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Protein

Fibroblast growth factor 8

Gene

FGF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).4 Publications

GO - Molecular functioni

  • chemoattractant activity Source: Ensembl
  • growth factor activity Source: UniProtKB
  • type 1 fibroblast growth factor receptor binding Source: UniProtKB
  • type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_110235. Phospholipase C-mediated cascade: FGFR1.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. FGFR3 mutant receptor activation.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355144. Negative regulation of FGFR3 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355159. SHC-mediated cascade:FGFR4.
REACT_355160. PI-3K cascade:FGFR3.
REACT_355194. SHC-mediated cascade:FGFR1.
REACT_355197. SHC-mediated cascade:FGFR3.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355212. FRS-mediated FGFR3 signaling.
REACT_355216. Phospholipase C-mediated cascade, FGFR4.
REACT_355218. Negative regulation of FGFR1 signaling.
REACT_355221. Signaling by FGFR1 mutants.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355304. PI-3K cascade:FGFR4.
REACT_355313. Signaling by FGFR3 mutants.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_355514. Phospholipase C-mediated cascade, FGFR3.
REACT_355552. PI-3K cascade:FGFR1.
REACT_355580. FRS2-mediated FGFR4 signaling.
REACT_355584. FRS-mediated FGFR1 signaling.
REACT_355588. Negative regulation of FGFR4 signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP55075.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 8
Short name:
FGF-8
Alternative name(s):
Androgen-induced growth factor
Short name:
AIGF
Heparin-binding growth factor 8
Short name:
HBGF-8
Gene namesi
Name:FGF8
Synonyms:AIGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:3686. FGF8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 6 with or without anosmia (HH6)2 Publications

The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).

Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).

See also OMIM:612702
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057962
Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
VAR_057963
Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057964
Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057965
Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_057966
Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057967

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MIMi612702. phenotype.
Orphaneti93925. Alobar holoprosencephaly.
478. Kallmann syndrome.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
432. Normosmic congenital hypogonadotropic hypogonadism.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28125.

Polymorphism and mutation databases

BioMutaiFGF8.
DMDMi1706791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 233211Fibroblast growth factor 8PRO_0000008970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55075.
PRIDEiP55075.

PTM databases

PhosphoSiteiP55075.

Expressioni

Developmental stagei

In adults expression is restricted to the gonads.

Gene expression databases

BgeeiP55075.
CleanExiHS_FGF8.
ExpressionAtlasiP55075. baseline and differential.
GenevisibleiP55075. HS.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

Protein-protein interaction databases

BioGridi108544. 1 interaction.
DIPiDIP-59630N.
IntActiP55075. 2 interactions.
STRINGi9606.ENSP00000321797.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 576Combined sources
Beta strandi63 – 653Combined sources
Beta strandi69 – 768Combined sources
Turni77 – 793Combined sources
Beta strandi80 – 856Combined sources
Beta strandi91 – 955Combined sources
Helixi100 – 1023Combined sources
Beta strandi104 – 1107Combined sources
Turni111 – 1133Combined sources
Beta strandi114 – 1196Combined sources
Turni120 – 1223Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi134 – 1385Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1516Combined sources
Beta strandi157 – 1648Combined sources
Helixi180 – 1823Combined sources
Helixi188 – 1903Combined sources
Beta strandi192 – 1954Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ProteinModelPortaliP55075.
SMRiP55075. Positions 52-198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55075.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327940.
GeneTreeiENSGT00730000110785.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP55075.
OMAiAATGFYI.
PhylomeDBiP55075.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.

Isoform FGF-8E (identifier: P55075-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS
60 70 80 90 100
QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP
110 120 130 140 150
FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI
160 170 180 190 200
VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH
210 220 230
HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR
Length:233
Mass (Da):26,525
Last modified:October 1, 1996 - v1
Checksum:i4C1EAF932A3A211D
GO
Isoform FGF-8A (identifier: P55075-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-52: Missing.

