Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P55075 (FGF8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 8

Short name=FGF-8
Alternative name(s):
Androgen-induced growth factor
Short name=AIGF
Heparin-binding growth factor 8
Short name=HBGF-8
Gene names
Name:FGF8
Synonyms:AIGF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Ref.9 Ref.10 Ref.12

Subunit structure

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.9 Ref.10

Subcellular location

Secreted.

Developmental stage

In adults expression is restricted to the gonads.

Involvement in disease

Hypogonadotropic hypogonadism 6 with or without anosmia (HH6) [MIM:612702]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in FGF8 as well as in other HH-associated genes including FGFR1 (Ref.14). Ref.13 Ref.14

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DiseaseDisease mutation
Hypogonadotropic hypogonadism
Kallmann syndrome
   DomainSignal
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

Fc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

MAPK cascade

Inferred from electronic annotation. Source: Ensembl

anatomical structure morphogenesis

Non-traceable author statement PubMed 8595889. Source: UniProtKB

aorta morphogenesis

Inferred from electronic annotation. Source: Ensembl

apoptotic process

Inferred from electronic annotation. Source: Ensembl

blood vessel remodeling

Inferred from electronic annotation. Source: Ensembl

bone development

Inferred from mutant phenotype Ref.13. Source: UniProtKB

branching involved in salivary gland morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cell migration involved in mesendoderm migration

Inferred from electronic annotation. Source: Ensembl

cell proliferation in forebrain

Inferred from electronic annotation. Source: Ensembl

corticotropin hormone secreting cell differentiation

Inferred from electronic annotation. Source: Ensembl

dopaminergic neuron differentiation

Inferred from direct assay PubMed 15193767. Source: UniProtKB

dorsal/ventral axon guidance

Inferred from electronic annotation. Source: Ensembl

embryonic hindlimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

epithelial to mesenchymal transition involved in endocardial cushion formation

Inferred from sequence or structural similarity. Source: BHF-UCL

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction Ref.9. Source: MGI

forebrain dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

forebrain morphogenesis

Inferred from electronic annotation. Source: Ensembl

forebrain neuron development

Inferred from electronic annotation. Source: Ensembl

gastrulation

Non-traceable author statement Ref.4. Source: UniProtKB

gonad development

Inferred from mutant phenotype Ref.13. Source: UniProtKB

heart looping

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

lung morphogenesis

Inferred from electronic annotation. Source: Ensembl

male genitalia development

Inferred from electronic annotation. Source: Ensembl

mesodermal cell migration

Inferred from electronic annotation. Source: Ensembl

mesonephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

metanephros development

Inferred from expression pattern PubMed 18437684. Source: UniProtKB

midbrain-hindbrain boundary development

Inferred from electronic annotation. Source: Ensembl

motor neuron axon guidance

Inferred from electronic annotation. Source: Ensembl

negative regulation of cardiac muscle tissue development

Inferred from mutant phenotype PubMed 20702560. Source: BHF-UCL

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neural plate morphogenesis

Inferred from electronic annotation. Source: Ensembl

neuroepithelial cell differentiation

Inferred from direct assay PubMed 17309880. Source: UniProtKB

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

odontogenesis

Inferred from expression pattern PubMed 17394220. Source: UniProtKB

organ induction

Inferred from electronic annotation. Source: Ensembl

otic vesicle formation

Inferred from electronic annotation. Source: Ensembl

outflow tract septum morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

pallium development

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

pharyngeal system development

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from direct assay PubMed 17265164. Source: UniProtKB

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of organ growth

Inferred from electronic annotation. Source: Ensembl

regulation of odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

response to oxidative stress

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

subpallium development

Inferred from electronic annotation. Source: Ensembl

thyroid gland development

Inferred from electronic annotation. Source: Ensembl

thyroid-stimulating hormone-secreting cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentexternal side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay Ref.2. Source: UniProtKB

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

growth factor activity

Inferred from direct assay Ref.2PubMed 17265164. Source: UniProtKB

type 1 fibroblast growth factor receptor binding

Inferred from direct assay Ref.12. Source: UniProtKB

type 2 fibroblast growth factor receptor binding

Inferred from direct assay Ref.12. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform FGF-8E (identifier: P55075-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform FGF-8A (identifier: P55075-2)

The sequence of this isoform differs from the canonical sequence as follows:
     24-52: Missing.
Isoform FGF-8B (identifier: P55075-3)

The sequence of this isoform differs from the canonical sequence as follows:
     24-51: EGPGRGPALGRELASLFRAGREPQGVSQ → VTVQSSPNFT
Isoform FGF-8F (identifier: P55075-4)

The sequence of this isoform differs from the canonical sequence as follows:
     52-52: Q → QVTVQSSPNFTQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 233211Fibroblast growth factor 8
PRO_0000008970

Amino acid modifications

Glycosylation1551N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence24 – 5229Missing in isoform FGF-8A.
VSP_001525
Alternative sequence24 – 5128EGPGR…QGVSQ → VTVQSSPNFT in isoform FGF-8B.
VSP_001524
Alternative sequence521Q → QVTVQSSPNFTQ in isoform FGF-8F.
VSP_001526
Natural variant141H → N in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. Ref.13
VAR_057962
Natural variant261P → L in HH6; phenotype consistent with Kallmann syndrome. Ref.13
Corresponds to variant rs137852660 [ dbSNP | Ensembl ].
VAR_057963
Natural variant401F → L in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. Ref.13 Ref.14
VAR_057964
Natural variant891K → E in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; some patients also carry mutations in FGFR1. Ref.13 Ref.14
VAR_057965
Natural variant1161R → G in HH6; phenotype consistent with Kallmann syndrome. Ref.13
VAR_057966
Natural variant2181T → M in HH6; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism. Ref.13
VAR_057967

Secondary structure

................................. 233
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform FGF-8E [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4C1EAF932A3A211D

FASTA23326,525
        10         20         30         40         50         60 
MGSPRSALSC LLLHLLVLCL QAQEGPGRGP ALGRELASLF RAGREPQGVS QQHVREQSLV 

        70         80         90        100        110        120 
TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA 

       130        140        150        160        170        180 
ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG 

       190        200        210        220        230 
SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPR 

« Hide

Isoform FGF-8A [UniParc].

Checksum: 9A4CAB7686A2B190
Show »

FASTA20423,522
Isoform FGF-8B [UniParc].

Checksum: A39424271EF7CBFF
Show »

FASTA21524,711
Isoform FGF-8F [UniParc].

Checksum: 73DA5874CA918E6A
Show »

