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P55075

- FGF8_HUMAN

UniProt

P55075 - FGF8_HUMAN

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Protein

Fibroblast growth factor 8

Gene

FGF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.3 Publications

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. growth factor activity Source: UniProtKB
  3. type 1 fibroblast growth factor receptor binding Source: UniProtKB
  4. type 2 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

  1. anatomical structure morphogenesis Source: UniProtKB
  2. aorta morphogenesis Source: Ensembl
  3. apoptotic process Source: Ensembl
  4. blood vessel remodeling Source: Ensembl
  5. BMP signaling pathway Source: Ensembl
  6. bone development Source: UniProtKB
  7. branching involved in salivary gland morphogenesis Source: Ensembl
  8. branching involved in ureteric bud morphogenesis Source: Ensembl
  9. canonical Wnt signaling pathway Source: Ensembl
  10. cell migration involved in mesendoderm migration Source: Ensembl
  11. cell proliferation in forebrain Source: Ensembl
  12. corticotropin hormone secreting cell differentiation Source: Ensembl
  13. dopaminergic neuron differentiation Source: UniProtKB
  14. dorsal/ventral axon guidance Source: Ensembl
  15. embryonic hindlimb morphogenesis Source: Ensembl
  16. epidermal growth factor receptor signaling pathway Source: Reactome
  17. epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  18. Fc-epsilon receptor signaling pathway Source: Reactome
  19. fibroblast growth factor receptor signaling pathway Source: MGI
  20. forebrain dorsal/ventral pattern formation Source: Ensembl
  21. forebrain morphogenesis Source: Ensembl
  22. forebrain neuron development Source: Ensembl
  23. gastrulation Source: UniProtKB
  24. gonad development Source: UniProtKB
  25. heart looping Source: Ensembl
  26. innate immune response Source: Reactome
  27. insulin receptor signaling pathway Source: Reactome
  28. lung morphogenesis Source: Ensembl
  29. male genitalia development Source: Ensembl
  30. MAPK cascade Source: Ensembl
  31. mesodermal cell migration Source: Ensembl
  32. mesonephros development Source: UniProtKB
  33. metanephros development Source: UniProtKB
  34. midbrain-hindbrain boundary development Source: Ensembl
  35. motor neuron axon guidance Source: Ensembl
  36. negative regulation of cardiac muscle tissue development Source: BHF-UCL
  37. negative regulation of neuron apoptotic process Source: Ensembl
  38. neural plate morphogenesis Source: Ensembl
  39. neuroepithelial cell differentiation Source: UniProtKB
  40. neurotrophin TRK receptor signaling pathway Source: Reactome
  41. odontogenesis Source: UniProtKB
  42. organ induction Source: Ensembl
  43. otic vesicle formation Source: Ensembl
  44. outflow tract septum morphogenesis Source: UniProtKB
  45. pallium development Source: Ensembl
  46. patterning of blood vessels Source: Ensembl
  47. pharyngeal system development Source: Ensembl
  48. phosphatidylinositol-mediated signaling Source: Reactome
  49. positive regulation of cell division Source: UniProtKB-KW
  50. positive regulation of cell proliferation Source: UniProtKB
  51. positive regulation of gene expression Source: Ensembl
  52. positive regulation of mitosis Source: Ensembl
  53. positive regulation of organ growth Source: Ensembl
  54. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
  55. response to drug Source: Ensembl
  56. response to organic cyclic compound Source: Ensembl
  57. response to oxidative stress Source: Ensembl
  58. signal transduction involved in regulation of gene expression Source: Ensembl
  59. subpallium development Source: Ensembl
  60. thyroid gland development Source: Ensembl
  61. thyroid-stimulating hormone-secreting cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiP55075.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 8
Short name:
FGF-8
Alternative name(s):
Androgen-induced growth factor
Short name:
AIGF
Heparin-binding growth factor 8
Short name:
HBGF-8
Gene namesi
Name:FGF8
Synonyms:AIGF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:3686. FGF8.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 6 with or without anosmia (HH6) [MIM:612702]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).2 Publications
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (PubMed:23643382).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057962
Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
VAR_057963
Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057964
Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057965
Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_057966
Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057967

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MIMi612702. phenotype.
Orphaneti93925. Alobar holoprosencephaly.
478. Kallmann syndrome.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
432. Normosmic congenital hypogonadotropic hypogonadism.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28125.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 233211Fibroblast growth factor 8PRO_0000008970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55075.
PRIDEiP55075.

PTM databases

PhosphoSiteiP55075.

Expressioni

Developmental stagei

In adults expression is restricted to the gonads.

