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P55089 (UCN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urocortin
Gene names
Name:UCN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length124 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

Subunit structure

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain). Ref.7

Subcellular location

Secreted.

Sequence similarities

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

activation of protein kinase A activity

Inferred from electronic annotation. Source: Ensembl

aerobic respiration

Inferred from electronic annotation. Source: Ensembl

associative learning

Inferred from electronic annotation. Source: Ensembl

drinking behavior

Inferred from electronic annotation. Source: Ensembl

female pregnancy

Inferred from electronic annotation. Source: Ensembl

gastric emptying

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of appetite

Inferred from electronic annotation. Source: Ensembl

negative regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell size

Inferred from electronic annotation. Source: Ensembl

negative regulation of feeding behavior

Inferred from electronic annotation. Source: Ensembl

negative regulation of gastric acid secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of necrotic cell death

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron death

Inferred from electronic annotation. Source: Ensembl

neuron projection development

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: Ensembl

pancreatic juice secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of behavioral fear response

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion import

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of corticotropin secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular permeability

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

response to pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentaxon terminus

Inferred from electronic annotation. Source: Ensembl

dendrite

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

perikaryon

Inferred from electronic annotation. Source: Ensembl

varicosity

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionhistone deacetylase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

neuropeptide hormone activity

Traceable author statement Ref.1. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 18234674. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Propeptide26 – 8257
PRO_0000006233
Peptide83 – 12240Urocortin
PRO_0000006234

Amino acid modifications

Modified residue1221Valine amide By similarity

Experimental info

Mutagenesis1161R → A: Reduced affinity for CRHR1. Ref.7
Mutagenesis1181I → A: Reduced affinity for CRHR2. Ref.7
Mutagenesis1191F → A: Strongly reduced affinity for CRHR2. Ref.7
Mutagenesis1221V → A: Reduced affinity for CRHR2. Ref.7

Secondary structure

... 124
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55089 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4F765DA75DDD4A5E

FASTA12413,458
        10         20         30         40         50         60 
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG ARALLLLLAE 

        70         80         90        100        110        120 
RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL ELARTQSQRE RAEQNRIIFD 


SVGK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of human urocortin."
Donaldson C.J., Sutton S.W., Perrin M.H., Corrigan A.Z., Lewis K.A., Rivier J.E., Vaughan J.M., Vale W.W.
Endocrinology 137:2167-2170(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[2]"The structures of the mouse and human urocortin genes (Ucn and UCN)."
Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 83-122.
[7]"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 107-122 IN COMPLEX WITH CRHR2, MUTAGENESIS OF ARG-116; ILE-118; PHE-119 AND VAL-122, INTERACTION WITH CRHR2 AND CRHR1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSCCDS1747.1.
RefSeqNP_003344.1. NM_003353.2.
UniGeneHs.534363.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortalP55089.
SMRP55089. Positions 83-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113196. 5 interactions.
STRING9606.ENSP00000296099.

Polymorphism databases

DMDM1718059.

Proteomic databases

PaxDbP55089.
PRIDEP55089.

Protocols and materials databases

DNASU7349.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296099; ENSP00000296099; ENSG00000163794.
GeneID7349.
KEGGhsa:7349.
UCSCuc002rjp.1. human.

Organism-specific databases

CTD7349.
GeneCardsGC02M027530.
HGNCHGNC:12516. UCN.
HPACAB010911.
MIM600945. gene.
neXtProtNX_P55089.
PharmGKBPA37163.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46022.
HOGENOMHOG000121779.
HOVERGENHBG036241.
InParanoidP55089.
OMALRWSPGA.
OrthoDBEOG73JKZD.
PhylomeDBP55089.
TreeFamTF332956.

Gene expression databases

BgeeP55089.
CleanExHS_UCN.
GenevestigatorP55089.

Family and domain databases

InterProIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERPTHR15035. PTHR15035. 1 hit.
PfamPF00473. CRF. 1 hit.
[Graphical view]
PRINTSPR01612. CRFFAMILY.
SMARTSM00039. CRF. 1 hit.
[Graphical view]
PROSITEPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55089.
GeneWikiUrocortin.
GenomeRNAi7349.
NextBio28770.
PROP55089.
SOURCESearch...

Entry information

Entry nameUCN1_HUMAN
AccessionPrimary (citable) accession number: P55089
Secondary accession number(s): Q6FG64
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM