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Protein

Brevican core protein

Gene

Bcan

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Alternative name(s):
Brain-enriched hyaluronan-binding protein
Short name:
BEHAB
Gene namesi
Name:Bcan
Synonyms:Behab
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2194 Bcan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751323 – 883Brevican core proteinAdd BLAST861

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 136By similarity
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 249By similarity
Disulfide bondi202 ↔ 223By similarity
Disulfide bondi276 ↔ 351By similarity
Disulfide bondi300 ↔ 321By similarity
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei413PhosphoserineCombined sources1
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 657By similarity
Disulfide bondi692 ↔ 784By similarity
Disulfide bondi760 ↔ 776By similarity
Disulfide bondi791 ↔ 834By similarity
Disulfide bondi820 ↔ 847By similarity
Isoform 2 (identifier: P55068-2)
Lipidationi622GPI-anchor amidated serine1 Publication1

Post-translational modificationi

Contains mostly chondroitin sulfate.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP55068
PRIDEiP55068

PTM databases

iPTMnetiP55068
PhosphoSitePlusiP55068
SwissPalmiP55068

Miscellaneous databases

PMAP-CutDBiP55068

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Isoform 1 increases from day P4 to P64. Isoform 2 increases after day P8.

Interactioni

Subunit structurei

Interacts with TNR.1 Publication

Protein-protein interaction databases

BioGridi247431, 1 interactor
STRINGi10116.ENSRNOP00000025496

Structurei

3D structure databases

ProteinModelPortaliP55068
SMRiP55068
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 154Ig-like V-typeAdd BLAST120
Domaini156 – 251Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini256 – 353Link 2PROSITE-ProRule annotationAdd BLAST98
Domaini622 – 658EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini658 – 786C-type lectinPROSITE-ProRule annotationAdd BLAST129
Domaini789 – 849SushiPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IG1W Eukaryota
ENOG410XW3U LUCA
HOGENOMiHOG000115520
HOVERGENiHBG008175
InParanoidiP55068
KOiK06795
PhylomeDBiP55068

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P55068-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG AAQLRGVLGG
60 70 80 90 100
ALAIPCHVHH LRPPPSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN
110 120 130 140 150
EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE
160 170 180 190 200
VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE
210 220 230 240 250
QCDAGWLSDQ TVRYPIQNPR EACYGDMDGY PGVRNYGVVG PDDLYDVYCY
260 270 280 290 300
AEDLNGELFL GAPPGKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC
310 320 330 340 350
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY
360 370 380 390 400
CFRDSAHPSA FSEASSPASD GLEAIVTVTE KLEELQLPQE AVESESRGAI
410 420 430 440 450
YSIPITEDGG GGSSTPEDPA EAPRTPLESE TQSVAPPTGS SEEEGEALEE
460 470 480 490 500
EERFKDTETP KEEKEQENLW VWPTELSSPL PTGLETEHSL SQVSPPAQAV
510 520 530 540 550
LQVGASPSPR PPRVHGPTVE TLQPPGEGSL TSTPDGAREV GGETGSPELS
560 570 580 590 600
GVPREREEAG SSSLEDGPSL LPETWAPVGT REVETPSEEK SGRTVLTGTS
610 620 630 640 650
VQAQPVLPTD SASRGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCVP
660 670 680 690 700
GYGGDLCDVG LHFCSPGWEP FQGACYKHFS TRRSWEEAES QCRALGAHLT
710 720 730 740 750
SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGPPL LYENWNPGQP
760 770 780 790 800
DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA
810 820 830 840 850
QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR
860 870 880
RPARALRSMT APEGPRGQLP RQRKALLTPP SSL
Length:883
Mass (Da):96,057
Last modified:November 1, 1997 - v2
Checksum:iAC7ACC40CB53ED37
GO
Isoform 2 (identifier: P55068-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-645: DCIPSPCHNGGTCLEEKEGFR → NSAEGSMPAFLLFLLLQLWDT
     646-883: Missing.

Show »
Length:645
Mass (Da):69,085
Checksum:i1BC9B7FF08970B89
GO

Sequence cautioni

The sequence CAA82215 differs from that shown. Reason: Frameshift at position 364.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51 – 52AL → WV in CAA82215 (PubMed:7512973).Curated2
Sequence conflicti503V → L in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti518 – 519TV → PA in AAA87847 (PubMed:7488217).Curated2
Sequence conflicti526G → R in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti541G → A in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti556R → S in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti573E → A in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti583V → L in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti649V → L in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti670P → A in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti738P → A in AAA87847 (PubMed:7488217).Curated1
Sequence conflicti809R → A in AAA87847 (PubMed:7488217).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003076625 – 645DCIPS…KEGFR → NSAEGSMPAFLLFLLLQLWD T in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_003077646 – 883Missing in isoform 2. CuratedAdd BLAST238

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79881 mRNA Translation: CAA56255.1
X86406 mRNA Translation: CAA60160.1
U37142 mRNA Translation: AAA87847.1
Z28366 mRNA Translation: CAA82215.1 Frameshift.
PIRiA53908
S49126
RefSeqiNP_001028837.1, NM_001033665.1
NP_037048.2, NM_012916.2
UniGeneiRn.10315
Rn.168035

Genome annotation databases

GeneIDi25393
KEGGirno:25393
UCSCiRGD:2194 rat [P55068-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPGCB_RAT
AccessioniPrimary (citable) accession number: P55068
Secondary accession number(s): Q62860, Q63040, Q63513
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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