Gene expression databases

BgeeiP55075.
CleanExiHS_FGF8.
ExpressionAtlasiP55075. baseline and differential.
GenevestigatoriP55075.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.3 Publications

Protein-protein interaction databases

BioGridi108544. 1 interaction.
DIPiDIP-59630N.
IntActiP55075. 2 interactions.
STRINGi9606.ENSP00000321797.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 576Combined sources
Beta strandi63 – 653Combined sources
Beta strandi69 – 768Combined sources
Turni77 – 793Combined sources
Beta strandi80 – 856Combined sources
Beta strandi91 – 955Combined sources
Helixi100 – 1023Combined sources
Beta strandi104 – 1107Combined sources
Turni111 – 1133Combined sources
Beta strandi114 – 1196Combined sources
Turni120 – 1223Combined sources
Beta strandi125 – 1284Combined sources
Beta strandi134 – 1385Combined sources
Helixi143 – 1453Combined sources
Beta strandi146 – 1516Combined sources
Beta strandi157 – 1648Combined sources
Helixi180 – 1823Combined sources
Helixi188 – 1903Combined sources
Beta strandi192 – 1954Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ProteinModelPortaliP55075.
SMRiP55075. Positions 52-198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55075.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327940.
GeneTreeiENSGT00730000110785.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiP55075.
KOiK04358.
OMAiKGHHTTE.
PhylomeDBiP55075.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform FGF-8E (identifier: P55075-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS
60 70 80 90 100
QQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP
110 120 130 140 150
FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI
160 170 180 190 200
VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH
210 220 230
HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR
Length:233
Mass (Da):26,525
Last modified:October 1, 1996 - v1
Checksum:i4C1EAF932A3A211D
GO
Isoform FGF-8A (identifier: P55075-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-52: Missing.

Show »
Length:204
Mass (Da):23,522
Checksum:i9A4CAB7686A2B190
GO
Isoform FGF-8B (identifier: P55075-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT

Show »
Length:215
Mass (Da):24,711
Checksum:iA39424271EF7CBFF
GO
Isoform FGF-8F (identifier: P55075-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QVTVQSSPNFTQ

Show »
Length:244
Mass (Da):27,715
Checksum:i73DA5874CA918E6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057962
Natural varianti26 – 261P → L in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
VAR_057963
Natural varianti40 – 401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057964
Natural varianti89 – 891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. 2 Publications
VAR_057965
Natural varianti116 – 1161R → G in HH6; phenotype consistent with Kallmann syndrome. 1 Publication
VAR_057966
Natural varianti218 – 2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. 1 Publication
VAR_057967

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei24 – 5229Missing in isoform FGF-8A. 3 PublicationsVSP_001525Add
BLAST
Alternative sequencei24 – 5128EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B. 1 PublicationVSP_001524Add
BLAST
Alternative sequencei52 – 521Q → QVTVQSSPNFTQ in isoform FGF-8F. 2 PublicationsVSP_001526

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78466
, S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
D38752 Genomic DNA. Translation: BAA22527.1.
U46213 mRNA. Translation: AAB40955.1.
U46212 mRNA. Translation: AAB40954.1.
U46211 mRNA. Translation: AAB40953.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
U36223 mRNA. Translation: AAB17893.1.
U36228
, U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
U56978 mRNA. Translation: AAB03787.1.
AB014615 mRNA. Translation: BAA28605.1.
AF520763 Genomic DNA. Translation: AAM55238.1.
CH471066 Genomic DNA. Translation: EAW49746.1.
BC128235 mRNA. Translation: AAI28236.1.
CCDSiCCDS7515.1. [P55075-3]
CCDS7516.1. [P55075-4]
CCDS7517.1. [P55075-1]
CCDS7518.1. [P55075-2]
RefSeqiNP_006110.1. NM_006119.4. [P55075-3]
NP_149353.1. NM_033163.3. [P55075-4]
NP_149354.1. NM_033164.3. [P55075-1]
NP_149355.1. NM_033165.3. [P55075-2]
UniGeneiHs.57710.

Genome annotation databases

EnsembliENST00000320185; ENSP00000321797; ENSG00000107831. [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831. [P55075-1]
ENST00000346714; ENSP00000344306; ENSG00000107831. [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831. [P55075-3]
GeneIDi2253.
KEGGihsa:2253.
UCSCiuc001ktp.2. human. [P55075-1]
uc001ktq.2. human. [P55075-4]
uc001ktr.2. human. [P55075-3]
uc001kts.2. human. [P55075-2]

Polymorphism databases

DMDMi1706791.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S78466
, S78462 , S78463 , S78464 , S78465 Genomic DNA. Translation: AAB34255.1 .
D38752 Genomic DNA. Translation: BAA22527.1 .
U46213 mRNA. Translation: AAB40955.1 .
U46212 mRNA. Translation: AAB40954.1 .
U46211 mRNA. Translation: AAB40953.1 .
U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50784.1 .
U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50785.1 .
U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50782.1 .
U36223 mRNA. Translation: AAB17893.1 .
U36228
, U36225 , U36226 , U36227 Genomic DNA. Translation: AAB17894.1 .
U47011 , U47009 , U47010 Genomic DNA. Translation: AAC50783.1 .
U56978 mRNA. Translation: AAB03787.1 .
AB014615 mRNA. Translation: BAA28605.1 .
AF520763 Genomic DNA. Translation: AAM55238.1 .
CH471066 Genomic DNA. Translation: EAW49746.1 .
BC128235 mRNA. Translation: AAI28236.1 .
CCDSi CCDS7515.1. [P55075-3 ]
CCDS7516.1. [P55075-4 ]
CCDS7517.1. [P55075-1 ]
CCDS7518.1. [P55075-2 ]
RefSeqi NP_006110.1. NM_006119.4. [P55075-3 ]
NP_149353.1. NM_033163.3. [P55075-4 ]
NP_149354.1. NM_033164.3. [P55075-1 ]
NP_149355.1. NM_033165.3. [P55075-2 ]
UniGenei Hs.57710.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FDB X-ray 2.28 M/N 52-204 [» ]
ProteinModelPortali P55075.
SMRi P55075. Positions 52-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108544. 1 interaction.
DIPi DIP-59630N.
IntActi P55075. 2 interactions.
STRINGi 9606.ENSP00000321797.