Show »
Length:204
Mass (Da):23,522
Checksum:i9A4CAB7686A2B190
GO
Isoform FGF-8B (identifier: P55075-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT

Show »
Length:215
Mass (Da):24,711
Checksum:iA39424271EF7CBFF
GO
Isoform FGF-8F (identifier: P55075-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QVTVQSSPNFTQ

Show »
Length:244
Mass (Da):27,715
Checksum:i73DA5874CA918E6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057962
Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
VAR_057963
Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057964
Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057965
Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_057966
Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057967

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 5229Missing in isoform FGF-8A. 3 PublicationsVSP_001525Add
BLAST
Alternative sequencei24 – 5128EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationVSP_001524Add
BLAST
Alternative sequencei52 – 521Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 PublicationsVSP_001526

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78466
, S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
D38752 Genomic DNA. Translation: BAA22527.1.
U46213 mRNA. Translation: AAB40955.1.
U46212 mRNA. Translation: AAB40954.1.
U46211 mRNA. Translation: AAB40953.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
U36223 mRNA. Translation: AAB17893.1.
U36228
, U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
U56978 mRNA. Translation: AAB03787.1.
AB014615 mRNA. Translation: BAA28605.1.
AF520763 Genomic DNA. Translation: AAM55238.1.
CH471066 Genomic DNA. Translation: EAW49746.1.
BC128235 mRNA. Translation: AAI28236.1.
CCDSiCCDS7515.1. [P55075-3]
CCDS7516.1. [P55075-4]
CCDS7517.1. [P55075-1]
CCDS7518.1. [P55075-2]
RefSeqiNP_006110.1. NM_006119.4. [P55075-3]
NP_149353.1. NM_033163.3. [P55075-4]
NP_149354.1. NM_033164.3. [P55075-1]
NP_149355.1. NM_033165.3. [P55075-2]
UniGeneiHs.57710.

Genome annotation databases

EnsembliENST00000320185; ENSP00000321797; ENSG00000107831. [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831.
ENST00000346714; ENSP00000344306; ENSG00000107831. [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831. [P55075-3]
GeneIDi2253.
UCSCiuc001ktp.2. human. [P55075-1]
uc001ktq.2. human. [P55075-4]
uc001ktr.2. human. [P55075-3]
uc001kts.2. human. [P55075-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78466
, S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
D38752 Genomic DNA. Translation: BAA22527.1.
U46213 mRNA. Translation: AAB40955.1.
U46212 mRNA. Translation: AAB40954.1.
U46211 mRNA. Translation: AAB40953.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
U36223 mRNA. Translation: AAB17893.1.
U36228
, U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
U56978 mRNA. Translation: AAB03787.1.
AB014615 mRNA. Translation: BAA28605.1.
AF520763 Genomic DNA. Translation: AAM55238.1.
CH471066 Genomic DNA. Translation: EAW49746.1.
BC128235 mRNA. Translation: AAI28236.1.
CCDSiCCDS7515.1. [P55075-3]
CCDS7516.1. [P55075-4]
CCDS7517.1. [P55075-1]
CCDS7518.1. [P55075-2]
RefSeqiNP_006110.1. NM_006119.4. [P55075-3]
NP_149353.1. NM_033163.3. [P55075-4]
NP_149354.1. NM_033164.3. [P55075-1]
NP_149355.1. NM_033165.3. [P55075-2]
UniGeneiHs.57710.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ProteinModelPortaliP55075.
SMRiP55075. Positions 52-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108544. 1 interaction.
DIPiDIP-59630N.
IntActiP55075. 2 interactions.
STRINGi9606.ENSP00000321797.

PTM databases

PhosphoSiteiP55075.

Polymorphism and mutation databases

BioMutaiFGF8.
DMDMi1706791.

