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P55089

- UCN1_HUMAN

UniProt

P55089 - UCN1_HUMAN

Protein

Urocortin

Gene

UCN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

    GO - Molecular functioni

    1. histone deacetylase inhibitor activity Source: Ensembl
    2. neuropeptide hormone activity Source: ProtInc
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase A activity Source: Ensembl
    2. aerobic respiration Source: Ensembl
    3. associative learning Source: Ensembl
    4. drinking behavior Source: Ensembl
    5. female pregnancy Source: Ensembl
    6. gastric emptying Source: Ensembl
    7. G-protein coupled receptor signaling pathway Source: ProtInc
    8. inflammatory response Source: Ensembl
    9. negative regulation of apoptotic process Source: Ensembl
    10. negative regulation of appetite Source: Ensembl
    11. negative regulation of blood pressure Source: Ensembl
    12. negative regulation of cell size Source: Ensembl
    13. negative regulation of feeding behavior Source: Ensembl
    14. negative regulation of gastric acid secretion Source: Ensembl
    15. negative regulation of gene expression Source: Ensembl
    16. negative regulation of hormone secretion Source: Ensembl
    17. negative regulation of necrotic cell death Source: Ensembl
    18. negative regulation of neuron death Source: Ensembl
    19. neuron projection development Source: Ensembl
    20. neuropeptide signaling pathway Source: Ensembl
    21. pancreatic juice secretion Source: Ensembl
    22. positive regulation of behavioral fear response Source: Ensembl
    23. positive regulation of calcium ion import Source: Ensembl
    24. positive regulation of cAMP biosynthetic process Source: Ensembl
    25. positive regulation of cardiac muscle contraction Source: Ensembl
    26. positive regulation of cell growth Source: Ensembl
    27. positive regulation of collagen biosynthetic process Source: Ensembl
    28. positive regulation of corticotropin secretion Source: Ensembl
    29. positive regulation of DNA replication Source: Ensembl
    30. positive regulation of gene expression Source: Ensembl
    31. positive regulation of interleukin-6 production Source: Ensembl
    32. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    33. positive regulation of translation Source: Ensembl
    34. positive regulation of vascular permeability Source: Ensembl
    35. positive regulation of vasodilation Source: Ensembl
    36. regulation of synaptic transmission, glutamatergic Source: Ensembl
    37. response to estradiol Source: Ensembl
    38. response to glucocorticoid Source: Ensembl
    39. response to oxidative stress Source: Ensembl
    40. response to pain Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urocortin
    Gene namesi
    Name:UCN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:12516. UCN.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. dendrite Source: Ensembl
    3. extracellular region Source: UniProtKB-SubCell
    4. perikaryon Source: Ensembl
    5. varicosity Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi116 – 1161R → A: Reduced affinity for CRHR1. 1 Publication
    Mutagenesisi118 – 1181I → A: Reduced affinity for CRHR2. 1 Publication
    Mutagenesisi119 – 1191F → A: Strongly reduced affinity for CRHR2. 1 Publication
    Mutagenesisi122 – 1221V → A: Reduced affinity for CRHR2. 1 Publication

    Organism-specific databases

    PharmGKBiPA37163.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 8257PRO_0000006233Add
    BLAST
    Peptidei83 – 12240UrocortinPRO_0000006234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221Valine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP55089.
    PRIDEiP55089.

    Expressioni

    Gene expression databases

    BgeeiP55089.
    CleanExiHS_UCN.
    GenevestigatoriP55089.

    Organism-specific databases

    HPAiCAB010911.

    Interactioni

    Subunit structurei

    Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).1 Publication

    Protein-protein interaction databases

    BioGridi113196. 5 interactions.
    STRINGi9606.ENSP00000296099.

    Structurei

    Secondary structure

    1
    124
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi108 – 12114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RMFNMR-A83-122[»]
    3N96X-ray2.75E/F/G/H107-122[»]
    ProteinModelPortaliP55089.
    SMRiP55089. Positions 83-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55089.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46022.
    HOGENOMiHOG000121779.
    HOVERGENiHBG036241.
    InParanoidiP55089.
    OMAiLRWSPGA.
    OrthoDBiEOG73JKZD.
    PhylomeDBiP55089.
    TreeFamiTF332956.

