Reviewed, UniProtKB/Swiss-Prot P55089 (UCN1_HUMAN)

Names and origin

Protein names

Recommended name:
    Urocortin

Gene names

Name:

UCN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF Receptor types 1, 2-alpha, and 2-beta.
Subcellular location	Secreted.
Sequence similarities	Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	3D-structure
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	neuropeptide hormone activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Propeptide	26 – 82	57			PRO_0000006233
	Peptide	83 – 122	40	Urocortin		PRO_0000006234
Amino acid modifications
	Modified residue	122	1	Valine amide By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55089-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 4F765DA75DDD4A5E	FASTA	124	13,458
	10 20 30 40 50 60 MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG ARALLLLLAE 70 80 90 100 110 120 RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL ELARTQSQRE RAEQNRIIFD SVGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human urocortin." Donaldson C.J., Sutton S.W., Perrin M.H., Corrigan A.Z., Lewis K.A., Rivier J.E., Vaughan J.M., Vale W.W. Endocrinology 137:2167-2170(1996) [PubMed: 8612563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[2]	"The structures of the mouse and human urocortin genes (Ucn and UCN)." Zhao L., Donaldson C.J., Smith G.W., Vale W.W. Genomics 50:23-33(1998) [PubMed: 9628819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Common and divergent structural features of a series of corticotropin releasing factor-related peptides." Grace C.R.R., Perrin M.H., Cantle J.P., Vale W.W., Rivier J.E., Riek R. J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed: 18052377] [Abstract] Cited for: STRUCTURE BY NMR OF 83-122.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF038633 Genomic DNA. Translation: AAC24204.1.
CR542244 mRNA. Translation: CAG47040.1.
AC013413 Genomic DNA. Translation: AAY24297.1.
BC104470 mRNA. Translation: AAI04471.1.
BC104471 mRNA. Translation: AAI04472.1.

IPI

IPI00022801.

RefSeq

NP_003344.1.

UniGene

Hs.534363
Hs.75659

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2RMF	NMR	-	A	83-122	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000163794. Homo sapiens. [Contig view]

GeneID

7349.

KEGG

hsa:7349.

Organism-specific databases

GeneCards

GC02M027383.

HGNC

HGNC:12516. UCN.

HPA

CAB010911.

MIM

600945. gene.

PharmGKB

PA37163.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P55089.

HOVERGEN

P55089.

OMA

P55089. QDPSLRW.

Gene expression databases

Bgee

P55089.

CleanEx

HS_UCN.

GermOnline

ENSG00000163794. Homo sapiens.

Family and domain databases

InterPro

IPR018447. Corticotropin-releasing_fac_C.
IPR018446. Corticotropin-releasing_fac_CS.
IPR000187. Corticotropin-releasing_factor.
IPR003620. Urocortin_CRF.
[Graphical view]

PANTHER

PTHR15035. Urocortin_CRF. 1 hit.

Pfam

PF00473. CRF. 1 hit.
[Graphical view]

PRINTS

PR01612. CRFFAMILY.

ProDom

PD005970. Urocortin_CRF. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00039. CRF. 1 hit.
[Graphical view]

PROSITE

PS00511. CRF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

28770.

SOURCE

Search...

Entry information

Entry name

UCN1_HUMAN

Accession

Primary (citable) accession number: P55089
Secondary accession number(s): Q6FG64

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)