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Reviewed, UniProtKB/Swiss-Prot P55075 (FGF8_HUMAN)

Last modified November 25, 2008. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fibroblast growth factor 8
      Short name=FGF-8
Alternative name(s):
    Heparin-binding growth factor 8
      Short name=HBGF-8
    Androgen-induced growth factor
      Short name=AIGF
Gene names
Name: FGF8
Synonyms: AIGF
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.

Subcellular location

Secreted.

Developmental stage

In adults expression is restricted to the gonads.

Sequence similarities

Belongs to the heparin-binding growth factors family.

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Ontologies

Keywords

   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionGrowth factor
Mitogen
   PTMGlycoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Biological processcell proliferation

Non-traceable author statement. Source: UniProtKB

fibroblast growth factor receptor signaling pathway

Inferred from Experiment. Source: Reactome

gastrulation Ref.4

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiongrowth factor activity

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Notes: Additional isoforms seem to exist.
Isoform FGF-8E (identifier: P55075-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform FGF-8A (identifier: P55075-2)

The sequence of this isoform differs from the canonical sequence as follows:
     24-52: Missing.
Isoform FGF-8B (identifier: P55075-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT
Isoform FGF-8F (identifier: P55075-4)

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QVTVQSSPNFTQ

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 233211Fibroblast growth factor 8
PRO_0000008970

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence24 – 5229Missing in isoform FGF-8A.
VSP_001525
Alternative sequence24 – 5128EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B.
VSP_001524
Alternative sequence521Q → QVTVQSSPNFTQ in isoform FGF-8F.
VSP_001526

Secondary structure

1 ................................. 233
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Isoform FGF-8E [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4C1EAF932A3A211D

FASTA23326,525
        10         20         30         40         50         60 
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 

        70         80         90        100        110        120 
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 

       130        140        150        160        170        180 
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 

       190        200        210        220        230 
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR

« Hide

Isoform FGF-8A [UniParc].

Checksum: 9A4CAB7686A2B190
Show »

20423,522
Isoform FGF-8B [UniParc].

Checksum: A39424271EF7CBFF
Show »

21524,711
Isoform FGF-8F [UniParc].

Checksum: 73DA5874CA918E6A
Show »

24427,715

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References

[1]"Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."
Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.
FEBS Lett. 363:226-230(1995) [PubMed: 7737407] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM FGF-8A).
[2]"Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."
Ghosh A.K., Shankar D.B., Shackleford G.M., Wu K., T'Ang A., Miller G.J., Zheng J., Roy-Burman P.
Cell Growth Differ. 7:1425-1434(1996) [PubMed: 8891346] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FGF-8A; FGF-8B AND FGF-8E).
Tissue: Prostate.
[3]"Structure and sequence of human FGF8."
Gemel J., Gorry M., Ehrlich G.D., Macarthur C.A.
Genomics 35:253-257(1996) [PubMed: 8661131] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS FGF-8B; FGF-8E AND FGF-8F).
Tissue: Placenta.
[4]"The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."
Payson R.A., Wu J., Liu Y., Chiu I.-M.
Oncogene 13:47-53(1996) [PubMed: 8700553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS FGF-8A AND FGF-8F).
[5]"A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."
Tanaka S., Ueo H., Mafune K., Mori M., Wands J.R., Sugimachi K.
Dig. Dis. Sci. 46:1016-1021(2001) [PubMed: 11341643] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FGF-8F).
Tissue: Oesophageal carcinoma.
[6]"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."
Rieder M.J., Livingston R.J., Braun A.C., Montoya M.A., Chung M.-W., Miyamoto K.E., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM FGF-8F).
+Additional computationally mapped references.

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Cross-references

Sequence databases

S78466 expand/collapse EMBL AC list , S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
D38752 Genomic DNA. Translation: BAA22527.1.
U46213 mRNA. Translation: AAB40955.1.
U46212 mRNA. Translation: AAB40954.1.
U46211 mRNA. Translation: AAB40953.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
U36223 mRNA. Translation: AAB17893.1.
U36228 expand/collapse EMBL AC list , U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
U56978 mRNA. Translation: AAB03787.1.
AB014615 mRNA. Translation: BAA28605.1.
AF520763 Genomic DNA. Translation: AAM55238.1.
RefSeqNP_149354.1.
UniGeneHs.57710

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ModBaseSearch...

PTM databases

PhosphoSiteP55075.

Polymorphism databases

NIEHS-SNPsSearch...

Genome annotation databases

EnsemblENSG00000107831. Homo sapiens. [Contig view]
GeneID2253.

Organism-specific databases

H-InvDBHIX0035300.
HGNCHGNC:3686. FGF8.
MIM600483. gene.
PharmGKBPA28125.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP55075.

Enzyme and pathway databases

ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpressP55075.
CleanExHS_FGF8.
GermOnlineENSG00000107831. Homo sapiens.

Family and domain databases

InterProIPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio9121.
SOURCESearch...

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Entry information

Entry nameFGF8_HUMAN
AccessionPrimary (citable) accession number: P55075
Secondary accession number(s): Q14915, Q15766
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents