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P55086

- PAR2_MOUSE

UniProt

P55086 - PAR2_MOUSE

Protein

Proteinase-activated receptor 2

Gene

F2rl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with Tlr4 and probably Tlr2 in inflammatory responses and modulates Tlr3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of Ripk1 and Tradd from Tnfr1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves Ikbkb and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of Cops5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by Cops5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 392Cleavage; by trypsinBy similarity

    GO - Molecular functioni

    1. G-protein alpha-subunit binding Source: UniProtKB
    2. G-protein beta-subunit binding Source: UniProtKB
    3. G-protein coupled receptor activity Source: UniProtKB
    4. heterotrimeric G-protein binding Source: UniProtKB
    5. thrombin receptor activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: InterPro
    2. chemokine (C-C motif) ligand 2 secretion Source: UniProtKB
    3. chemokine secretion Source: UniProtKB
    4. defense response to virus Source: UniProtKB
    5. establishment of endothelial barrier Source: Ensembl
    6. inflammatory response Source: UniProtKB-KW
    7. innate immune response Source: UniProtKB-KW
    8. interferon-gamma secretion Source: UniProtKB
    9. interleukin-10 secretion Source: UniProtKB
    10. interleukin-1 beta secretion Source: UniProtKB
    11. leukocyte migration Source: UniProtKB
    12. leukocyte proliferation Source: UniProtKB
    13. mature dendritic cell differentiation Source: UniProtKB
    14. negative regulation of chemokine secretion Source: Ensembl
    15. negative regulation of JNK cascade Source: Ensembl
    16. negative regulation of toll-like receptor 3 signaling pathway Source: Ensembl
    17. negative regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
    18. neutrophil activation Source: UniProtKB
    19. positive regulation of actin filament depolymerization Source: Ensembl
    20. positive regulation of cell migration Source: UniProtKB
    21. positive regulation of chemotaxis Source: UniProtKB
    22. positive regulation of cytokine secretion involved in immune response Source: UniProtKB
    23. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    24. positive regulation of eosinophil degranulation Source: Ensembl
    25. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    26. positive regulation of glomerular filtration Source: UniProtKB
    27. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    28. positive regulation of interleukin-6 secretion Source: UniProtKB
    29. positive regulation of interleukin-8 secretion Source: UniProtKB
    30. positive regulation of JNK cascade Source: Ensembl
    31. positive regulation of leukocyte chemotaxis Source: Ensembl
    32. positive regulation of neutrophil mediated killing of gram-negative bacterium Source: Ensembl
    33. positive regulation of phagocytosis, engulfment Source: Ensembl
    34. positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
    35. positive regulation of positive chemotaxis Source: Ensembl
    36. positive regulation of pseudopodium assembly Source: UniProtKB
    37. positive regulation of renin secretion into blood stream Source: UniProtKB
    38. positive regulation of Rho protein signal transduction Source: UniProtKB
    39. positive regulation of superoxide anion generation Source: UniProtKB
    40. positive regulation of toll-like receptor 2 signaling pathway Source: Ensembl
    41. positive regulation of toll-like receptor 3 signaling pathway Source: Ensembl
    42. positive regulation of toll-like receptor 4 signaling pathway Source: Ensembl
    43. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    44. positive regulation of vasodilation Source: UniProtKB
    45. regulation of blood coagulation Source: Ensembl
    46. regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    47. regulation of JNK cascade Source: UniProtKB
    48. T cell activation involved in immune response Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteinase-activated receptor 2
    Short name:
    PAR-2
    Alternative name(s):
    Coagulation factor II receptor-like 1
    G-protein coupled receptor 11
    Thrombin receptor-like 1
    Gene namesi
    Name:F2rl1
    Synonyms:Gpcr11, Gpr11, Par2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:101910. F2rl1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. pseudopodium Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Delayed onset of inflammation. Reduced progression of osteoarthritis, infectious colitis, allergic dermatitis and experimental autoimmune encephalomyelitis. Upon induced allergic and toxic contact dermatitis ear swelling responses, plasma extravasation and leuocyte adherence are significantly attenuated. Upon ovalbumin (OA) sensitization and following challenge infiltration of eosinophils and increse of eotaxin content in bronchoalveolar lavage fluid are abrogated.7 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 3813Removed for receptor activationBy similarityPRO_0000012752Add
    BLAST
    Chaini39 – 399361Proteinase-activated receptor 2PRO_0000012753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 228PROSITE-ProRule annotation
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Lipidationi363 – 3631S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/Prtn3 and membrane-type serine protease 1/St14. Proposed subsequent cleaveage by serine proteases is leading to receptor deactivation and include neutrophil elastase and cathepsin G. At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference By similarity.By similarity
    N-glycosylated and sialylated.By similarity
    Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
    Monoubiquitinated by Cbl at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves Stambp and Usp8; required for lysosomal trafficking and receptor degradation By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP55086.

