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P55075

- FGF8_HUMAN

UniProt

P55075 - FGF8_HUMAN

Protein

Fibroblast growth factor 8

Gene

FGF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.3 Publications

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. growth factor activity Source: UniProtKB
    3. type 1 fibroblast growth factor receptor binding Source: UniProtKB
    4. type 2 fibroblast growth factor receptor binding Source: UniProtKB

    GO - Biological processi

    1. anatomical structure morphogenesis Source: UniProtKB
    2. aorta morphogenesis Source: Ensembl
    3. apoptotic process Source: Ensembl
    4. blood vessel remodeling Source: Ensembl
    5. BMP signaling pathway Source: Ensembl
    6. bone development Source: UniProtKB
    7. branching involved in salivary gland morphogenesis Source: Ensembl
    8. branching involved in ureteric bud morphogenesis Source: Ensembl
    9. canonical Wnt signaling pathway Source: Ensembl
    10. cell migration involved in mesendoderm migration Source: Ensembl
    11. cell proliferation in forebrain Source: Ensembl
    12. corticotropin hormone secreting cell differentiation Source: Ensembl
    13. dopaminergic neuron differentiation Source: UniProtKB
    14. dorsal/ventral axon guidance Source: Ensembl
    15. embryonic hindlimb morphogenesis Source: Ensembl
    16. epidermal growth factor receptor signaling pathway Source: Reactome
    17. epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
    18. Fc-epsilon receptor signaling pathway Source: Reactome
    19. fibroblast growth factor receptor signaling pathway Source: MGI
    20. forebrain dorsal/ventral pattern formation Source: Ensembl
    21. forebrain morphogenesis Source: Ensembl
    22. forebrain neuron development Source: Ensembl
    23. gastrulation Source: UniProtKB
    24. gonad development Source: UniProtKB
    25. heart looping Source: Ensembl
    26. innate immune response Source: Reactome
    27. insulin receptor signaling pathway Source: Reactome
    28. lung morphogenesis Source: Ensembl
    29. male genitalia development Source: Ensembl
    30. MAPK cascade Source: Ensembl
    31. mesodermal cell migration Source: Ensembl
    32. mesonephros development Source: UniProtKB
    33. metanephros development Source: UniProtKB
    34. midbrain-hindbrain boundary development Source: Ensembl
    35. motor neuron axon guidance Source: Ensembl
    36. negative regulation of cardiac muscle tissue development Source: BHF-UCL
    37. negative regulation of neuron apoptotic process Source: Ensembl
    38. neural plate morphogenesis Source: Ensembl
    39. neuroepithelial cell differentiation Source: UniProtKB
    40. neurotrophin TRK receptor signaling pathway Source: Reactome
    41. odontogenesis Source: UniProtKB
    42. organ induction Source: Ensembl
    43. otic vesicle formation Source: Ensembl
    44. outflow tract septum morphogenesis Source: UniProtKB
    45. pallium development Source: Ensembl
    46. patterning of blood vessels Source: Ensembl
    47. pharyngeal system development Source: Ensembl
    48. phosphatidylinositol-mediated signaling Source: Reactome
    49. positive regulation of cell division Source: UniProtKB-KW
    50. positive regulation of cell proliferation Source: UniProtKB
    51. positive regulation of gene expression Source: Ensembl
    52. positive regulation of mitosis Source: Ensembl
    53. positive regulation of organ growth Source: Ensembl
    54. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
    55. response to drug Source: Ensembl
    56. response to organic cyclic compound Source: Ensembl
    57. response to oxidative stress Source: Ensembl
    58. signal transduction involved in regulation of gene expression Source: Ensembl
    59. subpallium development Source: Ensembl
    60. thyroid gland development Source: Ensembl
    61. thyroid-stimulating hormone-secreting cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiP55075.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 8
    Short name:
    FGF-8
    Alternative name(s):
    Androgen-induced growth factor
    Short name:
    AIGF
    Heparin-binding growth factor 8
    Short name:
    HBGF-8
    Gene namesi
    Name:FGF8
    Synonyms:AIGF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:3686. FGF8.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Hypogonadotropic hypogonadism 6 with or without anosmia (HH6) [MIM:612702]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).2 Publications
    Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
    VAR_057962
    Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
    VAR_057963
    Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
    VAR_057964
    Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
    VAR_057965
    Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
    VAR_057966
    Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
    VAR_057967

