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Protein

Urocortin

Gene

UCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).By similarity1 Publication

GO - Molecular functioni

  1. histone deacetylase inhibitor activity Source: Ensembl
  2. neuropeptide hormone activity Source: ProtInc

GO - Biological processi

  1. activation of protein kinase A activity Source: Ensembl
  2. aerobic respiration Source: Ensembl
  3. associative learning Source: Ensembl
  4. drinking behavior Source: Ensembl
  5. female pregnancy Source: Ensembl
  6. gastric emptying Source: Ensembl
  7. G-protein coupled receptor signaling pathway Source: ProtInc
  8. inflammatory response Source: Ensembl
  9. negative regulation of apoptotic process Source: Ensembl
  10. negative regulation of appetite Source: Ensembl
  11. negative regulation of blood pressure Source: Ensembl
  12. negative regulation of cell size Source: Ensembl
  13. negative regulation of feeding behavior Source: Ensembl
  14. negative regulation of gastric acid secretion Source: Ensembl
  15. negative regulation of gene expression Source: Ensembl
  16. negative regulation of hormone secretion Source: Ensembl
  17. negative regulation of necrotic cell death Source: Ensembl
  18. negative regulation of neuron death Source: Ensembl
  19. neuron projection development Source: Ensembl
  20. neuropeptide signaling pathway Source: Ensembl
  21. pancreatic juice secretion Source: Ensembl
  22. positive regulation of behavioral fear response Source: Ensembl
  23. positive regulation of calcium ion import Source: Ensembl
  24. positive regulation of cAMP biosynthetic process Source: Ensembl
  25. positive regulation of cardiac muscle contraction Source: Ensembl
  26. positive regulation of cell growth Source: Ensembl
  27. positive regulation of collagen biosynthetic process Source: Ensembl
  28. positive regulation of corticotropin secretion Source: Ensembl
  29. positive regulation of DNA replication Source: Ensembl
  30. positive regulation of interleukin-6 production Source: Ensembl
  31. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  32. positive regulation of translation Source: Ensembl
  33. positive regulation of vascular permeability Source: Ensembl
  34. positive regulation of vasodilation Source: Ensembl
  35. regulation of synaptic transmission, glutamatergic Source: Ensembl
  36. response to estradiol Source: Ensembl
  37. response to glucocorticoid Source: Ensembl
  38. response to oxidative stress Source: Ensembl
  39. response to pain Source: Ensembl
  40. social behavior Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin
Gene namesi
Name:UCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:12516. UCN.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. dendrite Source: Ensembl
  3. extracellular region Source: UniProtKB-SubCell
  4. perikaryon Source: Ensembl
  5. varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi116 – 1161R → A: Reduced affinity for CRHR1. 1 Publication
Mutagenesisi118 – 1181I → A: Reduced affinity for CRHR2. 1 Publication
Mutagenesisi119 – 1191F → A: Strongly reduced affinity for CRHR2. 1 Publication
Mutagenesisi122 – 1221V → A: Reduced affinity for CRHR2. 1 Publication

Organism-specific databases

PharmGKBiPA37163.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Propeptidei26 – 8257PRO_0000006233Add
BLAST
Peptidei83 – 12240UrocortinPRO_0000006234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221Valine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP55089.
PRIDEiP55089.

Expressioni

Tissue specificityi

Keratinocytes in epidermis and the outer and inner root sheaths of hair follicles, epithelium of sebaceous and sweat glands, erector pili muscle, cutaneous blood vessel walls, cutaneous nerves and dermal mononuclear cells (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481) (at protein level). Expressed in pituitary and adrenal glands (PubMed:10690896). Detected in plasma cells in the lamia propria in colon mucosa (PubMed:15531481).2 Publications

Gene expression databases

BgeeiP55089.
CleanExiHS_UCN.
GenevestigatoriP55089.

Organism-specific databases

HPAiCAB010911.

Interactioni

Subunit structurei

Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain).1 Publication

Protein-protein interaction databases

BioGridi113196. 5 interactions.
STRINGi9606.ENSP00000296099.

Structurei

Secondary structure

1
124
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi108 – 12114Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089.
SMRiP55089. Positions 83-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55089.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46022.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55089.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP55089.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG
60 70 80 90 100
ARALLLLLAE RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL
110 120
ELARTQSQRE RAEQNRIIFD SVGK
Length:124
Mass (Da):13,458
Last modified:October 1, 1996 - v1
Checksum:i4F765DA75DDD4A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSiCCDS1747.1.
RefSeqiNP_003344.1. NM_003353.2.
UniGeneiHs.534363.

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
GeneIDi7349.
KEGGihsa:7349.
UCSCiuc002rjp.1. human.

Polymorphism databases

DMDMi1718059.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.
CCDSiCCDS1747.1.
RefSeqiNP_003344.1. NM_003353.2.
UniGeneiHs.534363.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMFNMR-A83-122[»]
3N96X-ray2.75E/F/G/H107-122[»]
ProteinModelPortaliP55089.
SMRiP55089. Positions 83-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113196. 5 interactions.
STRINGi9606.ENSP00000296099.

Polymorphism databases

DMDMi1718059.

Proteomic databases

PaxDbiP55089.
PRIDEiP55089.

Protocols and materials databases

DNASUi7349.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296099; ENSP00000296099; ENSG00000163794.
GeneIDi7349.
KEGGihsa:7349.
UCSCiuc002rjp.1. human.

Organism-specific databases

CTDi7349.
GeneCardsiGC02M027530.
HGNCiHGNC:12516. UCN.
HPAiCAB010911.
MIMi600945. gene.
neXtProtiNX_P55089.
PharmGKBiPA37163.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46022.
GeneTreeiENSGT00510000049284.
HOGENOMiHOG000121779.
HOVERGENiHBG036241.
InParanoidiP55089.
OMAiLRWSPGA.
OrthoDBiEOG73JKZD.
PhylomeDBiP55089.
TreeFamiTF332956.

Miscellaneous databases

EvolutionaryTraceiP55089.
GeneWikiiUrocortin.
GenomeRNAii7349.
NextBioi28770.
PROiP55089.
SOURCEiSearch...

Gene expression databases

BgeeiP55089.
CleanExiHS_UCN.
GenevestigatoriP55089.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Tissue: Placenta.
  2. "The structures of the mouse and human urocortin genes (Ucn and UCN)."
    Zhao L., Donaldson C.J., Smith G.W., Vale W.W.
    Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Urocortin 1 in colonic mucosa in patients with ulcerative colitis."
    Saruta M., Takahashi K., Suzuki T., Torii A., Kawakami M., Sasano H.
    J. Clin. Endocrinol. Metab. 89:5352-5361(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ASSOCIATION WITH INFLAMMATION IN ULCERATIVE COLITIS.
  8. "Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
    Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R.
    J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 83-122.
  9. "Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
    Pal K., Swaminathan K., Xu H.E., Pioszak A.A.
    J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 107-122 IN COMPLEX WITH CRHR2, MUTAGENESIS OF ARG-116; ILE-118; PHE-119 AND VAL-122, INTERACTION WITH CRHR2 AND CRHR1.

Entry informationi

Entry nameiUCN1_HUMAN
AccessioniPrimary (citable) accession number: P55089
Secondary accession number(s): Q6FG64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Positive correlation between increased expression in colonic lamina propria and severity of inflammation in patients with ulcerative colitis.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.