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Protein

Neurocan core protein

Gene

Ncan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • central nervous system development Source: GO_Central
  • regulation of synapse structural plasticity Source: MGI
  • skeletal system development Source: GO_Central

Keywordsi

Biological processCell adhesion
LigandCalcium, Hyaluronic acid, Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocan core protein
Alternative name(s):
Chondroitin sulfate proteoglycan 3
Gene namesi
Name:Ncan
Synonyms:Cspg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104694 Ncan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751723 – 1268Neurocan core proteinAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 139By similarity
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi205 ↔ 226By similarity
Disulfide bondi279 ↔ 354By similarity
Disulfide bondi303 ↔ 324By similarity
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi742N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi964 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Glycosylationi978N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi986 ↔ 995By similarity
Disulfide bondi1002 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1022By similarity
Disulfide bondi1024 ↔ 1033By similarity
Disulfide bondi1040 ↔ 1051By similarity
Disulfide bondi1068 ↔ 1160By similarity
Disulfide bondi1136 ↔ 1152By similarity
Disulfide bondi1167 ↔ 1210By similarity
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1196 ↔ 1223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiP55066
PaxDbiP55066
PeptideAtlasiP55066
PRIDEiP55066

PTM databases

PhosphoSitePlusiP55066

Expressioni

Tissue specificityi

Brain.

Gene expression databases

CleanExiMM_NCAN

Interactioni

Protein-protein interaction databases

BioGridi198950, 5 interactors
IntActiP55066, 8 interactors
MINTiP55066
STRINGi10090.ENSMUSP00000002412

Structurei

3D structure databases

ProteinModelPortaliP55066
SMRiP55066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 157Ig-like V-typeAdd BLAST121
Domaini159 – 254Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini258 – 356Link 2PROSITE-ProRule annotationAdd BLAST99
Domaini960 – 996EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini998 – 1034EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1036 – 1165C-type lectinPROSITE-ProRule annotationAdd BLAST130
Domaini1165 – 1225SushiPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJ1R Eukaryota
ENOG410YR39 LUCA
HOGENOMiHOG000170487
HOVERGENiHBG078994
InParanoidiP55066
KOiK06794
PhylomeDBiP55066
TreeFamiTF332134

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.100.10, 3 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 1 hit
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00034 CLECT, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00409 IG, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 3 hits
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
PS50923 SUSHI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGSVWASG LLLLWLLLLV AGDQDTQDTT ATEKGLRMLK SGSGPVRAAL
60 70 80 90 100
AELVALPCFF TLQPRLSSLR DIPRIKWTKV QTASGQRQDL PILVAKDNVV
110 120 130 140 150
RVAKGWQGRV SLPAYPRHRA NATLLLGPLR ASDSGLYRCQ VVKGIEDEQD
160 170 180 190 200
LVTLEVTGVV FHYRAARDRY ALTFAEAQEA CRLSSATIAA PRHLQAAFED
210 220 230 240 250
GFDNCDAGWL SDRTVRYPIT QSRPGCYGDR SSLPGVRSYG RRDPQELYDV
260 270 280 290 300
YCFARELGGE VFYVGPARRL TLAGARAQCQ RQGAALASVG QLHLAWHEGL
310 320 330 340 350
DQCDPGWLAD GSVRYPIQTP RRRCGGPAPG VRTVYRFANR TGFPAPGARF
360 370 380 390 400
DAYCFRAHHH TAQHGDSEIP SSGDEGEIVS AEGPPGRELK PSLGEQEVIA
410 420 430 440 450
PDFQEPLMSS GEGEPPDLTW TQAPEETLGS TPGGPTLASW PSSEKWLFTG
460 470 480 490 500
APSSMGVSSP SDMGVDMEAT TPLGTQVAPT PTMRRGRFKG LNGRHFQQQG
510 520 530 540 550
PEDQLPEVAE PSAQPPTLGA TANHMRPSAA TEASESDQSH SPWAILTNEV
560 570 580 590 600
DEPGAGSLGS RSLPESLMWS PSLISPSVPS TESTPSPKPG AAEAPSVKSA
610 620 630 640 650
IPHLPRLPSE PPAPSPGPSE ALSAVSLQAS SADGSPDFPI VAMLRAPKLW
660 670 680 690 700
LLPRSTLVPN MTPVPLSPAS PLPSWVPEEQ AVRPVSLGAE DLETPFQTTI
710 720 730 740 750
AAPVEASHRS PDADSIEIEG TSSMRATKHP ISGPWASLDS SNVTMNPVPS
760 770 780 790 800
DAGILGTESG VLDLPGSPTS GGQATVEKVL ATWLPLPGQG LDPGSQSTPM
810 820 830 840 850
EAHGVAVSME PTVALEGGAT EGPMEATREV VPSTADATWE SESRSAISST
860 870 880 890 900
HIAVTMARAQ GMPTLTSTSS EGHPEPKGQM VAQESLEPLN TLPSHPWSSL
910 920 930 940 950
VVPMDEVASV SSGEPTGLWD IPSTLIPVSL GLDESVLNVV AESPSVEGFW
960 970 980 990 1000
EEVASGQEDP TDPCENNPCL HGGTCHTNGT VYGCSCDQGY AGENCEIDID
1010 1020 1030 1040 1050
DCLCSPCENG GTCIDEVNGF ICLCLPSYGG SLCEKDTEGC DRGWHKFQGH
1060 1070 1080 1090 1100
CYRYFAHRRA WEDAERDCRR RAGHLTSVHS PEEHKFINSF GHENSWIGLN
1110 1120 1130 1140 1150
DRTVERDFQW TDNTGLQYEN WREKQPDNFF AGGEDCVVMV AHESGRWNDV
1160 1170 1180 1190 1200
PCNYNLPYVC KKGTVLCGPP PAVENASLVG VRKIKYNVHA TVRYQCDEGF
1210 1220 1230 1240 1250
SQHRVATIRC RNNGKWDRPQ IMCIKPRRSH RMRRHHHHPH RHHKPRKEHR
1260
KHKRHPAEDW EKDEGDFC
Length:1,268
Mass (Da):137,200
Last modified:October 1, 1996 - v1
Checksum:i3014E8E202A2FAEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti582E → D in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti587P → A in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti936V → D in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti947E → K in AAH65118 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84727 mRNA Translation: CAA59216.1
BC065118 mRNA Translation: AAH65118.1
AK082298 mRNA Translation: BAC38458.1
CCDSiCCDS22358.1
PIRiS52781
RefSeqiNP_031815.2, NM_007789.3
UniGeneiMm.268079

Genome annotation databases

GeneIDi13004
KEGGimmu:13004
UCSCiuc009lys.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNCAN_MOUSE
AccessioniPrimary (citable) accession number: P55066
Secondary accession number(s): Q6P1E3, Q8C4F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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