PTM databases

PhosphoSitei P55075.

Polymorphism databases

DMDMi 1706791.

Proteomic databases

PaxDbi P55075.
PRIDEi P55075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320185 ; ENSP00000321797 ; ENSG00000107831 . [P55075-4 ]
ENST00000344255 ; ENSP00000340039 ; ENSG00000107831 . [P55075-1 ]
ENST00000346714 ; ENSP00000344306 ; ENSG00000107831 . [P55075-2 ]
ENST00000347978 ; ENSP00000321945 ; ENSG00000107831 . [P55075-3 ]
GeneIDi 2253.
KEGGi hsa:2253.
UCSCi uc001ktp.2. human. [P55075-1 ]
uc001ktq.2. human. [P55075-4 ]
uc001ktr.2. human. [P55075-3 ]
uc001kts.2. human. [P55075-2 ]

Organism-specific databases

CTDi 2253.
GeneCardsi GC10M103530.
GeneReviewsi FGF8.
HGNCi HGNC:3686. FGF8.
MIMi 600483. gene.
612702. phenotype.
neXtProti NX_P55075.
Orphaneti 93925. Alobar holoprosencephaly.
478. Kallmann syndrome.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
432. Normosmic congenital hypogonadotropic hypogonadism.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBi PA28125.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327940.
GeneTreei ENSGT00730000110785.
HOGENOMi HOG000115986.
HOVERGENi HBG005659.
InParanoidi P55075.
KOi K04358.
OMAi KGHHTTE.
PhylomeDBi P55075.
TreeFami TF331233.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121153. Signaling by activated point mutants of FGFR1.
REACT_121249. Signaling by FGFR3 mutants.
REACT_121337. Signaling by activated point mutants of FGFR3.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9413. FGFR2c ligand binding and activation.
REACT_9452. FGFR4 ligand binding and activation.
REACT_9508. FGFR3b ligand binding and activation.
REACT_9510. FGFR3c ligand binding and activation.
REACT_9515. FGFR1c ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinki P55075.

Miscellaneous databases

EvolutionaryTracei P55075.
GeneWikii FGF8.
GenomeRNAii 2253.
NextBioi 9121.
PROi P55075.
SOURCEi Search...

Gene expression databases

Bgeei P55075.
CleanExi HS_FGF8.
ExpressionAtlasi P55075. baseline and differential.
Genevestigatori P55075.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF3. PTHR11486:SF3. 1 hit.
PRINTSi PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."
    Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.
    FEBS Lett. 363:226-230(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM FGF-8A).
  2. "Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."
    Ghosh A.K., Shankar D.B., Shackleford G.M., Wu K., T'Ang A., Miller G.J., Zheng J., Roy-Burman P.
    Cell Growth Differ. 7:1425-1434(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FGF-8A; FGF-8B AND FGF-8E).
    Tissue: Prostate.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS FGF-8B; FGF-8E AND FGF-8F).
    Tissue: Placenta.
  4. "The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."
    Payson R.A., Wu J., Liu Y., Chiu I.-M.
    Oncogene 13:47-53(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS FGF-8A AND FGF-8F).
  5. "A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."
    Tanaka S., Ueo H., Mafune K., Mori M., Wands J.R., Sugimachi K.
    Dig. Dis. Sci. 46:1016-1021(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FGF-8F).
    Tissue: Esophageal carcinoma.
  6. NIEHS SNPs program
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM FGF-8F).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FGF-8A).
  9. Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
  10. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  11. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."
    Olsen S.K., Li J.Y.H., Bromleigh C., Eliseenkova A.V., Ibrahimi O.A., Lao Z., Zhang F., Linhardt R.J., Joyner A.L., Mohammadi M.
    Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 52-204 IN COMPLEX WITH FGFR2, FUNCTION.
  13. Cited for: VARIANTS HH6 ASN-14; LEU-26; LEU-40; GLU-89; GLY-116 AND MET-218.
  14. Cited for: VARIANTS HH6 LEU-40 AND GLU-89.

Entry informationi

Entry nameiFGF8_HUMAN
AccessioniPrimary (citable) accession number: P55075
Secondary accession number(s): A1A514, Q14915, Q15766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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