.
RefSeqiNP_003344.1. NM_003353.3.
UniGeneiHs.534363.

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
GeneIDi7349.
KEGGihsa:7349.
UCSCiuc002rjp.2. human.

Similar proteinsi

Entry informationi

Entry nameiUCN1_HUMAN
AccessioniPrimary (citable) accession number: P55089
Secondary accession number(s): Q6FG64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families