ID   MFAP4_HUMAN             Reviewed;         255 AA.
AC   P55083; Q6P680;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   16-JUN-2009, entry version 69.
DE   RecName: Full=Microfibril-associated glycoprotein 4;
DE   Flags: Precursor;
GN   Name=MFAP4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   MEDLINE=95359962; PubMed=7633408; DOI=10.1093/hmg/4.4.589;
RA   Zhao Z., Lee C.-C., Jiralerspong S., Juyal R.C., Lu F., Baldini A.,
RA   Greenberg F., Caskey C.T., Patel P.I.;
RT   "The gene for a human microfibril-associated glycoprotein is commonly
RT   deleted in Smith-Magenis syndrome patients.";
RL   Hum. Mol. Genet. 4:589-597(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 22-36.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [4]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-137, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA   Moore R.J., Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-87 AND ASN-137, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of
RT   multiple enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- FUNCTION: Could be involved in calcium-dependent cell adhesion or
CC       intercellular interactions.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix.
CC   -!- DISEASE: MFAP4 is deleted in the Smith-Magenis syndrome (SMS)
CC       [MIM:182290].
CC   -!- SIMILARITY: Contains 1 fibrinogen C-terminal domain.
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DR   EMBL; L38486; AAB00968.1; ALT_INIT; mRNA.
DR   EMBL; BC062415; AAH62415.1; -; mRNA.
DR   IPI; IPI00022792; -.
DR   RefSeq; NP_002395.1; -.
DR   UniGene; Hs.296049; -.
DR   HSSP; P02671; 1FZD.
DR   PRIDE; P55083; -.
DR   Ensembl; ENSG00000166482; Homo sapiens.
DR   GeneID; 4239; -.
DR   KEGG; hsa:4239; -.
DR   GeneCards; GC17M019227; -.
DR   H-InvDB; HIX0039181; -.
DR   HGNC; HGNC:7035; MFAP4.
DR   MIM; 182290; phenotype.
DR   MIM; 600596; gene.
DR   Orphanet; 819; Smith-Magenis syndrome.
DR   PharmGKB; PA30771; -.
DR   HOGENOM; P55083; -.
DR   HOVERGEN; P55083; -.
DR   NextBio; 16715; -.
DR   Bgee; P55083; -.
DR   CleanEx; HS_MFAP4; -.
DR   GermOnline; ENSG00000166482; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0001527; C:microfibril; NAS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:receptor binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR002181; Fibrinogen_a/b/g_C.
DR   InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR   Gene3D; G3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1.
DR   Pfam; PF00147; Fibrinogen_C; 1.
DR   SMART; SM00186; FBG; 1.
DR   PROSITE; PS00514; FIBRINOGEN_C_1; FALSE_NEG.
DR   PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE   1: Evidence at protein level;
KW   Calcium; Cell adhesion; Direct protein sequencing;
KW   Extracellular matrix; Glycoprotein; Secreted; Signal.
FT   SIGNAL        1     21
FT   CHAIN        22    255       Microfibril-associated glycoprotein 4.
FT                                /FTId=PRO_0000009134.
FT   DOMAIN       32    255       Fibrinogen C-terminal.
FT   MOTIF        26     28       Cell attachment site (Potential).
FT   CARBOHYD     87     87       N-linked (GlcNAc...).
FT   CARBOHYD    137    137       N-linked (GlcNAc...).
FT   CONFLICT    173    173       A -> V (in Ref. 2; AAH62415).
SQ   SEQUENCE   255 AA;  28648 MW;  B8F0B47AC694435E CRC64;
     MKALLALPLL LLLSTPPCAP QVSGIRGDAL ERFCLQQPLD CDDIYAQGYQ SDGVYLIYPS
     GPSVPVPVFC DMTTEGGKWT VFQKRFNGSV SFFRGWNDYK LGFGRADGEY WLGLQNMHLL
     TLKQKYELRV DLEDFENNTA YAKYADFSIS PNAVSAEEDG YTLFVAGFED GGAGDSLSYH
     SGQKFSTFDR DQDLFVQNCA ALSSGAFWFR SCHFANLNGF YLGGSHLSYA NGINWAQWKG
     FYYSLKRTEM KIRRA
//