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Protein

Neurocan core protein

Gene

Ncan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurocan core protein
Alternative name(s):
Chondroitin sulfate proteoglycan 3
Gene namesi
Name:Ncan
Synonyms:Cspg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104694. Ncan.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001751723 – 1268Neurocan core proteinAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 139By similarity
Glycosylationi121N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi205 ↔ 226By similarity
Disulfide bondi279 ↔ 354By similarity
Disulfide bondi303 ↔ 324By similarity
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi742N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi964 ↔ 975By similarity
Disulfide bondi969 ↔ 984By similarity
Glycosylationi978N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi986 ↔ 995By similarity
Disulfide bondi1002 ↔ 1013By similarity
Disulfide bondi1007 ↔ 1022By similarity
Disulfide bondi1024 ↔ 1033By similarity
Disulfide bondi1040 ↔ 1051By similarity
Disulfide bondi1068 ↔ 1160By similarity
Disulfide bondi1136 ↔ 1152By similarity
Disulfide bondi1167 ↔ 1210By similarity
Glycosylationi1175N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1196 ↔ 1223By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiP55066.
PaxDbiP55066.
PeptideAtlasiP55066.
PRIDEiP55066.

PTM databases

PhosphoSitePlusiP55066.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSMUSG00000002341.
CleanExiMM_NCAN.

Interactioni

Protein-protein interaction databases

IntActiP55066. 2 interactors.
MINTiMINT-4092285.
STRINGi10090.ENSMUSP00000002412.

Structurei

3D structure databases

ProteinModelPortaliP55066.
SMRiP55066.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 157Ig-like V-typeAdd BLAST121
Domaini159 – 254Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini258 – 356Link 2PROSITE-ProRule annotationAdd BLAST99
Domaini960 – 996EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini998 – 1034EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1036 – 1165C-type lectinPROSITE-ProRule annotationAdd BLAST130
Domaini1165 – 1225SushiPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 2 Link domains.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IJ1R. Eukaryota.
ENOG410YR39. LUCA.
HOGENOMiHOG000170487.
HOVERGENiHBG078994.
InParanoidiP55066.
KOiK06794.
PhylomeDBiP55066.
TreeFamiTF332134.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGSVWASG LLLLWLLLLV AGDQDTQDTT ATEKGLRMLK SGSGPVRAAL
60 70 80 90 100
AELVALPCFF TLQPRLSSLR DIPRIKWTKV QTASGQRQDL PILVAKDNVV
110 120 130 140 150
RVAKGWQGRV SLPAYPRHRA NATLLLGPLR ASDSGLYRCQ VVKGIEDEQD
160 170 180 190 200
LVTLEVTGVV FHYRAARDRY ALTFAEAQEA CRLSSATIAA PRHLQAAFED
210 220 230 240 250
GFDNCDAGWL SDRTVRYPIT QSRPGCYGDR SSLPGVRSYG RRDPQELYDV
260 270 280 290 300
YCFARELGGE VFYVGPARRL TLAGARAQCQ RQGAALASVG QLHLAWHEGL
310 320 330 340 350
DQCDPGWLAD GSVRYPIQTP RRRCGGPAPG VRTVYRFANR TGFPAPGARF
360 370 380 390 400
DAYCFRAHHH TAQHGDSEIP SSGDEGEIVS AEGPPGRELK PSLGEQEVIA
410 420 430 440 450
PDFQEPLMSS GEGEPPDLTW TQAPEETLGS TPGGPTLASW PSSEKWLFTG
460 470 480 490 500
APSSMGVSSP SDMGVDMEAT TPLGTQVAPT PTMRRGRFKG LNGRHFQQQG
510 520 530 540 550
PEDQLPEVAE PSAQPPTLGA TANHMRPSAA TEASESDQSH SPWAILTNEV
560 570 580 590 600
DEPGAGSLGS RSLPESLMWS PSLISPSVPS TESTPSPKPG AAEAPSVKSA
610 620 630 640 650
IPHLPRLPSE PPAPSPGPSE ALSAVSLQAS SADGSPDFPI VAMLRAPKLW
660 670 680 690 700
LLPRSTLVPN MTPVPLSPAS PLPSWVPEEQ AVRPVSLGAE DLETPFQTTI
710 720 730 740 750
AAPVEASHRS PDADSIEIEG TSSMRATKHP ISGPWASLDS SNVTMNPVPS
760 770 780 790 800
DAGILGTESG VLDLPGSPTS GGQATVEKVL ATWLPLPGQG LDPGSQSTPM
810 820 830 840 850
EAHGVAVSME PTVALEGGAT EGPMEATREV VPSTADATWE SESRSAISST
860 870 880 890 900
HIAVTMARAQ GMPTLTSTSS EGHPEPKGQM VAQESLEPLN TLPSHPWSSL
910 920 930 940 950
VVPMDEVASV SSGEPTGLWD IPSTLIPVSL GLDESVLNVV AESPSVEGFW
960 970 980 990 1000
EEVASGQEDP TDPCENNPCL HGGTCHTNGT VYGCSCDQGY AGENCEIDID
1010 1020 1030 1040 1050
DCLCSPCENG GTCIDEVNGF ICLCLPSYGG SLCEKDTEGC DRGWHKFQGH
1060 1070 1080 1090 1100
CYRYFAHRRA WEDAERDCRR RAGHLTSVHS PEEHKFINSF GHENSWIGLN
1110 1120 1130 1140 1150
DRTVERDFQW TDNTGLQYEN WREKQPDNFF AGGEDCVVMV AHESGRWNDV
1160 1170 1180 1190 1200
PCNYNLPYVC KKGTVLCGPP PAVENASLVG VRKIKYNVHA TVRYQCDEGF
1210 1220 1230 1240 1250
SQHRVATIRC RNNGKWDRPQ IMCIKPRRSH RMRRHHHHPH RHHKPRKEHR
1260
KHKRHPAEDW EKDEGDFC
Length:1,268
Mass (Da):137,200
Last modified:October 1, 1996 - v1
Checksum:i3014E8E202A2FAEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti582E → D in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti587P → A in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti936V → D in AAH65118 (PubMed:15489334).Curated1
Sequence conflicti947E → K in AAH65118 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84727 mRNA. Translation: CAA59216.1.
BC065118 mRNA. Translation: AAH65118.1.
AK082298 mRNA. Translation: BAC38458.1.
CCDSiCCDS22358.1.
PIRiS52781.
RefSeqiNP_031815.2. NM_007789.3.
UniGeneiMm.268079.