    Keywords - Diseasei

    Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

    Organism-specific databases

    MIMi612702. phenotype.
    Orphaneti93925. Alobar holoprosencephaly.
    478. Kallmann syndrome.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBiPA28125.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 233211Fibroblast growth factor 8PRO_0000008970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP55075.
    PRIDEiP55075.

    PTM databases

    PhosphoSiteiP55075.

    Expressioni

    Developmental stagei

    In adults expression is restricted to the gonads.

    Gene expression databases

    BgeeiP55075.
    CleanExiHS_FGF8.
    GenevestigatoriP55075.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

    Protein-protein interaction databases

    BioGridi108544. 1 interaction.
    DIPiDIP-59630N.
    IntActiP55075. 2 interactions.
    STRINGi9606.ENSP00000321797.

    Structurei

    Secondary structure

    1
    233
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi52 – 576
    Beta strandi63 – 653
    Beta strandi69 – 768
    Turni77 – 793
    Beta strandi80 – 856
    Beta strandi91 – 955
    Helixi100 – 1023
    Beta strandi104 – 1107
    Turni111 – 1133
    Beta strandi114 – 1196
    Turni120 – 1223
    Beta strandi125 – 1284
    Beta strandi134 – 1385
    Helixi143 – 1453
    Beta strandi146 – 1516
    Beta strandi157 – 1648
    Helixi180 – 1823
    Helixi188 – 1903
    Beta strandi192 – 1954

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FDBX-ray2.28M/N52-204[»]
    ProteinModelPortaliP55075.
    SMRiP55075. Positions 52-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55075.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG327940.
    HOGENOMiHOG000115986.
    HOVERGENiHBG005659.
    KOiK04358.
    OMAiKGHHTTE.
    PhylomeDBiP55075.
    TreeFamiTF331233.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028249. FGF8.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF3. PTHR11486:SF3. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform FGF-8E (identifier: P55075-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS    50
    QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP 100
    FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI 150
    VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH 200
    HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR 233
    Length:233
    Mass (Da):26,525
    Last modified:October 1, 1996 - v1
    Checksum:i4C1EAF932A3A211D
    GO
    Isoform FGF-8A (identifier: P55075-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-52: Missing.

    Show »
    Length:204
    Mass (Da):23,522
    Checksum:i9A4CAB7686A2B190
    GO
    Isoform FGF-8B (identifier: P55075-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT

    Show »
    Length:215
    Mass (Da):24,711
    Checksum:iA39424271EF7CBFF
    GO
    Isoform FGF-8F (identifier: P55075-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-52: Q → QVTVQSSPNFTQ

    Show »
    Length:244
    Mass (Da):27,715
    Checksum:i73DA5874CA918E6A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
    VAR_057962
    Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
    Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
    VAR_057963
    Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
    VAR_057964
    Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
    VAR_057965
    Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
    VAR_057966
    Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
    VAR_057967

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei24 – 5229Missing in isoform FGF-8A. 3 PublicationsVSP_001525Add
    BLAST
    Alternative sequencei24 – 5128EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationVSP_001524Add
    BLAST
    Alternative sequencei52 – 521Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 PublicationsVSP_001526