    Family and domain databases

    InterProiIPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view]
    PANTHERiPTHR15035. PTHR15035. 1 hit.
    PfamiPF00473. CRF. 1 hit.
    [Graphical view]
    PRINTSiPR01612. CRFFAMILY.
    SMARTiSM00039. CRF. 1 hit.
    [Graphical view]
    PROSITEiPS00511. CRF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55089-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG    50
    ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL 100
    ELARTQSQRE RAEQNRIIFD SVGK 124
    Length:124
    Mass (Da):13,458
    Last modified:October 1, 1996 - v1
    Checksum:i4F765DA75DDD4A5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038633 Genomic DNA. Translation: AAC24204.1.
    CR542244 mRNA. Translation: CAG47040.1.
    AC013413 Genomic DNA. Translation: AAY24297.1.
    BC104470 mRNA. Translation: AAI04471.1.
    BC104471 mRNA. Translation: AAI04472.1.
    CCDSiCCDS1747.1.
    RefSeqiNP_003344.1. NM_003353.2.
    UniGeneiHs.534363.

    Genome annotation databases

    EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
    GeneIDi7349.
    KEGGihsa:7349.
    UCSCiuc002rjp.1. human.

    Polymorphism databases

    DMDMi1718059.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038633 Genomic DNA. Translation: AAC24204.1 .
    CR542244 mRNA. Translation: CAG47040.1 .
    AC013413 Genomic DNA. Translation: AAY24297.1 .
    BC104470 mRNA. Translation: AAI04471.1 .
    BC104471 mRNA. Translation: AAI04472.1 .
    CCDSi CCDS1747.1.
    RefSeqi NP_003344.1. NM_003353.2.
    UniGenei Hs.534363.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RMF NMR - A 83-122 [» ]
    3N96 X-ray 2.75 E/F/G/H 107-122 [» ]
    ProteinModelPortali P55089.
    SMRi P55089. Positions 83-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113196. 5 interactions.
    STRINGi 9606.ENSP00000296099.

    Polymorphism databases

    DMDMi 1718059.

    Proteomic databases

    PaxDbi P55089.
    PRIDEi P55089.

    Protocols and materials databases

    DNASUi 7349.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296099 ; ENSP00000296099 ; ENSG00000163794 .
    GeneIDi 7349.
    KEGGi hsa:7349.
    UCSCi uc002rjp.1. human.

    Organism-specific databases

    CTDi 7349.
    GeneCardsi GC02M027530.
    HGNCi HGNC:12516. UCN.
    HPAi CAB010911.
    MIMi 600945. gene.
    neXtProti NX_P55089.
    PharmGKBi PA37163.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46022.
    HOGENOMi HOG000121779.
    HOVERGENi HBG036241.
    InParanoidi P55089.
    OMAi LRWSPGA.
    OrthoDBi EOG73JKZD.
    PhylomeDBi P55089.
    TreeFami TF332956.

    Miscellaneous databases

    EvolutionaryTracei P55089.
    GeneWikii Urocortin.
    GenomeRNAii 7349.
    NextBioi 28770.
    PROi P55089.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55089.
    CleanExi HS_UCN.
    Genevestigatori P55089.

    Family and domain databases

    InterProi IPR018446. Corticotropin-releasing_fac_CS.
    IPR000187. Corticotropin-releasing_factor.
    IPR003620. Urocortin_CRF.
    [Graphical view ]
    PANTHERi PTHR15035. PTHR15035. 1 hit.
    Pfami PF00473. CRF. 1 hit.
    [Graphical view ]
    PRINTSi PR01612. CRFFAMILY.
    SMARTi SM00039. CRF. 1 hit.
    [Graphical view ]
    PROSITEi PS00511. CRF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    2. "The structures of the mouse and human urocortin genes (Ucn and UCN)."
      Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
      Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
      Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
      J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 83-122.
    7. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
      Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
      J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 107-122 IN COMPLEX WITH CRHR2, MUTAGENESIS OF ARG-116; ILE-118; PHE-119 AND VAL-122, INTERACTION WITH CRHR2 AND CRHR1.

    Entry informationi

    Entry nameiUCN1_HUMAN
    AccessioniPrimary (citable) accession number: P55089
    Secondary accession number(s): Q6FG64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3