Genome annotation databases

GeneIDi13004.
KEGGimmu:13004.
UCSCiuc009lys.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Neurocan

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84727 mRNA. Translation: CAA59216.1.
BC065118 mRNA. Translation: AAH65118.1.
AK082298 mRNA. Translation: BAC38458.1.
CCDSiCCDS22358.1.
PIRiS52781.
RefSeqiNP_031815.2. NM_007789.3.
UniGeneiMm.268079.

3D structure databases

ProteinModelPortaliP55066.
SMRiP55066.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55066. 2 interactors.
MINTiMINT-4092285.
STRINGi10090.ENSMUSP00000002412.

PTM databases

PhosphoSitePlusiP55066.

Proteomic databases

MaxQBiP55066.
PaxDbiP55066.
PeptideAtlasiP55066.
PRIDEiP55066.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13004.
KEGGimmu:13004.
UCSCiuc009lys.2. mouse.

Organism-specific databases

CTDi1463.
MGIiMGI:104694. Ncan.

Phylogenomic databases

eggNOGiENOG410IJ1R. Eukaryota.
ENOG410YR39. LUCA.
HOGENOMiHOG000170487.
HOVERGENiHBG078994.
InParanoidiP55066.
KOiK06794.
PhylomeDBiP55066.
TreeFamiTF332134.

Enzyme and pathway databases

ReactomeiR-MMU-373760. L1CAM interactions.

Miscellaneous databases

PROiP55066.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002341.
CleanExiMM_NCAN.

Family and domain databases

CDDicd00033. CCP. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCAN_MOUSE
AccessioniPrimary (citable) accession number: P55066
Secondary accession number(s): Q6P1E3, Q8C4F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.