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78466
    , S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
    D38752 Genomic DNA. Translation: BAA22527.1.
    U46213 mRNA. Translation: AAB40955.1.
    U46212 mRNA. Translation: AAB40954.1.
    U46211 mRNA. Translation: AAB40953.1.
    U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
    U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
    U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
    U36223 mRNA. Translation: AAB17893.1.
    U36228
    , U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
    U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
    U56978 mRNA. Translation: AAB03787.1.
    AB014615 mRNA. Translation: BAA28605.1.
    AF520763 Genomic DNA. Translation: AAM55238.1.
    CH471066 Genomic DNA. Translation: EAW49746.1.
    BC128235 mRNA. Translation: AAI28236.1.
    CCDSiCCDS7515.1. [P55075-3]
    CCDS7516.1. [P55075-4]
    CCDS7517.1. [P55075-1]
    CCDS7518.1. [P55075-2]
    RefSeqiNP_006110.1. NM_006119.4. [P55075-3]
    NP_149353.1. NM_033163.3. [P55075-4]
    NP_149354.1. NM_033164.3. [P55075-1]
    NP_149355.1. NM_033165.3. [P55075-2]
    UniGeneiHs.57710.

    Genome annotation databases

    EnsembliENST00000320185; ENSP00000321797; ENSG00000107831. [P55075-4]
    ENST00000344255; ENSP00000340039; ENSG00000107831. [P55075-1]
    ENST00000346714; ENSP00000344306; ENSG00000107831. [P55075-2]
    ENST00000347978; ENSP00000321945; ENSG00000107831. [P55075-3]
    GeneIDi2253.
    KEGGihsa:2253.
    UCSCiuc001ktp.2. human. [P55075-1]
    uc001ktq.2. human. [P55075-4]
    uc001ktr.2. human. [P55075-3]
    uc001kts.2. human. [P55075-2]

    Polymorphism databases

    DMDMi1706791.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S78466
    , S78462 , S78463 , S78464 , S78465 Genomic DNA. Translation: AAB34255.1 .
    D38752 Genomic DNA. Translation: BAA22527.1 .
    U46213 mRNA. Translation: AAB40955.1 .
    U46212 mRNA. Translation: AAB40954.1 .
    U46211 mRNA. Translation: AAB40953.1 .
    U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50784.1 .
    U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50785.1 .
    U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50782.1 .
    U36223 mRNA. Translation: AAB17893.1 .
    U36228
    , U36225 , U36226 , U36227 Genomic DNA. Translation: AAB17894.1 .
    U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50783.1 .
    U56978 mRNA. Translation: AAB03787.1 .
    AB014615 mRNA. Translation: BAA28605.1 .
    AF520763 Genomic DNA. Translation: AAM55238.1 .
    CH471066 Genomic DNA. Translation: EAW49746.1 .
    BC128235 mRNA. Translation: AAI28236.1 .
    CCDSi CCDS7515.1. [P55075-3 ]
    CCDS7516.1. [P55075-4 ]
    CCDS7517.1. [P55075-1 ]
    CCDS7518.1. [P55075-2 ]
    RefSeqi NP_006110.1. NM_006119.4. [P55075-3 ]
    NP_149353.1. NM_033163.3. [P55075-4 ]
    NP_149354.1. NM_033164.3. [P55075-1 ]
    NP_149355.1. NM_033165.3. [P55075-2 ]
    UniGenei Hs.57710.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FDB X-ray 2.28 M/N 52-204 [» ]
    ProteinModelPortali P55075.
    SMRi P55075. Positions 52-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108544. 1 interaction.
    DIPi DIP-59630N.
    IntActi P55075. 2 interactions.
    STRINGi 9606.ENSP00000321797.

    PTM databases

    PhosphoSitei P55075.

    Polymorphism databases

    DMDMi 1706791.

