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Protein

Microfibrillar-associated protein 1

Gene

MFAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be required for pre-mRNA splicing.By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 1Imported
Gene namesi
Name:MFAP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140259.6.
HGNCiHGNC:7032. MFAP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4236.
OpenTargetsiENSG00000140259.
PharmGKBiPA30768.

Polymorphism and mutation databases

BioMutaiMFAP1.
DMDMi205831094.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000964582 – 439Microfibrillar-associated protein 1Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei94PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei267PhosphothreonineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei361PhosphoserineCombined sources1
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki381Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki415Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki418Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei432PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP55081.
MaxQBiP55081.
PaxDbiP55081.
PeptideAtlasiP55081.
PRIDEiP55081.
TopDownProteomicsiP55081.

PTM databases

iPTMnetiP55081.
PhosphoSitePlusiP55081.

Expressioni

Gene expression databases

BgeeiENSG00000140259.
CleanExiHS_MFAP1.
GenevisibleiP55081. HS.

Organism-specific databases

HPAiHPA042370.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110394. 69 interactors.
CORUMiP55081.
IntActiP55081. 102 interactors.
MINTiMINT-1682969.
STRINGi9606.ENSP00000267812.

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi273 – 321Combined sources49

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F5SX-ray2.40B267-344[»]
ProteinModelPortaliP55081.
SMRiP55081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 318Glu-richPROSITE-ProRule annotationAdd BLAST268

Sequence similaritiesi

Belongs to the MFAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1425. Eukaryota.
ENOG410Y1JB. LUCA.
GeneTreeiENSGT00690000102225.
HOGENOMiHOG000231845.
HOVERGENiHBG052462.
InParanoidiP55081.
KOiK13110.
OMAiDSAWAQE.
OrthoDBiEOG091G0DXV.
PhylomeDBiP55081.
TreeFamiTF314398.

Family and domain databases

InterProiView protein in InterPro
IPR009730. MFAP1_C.
PfamiView protein in Pfam
PF06991. MFAP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPSALMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM
60 70 80 90 100
ESSDEEDEEF QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER
110 120 130 140 150
LARHRKIVEP EVVGESDSEV EGDAWRMERE DSSEEEEEEI DDEEIERRRG
160 170 180 190 200
MMRQRAQERK NEEMEVMEVE DEGRSGEESE SESEYEEYTD SEDEMEPRLK
210 220 230 240 250
PVFIRKKDRV TVQEREAEAL KQKELEQEAK RMAEERRKYT LKIVEEETKK
260 270 280 290 300
ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRD REDREALEKE
310 320 330 340 350
KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD
360 370 380 390 400
EDEEVYKRDF SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT
410 420 430
SFDSAWGQES AQNTKFFKQK AAGVRDVFER PSAKKRKTT
Length:439
Mass (Da):51,958
Last modified:July 22, 2008 - v2
Checksum:i0EF6F4F091C05A88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238K → Q in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti242K → Q in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti245E → G in AAA92786 (PubMed:7835894).Curated1
Sequence conflicti249K → P in AAA92786 (PubMed:7835894).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04209 mRNA. Translation: AAA92786.1.
AK312867 mRNA. Translation: BAG35719.1.
AC018512 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77247.1.
BC023557 mRNA. Translation: AAH23557.1.
BC050742 mRNA. Translation: AAH50742.1.
CCDSiCCDS10105.1.
PIRiA55565.
RefSeqiNP_005917.2. NM_005926.2.
UniGeneiHs.61418.

Genome annotation databases

EnsembliENST00000267812; ENSP00000267812; ENSG00000140259.
GeneIDi4236.
KEGGihsa:4236.
UCSCiuc001zth.2. human.

Similar proteinsi

Entry informationi

Entry nameiMFAP1_HUMAN
AccessioniPrimary (citable) accession number: P55081
Secondary accession number(s): Q86TG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families