    PTM databases

    PhosphoSiteiP55086.

    Expressioni

    Gene expression databases

    ArrayExpressiP55086.
    BgeeiP55086.
    CleanExiMM_F2RL1.
    GenevestigatoriP55086.

    Interactioni

    Subunit structurei

    Interacts with TLR4, COPS5 and TMED2 By similarity. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP55086.
    SMRiP55086. Positions 67-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 7739ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini104 – 1129CytoplasmicSequence Analysis
    Topological domaini133 – 15119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini214 – 24330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini311 – 32515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini350 – 39950CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 10326Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26219Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 31023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34924Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi385 – 39410Poly-Ser

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145128.
    HOGENOMiHOG000116291.
    HOVERGENiHBG105658.
    InParanoidiP55086.
    KOiK04234.
    OMAiLAMYLIC.
    OrthoDBiEOG7DNNVR.
    PhylomeDBiP55086.
    TreeFamiTF330775.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002281. Pro_rcpt_2.
    IPR003912. Protea_act_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01428. PROTEASEAR.
    PR01152. PROTEASEAR2.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55086-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSLSLAWLL GGITLLAASV SCSRTENLAP GRNNSKGRSL IGRLETQPPI    50
    TGKGVPVEPG FSIDEFSASI LTGKLTTVFL PVVYIIVFVI GLPSNGMALW 100
    IFLFRTKKKH PAVIYMANLA LADLLSVIWF PLKISYHLHG NNWVYGEALC 150
    KVLIGFFYGN MYCSILFMTC LSVQRYWVIV NPMGHPRKKA NIAVGVSLAI 200
    WLLIFLVTIP LYVMKQTIYI PALNITTCHD VLPEEVLVGD MFNYFLSLAI 250
    GVFLFPALLT ASAYVLMIKT LRSSAMDEHS EKKRQRAIRL IITVLAMYFI 300
    CFAPSNLLLV VHYFLIKTQR QSHVYALYLV ALCLSTLNSC IDPFVYYFVS 350
    KDFRDHARNA LLCRSVRTVN RMQISLSSNK FSRKSGSYSS SSTSVKTSY 399
    Length:399
    Mass (Da):44,752
    Last modified:October 1, 1996 - v1
    Checksum:iA93749425ED0B194
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48043 mRNA. Translation: CAA88097.1.
    CCDSiCCDS26700.1.
    PIRiI48705.
    RefSeqiNP_032000.3. NM_007974.4.
    UniGeneiMm.1614.

    Genome annotation databases

    EnsembliENSMUST00000022185; ENSMUSP00000022185; ENSMUSG00000021678.
    GeneIDi14063.
    KEGGimmu:14063.
    UCSCiuc011zda.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48043 mRNA. Translation: CAA88097.1 .
    CCDSi CCDS26700.1.
    PIRi I48705.
    RefSeqi NP_032000.3. NM_007974.4.
    UniGenei Mm.1614.

    3D structure databases

    ProteinModelPortali P55086.
    SMRi P55086. Positions 67-354.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P55086.

    Proteomic databases

    PRIDEi P55086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022185 ; ENSMUSP00000022185 ; ENSMUSG00000021678 .
    GeneIDi 14063.
    KEGGi mmu:14063.
    UCSCi uc011zda.2. mouse.

    Organism-specific databases

    CTDi 2150.
    MGIi MGI:101910. F2rl1.