FASTA24427,715

References

« Hide 'large scale' references
[1]"Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."
Tanaka A., Miyamoto K., Matsuo H., Matsumoto K., Yoshida H.
FEBS Lett. 363:226-230(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM FGF-8A).
[2]"Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."
Ghosh A.K., Shankar D.B., Shackleford G.M., Wu K., T'Ang A., Miller G.J., Zheng J., Roy-Burman P.
Cell Growth Differ. 7:1425-1434(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS FGF-8A; FGF-8B AND FGF-8E).
Tissue: Prostate.
[3]"Structure and sequence of human FGF8."
Gemel J., Gorry M., Ehrlich G.D., Macarthur C.A.
Genomics 35:253-257(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS FGF-8B; FGF-8E AND FGF-8F).
Tissue: Placenta.
[4]"The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."
Payson R.A., Wu J., Liu Y., Chiu I.-M.
Oncogene 13:47-53(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS FGF-8A AND FGF-8F).
[5]"A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma."
Tanaka S., Ueo H., Mafune K., Mori M., Wands J.R., Sugimachi K.
Dig. Dis. Sci. 46:1016-1021(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FGF-8F).
Tissue: Esophageal carcinoma.
[6]NIEHS SNPs program
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM FGF-8F).
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FGF-8A).
[9]"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[10]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[11]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[12]"Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."
Olsen S.K., Li J.Y.H., Bromleigh C., Eliseenkova A.V., Ibrahimi O.A., Lao Z., Zhang F., Linhardt R.J., Joyner A.L., Mohammadi M.
Genes Dev. 20:185-198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 52-204 IN COMPLEX WITH FGFR2, FUNCTION.
[13]"Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice."
Falardeau J., Chung W.C.J., Beenken A., Raivio T., Plummer L., Sidis Y., Jacobson-Dickman E.E., Eliseenkova A.V., Ma J., Dwyer A., Quinton R., Na S., Hall J.E., Huot C., Alois N., Pearce S.H., Cole L.W., Hughes V. expand/collapse author list , Mohammadi M., Tsai P., Pitteloud N.
J. Clin. Invest. 118:2822-2831(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HH6 ASN-14; LEU-26; LEU-40; GLU-89; GLY-116 AND MET-218.
[14]"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Miraoui H., Dwyer A.A., Sykiotis G.P., Plummer L., Chung W., Feng B., Beenken A., Clarke J., Pers T.H., Dworzynski P., Keefe K., Niedziela M., Raivio T., Crowley W.F. Jr., Seminara S.B., Quinton R., Hughes V.A., Kumanov P. expand/collapse author list , Young J., Yialamas M.A., Hall J.E., Van Vliet G., Chanoine J.P., Rubenstein J., Mohammadi M., Tsai P.S., Sidis Y., Lage K., Pitteloud N.
Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HH6 LEU-40 AND GLU-89.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S78466 expand/collapse EMBL AC list , S78462, S78463, S78464, S78465 Genomic DNA. Translation: AAB34255.1.
D38752 Genomic DNA. Translation: BAA22527.1.
U46213 mRNA. Translation: AAB40955.1.
U46212 mRNA. Translation: AAB40954.1.
U46211 mRNA. Translation: AAB40953.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50784.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50785.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50782.1.
U36223 mRNA. Translation: AAB17893.1.
U36228 expand/collapse EMBL AC list , U36225, U36226, U36227 Genomic DNA. Translation: AAB17894.1.
U47011, U47009, U47010 Genomic DNA. Translation: AAC50783.1.
U56978 mRNA. Translation: AAB03787.1.
AB014615 mRNA. Translation: BAA28605.1.
AF520763 Genomic DNA. Translation: AAM55238.1.
CH471066 Genomic DNA. Translation: EAW49746.1.
BC128235 mRNA. Translation: AAI28236.1.
RefSeqNP_006110.1. NM_006119.4.
NP_149353.1. NM_033163.3.
NP_149354.1. NM_033164.3.
NP_149355.1. NM_033165.3.
UniGeneHs.57710.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FDBX-ray2.28M/N52-204[»]
ProteinModelPortalP55075.
SMRP55075. Positions 52-198.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108544. 1 interaction.
DIPDIP-59630N.
STRING9606.ENSP00000321797.

PTM databases

PhosphoSiteP55075.

Polymorphism databases

DMDM1706791.

Proteomic databases

PaxDbP55075.
PRIDEP55075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320185; ENSP00000321797; ENSG00000107831. [P55075-4]
ENST00000344255; ENSP00000340039; ENSG00000107831. [P55075-1]
ENST00000346714; ENSP00000344306; ENSG00000107831. [P55075-2]
ENST00000347978; ENSP00000321945; ENSG00000107831. [P55075-3]
GeneID2253.
KEGGhsa:2253.
UCSCuc001ktp.2. human. [P55075-1]
uc001ktq.2. human. [P55075-4]
uc001ktr.2. human. [P55075-3]
uc001kts.2. human. [P55075-2]

Organism-specific databases

CTD2253.
GeneCardsGC10M103530.
HGNCHGNC:3686. FGF8.
MIM600483. gene.
612702. phenotype.
neXtProtNX_P55075.
Orphanet93925. Alobar holoprosencephaly.
478. Kallmann syndrome.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
432. Normosmic congenital hypogonadotropic hypogonadism.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBPA28125.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327940.
HOGENOMHOG000115986.
HOVERGENHBG005659.
KOK04358.
OMAKGHHTTE.
PhylomeDBP55075.
TreeFamTF331233.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkP55075.

Gene expression databases

BgeeP55075.
CleanExHS_FGF8.
GenevestigatorP55075.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028249. FGF8.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF2. PTHR11486:SF2. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55075.
GeneWikiFGF8.
GenomeRNAi2253.
NextBio9121.
PROP55075.
SOURCESearch...

Entry information

Entry nameFGF8_HUMAN
AccessionPrimary (citable) accession number: P55075
Secondary accession number(s): A1A514, Q14915, Q15766
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM