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Protein

Urocortin

Gene

UCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Hearing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163794-MONOMER.
ReactomeiR-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:UCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12516. UCN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116R → A: Reduced affinity for CRHR1. 1 Publication1
Mutagenesisi118I → A: Reduced affinity for CRHR2. 1 Publication1
Mutagenesisi119F → A: Strongly reduced affinity for CRHR2. 1 Publication1
Mutagenesisi122V → A: Reduced affinity for CRHR2. 1 Publication1

Organism-specific databases

DisGeNETi7349.
OpenTargetsiENSG00000163794.
PharmGKBiPA37163.

Polymorphism and mutation databases

BioMutaiUCN.
DMDMi1718059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000623326 – 82Add BLAST57
PeptideiPRO_000000623483 – 122UrocortinAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122Valine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55089.
PeptideAtlasiP55089.
PRIDEiP55089.

Expressioni

Tissue specificityi

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications

Gene expression databases

BgeeiENSG00000163794.
CleanExiHS_UCN.
GenevisibleiP55089. HS.

Organism-specific databases

HPAiCAB010911.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).1 Publication

GO - Molecular functioni

  • corticotropin-releasing hormone activity Source: GO_Central
  • neuropeptide hormone activity Source: ProtInc

Protein-protein interaction databases

BioGridi113196. 4 interactors.
STRINGi9606.ENSP00000296099.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi108 – 121Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089.
SMRiP55089.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55089.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55089.
OMAiLRWSPGA.
PhylomeDBiP55089.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG
60 70 80 90 100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL
110 120
ELARTQSQRE RAEQNRIIFD SVGK
Length:124
Mass (Da):13,458
Last modified:October 1, 1996 - v1
Checksum:i4F765DA75DDD4A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSiCCDS1747.1.
RefSeqiNP_003344.1. NM_003353.3.
UniGeneiHs.534363.

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
GeneIDi7349.
KEGGihsa:7349.
UCSCiuc002rjp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSiCCDS1747.1.
RefSeqiNP_003344.1. NM_003353.3.
UniGeneiHs.534363.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089.
SMRiP55089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113196. 4 interactors.
STRINGi9606.ENSP00000296099.

Polymorphism and mutation databases

BioMutaiUCN.
DMDMi1718059.

Proteomic databases

PaxDbiP55089.
PeptideAtlasiP55089.
PRIDEiP55089.

Protocols and materials databases

DNASUi7349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
GeneIDi7349.
KEGGihsa:7349.
UCSCiuc002rjp.2. human.

Organism-specific databases

CTDi7349.
DisGeNETi7349.
GeneCardsiUCN.
HGNCiHGNC:12516. UCN.
HPAiCAB010911.
MIMi600945. gene.
neXtProtiNX_P55089.
OpenTargetsiENSG00000163794.
PharmGKBiPA37163.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8KZ. Eukaryota.
ENOG410Y0J4. LUCA.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55089.
OMAiLRWSPGA.
PhylomeDBiP55089.
TreeFamiTF332956.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163794-MONOMER.
ReactomeiR-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

EvolutionaryTraceiP55089.
GeneWikiiUrocortin.
GenomeRNAii7349.
PROiP55089.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163794.
CleanExiHS_UCN.
GenevisibleiP55089. HS.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCN1_HUMAN
AccessioniPrimary (citable) accession number: P55089
Secondary accession number(s): Q6FG64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.