    Phylogenomic databases

    eggNOGi NOG145128.
    HOGENOMi HOG000116291.
    HOVERGENi HBG105658.
    InParanoidi P55086.
    KOi K04234.
    OMAi LAMYLIC.
    OrthoDBi EOG7DNNVR.
    PhylomeDBi P55086.
    TreeFami TF330775.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi F2RL1. mouse.
    NextBioi 285036.
    PROi P55086.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55086.
    Bgeei P55086.
    CleanExi MM_F2RL1.
    Genevestigatori P55086.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002281. Pro_rcpt_2.
    IPR003912. Protea_act_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01428. PROTEASEAR.
    PR01152. PROTEASEAR2.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression."
      Nystedt S., Larsson A.-K., Aaberg H., Sundelin J.
      J. Biol. Chem. 270:5950-5955(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1."
      Damiano B.P., Cheung W.M., Santulli R.J., Fung-Leung W.P., Ngo K., Ye R.D., Darrow A.L., Derian C.K., de Garavilla L., Andrade-Gordon P.
      J. Pharmacol. Exp. Ther. 288:671-678(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CARDIOVASCULAR RESPONSES.
    3. "Delayed onset of inflammation in protease-activated receptor-2-deficient mice."
      Lindner J.R., Kahn M.L., Coughlin S.R., Sambrano G.R., Schauble E., Bernstein D., Foy D., Hafezi-Moghadam A., Ley K.
      J. Immunol. 165:6504-6510(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMATORY RESPONSE, DISRUPTION PHENOTYPE.
    4. "Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear."
      Kawagoe J., Takizawa T., Matsumoto J., Tamiya M., Meek S.E., Smith A.J., Hunter G.D., Plevin R., Saito N., Kanke T., Fujii M., Wada Y.
      Jpn. J. Pharmacol. 88:77-84(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    5. Cited for: DISRUPTION PHENOTYPE.
    6. "A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis."
      Ge L., Ly Y., Hollenberg M., DeFea K.
      J. Biol. Chem. 278:34418-34426(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CYTOSKELETAL REARRANGEMENT AND CHEMOTAXIS.
    7. "Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms."
      Su X., Camerer E., Hamilton J.R., Coughlin S.R., Matthay M.A.
      J. Immunol. 175:2598-2605(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN LUNG INFLAMMATION.
    8. "Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice."
      Takizawa T., Tamiya M., Hara T., Matsumoto J., Saito N., Kanke T., Kawagoe J., Hattori Y.
      J. Pharmacol. Sci. 98:99-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    9. "A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis."
      Hansen K.K., Sherman P.M., Cellars L., Andrade-Gordon P., Pan Z., Baruch A., Wallace J.L., Hollenberg M.D., Vergnolle N.
      Proc. Natl. Acad. Sci. U.S.A. 102:8363-8368(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN INFECTIOUS COLITIS, ACTIVATION BY GRANZYME A, DISRUPTION PHENOTYPE.
    10. "Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis."
      Noorbakhsh F., Tsutsui S., Vergnolle N., Boven L.A., Shariat N., Vodjgani M., Warren K.G., Andrade-Gordon P., Hollenberg M.D., Power C.
      J. Exp. Med. 203:425-435(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    11. "'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage."
      Kaneider N.C., Leger A.J., Agarwal A., Nguyen N., Perides G., Derian C., Covic L., Kuliopulos A.
      Nat. Immunol. 8:1303-1312(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TRANSACTIVATION BY F2R.
    12. "Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis."
      Ferrell W.R., Kelso E.B., Lockhart J.C., Plevin R., McInnes I.B.
      Ann. Rheum. Dis. 69:2051-2054(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    13. "Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo."
      Ramelli G., Fuertes S., Narayan S., Busso N., Acha-Orbea H., So A.
      Immunology 129:20-27(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology."
      McCoy K.L., Traynelis S.F., Hepler J.R.
      Mol. Pharmacol. 77:1005-1015(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GNAQ; GNA11; GNA12; GNA13 AND GNA14.

    Entry informationi

    Entry nameiPAR2_MOUSE
    AccessioniPrimary (citable) accession number: P55086
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3