    Proteomic databases

    PaxDbi P55075.
    PRIDEi P55075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320185 ; ENSP00000321797 ; ENSG00000107831 . [P55075-4 ]
    ENST00000344255 ; ENSP00000340039 ; ENSG00000107831 . [P55075-1 ]
    ENST00000346714 ; ENSP00000344306 ; ENSG00000107831 . [P55075-2 ]
    ENST00000347978 ; ENSP00000321945 ; ENSG00000107831 . [P55075-3 ]
    GeneIDi 2253.
    KEGGi hsa:2253.
    UCSCi uc001ktp.2. human. [P55075-1 ]
    uc001ktq.2. human. [P55075-4 ]
    uc001ktr.2. human. [P55075-3 ]
    uc001kts.2. human. [P55075-2 ]

    Organism-specific databases

    CTDi 2253.
    GeneCardsi GC10M103530.
    GeneReviewsi FGF8.
    HGNCi HGNC:3686. FGF8.
    MIMi 600483. gene.
    612702. phenotype.
    neXtProti NX_P55075.
    Orphaneti 93925. Alobar holoprosencephaly.
    478. Kallmann syndrome.
    93924. Lobar holoprosencephaly.
    280200. Microform holoprosencephaly.
    93926. Midline interhemispheric variant of holoprosencephaly.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    220386. Semilobar holoprosencephaly.
    280195. Septopreoptic holoprosencephaly.
    PharmGKBi PA28125.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327940.
    HOGENOMi HOG000115986.
    HOVERGENi HBG005659.
    KOi K04358.
    OMAi KGHHTTE.
    PhylomeDBi P55075.
    TreeFami TF331233.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121153. Signaling by activated point mutants of FGFR1.
    REACT_121249. Signaling by FGFR3 mutants.
    REACT_121337. Signaling by activated point mutants of FGFR3.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9413. FGFR2c ligand binding and activation.
    REACT_9452. FGFR4 ligand binding and activation.
    REACT_9508. FGFR3b ligand binding and activation.
    REACT_9510. FGFR3c ligand binding and activation.
    REACT_9515. FGFR1c ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki P55075.

    Miscellaneous databases

    EvolutionaryTracei P55075.
    GeneWikii FGF8.
    GenomeRNAii 2253.
    NextBioi 9121.
    PROi P55075.
    SOURCEi Search...

    Gene expression databases

    Bgeei P55075.
    CleanExi HS_FGF8.
    Genevestigatori P55075.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028249. FGF8.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF3. PTHR11486:SF3. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."
      Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.
      FEBS Lett. 363:226-230(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM FGF-8A).
    2. "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."
      Ghosh A.K., Shankar D.B., Shackleford G.M., Wu K., T'Ang A., Miller G.J., Zheng J., Roy-Burman P.
      Cell Growth Differ. 7:1425-1434(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FGF-8A; FGF-8B AND FGF-8E).
      Tissue: Prostate.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS FGF-8B; FGF-8E AND FGF-8F).
      Tissue: Placenta.
    4. "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."
      Payson R.A., Wu J., Liu Y., Chiu I.-M.
      Oncogene 13:47-53(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS FGF-8A AND FGF-8F).
    5. "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."
      Tanaka S., Ueo H., Mafune K., Mori M., Wands J.R., Sugimachi K.
      Dig. Dis. Sci. 46:1016-1021(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FGF-8F).
      Tissue: Esophageal carcinoma.
    6. NIEHS SNPs program
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM FGF-8F).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FGF-8A).
    9. Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
    10. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    11. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    12. "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."
      Olsen S.K., Li J.Y.H., Bromleigh C., Eliseenkova A.V., Ibrahimi O.A., Lao Z., Zhang F., Linhardt R.J., Joyner A.L., Mohammadi M.
      Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 52-204 IN COMPLEX WITH FGFR2, FUNCTION.
    13. Cited for: VARIANTS HH6 ASN-14; LEU-26; LEU-40; GLU-89; GLY-116 AND MET-218.
    14. Cited for: VARIANTS HH6 LEU-40 AND GLU-89.

    Entry informationi

    Entry nameiFGF8_HUMAN
    AccessioniPrimary (citable) accession number: P55075
    Secondary accession number(s): A1A514, Q14915, Q15766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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