Proteomic databases

PaxDbiP55075.
PRIDEiP55075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320185; ENSP00000321797; ENSG00000107831. [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831.
ENST00000346714; ENSP00000344306; ENSG00000107831. [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831. [P55075-3]
GeneIDi2253.
UCSCiuc001ktp.2. human. [P55075-1]
uc001ktq.2. human. [P55075-4]
uc001ktr.2. human. [P55075-3]
uc001kts.2. human. [P55075-2]

Organism-specific databases

CTDi2253.
GeneCardsiGC10M103530.
GeneReviewsiFGF8.
HGNCiHGNC:3686. FGF8.
MIMi600483. gene.
612702. phenotype.
neXtProtiNX_P55075.
Orphaneti93925. Alobar holoprosencephaly.
478. Kallmann syndrome.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
432. Normosmic congenital hypogonadotropic hypogonadism.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28125.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327940.
GeneTreeiENSGT00730000110785.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP55075.
OMAiAATGFYI.
PhylomeDBiP55075.
TreeFamiTF331233.

Enzyme and pathway databases

ReactomeiREACT_110235. Phospholipase C-mediated cascade: FGFR1.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. FGFR3 mutant receptor activation.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355144. Negative regulation of FGFR3 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355159. SHC-mediated cascade:FGFR4.
REACT_355160. PI-3K cascade:FGFR3.
REACT_355194. SHC-mediated cascade:FGFR1.
REACT_355197. SHC-mediated cascade:FGFR3.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355212. FRS-mediated FGFR3 signaling.
REACT_355216. Phospholipase C-mediated cascade, FGFR4.
REACT_355218. Negative regulation of FGFR1 signaling.
REACT_355221. Signaling by FGFR1 mutants.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355304. PI-3K cascade:FGFR4.
REACT_355313. Signaling by FGFR3 mutants.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_355514. Phospholipase C-mediated cascade, FGFR3.
REACT_355552. PI-3K cascade:FGFR1.
REACT_355580. FRS2-mediated FGFR4 signaling.
REACT_355584. FRS-mediated FGFR1 signaling.
REACT_355588. Negative regulation of FGFR4 signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP55075.

Miscellaneous databases

EvolutionaryTraceiP55075.
GeneWikiiFGF8.
GenomeRNAii2253.
NextBioi9121.
PROiP55075.
SOURCEiSearch...

Gene expression databases

BgeeiP55075.
CleanExiHS_FGF8.
ExpressionAtlasiP55075. baseline and differential.
GenevisibleiP55075. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."
    Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.
    FEBS Lett. 363:226-230(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM FGF-8A).
  2. "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."
    Ghosh A.K., Shankar D.B., Shackleford G.M., Wu K., T'Ang A., Miller G.J., Zheng J., Roy-Burman P.
    Cell Growth Differ. 7:1425-1434(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FGF-8A; FGF-8B AND FGF-8E).
    Tissue: Prostate.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS FGF-8B; FGF-8E AND FGF-8F).
    Tissue: Placenta.
  4. "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."
    Payson R.A., Wu J., Liu Y., Chiu I.-M.
    Oncogene 13:47-53(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS FGF-8A AND FGF-8F).
  5. "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."
    Tanaka S., Ueo H., Mafune K., Mori M., Wands J.R., Sugimachi K.
    Dig. Dis. Sci. 46:1016-1021(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FGF-8F).
    Tissue: Esophageal carcinoma.
  6. NIEHS SNPs program
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM FGF-8F).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FGF-8A).
  9. Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
  10. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  11. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Senataxin modulates neurite growth through fibroblast growth factor 8 signalling."
    Vantaggiato C., Bondioni S., Airoldi G., Bozzato A., Borsani G., Rugarli E.I., Bresolin N., Clementi E., Bassi M.T.
    Brain 134:1808-1828(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."
    Olsen S.K., Li J.Y.H., Bromleigh C., Eliseenkova A.V., Ibrahimi O.A., Lao Z., Zhang F., Linhardt R.J., Joyner A.L., Mohammadi M.
    Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 52-204 IN COMPLEX WITH FGFR2, FUNCTION.
  14. Cited for: VARIANTS HH6 ASN-14; LEU-26; LEU-40; GLU-89; GLY-116 AND MET-218.
  15. Cited for: VARIANTS HH6 LEU-40 AND GLU-89.

Entry informationi

Entry nameiFGF8_HUMAN
AccessioniPrimary (citable) accession number: P55075
Secondary accession number(s): A1A514, Q14915, Q15766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.